DOI: 10.1016/0921-8777(94)00040-d. Genetic changes and bioassays in bleomycin- and phleomycin-treated cells, and their relationship to chromosomal breaks

Genetic changes and bioassays in bleomycin- and phleomycin-treated cells, and their relationship to chromosomal breaks

10.1016/0921-8777(94)00040-d

Crossref journal-article

Elsevier BV

Mutation Research/DNA Repair (78)

Bibliography

Mc.Koy, J. F., Pleninger, P., Wall, L., Pramanik, A., Martinez, M., & Moore, C. W. (1995). Genetic changes and bioassays in bleomycin- and phleomycin-treated cells, and their relationship to chromosomal breaks. Mutation Research/DNA Repair, 336(1), 19â27.

Authors 6

Judith F. Mc.Koy (first)
Perrin Pleninger (additional)
Laurel Wall (additional)
Ajay Pramanik (additional)
Marcia Martinez (additional)
Carol Wood Moore (additional)

References 25 Referenced 16

10.1016/S0021-9258(19)70209-9 / J. Biol. Chem. / Origin of malondialdehyde from DNA degraded by Fe(II)·bleomycin by Burger (1980)
10.1016/0024-3205(81)90153-3 / Life Sci. / Mechanism of bleomycin action: in vitro studies by Burger (1981)
10.1016/0027-5107(88)90164-9 / Mutation Res. / The induction of reciprocal translocation in mouse germ cells by chemicals and ionizing radiations I. Dose-response relationships and combined effects of bleomycin with thio-tepa and gamma rays by De Luca (1988)
10.7164/antibiotics.33.426 / J. Antibiot. / Kinetics of the reaction of bleomycin-FE(II)-O2 complex with DNA by Ekimoto (1980)
10.1128/JB.93.5.1662-1670.1967 / J. Bacteriol. / Macromolecule synthesis in temperature-sensitive mutants of yeast by Hartwell (1967)
10.1021/bi00505a001 / Biochemistry / Single-strand and double-strand deoxyribonucleic acid breaks produced by several bleomycin analogues by Huang (1981)
10.1021/bi00258a028 / Biochemistry / Bifunctional intercalation of antitumor antibiotics BBM-928A and echinomycin with deoxyribonucleic acid. Effects of intercalation on deoxyribonucleic acid activity of bleomycin and phleomycin by Huang (1982)
{'key': '10.1016/0921-8777(94)00040-D_BIB8', 'first-page': '2849', 'article-title': 'Effects of DNA superhelical changes induced by ethidium bromide on the DNA-degrading activity of two antitumor antibiotics, bleomycin and phleomycin', 'volume': '43', 'author': 'Huang', 'year': '1983', 'journal-title': 'Cancer Res.'} / Cancer Res. / Effects of DNA superhelical changes induced by ethidium bromide on the DNA-degrading activity of two antitumor antibiotics, bleomycin and phleomycin by Huang (1983)
10.1016/0165-1218(78)90094-0 / Mutation Res. / Bleomycin-induced mutation and recombination in Saccharomyces cerevisiae by Moore (1978)
{'key': '10.1016/0921-8777(94)00040-D_BIB10', 'first-page': '929', 'article-title': 'Control of in vivo (cellular) phleomycin sensitivity by nuclear genotype, growth phase, and metal ions', 'volume': '42', 'author': 'Moore', 'year': '1982', 'journal-title': 'Cancer Res.'} / Cancer Res. / Control of in vivo (cellular) phleomycin sensitivity by nuclear genotype, growth phase, and metal ions by Moore (1982)
{'key': '10.1016/0921-8777(94)00040-D_BIB11', 'first-page': '6837', 'article-title': 'Internucleosomal cleavage and chromosomal degradation by bleomycin and phleomycin in yeast', 'volume': '48', 'author': 'Moore', 'year': '1988', 'journal-title': 'Cancer Res.'} / Cancer Res. / Internucleosomal cleavage and chromosomal degradation by bleomycin and phleomycin in yeast by Moore (1988)
