DOI: 10.1016/s0006-3495(03)75103-0. Evidence for Membrane Thinning Effect as the Mechanism for Peptide-Induced Pore Formation

Evidence for Membrane Thinning Effect as the Mechanism for Peptide-Induced Pore Formation

10.1016/s0006-3495(03)75103-0

Crossref journal-article

Elsevier BV

Biophysical Journal (78)

Bibliography

Chen, F.-Y., Lee, M.-T., & Huang, H. W. (2003). Evidence for Membrane Thinning Effect as the Mechanism for Peptide-Induced Pore Formation. Biophysical Journal, 84(6), 3751â3758.

Authors 3

Fang-Yu Chen (first)
Ming-Tao Lee (additional)
Huey W. Huang (additional)

References 54 Referenced 245

10.1016/S0006-3495(94)80466-7 / Biophys. J. / Collisions between helical peptides in membranes monitored using electron paramagnetic resonance: evidence that alamethicin is monomeric in the absence of a membrane potential by Barranger-Mathys (1993)
10.1002/jss.400020504 / J. Supramol. Struct. / A molecular model of membrane excitability by Baumann (1974)
10.1007/BF01877228 / J. Biomol. NMR. / Orientations of amphipathic helical peptides in membrane bilayers determined by solid-state NMR spectroscopy by Bechinger (1991)
10.1016/0022-2836(71)90082-9 / J. Mol. Biol. / Structure of the nerve myelin membrane: proof of the low resolution profile by Blaurock (1971)
{'key': '10.1016/S0006-3495(03)75103-0_bib5', 'series-title': 'Antimicrobial peptides. Ciba Foundation Symposium 186', 'author': 'Boman', 'year': '1994'} / Antimicrobial peptides. Ciba Foundation Symposium 186 by Boman (1994)
10.1103/PhysRevLett.79.4026 / Phys. Rev. Lett. / Critical swelling of phospholipid bilayers by Chen (1997)
10.1016/S0006-3495(02)75452-0 / Biophys. J. / Sigmoidal concentration dependence of antimicrobial peptide activities: a case study on alamethicin by Chen (2002)
10.1021/ja00393a035 / J. Am. Chem. Soc. / Design, synthesis, and characterization of a cytotoxic peptide with melittin-like activity by DeGrado (1981)
10.1021/j100300a003 / J. Phys. Chem. / Physical properties of surfactant bilayer membranes: thermal transitions, elasticity, rigidity, cohesion, and colloidal interactions by Evans (1987)
10.1126/science.286.5439.420 / Science. / Defensins and host defense by Ganz (1999)
10.1021/bi00201a016 / Biochemistry / Mode of action of the antibacterial cecropin B2: a spectrofluorometric study by Gazit (1994)
10.1021/bi00036a021 / Biochemistry / Interaction of the mammalian antibacterial peptide cecropin P1 with phospholipid vesicles by Gazit (1995)
{'key': '10.1016/S0006-3495(03)75103-0_bib13', 'series-title': 'X-ray diffraction in crystals, imperfect crystals, and amorphous bodies', 'author': 'Guinier', 'year': '1994'} / X-ray diffraction in crystals, imperfect crystals, and amorphous bodies by Guinier (1994)
10.1016/S0006-3495(99)77257-7 / Biophys. J. / Experimental evidence for hydrophobic matching and membrane-mediated interactions in lipid bilayers containing gramicidin by Harroun (1999)
10.1016/S0006-3495(99)77469-2 / Biophys. J. / Theoretical analysis of hydrophobic matching and membrane-mediated interactions in lipid bilayers containing gramicidin by Harroun (1999)
10.1021/bi00048a002 / Biochemistry / Antimicrobial peptide pores in membranes detected by neutron in-plane scattering by He (1995)
10.1016/S0006-3495(96)79835-1 / Biophys. J. / Neutron scattering in the plane of membranes: structure of alamethicin pores by He (1996)
10.1016/0304-4157(75)90016-7 / Biochim. Biophys. Acta. / Solubilization of membranes by detergents by Helenius (1975)
10.1016/S0006-3495(97)78064-0 / Biophys. J. / Effect of changing the size of lipid headgroup on peptide insertion into membranes by Heller (1997)
10.1021/bi981314q / Biochemistry / Multiple states of β-sheet peptide protegrin in lipid bilayers by Heller (1998)
10.1021/bi991892m / Biochemistry / Membrane thinning effect of the β-sheet antimicrobial protegrin by Heller (2000)
10.1021/bi961468a / Biochemistry / Secondary structure and location of a magainin analogue in synthetic phospholipid bilayers by Hirsh (1996)
10.1016/S0006-3495(86)83550-0 / Biophys. J. / Deformation free energy of bilayer membrane and its effect on gramicidin channel lifetime by Huang (1986)
10.1051/jp2:1995103 / J. Phys. II France. / Elasticity of lipid bilayer interaction with amphiphilic helical peptides by Huang (1995)
10.1021/bi000946l / Biochemistry. / Action of antimicrobial peptides: two-state model by Huang (2000)
10.1016/S0006-3495(91)82144-0 / Biophys. J. / Lipid-alamethicin interactions influence alamethicin orientation by Huang (1991)
