DOI: 10.1016/0960-9822(93)90019-k. Evolution in vitro: analysis of a lineage of ribozymes

Evolution in vitro: analysis of a lineage of ribozymes

10.1016/0960-9822(93)90019-k

Crossref journal-article

Elsevier BV

Current Biology (78)

Bibliography

Lehman, N., & Joyce, G. F. (1993). Evolution in vitro: analysis of a lineage of ribozymes. Current Biology, 3(11), 723â734.

Authors 2

Niles Lehman (first)
Gerald F. Joyce (additional)

References 48 Referenced 54

{'key': '10.1016/0960-9822(93)90019-K_BIB1', 'first-page': '5381', 'article-title': 'Encoded combinatorial chemistry', 'volume': '89', 'author': 'Brenner', 'year': '1992'} / Encoded combinatorial chemistry by Brenner (1992)
10.1016/0968-0004(92)90242-2 / Trends Biochem Sci / In vitro genetics by Szostak (1992)
10.1038/scientificamerican1292-90 / Sci Am / Directed molecular evolution by Joyce (1992)
10.1126/science.1496376 / Science / Directed evolution of an RNA enzyme by Beaudry (1992)
10.1038/361182a0 / Nature / Evolution in vitro of an RNA enzyme by Lehman (1993)
10.1016/0378-1119(88)90493-3 / Gene / Molecular genetics of group I introns: RNA structures and protein factors required for splicing — a review by Burke (1988)
10.1146/annurev.bi.59.070190.002551 / Annu Rev Biochem / Self-splicing of group I introns by Cech (1990)
{'key': '10.1016/0960-9822(93)90019-K_BIB8', 'first-page': '8187', 'article-title': 'Direct measurement of oligonucleotide substrate binding to wild-type and mutant ribozymes from Tetrahymena', 'volume': '87', 'author': 'Pyle', 'year': '1990'} / Direct measurement of oligonucleotide substrate binding to wild-type and mutant ribozymes from Tetrahymena by Pyle (1990)
10.1038/361085a0 / Nature / Metal ion catalysis in the Tetrahymena ribozyme reaction by Piccirilia (1993)
10.1021/bi00443a017 / Biochemistry / Metal ion requirements for sequence-specific endoribonuclease activity of the Tetrahymena ribozyme by Grosshans (1989)
10.1126/science.1989074 / Science / Visualizing the higher order folding of a catalytic RNA molecule by Celander (1991)
10.1021/bi00496a003 / Biochemistry / Catalysis of RNA cleavage by the Tetrahymena thermophila ribozyme. I. Kinetic description of the reaction of an RNA substrate complementary to the active site by Herschlag (1990)
10.1016/S0300-9084(82)80349-0 / Biochimie / Comparison of fungal mitochondrial introns reveals extensive homologies in RNA secondary structure by Michel (1982)
10.1038/300719a0 / Nature / Making ends meet: a model for RNA splicing in fungal mitochondria by Davies (1982)
10.1016/0022-2836(90)90386-Z / J Mol Biol / Modelling of the three-dimensional architecture of group I catalytic introns based on comparative sequence analysis by Michel (1990)
10.1038/342391a0 / Nature / The guanosine binding site of the Tetrahymena ribozyme by Michel (1989)
{'key': '10.1016/0960-9822(93)90019-K_BIB17', 'series-title': 'Coding and Information Theory', 'author': 'Hamming', 'year': '1980'} / Coding and Information Theory by Hamming (1980)
