DOI: 10.1016/s0014-5793(00)01662-8. Bacterial protein translocase: a unique molecular machine with an army of substrates

Bacterial protein translocase: a unique molecular machine with an army of substrates

10.1016/s0014-5793(00)01662-8

Crossref journal-article

Wiley

FEBS Letters (311)

Abstract

Secretion of most polypeptides across the bacterial plasma membrane is catalyzed by the Sec protein translocase. This complex molecular machine comprises a flexible transmembrane conduit coupled to a motor‐like component and displays four activities: (a) it is a specific receptor at its cytoplasmic side for all secretory polypeptides, (b) it converts metabolic energy from ATP and proton gradients into mechanical motion, (c) it prevents substrates from folding in statu translocanti and (d) it binds and releases short segments of the polymeric substrate sequentially. Combination of these activities allows translocase to move processively along the length of the substrate. Substrates are thus gradually expelled from the membrane and are released for subsequent extracytoplasmic folding.

Bibliography

Economou, A. (2000). Bacterial protein translocase: a unique molecular machine with an army of substrates. FEBS Letters, 476(1â2), 18â21. Portico.

Authors 1

Anastassios Economou (first)

References 48 Referenced 30

Dates

Type	When
Created	23 years, 1 month ago (July 25, 2002, 12:02 p.m.)
Deposited	1 year, 11 months ago (Sept. 16, 2023, 1:47 p.m.)
Indexed	5 months, 2 weeks ago (March 19, 2025, 11:23 a.m.)
Issued	25 years, 2 months ago (June 26, 2000)
Published	25 years, 2 months ago (June 26, 2000)
Published Online	25 years, 2 months ago (June 26, 2000)
Published Print	25 years, 2 months ago (June 30, 2000)

Funders 0

None

BibTeX

@article{Economou_2000, title={Bacterial protein translocase: a unique molecular machine with an army of substrates}, volume={476}, ISSN={1873-3468}, url={http://dx.doi.org/10.1016/s0014-5793(00)01662-8}, DOI={10.1016/s0014-5793(00)01662-8}, number={1–2}, journal={FEBS Letters}, publisher={Wiley}, author={Economou, Anastassios}, year={2000}, month=jun, pages={18–21} }

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