DOI: 10.1016/s0002-9440(10)65001-8. Increased Phosphorylated Extracellular Signal-Regulated Kinase Immunoreactivity Associated with Proliferative and Morphologic Lung Alterations after Chrysotile Asbestos Inhalation in Mice

Increased Phosphorylated Extracellular Signal-Regulated Kinase Immunoreactivity Associated with Proliferative and Morphologic Lung Alterations after Chrysotile Asbestos Inhalation in Mice

10.1016/s0002-9440(10)65001-8

Crossref journal-article

Elsevier BV

The American Journal of Pathology (78)

Bibliography

Robledo, R. F., Buder-Hoffmann, S. A., Cummins, A. B., Walsh, E. S., Taatjes, D. J., & Mossman, B. T. (2000). Increased Phosphorylated Extracellular Signal-Regulated Kinase Immunoreactivity Associated with Proliferative and Morphologic Lung Alterations after Chrysotile Asbestos Inhalation in Mice. The American Journal of Pathology, 156(4), 1307â1316.

Authors 6

Raymond F. Robledo (first)
Sylke A. Buder-Hoffmann (additional)
Andrew B. Cummins (additional)
Eric S. Walsh (additional)
Douglas J. Taatjes (additional)
Brooke T. Mossman (additional)

References 42 Referenced 65

10.1164/ajrccm.150.1.8025751 / Am J Crit Care Med / Dose-responsive increases in pulmonary fibrosis after inhalation of asbestos by Quinlan (1994)
{'key': '10.1016/S0002-9440(10)65001-8_bib2', 'first-page': '728', 'article-title': 'Patterns of inflammation, cell proliferation, and related gene expression in lung after inhalation of chrysotile asbestos', 'volume': '147', 'author': 'Quinlan', 'year': '1995', 'journal-title': 'Am J Pathol'} / Am J Pathol / Patterns of inflammation, cell proliferation, and related gene expression in lung after inhalation of chrysotile asbestos by Quinlan (1995)
10.1006/taap.1996.0058 / Toxicol Appl Pharm / Comparative proliferative and histopathologic changes in rat lungs after inhalation of chrysotile or crocidolite asbestos by BéruBé (1996)
10.1289/ehp.97105s51121 / Environ Health Perspect / Cell signaling pathways elicited by asbestos by Mossman (1997)
10.1074/jbc.270.28.16483 / J Biol Chem / The regulation of AP-1 activity by mitogen-activated protein kinases by Karin (1995)
{'key': '10.1016/S0002-9440(10)65001-8_bib6', 'first-page': '5334', 'article-title': 'Asbestos cause stimulation of the extracellular signal-related kinase 1 mitogen-activated protein kinase cascade after phosphorylation of the epidermal growth factor receptor', 'volume': '56', 'author': 'Zanella', 'year': '1996', 'journal-title': 'Cancer Res'} / Cancer Res / Asbestos cause stimulation of the extracellular signal-related kinase 1 mitogen-activated protein kinase cascade after phosphorylation of the epidermal growth factor receptor by Zanella (1996)
{'key': '10.1016/S0002-9440(10)65001-8_bib7', 'first-page': 'L1029', 'article-title': 'Role of extracellular signal-related protein kinases in apoptosis by asbestos and H2O2', 'volume': '273', 'author': 'Jiménez', 'year': '1997', 'journal-title': 'Am J Physiol'} / Am J Physiol / Role of extracellular signal-related protein kinases in apoptosis by asbestos and H2O2 by Jiménez (1997)
Campbell WJ, Huggins CW, Wylie AG: Chemical and physical characterization of amosite, chrysotile, crocidolite, and nonfibrous tremolite for oral ingestion studies by the National Institute of Environmental Health Sciences. Washington, DC, US Bureau of Mines Report of Investigations no. 8452, 1980
10.1080/15298668291410738 / Am Ind Hyg Assoc J / Design, development, and test results of a horizontal flow facility by Hemenway (1982)
10.1016/S0021-9258(19)50063-1 / J Biol Chem / Expression of antioxidant enzymes in rat lungs after inhalation of asbestos or silica by Janssen (1992)
10.1016/0003-9861(61)90291-0 / Arch Biochem Biophys / Determinations of hydroxyproline in tissue and protein samples containing small proportions of the amino acid by Woessner (1961)