{'key': '10.1016/0960-9822(93)90019-K_BIB18', 'first-page': '217', 'article-title': 'An extracellular Darwinian experiment with a self-duplicating nucleic acid molecule', 'volume': '58', 'author': 'Mills', 'year': '1967'} / An extracellular Darwinian experiment with a self-duplicating nucleic acid molecule by Mills (1967)
{'key': '10.1016/0960-9822(93)90019-K_BIB19', 'first-page': '805', 'article-title': 'Further extracellular Darwinian experiments with replicating RNA molecules: diverse variants isolated under different selection conditions', 'volume': '63', 'author': 'Levisohn', 'year': '1969'} / Further extracellular Darwinian experiments with replicating RNA molecules: diverse variants isolated under different selection conditions by Levisohn (1969)
10.1016/0022-2836(70)90006-9 / J Mol Biol / In vitro selection of bacteriophage Qβ ribonucleic acid variants resistant to ethidium bromide by Saffhill (1970)
10.1128/MMBR.47.2.150-168.1983 / Microbiol Rev / Selection in chemostats by Dykhuizen (1983)
10.2307/2408316 / Evolution / Natural selection in color patterns in Poecilla reticulata by Endler (1980)
10.1038/353347a0 / Nature / Experimental detection of rapid evolutionary response in natural lizard populations by Malhotra (1991)
10.1007/BF00450633 / Naturwissenschaften / The hypercycle: a principle of natural self-organization. Part A: emergence of the hypercycle by Eigen (1977)
10.1038/347578a0 / Nature / Phylogenetic and genetic evidence for base-triples in the catalytic domain of group I introns by Michel (1990)
{'key': '10.1016/0960-9822(93)90019-K_BIB26', 'first-page': '8788', 'article-title': 'Three-dimensional model of the active site of the self-splicing -RNA precursor of Tetrahymena', 'volume': '84', 'author': 'Kim', 'year': '1987'} / Three-dimensional model of the active site of the self-splicing -RNA precursor of Tetrahymena by Kim (1987)
10.1016/S0022-2836(05)80356-0 / J Mol Biol / Mutational analysis of conserved nucleotides in a self-splicing group I intron by Couture (1990)
10.1038/347406a0 / Nature / In vitro genetic analysis of the Tetrahymena self-splicing intron by Green (1990)
10.1093/nar/19.16.4429 / Nucleic Acids Res / A self-splicing group I intron in the nuclear pre-RNA of the green alga, Ankistrodesmus stiptatus by Davila-Aponte (1991)
10.1016/0022-2836(92)90819-6 / J Mol Biol / Numerous group I introns with variable distribution in the ribosomal DNA of a lichen fungus by DePriest (1992)
10.1093/nar/21.5.1297 / Nucleic Acids Res / Group I introns in the liverwort mitochondrial genome: the gene coding for subunit 1 of cytochrome oxidase shares five intron positions with its fungal counterparts by Ohta (1993)
10.1093/nar/21.7.1667 / Nucleic Acids Res / Nucleotide sequence and secondary structure of the chloroplast group I intron Cr.psbA-2: novel features of this self-splicing ribozyme by Bao (1993)
10.1002/j.1460-2075.1989.tb08503.x / EMBO J / A conserved base pair within helix P4 of the Tetrahymena ribozyme helps to form the tertiary structure required for self-splicing by Flor (1989)
10.1021/bi00071a003 / Biochemistry / An independently folding domain of RNA tertiary structure within the Tetrahymena ribozyme by Murphy (1993)
