DOI: 10.1016/s0014-5793(00)01416-2. MAPK‐dependent expression of p21<sup>WAF</sup> and p27<sup>kip1</sup> in PMA‐induced differentiation of HL60 cells

MAPK‐dependent expression of p21WAF and p27kip1 in PMA‐induced differentiation of HL60 cells

10.1016/s0014-5793(00)01416-2

Crossref journal-article

Wiley

FEBS Letters (311)

Abstract

Treatment of HL60 cells with phorbol 12‐myristate 13‐acetate (PMA) results in growth arrest and differentiation towards the macrophage lineage. PMA‐induced changes are easily monitored by morphological changes while cells in suspension start adhering onto substrate. PMA induces rapid activation of the extracellular signal‐regulated kinases (ERKs). Activation of the ERK pathway is essential to PMA‐induced differentiation of HL60 cells. PMA also induces the expression of the cyclin‐dependent kinase inhibitors p21WAF and p27kip1, which is modulated by the use of an inhibitor of the ERK cascade. This implies that a link exists between ERK activation and p21WAF and p27kip1 induction in the process of terminal differentiation.

Bibliography

Das, D., Pintucci, G., & Stern, A. (2000). MAPKâdependent expression of p21WAF and p27kip1 in PMAâinduced differentiation of HL60 cells. FEBS Letters, 472(1), 50â52. Portico.

Authors 3

Dipak Das (first)
Giuseppe Pintucci (additional)
Arnold Stern (additional)

References 13 Referenced 84

10.1016/S0021-9258(19)38423-6
10.1073/pnas.86.18.6940
10.1016/S0021-9258(19)39623-1
10.1091/mbc.3.5.545
10.1074/jbc.271.14.8161
10.1073/pnas.94.2.448
10.1126/science.7863329
10.1016/0092-8674(93)90500-P
{'key': 'e_1_2_6_10_1', 'first-page': '3391', 'volume': '54', 'author': 'Michieli P.', 'year': '1994', 'journal-title': 'Cancer Res.'} / Cancer Res. by Michieli P. (1994)
{'key': 'e_1_2_6_11_1', 'first-page': '668', 'volume': '55', 'author': 'Zhang W.', 'year': '1995', 'journal-title': 'Cancer Res.'} / Cancer Res. by Zhang W. (1995)
10.1074/jbc.272.37.23366
10.1074/jbc.272.38.24002
{'key': 'e_1_2_6_14_1', 'first-page': '31', 'volume': '56', 'author': 'Liu Y.', 'year': '1996', 'journal-title': 'Cancer Res.'} / Cancer Res. by Liu Y. (1996)

Dates

Type	When
Created	23 years, 1 month ago (July 25, 2002, 10:22 p.m.)
Deposited	1 year, 11 months ago (Sept. 16, 2023, 10:09 a.m.)
Indexed	4 months, 1 week ago (April 19, 2025, 4:47 a.m.)
Issued	25 years, 4 months ago (April 20, 2000)
Published	25 years, 4 months ago (April 20, 2000)
Published Online	25 years, 4 months ago (April 20, 2000)
Published Print	25 years, 4 months ago (April 21, 2000)

Funders 0

None

BibTeX

@article{Das_2000, title={MAPK‐dependent expression of p21WAF and p27kip1 in PMA‐induced differentiation of HL60 cells}, volume={472}, ISSN={1873-3468}, url={http://dx.doi.org/10.1016/s0014-5793(00)01416-2}, DOI={10.1016/s0014-5793(00)01416-2}, number={1}, journal={FEBS Letters}, publisher={Wiley}, author={Das, Dipak and Pintucci, Giuseppe and Stern, Arnold}, year={2000}, month=apr, pages={50–52} }

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