{'key': '10.1016/0921-8777(94)00040-D_BIB12', 'first-page': '6935', 'article-title': 'Cleavage of cellular and extracellular Saccharomyces cerevisiae DNA by bleomycin and phleomycin', 'volume': '49', 'author': 'Moore', 'year': '1989', 'journal-title': 'Cancer Res.'} / Cancer Res. / Cleavage of cellular and extracellular Saccharomyces cerevisiae DNA by bleomycin and phleomycin by Moore (1989)
{'key': '10.1016/0921-8777(94)00040-D_BIB13', 'first-page': '1982', 'article-title': 'Rapid and slow DNA rejoining in nondividing human diploid fibroblasts treated with bleomycin and ionizing radiation', 'volume': '45', 'author': 'Moore', 'year': '1985', 'journal-title': 'Cancer Res.'} / Cancer Res. / Rapid and slow DNA rejoining in nondividing human diploid fibroblasts treated with bleomycin and ionizing radiation by Moore (1985)
10.1126/science.382356 / Science / Genetic effects of impure and pure saccharin in yeast by Moore (1979)
{'key': '10.1016/0921-8777(94)00040-D_BIB15', 'first-page': '51', 'article-title': 'Bleomycin: Mode of action on DNA', 'volume': '19', 'author': 'Mueller', 'year': '1976', 'journal-title': 'GANN'} / GANN / Bleomycin: Mode of action on DNA by Mueller (1976)
10.1093/oxfordjournals.jbchem.a130778 / J. Biochem. / Effects of reducing and oxidizing agents on the action of bleomycin by Onishi (1975)
10.1021/bi00585a023 / Biochemistry / Catalytic release of DNA bases by oxidation-reduction of an iron-bleomycin complex by Povirk (1979)
{'key': '10.1016/0921-8777(94)00040-D_BIB18', 'series-title': 'Molecular Aspects of Anti-Cancer Drug Action', 'first-page': '157', 'article-title': 'Bleomycin', 'author': 'Povirk', 'year': '1983'} / Molecular Aspects of Anti-Cancer Drug Action / Bleomycin by Povirk (1983)
10.1016/0165-1110(91)90022-N / Mutation Res. / Genotoxicity of bleomycin by Povirk (1991)
10.1021/bi00506a034 / Biochemistry / Copper(II) bleomycin, iron(III) bleomycin and copper(II) phleomycin: comparative study of deoxyribonucleic acid binding by Povirk (1981)
{'issue': 'S', 'key': '10.1016/0921-8777(94)00040-D_BIB21', 'first-page': 'A106', 'article-title': 'Some chemotherapeutic agents are capable of inducing aneuploidy, translocation and breakage in the spermatogonial stem cells of treated mice', 'volume': '45', 'author': 'Sen', 'year': '1989', 'journal-title': 'Am. J. Hum. Genet.'} / Am. J. Hum. Genet. / Some chemotherapeutic agents are capable of inducing aneuploidy, translocation and breakage in the spermatogonial stem cells of treated mice by Sen (1989)
10.1002/em.2860060616 / Environ. Mutagen. / Aneuploidy induced by bleomycin in oocytes of Drosophila melanogaster: studies with the aneuploidy pattern method by Traut (1984)
10.1016/0027-5107(80)90096-2 / Mutation Res. / Bleomycin-induced structural chromosomal aberrations in spermatogonia and bone-marrow cells of mice by Van Buul (1980)
10.1016/0165-1110(78)90019-2 / Mutation Res. / Genetic toxicology of bleomycin by Vig (1978)
10.1007/BF00268976 / Mol. Gen. Genet. / Mutagen specificity in the induction of mitotic crossing-over in Saccharomyces cerevisiae by Zimmermann (1975)

Dates

Type	When
Created	23 years, 1 month ago (July 25, 2002, 9:39 p.m.)
Deposited	4 years, 3 months ago (May 13, 2021, 10:22 p.m.)
Indexed	3 months ago (June 3, 2025, 9:28 a.m.)
Issued	30 years, 8 months ago (Jan. 1, 1995)
Published	30 years, 8 months ago (Jan. 1, 1995)
Published Print	30 years, 8 months ago (Jan. 1, 1995)