10.1016/S0005-2736(00)00221-2 / Biochim. Biophys. Acta. / Order-disorder transition in bilayers of diphytanoyl phosphatidylcholine by Hung (2000)
10.1016/0005-2736(94)90050-7 / Biochim. Biophys. Acta. / Cooperative membrane insertion of magainin correlated with its cytolytic activity by Ludtke (1994)
10.1021/bi00051a026 / Biochemistry / Membrane thinning caused by magainin 2 by Ludtke (1995)
10.1021/bi9620621 / Biochemistry / Membrane pores induced by magainin by Ludtke (1996)
10.1021/bi00365a034 / Biochemistry / Area per molecule and distribution of water in fully hydrated dilauroylphosphatidylethanolamine bilayers by McIntosh (1986)
10.1002/jlb.58.2.128 / J. Leukoc. Biol. / Defensins and other endogenous peptide antibiotics of vertebrates by Martin (1995)
10.1016/0005-2736(91)90366-G / Biochim. Biophys. Acta. / Physicochemical determinants for the interactions of magainins 1 and 2 with acidic lipid blayers by Matsuzaki (1991)
10.1021/bi00177a027 / Biochemistry / Orientational and aggregational states of magainin 2 in phospholipid bilayers by Matsuzaki (1994)
10.1021/bi00019a033 / Biochemistry / Translocation of a channel-forming antimicrobial peptide, magainin 2, across lipid bilayers by forming a pore by Matsuzaki (1995)
10.1021/bi960016v / Biochemistry / An antimicrobial peptide, magainin 2, induced rapid flip-flop of phospholipids coupled with pore formation and peptide translocation by Matsuzaki (1996)
{'key': '10.1016/S0006-3495(03)75103-0_bib37', 'series-title': 'Antimicrobial peptides Ciba Foundation Symposium 186', 'first-page': '5', 'article-title': 'Design and synthesis of antimicrobial peptides', 'author': 'Merrifield', 'year': '1994'} / Antimicrobial peptides Ciba Foundation Symposium 186 / Design and synthesis of antimicrobial peptides by Merrifield (1994)
10.1016/S0304-4157(00)00016-2 / Biochim. Biophys. Acta. / Structure of lipid bilayers by Nagle (2000)
10.1021/bi00198a009 / Biochemistry / Vesicle-bound conformation of melittin: transferred nuclear Overhauser enhancement analysis in the presence of perdeuterated phosphatidylcholine vesicles by Okada (1994)
10.1063/1.455047 / J. Chem. Phys. / Circular dichroism of oriented α-helices. I. Proof of the exciton theory by Olah (1988)
10.1016/0022-2836(91)90272-8 / J. Mol. Biol. / Location of ion binding sites in the gramicidin channel by x-ray diffraction by Olah (1991)
{'key': '10.1016/S0006-3495(03)75103-0_bib42', 'first-page': '264', 'article-title': 'The structure of haemoglobin. III. Direct determination of the molecular transform', 'volume': '225', 'author': 'Perutz', 'year': '1954', 'journal-title': 'Proc. R. Soc. A.'} / Proc. R. Soc. A. / The structure of haemoglobin. III. Direct determination of the molecular transform by Perutz (1954)
10.1016/S0006-3495(00)76295-3 / Biophys. J. / Effect of chain length and unsaturation on elasticity of lipid bilayers by Rawicz (2000)
10.1021/bi962304x / Biochemistry / The tendency of magainin to associate upon binding to phospholipid bilayers by Schümann (1996)
10.1063/1.457764 / J. Chem. Phys. / X-ray structural studies of freely suspended ordered hydrated DMPC mutimembrane films by Smith (1990)
10.1016/0005-2736(88)90069-7 / Biochim. Biophys. Acta. / Binding and action of cecropin and cecropin analogues: antibacterial peptides from insects by Steiner (1988)
10.1016/S0006-3495(82)84683-3 / Biophys. J. / The structure of melittin in the form I crystals and its implication for melittin’s lytic and surface activities by Terwilliger (1982)
10.1016/0022-5193(76)90129-6 / J. Theor. Biol. / X-ray diffraction studies of lecithin bilayers by Torbet (1976)
10.1021/bi025853d / Biochemistry / Two states of cyclic antimicrobial peptide RTD-1 in lipid bilayers by Weiss (2002)
10.1021/bi00470a031 / Biochemistry / Raman spectroscopy of synthetic antimicrobial frog peptides magainin 2a and PGLa by Williams (1990)
10.1016/S0006-3495(90)82599-6 / Biophys. J. / Method of oriented circular dichroism by Wu (1990)
10.1016/S0006-3495(95)80418-2 / Biophys. J. / X-ray diffraction study of lipid bilayer membrane interacting with amphiphilic helical peptides: diphytanoyl phosphatidylcholine with alamethicin at low concentrations by Wu (1995)
10.1016/S0006-3495(01)75802-X / Biophys. J. / Barrel-stave model or toroidal model? A case study on melittin pores by Yang (2001)
10.1038/415389a / Nature / Antimicrobial peptides of multicellular organisms by Zasloff (2002)

