DOI: 10.1016/s0014-5793(01)03204-5. Transferrin binds insulin‐like growth factors and affects binding properties of insulin‐like growth factor binding protein‐3

Transferrin binds insulin‐like growth factors and affects binding properties of insulin‐like growth factor binding protein‐3

10.1016/s0014-5793(01)03204-5

Crossref journal-article

Wiley

FEBS Letters (311)

Abstract

In the circulation, most of the insulin‐like growth factors (IGFs) are bound to a ternary 150 kDa complex with IGF‐binding protein (IGFBP)‐3 and the acid labile subunit. In the current study, we identify transferrin (Tf) by mass spectrometry, and immunoprecipitation as a component of a major IGF‐binding fraction separated from human plasma. IGF ligand blotting, cross‐linkage experiments and surface plasmon resonance spectrometry have been used to demonstrate the capability of Tf to bind IGFs specifically. In combination with Tf, IGFBP‐3 showed a 5‐fold higher affinity for IGF‐II than IGFBP‐3 alone. The data suggest that Tf may play an important role in regulating IGF/IGFBP‐3 functions.

Bibliography

Storch, S., KÃ¼bler, B., HÃ¶ning, S., Ackmann, M., Zapf, J., Blum, W., & Braulke, T. (2001). Transferrin binds insulinâlike growth factors and affects binding properties of insulinâlike growth factor binding proteinâ3. FEBS Letters, 509(3), 395â398. Portico.

Authors 7

Stephan Storch (first)
Bernd Kübler (additional)
Stefan Höning (additional)
Michael Ackmann (additional)
Jürgen Zapf (additional)
Werner Blum (additional)
Thomas Braulke (additional)

References 19 Referenced 22

10.1210/er.16.1.3
10.1152/ajpendo.2000.278.6.E967
10.1074/jbc.M002172200
10.1210/jc.83.8.2843
10.1210/en.137.5.1913
10.1152/ajpendo.1998.275.2.E321
10.1074/jbc.274.42.30215
10.1172/JCI110379
10.1210/jcem-70-5-1292
10.1021/bi992513s
10.1074/jbc.M005548200
10.1074/jbc.272.32.19884
10.1210/jc.86.4.1806
10.1016/S0167-4838(99)00106-5
10.1210/er.20.6.761
{'key': 'e_1_2_6_17_1', 'first-page': '35', 'volume': '35', 'author': 'Beaumont P.P.', 'year': '1998', 'journal-title': 'Semin. Hematol.'} / Semin. Hematol. by Beaumont P.P. (1998)
10.1073/pnas.80.9.2651
10.1021/bp000102t
10.1023/A:1006948027674

Dates

Type	When
Created	22 years, 10 months ago (Oct. 14, 2002, 11:56 a.m.)
Deposited	1 year, 11 months ago (Sept. 16, 2023, 7:17 p.m.)
Indexed	1 year, 6 months ago (Feb. 3, 2024, 2:20 p.m.)
Issued	23 years, 9 months ago (Nov. 29, 2001)
Published	23 years, 9 months ago (Nov. 29, 2001)
Published Online	23 years, 9 months ago (Nov. 29, 2001)
Published Print	23 years, 8 months ago (Dec. 14, 2001)

Funders 0

None

BibTeX

@article{Storch_2001, title={Transferrin binds insulin‐like growth factors and affects binding properties of insulin‐like growth factor binding protein‐3}, volume={509}, ISSN={1873-3468}, url={http://dx.doi.org/10.1016/s0014-5793(01)03204-5}, DOI={10.1016/s0014-5793(01)03204-5}, number={3}, journal={FEBS Letters}, publisher={Wiley}, author={Storch, Stephan and Kübler, Bernd and Höning, Stefan and Ackmann, Michael and Zapf, Jürgen and Blum, Werner and Braulke, Thomas}, year={2001}, month=nov, pages={395–398} }

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