Funders 0

None

BibTeX

@article{Mc_Koy_1995, title={Genetic changes and bioassays in bleomycin- and phleomycin-treated cells, and their relationship to chromosomal breaks}, volume={336}, ISSN={0921-8777}, url={http://dx.doi.org/10.1016/0921-8777(94)00040-d}, DOI={10.1016/0921-8777(94)00040-d}, number={1}, journal={Mutation Research/DNA Repair}, publisher={Elsevier BV}, author={Mc.Koy, Judith F. and Pleninger, Perrin and Wall, Laurel and Pramanik, Ajay and Martinez, Marcia and Moore, Carol Wood}, year={1995}, month=jan, pages={19–27} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        6,
        3
      ]
    ],
    "date-time": "2025-06-03T13:28:05Z",
    "timestamp": 1748957285455
  },
  "reference-count": 25,
  "publisher": "Elsevier BV",
  "issue": "1",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            1995,
            1,
            1
          ]
        ],
        "date-time": "1995-01-01T00:00:00Z",
        "timestamp": 788918400000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://www.elsevier.com/tdm/userlicense/1.0/"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        1995,
        1
      ]
    ]
  },
  "DOI": "10.1016/0921-8777(94)00040-d",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2002,
        7,
        26
      ]
    ],
    "date-time": "2002-07-26T01:39:05Z",
    "timestamp": 1027647545000
  },
  "page": "19-27",
  "source": "Crossref",
  "is-referenced-by-count": 16,
  "title": "Genetic changes and bioassays in bleomycin- and phleomycin-treated cells, and their relationship to chromosomal breaks",
  "prefix": "10.1016",
  "volume": "336",
  "author": [
    {
      "given": "Judith F.",
      "family": "Mc.Koy",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Perrin",
      "family": "Pleninger",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Laurel",
      "family": "Wall",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Ajay",
      "family": "Pramanik",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Marcia",
      "family": "Martinez",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Carol Wood",
      "family": "Moore",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "78",
  "reference": [
    {
      "key": "10.1016/0921-8777(94)00040-D_BIB1",
      "doi-asserted-by": "crossref",
      "first-page": "11832",
      "DOI": "10.1016/S0021-9258(19)70209-9",
      "article-title": "Origin of malondialdehyde from DNA degraded by Fe(II)\u00b7bleomycin",
      "volume": "255",
      "author": "Burger",
      "year": "1980",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/0921-8777(94)00040-D_BIB2",
      "doi-asserted-by": "crossref",
      "first-page": "715",
      "DOI": "10.1016/0024-3205(81)90153-3",
      "article-title": "Mechanism of bleomycin action: in vitro studies",
      "volume": "28",
      "author": "Burger",
      "year": "1981",
      "journal-title": "Life Sci."
    },
    {
      "key": "10.1016/0921-8777(94)00040-D_BIB3",
      "doi-asserted-by": "crossref",
      "first-page": "65",
      "DOI": "10.1016/0027-5107(88)90164-9",
      "article-title": "The induction of reciprocal translocation in mouse germ cells by chemicals and ionizing radiations I. Dose-response relationships and combined effects of bleomycin with thio-tepa and gamma rays",
      "volume": "202",
      "author": "De Luca",
      "year": "1988",
      "journal-title": "Mutation Res."
    },
    {
      "key": "10.1016/0921-8777(94)00040-D_BIB4",
      "doi-asserted-by": "crossref",
      "first-page": "426",
      "DOI": "10.7164/antibiotics.33.426",
      "article-title": "Kinetics of the reaction of bleomycin-FE(II)-O2 complex with DNA",
      "volume": "33",
      "author": "Ekimoto",
      "year": "1980",
      "journal-title": "J. Antibiot."
    },
    {
      "key": "10.1016/0921-8777(94)00040-D_BIB5",
      "doi-asserted-by": "crossref",
      "first-page": "1662",
      "DOI": "10.1128/JB.93.5.1662-1670.1967",
      "article-title": "Macromolecule synthesis in temperature-sensitive mutants of yeast",
      "volume": "93",
      "author": "Hartwell",
      "year": "1967",
      "journal-title": "J. Bacteriol."
    },
    {
      "key": "10.1016/0921-8777(94)00040-D_BIB6",