Dates

Type	When
Created	16 years, 8 months ago (Jan. 6, 2009, 2:33 a.m.)
Deposited	6 years, 6 months ago (Feb. 8, 2019, 4:53 p.m.)
Indexed	2 weeks, 3 days ago (Aug. 21, 2025, 1:56 p.m.)
Issued	22 years, 3 months ago (June 1, 2003)
Published	22 years, 3 months ago (June 1, 2003)
Published Print	22 years, 3 months ago (June 1, 2003)

Funders 0

None

BibTeX

@article{Chen_2003, title={Evidence for Membrane Thinning Effect as the Mechanism for Peptide-Induced Pore Formation}, volume={84}, ISSN={0006-3495}, url={http://dx.doi.org/10.1016/s0006-3495(03)75103-0}, DOI={10.1016/s0006-3495(03)75103-0}, number={6}, journal={Biophysical Journal}, publisher={Elsevier BV}, author={Chen, Fang-Yu and Lee, Ming-Tao and Huang, Huey W.}, year={2003}, month=jun, pages={3751–3758} }

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      "author": "Evans",
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      "article-title": "Lipid-alamethicin interactions influence alamethicin orientation",
      "volume": "60",
      "author": "Huang",
      "year": "1991",
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      "first-page": "198",
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      "volume": "1467",
      "author": "Hung",
      "year": "2000",
      "journal-title": "Biochim. Biophys. Acta."
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      "author": "Ludtke",
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      "first-page": "13723",
      "DOI": "10.1021/bi9620621",
      "article-title": "Membrane pores induced by magainin",
      "volume": "35",
      "author": "Ludtke",
      "year": "1996",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1016/S0006-3495(03)75103-0_bib31",
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      "first-page": "4948",
      "DOI": "10.1021/bi00365a034",
      "article-title": "Area per molecule and distribution of water in fully hydrated dilauroylphosphatidylethanolamine bilayers",
      "volume": "25",
      "author": "McIntosh",
      "year": "1986",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1016/S0006-3495(03)75103-0_bib32",
      "doi-asserted-by": "crossref",
      "first-page": "128",
      "DOI": "10.1002/jlb.58.2.128",
      "article-title": "Defensins and other endogenous peptide antibiotics of vertebrates",
      "volume": "58",
      "author": "Martin",
      "year": "1995",
      "journal-title": "J. Leukoc. Biol."
    },
    {
      "key": "10.1016/S0006-3495(03)75103-0_bib33",
      "doi-asserted-by": "crossref",
      "first-page": "162",
      "DOI": "10.1016/0005-2736(91)90366-G",
      "article-title": "Physicochemical determinants for the interactions of magainins 1 and 2 with acidic lipid blayers",
      "volume": "1063",
      "author": "Matsuzaki",
      "year": "1991",
      "journal-title": "Biochim. Biophys. Acta."
    },
    {
      "key": "10.1016/S0006-3495(03)75103-0_bib34",
      "doi-asserted-by": "crossref",
      "first-page": "3342",
      "DOI": "10.1021/bi00177a027",
      "article-title": "Orientational and aggregational states of magainin 2 in phospholipid bilayers",
      "volume": "33",
      "author": "Matsuzaki",
      "year": "1994",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1016/S0006-3495(03)75103-0_bib35",
      "doi-asserted-by": "crossref",
      "first-page": "6521",
      "DOI": "10.1021/bi00019a033",
      "article-title": "Translocation of a channel-forming antimicrobial peptide, magainin 2, across lipid bilayers by forming a pore",
      "volume": "34",
      "author": "Matsuzaki",