10.1038/362181a0 / Nature / Yeast tRNA-Asp reconition by its cognate class II aminoacyl-tRNA synthetase by Cavarelli (1993)
{'key': '10.1016/0960-9822(93)90019-K_BIB36', 'first-page': '4298', 'article-title': 'The three-dimensional structure of a phosphorylcholine-binding mouse immunoglobulin Fab and the nature of the antigen binding site', 'volume': '71', 'author': 'Segal', 'year': '1974'} / The three-dimensional structure of a phosphorylcholine-binding mouse immunoglobulin Fab and the nature of the antigen binding site by Segal (1974)
10.1126/science.1546293 / Science / Structural evidence for induced fit as a mechanism for antibody-antigen recognition by Rini (1992)
10.1021/bi00425a008 / Biochemistry / Sequence-specific endoribonuclease activity of the Tetrahymena ribozyme: enhanced cleavage of certain oligonucleotide substrates that form mismatched ribozyme-substrate complexes by Zaug (1988)
{'key': '10.1016/0960-9822(93)90019-K_BIB39', 'first-page': '711', 'article-title': 'A novel technique for the rapid preparation of mutant RNAs', 'volume': '17', 'author': 'Joyce', 'year': '1989', 'journal-title': 'Nucleic Acids Res'} / Nucleic Acids Res / A novel technique for the rapid preparation of mutant RNAs by Joyce (1989)
10.1093/nar/15.21.8783 / Nucleic Acids Res / Oligoribonucleotide synthesis using T7 RNA polymerase and synthetic DNA templates by Milligan (1987)
{'key': '10.1016/0960-9822(93)90019-K_BIB41', 'first-page': '1874', 'article-title': 'Isothermal in vitro amplification of nucleic acids by a multienzyme reaction modeled after retroviral replication', 'volume': '87', 'author': 'Guatelli', 'year': '1990'} / Isothermal in vitro amplification of nucleic acids by a multienzyme reaction modeled after retroviral replication by Guatelli (1990)
{'key': '10.1016/0960-9822(93)90019-K_BIB42', 'series-title': 'Antisense RNA and DNA', 'first-page': '353', 'article-title': 'Selective amplification techniques for optimization of ribozyme function', 'author': 'Joyce', 'year': '1992'} / Antisense RNA and DNA / Selective amplification techniques for optimization of ribozyme function by Joyce (1992)
{'key': '10.1016/0960-9822(93)90019-K_BIB43', 'series-title': 'DNA Cloning: A Practical Approach', 'first-page': '109', 'article-title': 'Techniques for transformation of E. coli.', 'author': 'Hanahan', 'year': '1985'} / DNA Cloning: A Practical Approach / Techniques for transformation of E. coli. by Hanahan (1985)
10.1016/0003-2697(81)90473-5 / Anal Biochem / A rapid boiling method for the preparation of bacterial plasmids by Holmes (1981)
{'key': '10.1016/0960-9822(93)90019-K_BIB45', 'first-page': '5463', 'article-title': 'DNA sequencing with chain-terminating inhibitors', 'volume': '74', 'author': 'Sanger', 'year': '1977'} / DNA sequencing with chain-terminating inhibitors by Sanger (1977)
10.1016/0735-0651(85)90011-1 / Genet Anal Tech / Rapid and easy sequencing of large linear double-stranded DNA and supercoiled plasmid DNA by Zagursky (1985)
10.1101/gr.2.1.28 / PCR Methods Applic / Randomization of genes by PCR mutagenesis by Cadwell (1992)
10.1093/nar/15.18.7217 / Nucleic Acids Res / Structural conventions for group I introns by Burke (1987)