      "doi-asserted-by": "crossref",
      "first-page": "233",
      "DOI": "10.1021/bi00505a001",
      "article-title": "Single-strand and double-strand deoxyribonucleic acid breaks produced by several bleomycin analogues",
      "volume": "20",
      "author": "Huang",
      "year": "1981",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1016/0921-8777(94)00040-D_BIB7",
      "doi-asserted-by": "crossref",
      "first-page": "3704",
      "DOI": "10.1021/bi00258a028",
      "article-title": "Bifunctional intercalation of antitumor antibiotics BBM-928A and echinomycin with deoxyribonucleic acid. Effects of intercalation on deoxyribonucleic acid activity of bleomycin and phleomycin",
      "volume": "21",
      "author": "Huang",
      "year": "1982",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1016/0921-8777(94)00040-D_BIB8",
      "first-page": "2849",
      "article-title": "Effects of DNA superhelical changes induced by ethidium bromide on the DNA-degrading activity of two antitumor antibiotics, bleomycin and phleomycin",
      "volume": "43",
      "author": "Huang",
      "year": "1983",
      "journal-title": "Cancer Res."
    },
    {
      "key": "10.1016/0921-8777(94)00040-D_BIB9",
      "doi-asserted-by": "crossref",
      "first-page": "41",
      "DOI": "10.1016/0165-1218(78)90094-0",
      "article-title": "Bleomycin-induced mutation and recombination in Saccharomyces cerevisiae",
      "volume": "58",
      "author": "Moore",
      "year": "1978",
      "journal-title": "Mutation Res."
    },
    {
      "key": "10.1016/0921-8777(94)00040-D_BIB10",
      "first-page": "929",
      "article-title": "Control of in vivo (cellular) phleomycin sensitivity by nuclear genotype, growth phase, and metal ions",
      "volume": "42",
      "author": "Moore",
      "year": "1982",
      "journal-title": "Cancer Res."
    },
    {
      "key": "10.1016/0921-8777(94)00040-D_BIB11",
      "first-page": "6837",
      "article-title": "Internucleosomal cleavage and chromosomal degradation by bleomycin and phleomycin in yeast",
      "volume": "48",
      "author": "Moore",
      "year": "1988",
      "journal-title": "Cancer Res."
    },
    {
      "key": "10.1016/0921-8777(94)00040-D_BIB12",
      "first-page": "6935",
      "article-title": "Cleavage of cellular and extracellular Saccharomyces cerevisiae DNA by bleomycin and phleomycin",
      "volume": "49",
      "author": "Moore",
      "year": "1989",
      "journal-title": "Cancer Res."
    },
    {
      "key": "10.1016/0921-8777(94)00040-D_BIB13",
      "first-page": "1982",
      "article-title": "Rapid and slow DNA rejoining in nondividing human diploid fibroblasts treated with bleomycin and ionizing radiation",
      "volume": "45",
      "author": "Moore",
      "year": "1985",
      "journal-title": "Cancer Res."
    },
    {
      "key": "10.1016/0921-8777(94)00040-D_BIB14",
      "doi-asserted-by": "crossref",
      "first-page": "1007",
      "DOI": "10.1126/science.382356",
      "article-title": "Genetic effects of impure and pure saccharin in yeast",
      "volume": "205",
      "author": "Moore",
      "year": "1979",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/0921-8777(94)00040-D_BIB15",
      "first-page": "51",
      "article-title": "Bleomycin: Mode of action on DNA",
      "volume": "19",
      "author": "Mueller",
      "year": "1976",
      "journal-title": "GANN"
    },
    {
      "key": "10.1016/0921-8777(94)00040-D_BIB16",
      "doi-asserted-by": "crossref",
      "first-page": "745",
      "DOI": "10.1093/oxfordjournals.jbchem.a130778",
      "article-title": "Effects of reducing and oxidizing agents on the action of bleomycin",
      "volume": "77",
      "author": "Onishi",
      "year": "1975",
      "journal-title": "J. Biochem."
    },
    {
      "key": "10.1016/0921-8777(94)00040-D_BIB17",
      "doi-asserted-by": "crossref",
      "first-page": "3989",
      "DOI": "10.1021/bi00585a023",
      "article-title": "Catalytic release of DNA bases by oxidation-reduction of an iron-bleomycin complex",
      "volume": "18",
      "author": "Povirk",
      "year": "1979",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1016/0921-8777(94)00040-D_BIB18",