10.1093/carcin/11.12.2245 / Carcinogenesis / Measurement of chemically induced cell proliferation in rodent liver and kidney: A comparison of 5-bromo-2′-deoxyuridine and [3H]-thymidine administered by injectionor osmotic pump by Eldridge (1990)
10.3109/08958379509015211 / Inhal Toxicol / Chronic inhalation exposure of Wistar rats and two different strains of mice to diesel engine exhaust, carbon black, and titanium dioxide by Heinrich (1995)
10.1002/jat.2550060602 / J Appl Toxicol / Chronic effects on the respiratory tract of hamsters, mice and rats after long-term inhalation of high concentrations of filtered and unfiltered diesel engine emissions by Heinrich (1986)
10.1006/faat.1996.0061 / Fundam Appl Toxicol / Diesel exhaust is not a pulmonary carcinogen in CD-1 mice exposed under conditions carcinogenic to F344 rats by Mauderly (1996)
10.1016/S0002-9440(10)65332-1 / Am J Pathol / Reduced tumor necrosis factor-α and transforming growth factor-β1 expression in the lungs of inbred mice that fail to develop fibroproliferative lesions consequent to asbestos exposure by Brass (1999)
{'key': '10.1016/S0002-9440(10)65001-8_bib17', 'first-page': '205', 'article-title': 'Incorporation of bromodeoxyuridine (BrdU) in the bronchiolar-alveolar regions of the lungs following two inhalation exposures to chrysotile asbestos in strain A/J mice', 'volume': '14', 'author': 'Dixon', 'year': '1995', 'journal-title': 'J Environ Pathol Toxicol Oncol'} / J Environ Pathol Toxicol Oncol / Incorporation of bromodeoxyuridine (BrdU) in the bronchiolar-alveolar regions of the lungs following two inhalation exposures to chrysotile asbestos in strain A/J mice by Dixon (1995)
10.1016/S0940-2993(11)80316-7 / Exp Toxicol Pathol / Bromodeoxyuridine (BrdU) uptake in the lungs of rats inhaling amosite asbestos or vitreous fibers at equal airborne fibre concentrations by Donaldson (1995)
10.1016/S0002-9440(10)65698-2 / Am J Pathol / TNF-α receptor knockout mice are protected from the fibroproliferative effects of inhaled asbestos fibers by Liu (1998)
{'key': '10.1016/S0002-9440(10)65001-8_bib20', 'first-page': '333', 'article-title': 'Increased epidermal growth factor-receptor protein in a human mesothelial cell line in response to long asbestos fibers', 'volume': '152', 'author': 'Pache', 'year': '1998', 'journal-title': 'Am J Pathol'} / Am J Pathol / Increased epidermal growth factor-receptor protein in a human mesothelial cell line in response to long asbestos fibers by Pache (1998)
10.1038/sj.onc.1201275 / Oncogene / Radiation-induced proliferation of the human A341 squamous carcinoma cells is dependent on EGFR tyrosine phosphorylation by Schmidt-Ullrich (1997)
10.1083/jcb.146.4.697 / J Cell Biol / Employment of the epidermal growth factor receptor in growth factor-independent signaling pathways by Carpenter (1999)
{'key': '10.1016/S0002-9440(10)65001-8_bib23', 'first-page': '1324', 'article-title': 'The detection of increased amounts of the extracellular domain of the epidermal growth factor receptor in serum during carcinogenesis in asbestosis patients', 'volume': '36', 'author': 'Partanen', 'year': '1994', 'journal-title': 'J Med'} / J Med / The detection of increased amounts of the extracellular domain of the epidermal growth factor receptor in serum during carcinogenesis in asbestosis patients by Partanen (1994)
{'key': '10.1016/S0002-9440(10)65001-8_bib24', 'first-page': '205', 'article-title': 'Up-regulated expression of transforming growth factor-α in the bronchiolar-alveolar duct regions of asbestos-exposed rats', 'volume': '149', 'author': 'Liu', 'year': '1996', 'journal-title': 'Am J Pathol'} / Am J Pathol / Up-regulated expression of transforming growth factor-α in the bronchiolar-alveolar duct regions of asbestos-exposed rats by Liu (1996)
10.1165/ajrcmb.17.3.2991 / Am J Respir Cell Mol Biol / Novel cell imaging techniques show induction of apoptosis and proliferation in mesothelial cells by asbestos by Goldberg (1997)