      "year": "1995",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1016/S0006-3495(03)75103-0_bib36",
      "doi-asserted-by": "crossref",
      "first-page": "11361",
      "DOI": "10.1021/bi960016v",
      "article-title": "An antimicrobial peptide, magainin 2, induced rapid flip-flop of phospholipids coupled with pore formation and peptide translocation",
      "volume": "35",
      "author": "Matsuzaki",
      "year": "1996",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1016/S0006-3495(03)75103-0_bib37",
      "series-title": "Antimicrobial peptides Ciba Foundation Symposium 186",
      "first-page": "5",
      "article-title": "Design and synthesis of antimicrobial peptides",
      "author": "Merrifield",
      "year": "1994"
    },
    {
      "key": "10.1016/S0006-3495(03)75103-0_bib38",
      "doi-asserted-by": "crossref",
      "first-page": "159",
      "DOI": "10.1016/S0304-4157(00)00016-2",
      "article-title": "Structure of lipid bilayers",
      "volume": "1469",
      "author": "Nagle",
      "year": "2000",
      "journal-title": "Biochim. Biophys. Acta."
    },
    {
      "key": "10.1016/S0006-3495(03)75103-0_bib39",
      "doi-asserted-by": "crossref",
      "first-page": "9438",
      "DOI": "10.1021/bi00198a009",
      "article-title": "Vesicle-bound conformation of melittin: transferred nuclear Overhauser enhancement analysis in the presence of perdeuterated phosphatidylcholine vesicles",
      "volume": "33",
      "author": "Okada",
      "year": "1994",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1016/S0006-3495(03)75103-0_bib40",
      "doi-asserted-by": "crossref",
      "first-page": "2531",
      "DOI": "10.1063/1.455047",
      "article-title": "Circular dichroism of oriented \u03b1-helices. I. Proof of the exciton theory",
      "volume": "89",
      "author": "Olah",
      "year": "1988",
      "journal-title": "J. Chem. Phys."
    },
    {
      "key": "10.1016/S0006-3495(03)75103-0_bib41",
      "doi-asserted-by": "crossref",
      "first-page": "847",
      "DOI": "10.1016/0022-2836(91)90272-8",
      "article-title": "Location of ion binding sites in the gramicidin channel by x-ray diffraction",
      "volume": "218",
      "author": "Olah",
      "year": "1991",
      "journal-title": "J. Mol. Biol."
    },
    {
      "key": "10.1016/S0006-3495(03)75103-0_bib42",
      "first-page": "264",
      "article-title": "The structure of haemoglobin. III. Direct determination of the molecular transform",
      "volume": "225",
      "author": "Perutz",
      "year": "1954",
      "journal-title": "Proc. R. Soc. A."
    },
    {
      "key": "10.1016/S0006-3495(03)75103-0_bib43",
      "doi-asserted-by": "crossref",
      "first-page": "328",
      "DOI": "10.1016/S0006-3495(00)76295-3",
      "article-title": "Effect of chain length and unsaturation on elasticity of lipid bilayers",
      "volume": "79",
      "author": "Rawicz",
      "year": "2000",
      "journal-title": "Biophys. J."
    },
    {
      "key": "10.1016/S0006-3495(03)75103-0_bib44",
      "doi-asserted-by": "crossref",
      "first-page": "4345",
      "DOI": "10.1021/bi962304x",
      "article-title": "The tendency of magainin to associate upon binding to phospholipid bilayers",
      "volume": "36",
      "author": "Sch\u00fcmann",
      "year": "1996",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1016/S0006-3495(03)75103-0_bib45",
      "doi-asserted-by": "crossref",
      "first-page": "4519",
      "DOI": "10.1063/1.457764",
      "article-title": "X-ray structural studies of freely suspended ordered hydrated DMPC mutimembrane films",