Dates

Type	When
Created	21 years, 1 month ago (Aug. 5, 2004, 11:26 a.m.)
Deposited	5 years, 5 months ago (April 2, 2020, 7:01 p.m.)
Indexed	2 months, 3 weeks ago (June 16, 2025, 9:29 a.m.)
Issued	31 years, 10 months ago (Nov. 1, 1993)
Published	31 years, 10 months ago (Nov. 1, 1993)
Published Print	31 years, 10 months ago (Nov. 1, 1993)

Funders 0

None

BibTeX

@article{Lehman_1993, title={Evolution in vitro: analysis of a lineage of ribozymes}, volume={3}, ISSN={0960-9822}, url={http://dx.doi.org/10.1016/0960-9822(93)90019-k}, DOI={10.1016/0960-9822(93)90019-k}, number={11}, journal={Current Biology}, publisher={Elsevier BV}, author={Lehman, Niles and Joyce, Gerald F.}, year={1993}, month=nov, pages={723–734} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        6,
        16
      ]
    ],
    "date-time": "2025-06-16T13:29:41Z",
    "timestamp": 1750080581669
  },
  "reference-count": 48,
  "publisher": "Elsevier BV",
  "issue": "11",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            1993,
            11,
            1
          ]
        ],
        "date-time": "1993-11-01T00:00:00Z",
        "timestamp": 752112000000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://www.elsevier.com/tdm/userlicense/1.0/"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        1993,
        11
      ]
    ]
  },
  "DOI": "10.1016/0960-9822(93)90019-k",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2004,
        8,
        5
      ]
    ],
    "date-time": "2004-08-05T15:26:14Z",
    "timestamp": 1091719574000
  },
  "page": "723-734",
  "source": "Crossref",
  "is-referenced-by-count": 54,
  "title": "Evolution in vitro: analysis of a lineage of ribozymes",
  "prefix": "10.1016",
  "volume": "3",
  "author": [
    {
      "given": "Niles",
      "family": "Lehman",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Gerald F.",
      "family": "Joyce",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "78",
  "reference": [
    {
      "key": "10.1016/0960-9822(93)90019-K_BIB1",
      "first-page": "5381",
      "article-title": "Encoded combinatorial chemistry",
      "volume": "89",
      "author": "Brenner",
      "year": "1992"
    },
    {
      "key": "10.1016/0960-9822(93)90019-K_BIB2",
      "doi-asserted-by": "crossref",
      "first-page": "89",
      "DOI": "10.1016/0968-0004(92)90242-2",
      "article-title": "In vitro genetics",
      "volume": "17",
      "author": "Szostak",
      "year": "1992",
      "journal-title": "Trends Biochem Sci"
    },
    {
      "key": "10.1016/0960-9822(93)90019-K_BIB3",
      "doi-asserted-by": "crossref",
      "first-page": "90",
      "DOI": "10.1038/scientificamerican1292-90",
      "article-title": "Directed molecular evolution",
      "volume": "267",
      "author": "Joyce",
      "year": "1992",
      "journal-title": "Sci Am"
    },
    {
      "key": "10.1016/0960-9822(93)90019-K_BIB4",
      "doi-asserted-by": "crossref",
      "first-page": "635",
      "DOI": "10.1126/science.1496376",
      "article-title": "Directed evolution of an RNA enzyme",
      "volume": "257",
      "author": "Beaudry",
      "year": "1992",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/0960-9822(93)90019-K_BIB5",
      "doi-asserted-by": "crossref",
      "first-page": "182",
      "DOI": "10.1038/361182a0",
      "article-title": "Evolution in vitro of an RNA enzyme",
      "volume": "361",
      "author": "Lehman",
      "year": "1993",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/0960-9822(93)90019-K_BIB6",
      "doi-asserted-by": "crossref",
      "first-page": "273",
      "DOI": "10.1016/0378-1119(88)90493-3",
      "article-title": "Molecular genetics of group I introns: RNA structures and protein factors required for splicing \u2014 a review",
      "volume": "73",
      "author": "Burke",
      "year": "1988",
      "journal-title": "Gene"
    },
    {
      "key": "10.1016/0960-9822(93)90019-K_BIB7",
      "doi-asserted-by": "crossref",
      "first-page": "543",