{'key': '10.1016/S0002-9440(10)65001-8_bib26', 'first-page': 'L684', 'article-title': 'Asbestos-induced phosphorylation of the epidermal growth factor receptor (EGF-R) is linked causally to c-fos expression and apoptosis in mesothelial cells', 'volume': '277', 'author': 'Zanella', 'year': '1999', 'journal-title': 'Am J Physiol'} / Am J Physiol / Asbestos-induced phosphorylation of the epidermal growth factor receptor (EGF-R) is linked causally to c-fos expression and apoptosis in mesothelial cells by Zanella (1999)
{'key': '10.1016/S0002-9440(10)65001-8_bib27', 'first-page': '724', 'article-title': 'Deposition pattern of inorganic particles at the alveolar level in the lungs of rats and mice', 'volume': '128', 'author': 'Brody', 'year': '1983', 'journal-title': 'Am Rev Respir Dis'} / Am Rev Respir Dis / Deposition pattern of inorganic particles at the alveolar level in the lungs of rats and mice by Brody (1983)
{'key': '10.1016/S0002-9440(10)65001-8_bib28', 'first-page': '670', 'article-title': 'Chrysotile asbestos inhalation in rats: deposition pattern and reaction of alveolar epithelium and pulmonary macrophages', 'volume': '123', 'author': 'Brody', 'year': '1981', 'journal-title': 'Am Rev Respir Dis'} / Am Rev Respir Dis / Chrysotile asbestos inhalation in rats: deposition pattern and reaction of alveolar epithelium and pulmonary macrophages by Brody (1981)
{'key': '10.1016/S0002-9440(10)65001-8_bib29', 'first-page': 'L159', 'article-title': 'Pathobiology of pulmonary fibrosis', 'author': 'Crouch', 'year': '1990', 'journal-title': 'Am J Physiol'} / Am J Physiol / Pathobiology of pulmonary fibrosis by Crouch (1990)
10.1002/(SICI)1097-4652(199908)180:2<158::AID-JCP3>3.0.CO;2-R / J Cell Physiol / Cellular and molecular mechanisms of asbestos-induced fibrosis by Robledo (1999)
10.1164/ajrccm.157.5.9704116 / Am J Respir Cri Care Med / Upregulation of the PDGF-alpha receptor precedes asbestos-induced lung fibrosis in rats by Lasky (1998)
10.1165/ajrcmb.17.2.2956 / Am J Respir Cell Mol Biol / Rapid activation of PDGF-A and PDGF-B expression at sites of lung injury in asbestos-exposed rats by Liu (1997)
10.1177/42.8.8027525 / J Histochem Cytochem / Distribution of transforming growth factor-β1, fibronectin, and smooth muscle actin in asbestos-induced pulmonary fibrosis in rats by Perdue (1994)
10.1016/S0169-328X(97)00306-9 / Brain Res Mol Brain Res / Abundance of platelet-derived growth factors (PDGFs), PDGF receptors and activation of mitogen-activated protein kinases in brain decline with age by Hu (1998)
10.1074/jbc.274.16.11362 / J Biol Chem / Transforming growth factor beta 1 rescues serum deprivation-induced apoptosis via the mitogen-activated protein kinase (MAPK) pathway in macrophages by Chin (1999)
10.1165/ajrcmb.20.5.3452 / Am J Respir Cell Mol Biol / Cooperativity between oxidants and tumor necrosis factor in the activation of nuclear factor (NF)-kappaB: requirement of ras/mitogen-activated protein kinases in the activation of nf-kappa-b by oxidants by Janssen-Heininger (1999)
10.1165/ajrcmb.20.4.3420 / Am J Respir Cell Mol Biol / Both Erk and p38 kinases are necessary for cytokine gene transcription by Carter (1999)
10.1016/S0024-3205(98)00558-X / Life Sci / Activation of extracellular signal-regulated kinase in lung tissues of mice treated with carcinogen by Yano (1999)
10.1165/ajrcmb.20.4.f147 / Am J Respir Cell Mol Biol / Dormant tumor-suppressor pathways in tumors by Weintraub (1999)
10.1165/ajrcmb.20.4.3406 / Am J Respir Cell Mol Biol / Raf-1 causes growth suppression and alteration of neuroendocrine markers in DMS53 human small-cell lung cancer cells by Ravi (1999)
10.1016/S0002-9440(10)65728-8 / Am J Pathol / In situ visualization of intratumor growth factor signaling: immunohistochemical localization of activated ERK/MAP kinase in glial neoplasms by Mandell (1998)
10.1165/ajrcmb.15.4.8879184 / Am J Respir Cell Mol Biol / Reversal of lung lesions in transgenic transforming growth factor α mice by expression of mutant epidermal growth factor receptor by Hardie (1996)