      "series-title": "Molecular Aspects of Anti-Cancer Drug Action",
      "first-page": "157",
      "article-title": "Bleomycin",
      "author": "Povirk",
      "year": "1983"
    },
    {
      "key": "10.1016/0921-8777(94)00040-D_BIB19",
      "doi-asserted-by": "crossref",
      "first-page": "127",
      "DOI": "10.1016/0165-1110(91)90022-N",
      "article-title": "Genotoxicity of bleomycin",
      "volume": "257",
      "author": "Povirk",
      "year": "1991",
      "journal-title": "Mutation Res."
    },
    {
      "key": "10.1016/0921-8777(94)00040-D_BIB20",
      "doi-asserted-by": "crossref",
      "first-page": "665",
      "DOI": "10.1021/bi00506a034",
      "article-title": "Copper(II) bleomycin, iron(III) bleomycin and copper(II) phleomycin: comparative study of deoxyribonucleic acid binding",
      "volume": "20",
      "author": "Povirk",
      "year": "1981",
      "journal-title": "Biochemistry"
    },
    {
      "issue": "S",
      "key": "10.1016/0921-8777(94)00040-D_BIB21",
      "first-page": "A106",
      "article-title": "Some chemotherapeutic agents are capable of inducing aneuploidy, translocation and breakage in the spermatogonial stem cells of treated mice",
      "volume": "45",
      "author": "Sen",
      "year": "1989",
      "journal-title": "Am. J. Hum. Genet."
    },
    {
      "key": "10.1016/0921-8777(94)00040-D_BIB22",
      "doi-asserted-by": "crossref",
      "first-page": "889",
      "DOI": "10.1002/em.2860060616",
      "article-title": "Aneuploidy induced by bleomycin in oocytes of Drosophila melanogaster: studies with the aneuploidy pattern method",
      "volume": "6",
      "author": "Traut",
      "year": "1984",
      "journal-title": "Environ. Mutagen."
    },
    {
      "key": "10.1016/0921-8777(94)00040-D_BIB23",
      "doi-asserted-by": "crossref",
      "first-page": "319",
      "DOI": "10.1016/0027-5107(80)90096-2",
      "article-title": "Bleomycin-induced structural chromosomal aberrations in spermatogonia and bone-marrow cells of mice",
      "volume": "69",
      "author": "Van Buul",
      "year": "1980",
      "journal-title": "Mutation Res."
    },
    {
      "key": "10.1016/0921-8777(94)00040-D_BIB24",
      "doi-asserted-by": "crossref",
      "first-page": "121",
      "DOI": "10.1016/0165-1110(78)90019-2",
      "article-title": "Genetic toxicology of bleomycin",
      "volume": "55",
      "author": "Vig",
      "year": "1978",
      "journal-title": "Mutation Res."
    },
    {
      "key": "10.1016/0921-8777(94)00040-D_BIB25",
      "doi-asserted-by": "crossref",
      "first-page": "255",
      "DOI": "10.1007/BF00268976",
      "article-title": "Mutagen specificity in the induction of mitotic crossing-over in Saccharomyces cerevisiae",
      "volume": "139",
      "author": "Zimmermann",
      "year": "1975",
      "journal-title": "Mol. Gen. Genet."
    }
  ],
  "container-title": "Mutation Research/DNA Repair",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.elsevier.com/content/article/PII:092187779400040D?httpAccept=text/xml",
      "content-type": "text/xml",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://api.elsevier.com/content/article/PII:092187779400040D?httpAccept=text/plain",
      "content-type": "text/plain",
      "content-version": "vor",
      "intended-application": "text-mining"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2021,
        5,
        14
      ]
    ],
    "date-time": "2021-05-14T02:22:45Z",
    "timestamp": 1620958965000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://linkinghub.elsevier.com/retrieve/pii/092187779400040D"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1995,
        1
      ]
    ]
  },
  "references-count": 25,
  "journal-issue": {
    "issue": "1",
    "published-print": {
      "date-parts": [
        [
          1995,
          1
        ]
      ]
    }
  },
  "alternative-id": [
    "092187779400040D"
  ],
  "URL": "http://dx.doi.org/10.1016/0921-8777(94)00040-D",
  "relation": {},
  "ISSN": [
    "0921-8777"
  ],
  "subject": [],
  "container-title-short": "Mutation Research/DNA Repair",
  "published": {
    "date-parts": [
      [
        1995,
        1
      ]
    ]
  }
}