      "DOI": "10.1146/annurev.bi.59.070190.002551",
      "article-title": "Self-splicing of group I introns",
      "volume": "59",
      "author": "Cech",
      "year": "1990",
      "journal-title": "Annu Rev Biochem"
    },
    {
      "key": "10.1016/0960-9822(93)90019-K_BIB8",
      "first-page": "8187",
      "article-title": "Direct measurement of oligonucleotide substrate binding to wild-type and mutant ribozymes from Tetrahymena",
      "volume": "87",
      "author": "Pyle",
      "year": "1990"
    },
    {
      "key": "10.1016/0960-9822(93)90019-K_BIB9",
      "doi-asserted-by": "crossref",
      "first-page": "85",
      "DOI": "10.1038/361085a0",
      "article-title": "Metal ion catalysis in the Tetrahymena ribozyme reaction",
      "volume": "361",
      "author": "Piccirilia",
      "year": "1993",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/0960-9822(93)90019-K_BIB10",
      "doi-asserted-by": "crossref",
      "first-page": "6888",
      "DOI": "10.1021/bi00443a017",
      "article-title": "Metal ion requirements for sequence-specific endoribonuclease activity of the Tetrahymena ribozyme",
      "volume": "28",
      "author": "Grosshans",
      "year": "1989",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1016/0960-9822(93)90019-K_BIB11",
      "doi-asserted-by": "crossref",
      "first-page": "401",
      "DOI": "10.1126/science.1989074",
      "article-title": "Visualizing the higher order folding of a catalytic RNA molecule",
      "volume": "251",
      "author": "Celander",
      "year": "1991",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/0960-9822(93)90019-K_BIB12",
      "doi-asserted-by": "crossref",
      "first-page": "10159",
      "DOI": "10.1021/bi00496a003",
      "article-title": "Catalysis of RNA cleavage by the Tetrahymena thermophila ribozyme. I. Kinetic description of the reaction of an RNA substrate complementary to the active site",
      "volume": "29",
      "author": "Herschlag",
      "year": "1990",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1016/0960-9822(93)90019-K_BIB13",
      "doi-asserted-by": "crossref",
      "first-page": "867",
      "DOI": "10.1016/S0300-9084(82)80349-0",
      "article-title": "Comparison of fungal mitochondrial introns reveals extensive homologies in RNA secondary structure",
      "volume": "64",
      "author": "Michel",
      "year": "1982",
      "journal-title": "Biochimie"
    },
    {
      "key": "10.1016/0960-9822(93)90019-K_BIB14",
      "doi-asserted-by": "crossref",
      "first-page": "719",
      "DOI": "10.1038/300719a0",
      "article-title": "Making ends meet: a model for RNA splicing in fungal mitochondria",
      "volume": "300",
      "author": "Davies",
      "year": "1982",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/0960-9822(93)90019-K_BIB15",
      "doi-asserted-by": "crossref",
      "first-page": "585",
      "DOI": "10.1016/0022-2836(90)90386-Z",
      "article-title": "Modelling of the three-dimensional architecture of group I catalytic introns based on comparative sequence analysis",
      "volume": "216",
      "author": "Michel",
      "year": "1990",
      "journal-title": "J Mol Biol"
    },
    {
      "key": "10.1016/0960-9822(93)90019-K_BIB16",
      "doi-asserted-by": "crossref",
      "first-page": "391",
      "DOI": "10.1038/342391a0",
      "article-title": "The guanosine binding site of the Tetrahymena ribozyme",
      "volume": "342",
      "author": "Michel",
      "year": "1989",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/0960-9822(93)90019-K_BIB17",
      "series-title": "Coding and Information Theory",
      "author": "Hamming",
      "year": "1980"
    },
    {
      "key": "10.1016/0960-9822(93)90019-K_BIB18",
      "first-page": "217",
      "article-title": "An extracellular Darwinian experiment with a self-duplicating nucleic acid molecule",
      "volume": "58",
      "author": "Mills",
      "year": "1967"
    },
    {
      "key": "10.1016/0960-9822(93)90019-K_BIB19",