Dates

Type	When
Created	14 years, 7 months ago (Jan. 28, 2011, 12:02 a.m.)
Deposited	3 years, 9 months ago (Nov. 18, 2021, 12:07 a.m.)
Indexed	4 weeks ago (Aug. 2, 2025, 12:36 a.m.)
Issued	25 years, 4 months ago (April 1, 2000)
Published	25 years, 4 months ago (April 1, 2000)
Published Print	25 years, 4 months ago (April 1, 2000)

Funders 0

None

BibTeX

@article{Robledo_2000, title={Increased Phosphorylated Extracellular Signal-Regulated Kinase Immunoreactivity Associated with Proliferative and Morphologic Lung Alterations after Chrysotile Asbestos Inhalation in Mice}, volume={156}, ISSN={0002-9440}, url={http://dx.doi.org/10.1016/s0002-9440(10)65001-8}, DOI={10.1016/s0002-9440(10)65001-8}, number={4}, journal={The American Journal of Pathology}, publisher={Elsevier BV}, author={Robledo, Raymond F. and Buder-Hoffmann, Sylke A. and Cummins, Andrew B. and Walsh, Eric S. and Taatjes, Douglas J. and Mossman, Brooke T.}, year={2000}, month=apr, pages={1307–1316} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        8,
        2
      ]
    ],
    "date-time": "2025-08-02T04:36:34Z",
    "timestamp": 1754109394592
  },
  "reference-count": 42,
  "publisher": "Elsevier BV",
  "issue": "4",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2000,
            4,
            1
          ]
        ],
        "date-time": "2000-04-01T00:00:00Z",
        "timestamp": 954547200000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://www.elsevier.com/tdm/userlicense/1.0/"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        2000,
        4
      ]
    ]
  },
  "DOI": "10.1016/s0002-9440(10)65001-8",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2011,
        1,
        28
      ]
    ],
    "date-time": "2011-01-28T05:02:45Z",
    "timestamp": 1296190965000
  },
  "page": "1307-1316",
  "source": "Crossref",
  "is-referenced-by-count": 65,
  "title": "Increased Phosphorylated Extracellular Signal-Regulated Kinase Immunoreactivity Associated with Proliferative and Morphologic Lung Alterations after Chrysotile Asbestos Inhalation in Mice",
  "prefix": "10.1016",
  "volume": "156",
  "author": [
    {
      "given": "Raymond F.",
      "family": "Robledo",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Sylke A.",
      "family": "Buder-Hoffmann",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Andrew B.",
      "family": "Cummins",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Eric S.",
      "family": "Walsh",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Douglas J.",
      "family": "Taatjes",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Brooke T.",
      "family": "Mossman",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "78",
  "reference": [
    {
      "key": "10.1016/S0002-9440(10)65001-8_bib1",
      "doi-asserted-by": "crossref",
      "first-page": "200",
      "DOI": "10.1164/ajrccm.150.1.8025751",
      "article-title": "Dose-responsive increases in pulmonary fibrosis after inhalation of asbestos",
      "volume": "150",
      "author": "Quinlan",
      "year": "1994",
      "journal-title": "Am J Crit Care Med"
    },
    {
      "key": "10.1016/S0002-9440(10)65001-8_bib2",
      "first-page": "728",
      "article-title": "Patterns of inflammation, cell proliferation, and related gene expression in lung after inhalation of chrysotile asbestos",
      "volume": "147",
      "author": "Quinlan",
      "year": "1995",
      "journal-title": "Am J Pathol"
    },
    {
      "key": "10.1016/S0002-9440(10)65001-8_bib3",
      "doi-asserted-by": "crossref",
      "first-page": "67",
      "DOI": "10.1006/taap.1996.0058",
      "article-title": "Comparative proliferative and histopathologic changes in rat lungs after inhalation of chrysotile or crocidolite asbestos",
      "volume": "137",
      "author": "B\u00e9ruB\u00e9",
      "year": "1996",
      "journal-title": "Toxicol Appl Pharm"
    },
    {
      "issue": "suppl 5",
      "key": "10.1016/S0002-9440(10)65001-8_bib4",
      "doi-asserted-by": "crossref",
      "first-page": "1121",
      "DOI": "10.1289/ehp.97105s51121",
      "article-title": "Cell signaling pathways elicited by asbestos",
      "volume": "105",
      "author": "Mossman",