      "volume": "92",
      "author": "Smith",
      "year": "1990",
      "journal-title": "J. Chem. Phys."
    },
    {
      "key": "10.1016/S0006-3495(03)75103-0_bib46",
      "doi-asserted-by": "crossref",
      "first-page": "260",
      "DOI": "10.1016/0005-2736(88)90069-7",
      "article-title": "Binding and action of cecropin and cecropin analogues: antibacterial peptides from insects",
      "volume": "939",
      "author": "Steiner",
      "year": "1988",
      "journal-title": "Biochim. Biophys. Acta."
    },
    {
      "key": "10.1016/S0006-3495(03)75103-0_bib47",
      "doi-asserted-by": "crossref",
      "first-page": "353",
      "DOI": "10.1016/S0006-3495(82)84683-3",
      "article-title": "The structure of melittin in the form I crystals and its implication for melittin\u2019s lytic and surface activities",
      "volume": "37",
      "author": "Terwilliger",
      "year": "1982",
      "journal-title": "Biophys. J."
    },
    {
      "key": "10.1016/S0006-3495(03)75103-0_bib48",
      "doi-asserted-by": "crossref",
      "first-page": "447",
      "DOI": "10.1016/0022-5193(76)90129-6",
      "article-title": "X-ray diffraction studies of lecithin bilayers",
      "volume": "62",
      "author": "Torbet",
      "year": "1976",
      "journal-title": "J. Theor. Biol."
    },
    {
      "key": "10.1016/S0006-3495(03)75103-0_bib49",
      "doi-asserted-by": "crossref",
      "first-page": "10070",
      "DOI": "10.1021/bi025853d",
      "article-title": "Two states of cyclic antimicrobial peptide RTD-1 in lipid bilayers",
      "volume": "41",
      "author": "Weiss",
      "year": "2002",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1016/S0006-3495(03)75103-0_bib50",
      "doi-asserted-by": "crossref",
      "first-page": "4490",
      "DOI": "10.1021/bi00470a031",
      "article-title": "Raman spectroscopy of synthetic antimicrobial frog peptides magainin 2a and PGLa",
      "volume": "29",
      "author": "Williams",
      "year": "1990",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1016/S0006-3495(03)75103-0_bib51",
      "doi-asserted-by": "crossref",
      "first-page": "797",
      "DOI": "10.1016/S0006-3495(90)82599-6",
      "article-title": "Method of oriented circular dichroism",
      "volume": "57",
      "author": "Wu",
      "year": "1990",
      "journal-title": "Biophys. J."
    },
    {
      "key": "10.1016/S0006-3495(03)75103-0_bib52",
      "doi-asserted-by": "crossref",
      "first-page": "2361",
      "DOI": "10.1016/S0006-3495(95)80418-2",
      "article-title": "X-ray diffraction study of lipid bilayer membrane interacting with amphiphilic helical peptides: diphytanoyl phosphatidylcholine with alamethicin at low concentrations",
      "volume": "68",
      "author": "Wu",
      "year": "1995",
      "journal-title": "Biophys. J."
    },
    {
      "key": "10.1016/S0006-3495(03)75103-0_bib53",
      "doi-asserted-by": "crossref",
      "first-page": "1475",
      "DOI": "10.1016/S0006-3495(01)75802-X",
      "article-title": "Barrel-stave model or toroidal model? A case study on melittin pores",
      "volume": "81",
      "author": "Yang",
      "year": "2001",
      "journal-title": "Biophys. J."
    },
    {
      "key": "10.1016/S0006-3495(03)75103-0_bib54",
      "doi-asserted-by": "crossref",
      "first-page": "389",
      "DOI": "10.1038/415389a",
      "article-title": "Antimicrobial peptides of multicellular organisms",
      "volume": "415",
      "author": "Zasloff",
      "year": "2002",
      "journal-title": "Nature"
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