      "first-page": "805",
      "article-title": "Further extracellular Darwinian experiments with replicating RNA molecules: diverse variants isolated under different selection conditions",
      "volume": "63",
      "author": "Levisohn",
      "year": "1969"
    },
    {
      "key": "10.1016/0960-9822(93)90019-K_BIB20",
      "doi-asserted-by": "crossref",
      "first-page": "531",
      "DOI": "10.1016/0022-2836(70)90006-9",
      "article-title": "In vitro selection of bacteriophage Q\u03b2 ribonucleic acid variants resistant to ethidium bromide",
      "volume": "51",
      "author": "Saffhill",
      "year": "1970",
      "journal-title": "J Mol Biol"
    },
    {
      "key": "10.1016/0960-9822(93)90019-K_BIB21",
      "doi-asserted-by": "crossref",
      "first-page": "150",
      "DOI": "10.1128/MMBR.47.2.150-168.1983",
      "article-title": "Selection in chemostats",
      "volume": "47",
      "author": "Dykhuizen",
      "year": "1983",
      "journal-title": "Microbiol Rev"
    },
    {
      "key": "10.1016/0960-9822(93)90019-K_BIB22",
      "doi-asserted-by": "crossref",
      "first-page": "76",
      "DOI": "10.2307/2408316",
      "article-title": "Natural selection in color patterns in Poecilla reticulata",
      "volume": "34",
      "author": "Endler",
      "year": "1980",
      "journal-title": "Evolution"
    },
    {
      "key": "10.1016/0960-9822(93)90019-K_BIB23",
      "doi-asserted-by": "crossref",
      "first-page": "347",
      "DOI": "10.1038/353347a0",
      "article-title": "Experimental detection of rapid evolutionary response in natural lizard populations",
      "volume": "353",
      "author": "Malhotra",
      "year": "1991",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/0960-9822(93)90019-K_BIB24",
      "doi-asserted-by": "crossref",
      "first-page": "541",
      "DOI": "10.1007/BF00450633",
      "article-title": "The hypercycle: a principle of natural self-organization. Part A: emergence of the hypercycle",
      "volume": "64",
      "author": "Eigen",
      "year": "1977",
      "journal-title": "Naturwissenschaften"
    },
    {
      "key": "10.1016/0960-9822(93)90019-K_BIB25",
      "doi-asserted-by": "crossref",
      "first-page": "578",
      "DOI": "10.1038/347578a0",
      "article-title": "Phylogenetic and genetic evidence for base-triples in the catalytic domain of group I introns",
      "volume": "347",
      "author": "Michel",
      "year": "1990",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/0960-9822(93)90019-K_BIB26",
      "first-page": "8788",
      "article-title": "Three-dimensional model of the active site of the self-splicing -RNA precursor of Tetrahymena",
      "volume": "84",
      "author": "Kim",
      "year": "1987"
    },
    {
      "key": "10.1016/0960-9822(93)90019-K_BIB27",
      "doi-asserted-by": "crossref",
      "first-page": "345",
      "DOI": "10.1016/S0022-2836(05)80356-0",
      "article-title": "Mutational analysis of conserved nucleotides in a self-splicing group I intron",
      "volume": "215",
      "author": "Couture",
      "year": "1990",
      "journal-title": "J Mol Biol"
    },
    {
      "key": "10.1016/0960-9822(93)90019-K_BIB28",
      "doi-asserted-by": "crossref",
      "first-page": "406",
      "DOI": "10.1038/347406a0",
      "article-title": "In vitro genetic analysis of the Tetrahymena self-splicing intron",
      "volume": "347",
      "author": "Green",
      "year": "1990",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/0960-9822(93)90019-K_BIB29",
      "doi-asserted-by": "crossref",
      "first-page": "4429",
      "DOI": "10.1093/nar/19.16.4429",
      "article-title": "A self-splicing group I intron in the nuclear pre-RNA of the green alga, Ankistrodesmus stiptatus",
      "volume": "19",
      "author": "Davila-Aponte",
      "year": "1991",
      "journal-title": "Nucleic Acids Res"
    },
    {
      "key": "10.1016/0960-9822(93)90019-K_BIB30",
      "doi-asserted-by": "crossref",