      "year": "1997",
      "journal-title": "Environ Health Perspect"
    },
    {
      "key": "10.1016/S0002-9440(10)65001-8_bib5",
      "doi-asserted-by": "crossref",
      "first-page": "16483",
      "DOI": "10.1074/jbc.270.28.16483",
      "article-title": "The regulation of AP-1 activity by mitogen-activated protein kinases",
      "volume": "270",
      "author": "Karin",
      "year": "1995",
      "journal-title": "J Biol Chem"
    },
    {
      "key": "10.1016/S0002-9440(10)65001-8_bib6",
      "first-page": "5334",
      "article-title": "Asbestos cause stimulation of the extracellular signal-related kinase 1 mitogen-activated protein kinase cascade after phosphorylation of the epidermal growth factor receptor",
      "volume": "56",
      "author": "Zanella",
      "year": "1996",
      "journal-title": "Cancer Res"
    },
    {
      "key": "10.1016/S0002-9440(10)65001-8_bib7",
      "first-page": "L1029",
      "article-title": "Role of extracellular signal-related protein kinases in apoptosis by asbestos and H2O2",
      "volume": "273",
      "author": "Jim\u00e9nez",
      "year": "1997",
      "journal-title": "Am J Physiol"
    },
    {
      "key": "10.1016/S0002-9440(10)65001-8_bib8",
      "unstructured": "Campbell WJ, Huggins CW, Wylie AG: Chemical and physical characterization of amosite, chrysotile, crocidolite, and nonfibrous tremolite for oral ingestion studies by the National Institute of Environmental Health Sciences. Washington, DC, US Bureau of Mines Report of Investigations no. 8452, 1980"
    },
    {
      "key": "10.1016/S0002-9440(10)65001-8_bib9",
      "doi-asserted-by": "crossref",
      "first-page": "874",
      "DOI": "10.1080/15298668291410738",
      "article-title": "Design, development, and test results of a horizontal flow facility",
      "volume": "43",
      "author": "Hemenway",
      "year": "1982",
      "journal-title": "Am Ind Hyg Assoc J"
    },
    {
      "key": "10.1016/S0002-9440(10)65001-8_bib10",
      "doi-asserted-by": "crossref",
      "first-page": "10625",
      "DOI": "10.1016/S0021-9258(19)50063-1",
      "article-title": "Expression of antioxidant enzymes in rat lungs after inhalation of asbestos or silica",
      "volume": "267",
      "author": "Janssen",
      "year": "1992",
      "journal-title": "J Biol Chem"
    },
    {
      "key": "10.1016/S0002-9440(10)65001-8_bib11",
      "doi-asserted-by": "crossref",
      "first-page": "440",
      "DOI": "10.1016/0003-9861(61)90291-0",
      "article-title": "Determinations of hydroxyproline in tissue and protein samples containing small proportions of the amino acid",
      "volume": "93",
      "author": "Woessner",
      "year": "1961",
      "journal-title": "Arch Biochem Biophys"
    },
    {
      "key": "10.1016/S0002-9440(10)65001-8_bib12",
      "doi-asserted-by": "crossref",
      "first-page": "2245",
      "DOI": "10.1093/carcin/11.12.2245",
      "article-title": "Measurement of chemically induced cell proliferation in rodent liver and kidney: A comparison of 5-bromo-2\u2032-deoxyuridine and [3H]-thymidine administered by injectionor osmotic pump",
      "volume": "11",
      "author": "Eldridge",
      "year": "1990",
      "journal-title": "Carcinogenesis"
    },
    {
      "key": "10.1016/S0002-9440(10)65001-8_bib13",
      "doi-asserted-by": "crossref",
      "first-page": "533",
      "DOI": "10.3109/08958379509015211",
      "article-title": "Chronic inhalation exposure of Wistar rats and two different strains of mice to diesel engine exhaust, carbon black, and titanium dioxide",
      "volume": "7",
      "author": "Heinrich",
      "year": "1995",
      "journal-title": "Inhal Toxicol"
    },
    {
      "key": "10.1016/S0002-9440(10)65001-8_bib14",
      "doi-asserted-by": "crossref",
      "first-page": "383",
      "DOI": "10.1002/jat.2550060602",
      "article-title": "Chronic effects on the respiratory tract of hamsters, mice and rats after long-term inhalation of high concentrations of filtered and unfiltered diesel engine emissions",
      "volume": "6",
      "author": "Heinrich",
      "year": "1986",
      "journal-title": "J Appl Toxicol"
    },
    {
      "key": "10.1016/S0002-9440(10)65001-8_bib15",
