DOI: 10.1016/s0014-5793(01)03103-9. <i>Drosophila</i> Chk2 is required for DNA damage‐mediated cell cycle arrest and apoptosis

Drosophila Chk2 is required for DNA damage‐mediated cell cycle arrest and apoptosis

10.1016/s0014-5793(01)03103-9

Crossref journal-article

Wiley

FEBS Letters (311)

Abstract

Chk2 is a major target of ataxia telangiectasia‐mutated (ATM) and ATM‐ and Rad3‐related (ATR). Germline mutations in Chk2 have been identified in a subset of patients with Li–Fraumeni syndrome, suggesting that Chk2 is a tumor suppressor gene. To investigate the role of Chk2 in multicellular organisms, a Drosophila chk2 (Dmchk2) mutant was generated. Dmchk2 mutants are viable but show defects in maintaining genome stability and are highly sensitive to ionizing radiation. Interestingly, mutating Dmchk2 completely blocks DNA damage‐induced apoptosis and partially blocks DNA damage‐induced cell cycle arrest. These results indicate that Chk2 protein plays a crucial role in the DNA damage response pathway mediating cell cycle arrest and apoptosis, and that the ATM‐Chk2 pathway is likely conserved in Drosophila.

Bibliography

Xu, J., Xin, S., & Du, W. (2001). Drosophila Chk2 is required for DNA damageâmediated cell cycle arrest and apoptosis. FEBS Letters, 508(3), 394â398. Portico.

Authors 3

Jinhua Xu (first)
Shijie Xin (additional)
Wei Du (additional)

References 26 Referenced 71

Dates

Type	When
Created	22 years, 10 months ago (Oct. 14, 2002, 11:56 a.m.)
Deposited	1 year, 11 months ago (Sept. 16, 2023, 4:23 p.m.)
Indexed	1 month, 1 week ago (July 14, 2025, 11:26 p.m.)
Issued	23 years, 9 months ago (Nov. 7, 2001)
Published	23 years, 9 months ago (Nov. 7, 2001)
Published Online	23 years, 9 months ago (Nov. 7, 2001)
Published Print	23 years, 9 months ago (Nov. 23, 2001)

Funders 0

None

BibTeX

@article{Xu_2001, title={Drosophila Chk2 is required for DNA damage‐mediated cell cycle arrest and apoptosis}, volume={508}, ISSN={1873-3468}, url={http://dx.doi.org/10.1016/s0014-5793(01)03103-9}, DOI={10.1016/s0014-5793(01)03103-9}, number={3}, journal={FEBS Letters}, publisher={Wiley}, author={Xu, Jinhua and Xin, Shijie and Du, Wei}, year={2001}, month=nov, pages={394–398} }

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