DOI: 10.1016/s0014-5793(00)01134-0. The molecular chaperone Cdc37 is required for Ste11 function and pheromone‐induced cell cycle arrest

The molecular chaperone Cdc37 is required for Ste11 function and pheromone‐induced cell cycle arrest

10.1016/s0014-5793(00)01134-0

Crossref journal-article

Wiley

FEBS Letters (311)

Abstract

The molecular chaperone Cdc37 is thought to act in part as a targeting subunit of the heat‐shock protein 90 (Hsp90) chaperone complex. We demonstrate here that Cdc37 is required for activity of the kinase Ste11 in budding yeast. A cdc37 mutant strain is defective in Ste11‐mediated pheromone signaling and in accumulation and functional maturation of the constitutively active Ste11 version Ste11ΔN. Moreover, Cdc37, Ste11ΔN and Hsp90 coprecipitate pairwise. Thus, Hsp90 and Cdc37 may transiently associate with Ste11 to promote proper folding and/or association with additional regulatory factors. Our results establish Ste11 as the first endogenous Cdc37 client protein in yeast.

Bibliography

Abbas-Terki, T., DonzÃ©, O., & Picard, D. (2000). The molecular chaperone Cdc37 is required for Ste11 function and pheromoneâinduced cell cycle arrest. FEBS Letters, 467(1), 111â116. Portico.

Authors 3

Toufik Abbas-Terki (first)
Olivier Donzé (additional)
Didier Picard (additional)

References 40 Referenced 46

Dates

Type	When
Created	23 years, 1 month ago (July 25, 2002, 1:52 p.m.)
Deposited	1 year, 11 months ago (Sept. 16, 2023, 9:26 p.m.)
Indexed	1 week, 6 days ago (Aug. 19, 2025, 7:03 a.m.)
Issued	25 years, 6 months ago (Feb. 2, 2000)
Published	25 years, 6 months ago (Feb. 2, 2000)
Published Online	25 years, 6 months ago (Feb. 2, 2000)
Published Print	25 years, 6 months ago (Feb. 4, 2000)

Funders 0

None

BibTeX

@article{Abbas_Terki_2000, title={The molecular chaperone Cdc37 is required for Ste11 function and pheromone‐induced cell cycle arrest}, volume={467}, ISSN={1873-3468}, url={http://dx.doi.org/10.1016/s0014-5793(00)01134-0}, DOI={10.1016/s0014-5793(00)01134-0}, number={1}, journal={FEBS Letters}, publisher={Wiley}, author={Abbas-Terki, Toufik and Donzé, Olivier and Picard, Didier}, year={2000}, month=feb, pages={111–116} }

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