      "doi-asserted-by": "crossref",
      "first-page": "233",
      "DOI": "10.1006/faat.1996.0061",
      "article-title": "Diesel exhaust is not a pulmonary carcinogen in CD-1 mice exposed under conditions carcinogenic to F344 rats",
      "volume": "30",
      "author": "Mauderly",
      "year": "1996",
      "journal-title": "Fundam Appl Toxicol"
    },
    {
      "key": "10.1016/S0002-9440(10)65001-8_bib16",
      "doi-asserted-by": "crossref",
      "first-page": "853",
      "DOI": "10.1016/S0002-9440(10)65332-1",
      "article-title": "Reduced tumor necrosis factor-\u03b1 and transforming growth factor-\u03b21 expression in the lungs of inbred mice that fail to develop fibroproliferative lesions consequent to asbestos exposure",
      "volume": "154",
      "author": "Brass",
      "year": "1999",
      "journal-title": "Am J Pathol"
    },
    {
      "key": "10.1016/S0002-9440(10)65001-8_bib17",
      "first-page": "205",
      "article-title": "Incorporation of bromodeoxyuridine (BrdU) in the bronchiolar-alveolar regions of the lungs following two inhalation exposures to chrysotile asbestos in strain A/J mice",
      "volume": "14",
      "author": "Dixon",
      "year": "1995",
      "journal-title": "J Environ Pathol Toxicol Oncol"
    },
    {
      "key": "10.1016/S0002-9440(10)65001-8_bib18",
      "doi-asserted-by": "crossref",
      "first-page": "207",
      "DOI": "10.1016/S0940-2993(11)80316-7",
      "article-title": "Bromodeoxyuridine (BrdU) uptake in the lungs of rats inhaling amosite asbestos or vitreous fibers at equal airborne fibre concentrations",
      "volume": "47",
      "author": "Donaldson",
      "year": "1995",
      "journal-title": "Exp Toxicol Pathol"
    },
    {
      "key": "10.1016/S0002-9440(10)65001-8_bib19",
      "doi-asserted-by": "crossref",
      "first-page": "1839",
      "DOI": "10.1016/S0002-9440(10)65698-2",
      "article-title": "TNF-\u03b1 receptor knockout mice are protected from the fibroproliferative effects of inhaled asbestos fibers",
      "volume": "153",
      "author": "Liu",
      "year": "1998",
      "journal-title": "Am J Pathol"
    },
    {
      "key": "10.1016/S0002-9440(10)65001-8_bib20",
      "first-page": "333",
      "article-title": "Increased epidermal growth factor-receptor protein in a human mesothelial cell line in response to long asbestos fibers",
      "volume": "152",
      "author": "Pache",
      "year": "1998",
      "journal-title": "Am J Pathol"
    },
    {
      "key": "10.1016/S0002-9440(10)65001-8_bib21",
      "doi-asserted-by": "crossref",
      "first-page": "1191",
      "DOI": "10.1038/sj.onc.1201275",
      "article-title": "Radiation-induced proliferation of the human A341 squamous carcinoma cells is dependent on EGFR tyrosine phosphorylation",
      "volume": "15",
      "author": "Schmidt-Ullrich",
      "year": "1997",
      "journal-title": "Oncogene"
    },
    {
      "key": "10.1016/S0002-9440(10)65001-8_bib22",
      "doi-asserted-by": "crossref",
      "first-page": "697",
      "DOI": "10.1083/jcb.146.4.697",
      "article-title": "Employment of the epidermal growth factor receptor in growth factor-independent signaling pathways",
      "volume": "146",
      "author": "Carpenter",
      "year": "1999",
      "journal-title": "J Cell Biol"
    },
    {
      "key": "10.1016/S0002-9440(10)65001-8_bib23",
      "first-page": "1324",
      "article-title": "The detection of increased amounts of the extracellular domain of the epidermal growth factor receptor in serum during carcinogenesis in asbestosis patients",
      "volume": "36",
      "author": "Partanen",
      "year": "1994",
      "journal-title": "J Med"
    },
    {
      "key": "10.1016/S0002-9440(10)65001-8_bib24",
      "first-page": "205",
      "article-title": "Up-regulated expression of transforming growth factor-\u03b1 in the bronchiolar-alveolar duct regions of asbestos-exposed rats",
      "volume": "149",
      "author": "Liu",
      "year": "1996",
      "journal-title": "Am J Pathol"
    },
    {
      "key": "10.1016/S0002-9440(10)65001-8_bib25",
      "doi-asserted-by": "crossref",
      "first-page": "265",
      "DOI": "10.1165/ajrcmb.17.3.2991",