      "first-page": "315",
      "DOI": "10.1016/0022-2836(92)90819-6",
      "article-title": "Numerous group I introns with variable distribution in the ribosomal DNA of a lichen fungus",
      "volume": "228",
      "author": "DePriest",
      "year": "1992",
      "journal-title": "J Mol Biol"
    },
    {
      "key": "10.1016/0960-9822(93)90019-K_BIB31",
      "doi-asserted-by": "crossref",
      "first-page": "1297",
      "DOI": "10.1093/nar/21.5.1297",
      "article-title": "Group I introns in the liverwort mitochondrial genome: the gene coding for subunit 1 of cytochrome oxidase shares five intron positions with its fungal counterparts",
      "volume": "21",
      "author": "Ohta",
      "year": "1993",
      "journal-title": "Nucleic Acids Res"
    },
    {
      "key": "10.1016/0960-9822(93)90019-K_BIB32",
      "doi-asserted-by": "crossref",
      "first-page": "1667",
      "DOI": "10.1093/nar/21.7.1667",
      "article-title": "Nucleotide sequence and secondary structure of the chloroplast group I intron Cr.psbA-2: novel features of this self-splicing ribozyme",
      "volume": "21",
      "author": "Bao",
      "year": "1993",
      "journal-title": "Nucleic Acids Res"
    },
    {
      "key": "10.1016/0960-9822(93)90019-K_BIB33",
      "doi-asserted-by": "crossref",
      "first-page": "3391",
      "DOI": "10.1002/j.1460-2075.1989.tb08503.x",
      "article-title": "A conserved base pair within helix P4 of the Tetrahymena ribozyme helps to form the tertiary structure required for self-splicing",
      "volume": "8",
      "author": "Flor",
      "year": "1989",
      "journal-title": "EMBO J"
    },
    {
      "key": "10.1016/0960-9822(93)90019-K_BIB34",
      "doi-asserted-by": "crossref",
      "first-page": "5291",
      "DOI": "10.1021/bi00071a003",
      "article-title": "An independently folding domain of RNA tertiary structure within the Tetrahymena ribozyme",
      "volume": "32",
      "author": "Murphy",
      "year": "1993",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1016/0960-9822(93)90019-K_BIB35",
      "doi-asserted-by": "crossref",
      "first-page": "181",
      "DOI": "10.1038/362181a0",
      "article-title": "Yeast tRNA-Asp reconition by its cognate class II aminoacyl-tRNA synthetase",
      "volume": "362",
      "author": "Cavarelli",
      "year": "1993",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/0960-9822(93)90019-K_BIB36",
      "first-page": "4298",
      "article-title": "The three-dimensional structure of a phosphorylcholine-binding mouse immunoglobulin Fab and the nature of the antigen binding site",
      "volume": "71",
      "author": "Segal",
      "year": "1974"
    },
    {
      "key": "10.1016/0960-9822(93)90019-K_BIB37",
      "doi-asserted-by": "crossref",
      "first-page": "959",
      "DOI": "10.1126/science.1546293",
      "article-title": "Structural evidence for induced fit as a mechanism for antibody-antigen recognition",
      "volume": "255",
      "author": "Rini",
      "year": "1992",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/0960-9822(93)90019-K_BIB38",
      "doi-asserted-by": "crossref",
      "first-page": "8924",
      "DOI": "10.1021/bi00425a008",
      "article-title": "Sequence-specific endoribonuclease activity of the Tetrahymena ribozyme: enhanced cleavage of certain oligonucleotide substrates that form mismatched ribozyme-substrate complexes",
      "volume": "27",
      "author": "Zaug",
      "year": "1988",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1016/0960-9822(93)90019-K_BIB39",
      "first-page": "711",
      "article-title": "A novel technique for the rapid preparation of mutant RNAs",
      "volume": "17",
      "author": "Joyce",
      "year": "1989",
      "journal-title": "Nucleic Acids Res"
    },
    {
      "key": "10.1016/0960-9822(93)90019-K_BIB40",
      "doi-asserted-by": "crossref",
      "first-page": "8783",
      "DOI": "10.1093/nar/15.21.8783",
      "article-title": "Oligoribonucleotide synthesis using T7 RNA polymerase and synthetic DNA templates",
