DOI: 10.1016/s0014-5793(00)02145-1. Malignant transformation of B lymphoma cell line BJAB by Epstein

Malignant transformation of B lymphoma cell line BJAB by Epstein–Barr virus‐encoded small RNAs

10.1016/s0014-5793(00)02145-1

Crossref journal-article

Wiley

FEBS Letters (311)

Abstract

EBV‐encoded small RNAs (EBERs) are non‐polyadenylated and abundantly transcribed RNAs, whose functions have not yet been fully elucidated. Here, we report that the EBV‐negative B lymphoma cell line, BJAB, was rendered more malignant and resistant to apoptosis by EBERs. EBER‐transfected cells exhibited enhanced growth potential in SCID mice as well as in soft agar, and showed resistance to apoptotic stimuli in comparison with the vector control. EBERs inhibited the activity of the double‐stranded RNA‐dependent protein kinase, PKR, which is reputed to act as a tumor‐suppressor. These results suggest that EBERs play an important role in the pathogenesis of EBV‐associated malignancies through the inhibition of PKR.

Bibliography

Yamamoto, N., Takizawa, T., Iwanaga, Y., Shimizu, N., & Yamamoto, N. (2000). Malignant transformation of B lymphoma cell line BJAB by EpsteinâBarr virusâencoded small RNAs. FEBS Letters, 484(2), 153â158. Portico.

Authors 5

Norio Yamamoto (first)
Takenori Takizawa (additional)
Yoichi Iwanaga (additional)
Norio Shimizu (additional)
Naoki Yamamoto (additional)

References 47 Referenced 65

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Dates

Type	When
Created	23 years, 1 month ago (July 25, 2002, 1:18 p.m.)
Deposited	1 year, 11 months ago (Sept. 16, 2023, 7:45 p.m.)
Indexed	3 weeks, 4 days ago (Aug. 3, 2025, 6:50 p.m.)
Issued	24 years, 9 months ago (Oct. 31, 2000)
Published	24 years, 9 months ago (Oct. 31, 2000)
Published Online	24 years, 9 months ago (Oct. 31, 2000)
Published Print	24 years, 9 months ago (Nov. 3, 2000)

Funders 0

None

BibTeX

@article{Yamamoto_2000, title={Malignant transformation of B lymphoma cell line BJAB by Epstein–Barr virus‐encoded small RNAs}, volume={484}, ISSN={1873-3468}, url={http://dx.doi.org/10.1016/s0014-5793(00)02145-1}, DOI={10.1016/s0014-5793(00)02145-1}, number={2}, journal={FEBS Letters}, publisher={Wiley}, author={Yamamoto, Norio and Takizawa, Takenori and Iwanaga, Yoichi and Shimizu, Norio and Yamamoto, Naoki}, year={2000}, month=oct, pages={153–158} }

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