      "article-title": "Novel cell imaging techniques show induction of apoptosis and proliferation in mesothelial cells by asbestos",
      "volume": "17",
      "author": "Goldberg",
      "year": "1997",
      "journal-title": "Am J Respir Cell Mol Biol"
    },
    {
      "key": "10.1016/S0002-9440(10)65001-8_bib26",
      "first-page": "L684",
      "article-title": "Asbestos-induced phosphorylation of the epidermal growth factor receptor (EGF-R) is linked causally to c-fos expression and apoptosis in mesothelial cells",
      "volume": "277",
      "author": "Zanella",
      "year": "1999",
      "journal-title": "Am J Physiol"
    },
    {
      "key": "10.1016/S0002-9440(10)65001-8_bib27",
      "first-page": "724",
      "article-title": "Deposition pattern of inorganic particles at the alveolar level in the lungs of rats and mice",
      "volume": "128",
      "author": "Brody",
      "year": "1983",
      "journal-title": "Am Rev Respir Dis"
    },
    {
      "key": "10.1016/S0002-9440(10)65001-8_bib28",
      "first-page": "670",
      "article-title": "Chrysotile asbestos inhalation in rats: deposition pattern and reaction of alveolar epithelium and pulmonary macrophages",
      "volume": "123",
      "author": "Brody",
      "year": "1981",
      "journal-title": "Am Rev Respir Dis"
    },
    {
      "key": "10.1016/S0002-9440(10)65001-8_bib29",
      "first-page": "L159",
      "article-title": "Pathobiology of pulmonary fibrosis",
      "author": "Crouch",
      "year": "1990",
      "journal-title": "Am J Physiol"
    },
    {
      "key": "10.1016/S0002-9440(10)65001-8_bib30",
      "doi-asserted-by": "crossref",
      "first-page": "158",
      "DOI": "10.1002/(SICI)1097-4652(199908)180:2<158::AID-JCP3>3.0.CO;2-R",
      "article-title": "Cellular and molecular mechanisms of asbestos-induced fibrosis",
      "volume": "180",
      "author": "Robledo",
      "year": "1999",
      "journal-title": "J Cell Physiol"
    },
    {
      "key": "10.1016/S0002-9440(10)65001-8_bib31",
      "doi-asserted-by": "crossref",
      "first-page": "1652",
      "DOI": "10.1164/ajrccm.157.5.9704116",
      "article-title": "Upregulation of the PDGF-alpha receptor precedes asbestos-induced lung fibrosis in rats",
      "volume": "157",
      "author": "Lasky",
      "year": "1998",
      "journal-title": "Am J Respir Cri Care Med"
    },
    {
      "key": "10.1016/S0002-9440(10)65001-8_bib32",
      "doi-asserted-by": "crossref",
      "first-page": "129",
      "DOI": "10.1165/ajrcmb.17.2.2956",
      "article-title": "Rapid activation of PDGF-A and PDGF-B expression at sites of lung injury in asbestos-exposed rats",
      "volume": "17",
      "author": "Liu",
      "year": "1997",
      "journal-title": "Am J Respir Cell Mol Biol"
    },
    {
      "key": "10.1016/S0002-9440(10)65001-8_bib33",
      "doi-asserted-by": "crossref",
      "first-page": "1061",
      "DOI": "10.1177/42.8.8027525",
      "article-title": "Distribution of transforming growth factor-\u03b21, fibronectin, and smooth muscle actin in asbestos-induced pulmonary fibrosis in rats",
      "volume": "42",
      "author": "Perdue",
      "year": "1994",
      "journal-title": "J Histochem Cytochem"
    },
    {
      "key": "10.1016/S0002-9440(10)65001-8_bib34",
      "doi-asserted-by": "crossref",
      "first-page": "252",
      "DOI": "10.1016/S0169-328X(97)00306-9",
      "article-title": "Abundance of platelet-derived growth factors (PDGFs), PDGF receptors and activation of mitogen-activated protein kinases in brain decline with age",
      "volume": "53",
      "author": "Hu",
      "year": "1998",
      "journal-title": "Brain Res Mol Brain Res"
    },
    {
      "key": "10.1016/S0002-9440(10)65001-8_bib35",
      "doi-asserted-by": "crossref",
      "first-page": "11362",
      "DOI": "10.1074/jbc.274.16.11362",
      "article-title": "Transforming growth factor beta 1 rescues serum deprivation-induced apoptosis via the mitogen-activated protein kinase (MAPK) pathway in macrophages",
      "volume": "274",
      "author": "Chin",
      "year": "1999",
      "journal-title": "J Biol Chem"
    },
    {
      "key": "10.1016/S0002-9440(10)65001-8_bib36",