      "volume": "15",
      "author": "Milligan",
      "year": "1987",
      "journal-title": "Nucleic Acids Res"
    },
    {
      "key": "10.1016/0960-9822(93)90019-K_BIB41",
      "first-page": "1874",
      "article-title": "Isothermal in vitro amplification of nucleic acids by a multienzyme reaction modeled after retroviral replication",
      "volume": "87",
      "author": "Guatelli",
      "year": "1990"
    },
    {
      "key": "10.1016/0960-9822(93)90019-K_BIB42",
      "series-title": "Antisense RNA and DNA",
      "first-page": "353",
      "article-title": "Selective amplification techniques for optimization of ribozyme function",
      "author": "Joyce",
      "year": "1992"
    },
    {
      "key": "10.1016/0960-9822(93)90019-K_BIB43",
      "series-title": "DNA Cloning: A Practical Approach",
      "first-page": "109",
      "article-title": "Techniques for transformation of E. coli.",
      "author": "Hanahan",
      "year": "1985"
    },
    {
      "key": "10.1016/0960-9822(93)90019-K_BIB44",
      "doi-asserted-by": "crossref",
      "first-page": "193",
      "DOI": "10.1016/0003-2697(81)90473-5",
      "article-title": "A rapid boiling method for the preparation of bacterial plasmids",
      "volume": "114",
      "author": "Holmes",
      "year": "1981",
      "journal-title": "Anal Biochem"
    },
    {
      "key": "10.1016/0960-9822(93)90019-K_BIB45",
      "first-page": "5463",
      "article-title": "DNA sequencing with chain-terminating inhibitors",
      "volume": "74",
      "author": "Sanger",
      "year": "1977"
    },
    {
      "key": "10.1016/0960-9822(93)90019-K_BIB46",
      "doi-asserted-by": "crossref",
      "first-page": "89",
      "DOI": "10.1016/0735-0651(85)90011-1",
      "article-title": "Rapid and easy sequencing of large linear double-stranded DNA and supercoiled plasmid DNA",
      "volume": "2",
      "author": "Zagursky",
      "year": "1985",
      "journal-title": "Genet Anal Tech"
    },
    {
      "key": "10.1016/0960-9822(93)90019-K_BIB47",
      "doi-asserted-by": "crossref",
      "first-page": "28",
      "DOI": "10.1101/gr.2.1.28",
      "article-title": "Randomization of genes by PCR mutagenesis",
      "volume": "2",
      "author": "Cadwell",
      "year": "1992",
      "journal-title": "PCR Methods Applic"
    },
    {
      "key": "10.1016/0960-9822(93)90019-K_BIB48",
      "doi-asserted-by": "crossref",
      "first-page": "7217",
      "DOI": "10.1093/nar/15.18.7217",
      "article-title": "Structural conventions for group I introns",
      "volume": "15",
      "author": "Burke",
      "year": "1987",
      "journal-title": "Nucleic Acids Res"
    }
  ],
  "container-title": "Current Biology",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.elsevier.com/content/article/PII:096098229390019K?httpAccept=text/xml",
      "content-type": "text/xml",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://api.elsevier.com/content/article/PII:096098229390019K?httpAccept=text/plain",
      "content-type": "text/plain",
      "content-version": "vor",
      "intended-application": "text-mining"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2020,
        4,
        2
      ]
    ],
    "date-time": "2020-04-02T23:01:29Z",
    "timestamp": 1585868489000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://linkinghub.elsevier.com/retrieve/pii/096098229390019K"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1993,
        11
      ]
    ]
  },
  "references-count": 48,
  "journal-issue": {
    "issue": "11",
    "published-print": {
      "date-parts": [
        [
          1993,
          11
        ]
      ]
    }
  },
  "alternative-id": [
    "096098229390019K"
  ],
  "URL": "http://dx.doi.org/10.1016/0960-9822(93)90019-K",
  "relation": {},
  "ISSN": [
    "0960-9822"
  ],
  "subject": [],
  "container-title-short": "Current Biology",
  "published": {
    "date-parts": [
      [
        1993,
        11
      ]
    ]
  }
}