      "doi-asserted-by": "crossref",
      "first-page": "942",
      "DOI": "10.1165/ajrcmb.20.5.3452",
      "article-title": "Cooperativity between oxidants and tumor necrosis factor in the activation of nuclear factor (NF)-kappaB: requirement of ras/mitogen-activated protein kinases in the activation of nf-kappa-b by oxidants",
      "volume": "20",
      "author": "Janssen-Heininger",
      "year": "1999",
      "journal-title": "Am J Respir Cell Mol Biol"
    },
    {
      "key": "10.1016/S0002-9440(10)65001-8_bib37",
      "doi-asserted-by": "crossref",
      "first-page": "751",
      "DOI": "10.1165/ajrcmb.20.4.3420",
      "article-title": "Both Erk and p38 kinases are necessary for cytokine gene transcription",
      "volume": "20",
      "author": "Carter",
      "year": "1999",
      "journal-title": "Am J Respir Cell Mol Biol"
    },
    {
      "key": "10.1016/S0002-9440(10)65001-8_bib38",
      "doi-asserted-by": "crossref",
      "first-page": "229",
      "DOI": "10.1016/S0024-3205(98)00558-X",
      "article-title": "Activation of extracellular signal-regulated kinase in lung tissues of mice treated with carcinogen",
      "volume": "64",
      "author": "Yano",
      "year": "1999",
      "journal-title": "Life Sci"
    },
    {
      "key": "10.1016/S0002-9440(10)65001-8_bib39",
      "doi-asserted-by": "crossref",
      "first-page": "541",
      "DOI": "10.1165/ajrcmb.20.4.f147",
      "article-title": "Dormant tumor-suppressor pathways in tumors",
      "volume": "20",
      "author": "Weintraub",
      "year": "1999",
      "journal-title": "Am J Respir Cell Mol Biol"
    },
    {
      "key": "10.1016/S0002-9440(10)65001-8_bib40",
      "doi-asserted-by": "crossref",
      "first-page": "541",
      "DOI": "10.1165/ajrcmb.20.4.3406",
      "article-title": "Raf-1 causes growth suppression and alteration of neuroendocrine markers in DMS53 human small-cell lung cancer cells",
      "volume": "20",
      "author": "Ravi",
      "year": "1999",
      "journal-title": "Am J Respir Cell Mol Biol"
    },
    {
      "key": "10.1016/S0002-9440(10)65001-8_bib41",
      "doi-asserted-by": "crossref",
      "first-page": "1411",
      "DOI": "10.1016/S0002-9440(10)65728-8",
      "article-title": "In situ visualization of intratumor growth factor signaling: immunohistochemical localization of activated ERK/MAP kinase in glial neoplasms",
      "volume": "153",
      "author": "Mandell",
      "year": "1998",
      "journal-title": "Am J Pathol"
    },
    {
      "key": "10.1016/S0002-9440(10)65001-8_bib42",
      "doi-asserted-by": "crossref",
      "first-page": "499",
      "DOI": "10.1165/ajrcmb.15.4.8879184",
      "article-title": "Reversal of lung lesions in transgenic transforming growth factor \u03b1 mice by expression of mutant epidermal growth factor receptor",
      "volume": "15",
      "author": "Hardie",
      "year": "1996",
      "journal-title": "Am J Respir Cell Mol Biol"
    }
  ],
  "container-title": "The American Journal of Pathology",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0002944010650018?httpAccept=text/xml",
      "content-type": "text/xml",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0002944010650018?httpAccept=text/plain",
      "content-type": "text/plain",
      "content-version": "vor",
      "intended-application": "text-mining"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2021,
        11,
        18
      ]
    ],
    "date-time": "2021-11-18T05:07:45Z",
    "timestamp": 1637212065000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://linkinghub.elsevier.com/retrieve/pii/S0002944010650018"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2000,
        4
      ]
    ]
  },
  "references-count": 42,
  "journal-issue": {
    "issue": "4",
    "published-print": {
      "date-parts": [
        [
          2000,
          4
        ]
      ]
    }
  },
  "alternative-id": [
    "S0002944010650018"
  ],
  "URL": "http://dx.doi.org/10.1016/S0002-9440(10)65001-8",
  "relation": {},
  "ISSN": [
    "0002-9440"
  ],
  "subject": [],
  "container-title-short": "The American Journal of Pathology",
  "published": {
    "date-parts": [
      [
        2000,
        4
      ]
    ]
  }
}