DOI: 10.1016/0896-6273(92)90117-v. Tau proteins of alzheimer paired helical filaments: Abnormal phosphorylation of all six brain isoforms

Tau proteins of alzheimer paired helical filaments: Abnormal phosphorylation of all six brain isoforms

10.1016/0896-6273(92)90117-v

Crossref journal-article

Elsevier BV

Neuron (78)

Bibliography

Goedert, M., Spillantini, M. G., Cairns, N. J., & Crowther, R. A. (1992). Tau proteins of alzheimer paired helical filaments: Abnormal phosphorylation of all six brain isoforms. Neuron, 8(1), 159â168.

Authors 4

M. Goedert (first)
M.G. Spillantini (additional)
N.J. Cairns (additional)
R.A. Crowther (additional)

References 37 Referenced 892

10.1016/S0021-9258(18)83632-8 / J. Biol. Chem. / A common amino acid sequence in 190-kd microtubule-associated protein and the promotion of microtubule assembly by Aizawa (1989)
{'key': '10.1016/0896-6273(92)90117-V_BIB2', 'first-page': '146', 'article-title': 'Über eine eigenartige Erkrankung der Hirnrinde', 'volume': '64', 'author': 'Alzheimer', 'year': '1907', 'journal-title': 'Allg. Z. Psychiat.'} / Allg. Z. Psychiat. / Über eine eigenartige Erkrankung der Hirnrinde by Alzheimer (1907)
{'key': '10.1016/0896-6273(92)90117-V_BIB3', 'first-page': '229', 'article-title': "Mise en evidence immunologique de la protéine tau au niveau des lesions de dégénérescence neurofibrillaire de la maladie d'Alzheimer", 'volume': '95', 'author': 'Brion', 'year': '1985', 'journal-title': 'Arch. Biol.(Bruxelles)'} / Arch. Biol.(Bruxelles) / Mise en evidence immunologique de la protéine tau au niveau des lesions de dégénérescence neurofibrillaire de la maladie d'Alzheimer by Brion (1985)
10.1042/bj2730127 / Biochem. J. / Tau in Alzheimer neurofibrillary tangles.N-and C-terminal regions are differentially associated with paired helical filaments and the location of a putative abnormal phosphorylation site by Brion (1991)
{'key': '10.1016/0896-6273(92)90117-V_BIB5', 'first-page': '2288', 'article-title': 'Straight and paired helical filaments in Alzheimer disease have a common structural unit', 'volume': '88', 'author': 'Crowther', 'year': '1991'} / Straight and paired helical filaments in Alzheimer disease have a common structural unit by Crowther (1991)
10.1016/0022-510X(86)90167-X / J. Neurol. Sci. / Alzheimer's disease: tau proteins, the promoting factors of microtubule assembly, are major components of paired helical filaments by Delacourte (1986)
10.1016/S0021-9258(18)83547-5 / J. Biol. Chem. / Two separate 18-amino acid domains of tau promote the polymerization of tubulin by Ennulat (1989)
10.1016/0014-5793(89)81337-7 / FEBS Lett. / Abnormal tau species are produced during Alzheimer's disease neurodegenerating process by Flament (1989)
10.1016/0006-8993(90)90891-E / Brain Res. / Phosphorylation of tau proteins: a major event during the process of neurofibrillary degeneration. A comparative study between Alzheimer's disease and Down's syndrome by Flament (1990)
10.1002/j.1460-2075.1990.tb07870.x / EMBO J. / Expression of separate isoforms of human tau protein: correlation with the tau pattern in brain and effects on tubulin polymerization by Goedert (1990)
{'key': '10.1016/0896-6273(92)90117-V_BIB11', 'first-page': '4051', 'article-title': 'Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau', 'volume': '85', 'author': 'Goedert', 'year': '1988'} / Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau by Goedert (1988)
10.1016/0896-6273(89)90210-9 / Neuron / Multiple isoforms of human microtubuleassociated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease by Goedert (1989)
10.1016/0166-2236(91)90105-4 / Trends Neurosci. / Molecular characterization of microtubule-associated proteins tau and MAP2 by Goedert (1991)
{'key': '10.1016/0896-6273(92)90117-V_BIB14', 'first-page': '5827', 'article-title': 'A preparation of Alzheimer paired helical filaments that displays distinct tau proteins by polyacrylamide gel electrophoresis', 'volume': '87', 'author': 'Greenberg', 'year': '1990'} / A preparation of Alzheimer paired helical filaments that displays distinct tau proteins by polyacrylamide gel electrophoresis by Greenberg (1990)
{'key': '10.1016/0896-6273(92)90117-V_BIB15', 'first-page': '4913', 'article-title': 'Abnormal phosphorylation of the microtubule-associated protein tau in Alzheimer cytoskeletal pathology', 'volume': '83', 'author': 'Grundke-Iqbal', 'year': '1986'} / Abnormal phosphorylation of the microtubule-associated protein tau in Alzheimer cytoskeletal pathology by Grundke-Iqbal (1986)
10.1042/bj2750099 / Biochem. J. / Tau in Alzheimer's disease and Down's syndrome is insoluble and abnormally phosphorylated by Hanger (1991)
10.1128/MCB.9.4.1381 / Mol. Cell. Biol. / Tau consists of a set of proteins with repeated C-terminal microtubule-binding domains and variable N-terminal domains by Himmler (1989)
10.1093/oxfordjournals.jbchem.a135662 / J. Biochem. / Phosphorylated tau protein is integrated into paired helical filaments in Alzheimer's disease by Ihara (1986)
{'key': '10.1016/0896-6273(92)90117-V_BIB19', 'first-page': '5646', 'article-title': 'Identification and localization of a tau peptide to paired helical filaments of Alzheimer disease', 'volume': '86', 'author': 'Iqbal', 'year': '1989'} / Identification and localization of a tau peptide to paired helical filaments of Alzheimer disease by Iqbal (1989)
10.1176/ajp.105.2.102 / Am. J. Psychiatry / Early senile dementia in mongoloid idiocy by Jervis (1948)
10.1038/197192b0 / Nature / Paired helical filaments in electron microscopy of Alzheimer's disease by Kidd (1963)
10.1016/0896-6273(88)90130-4 / Neuron / The carboxyl third of tau is tightly bound to paired helical filaments by Kondo (1988)
{'key': '10.1016/0896-6273(92)90117-V_BIB23', 'first-page': '4044', 'article-title': "Microtubuleassociated protein tau is a major antigenic component of paired helical filaments in Alzheimer's disease", 'volume': '83', 'author': 'Kosik', 'year': '1986'} / Microtubuleassociated protein tau is a major antigenic component of paired helical filaments in Alzheimer's disease by Kosik (1986)
10.1016/0896-6273(88)90129-8 / Neuron / Epitopes that span the tau molecule are shared with paired helical filaments by Kosik (1988)
10.1016/0896-6273(91)90169-Z / Neuron / Structural stability of paired helical filaments requires microtubule-binding domains of tau: a model for self-association by Ksiezak-Reding (1991)
10.1038/227680a0 / Nature / Cleavage of structural proteins during the assembly of the head of bacteriophage T4 by Laemmli (1970)
10.1016/0896-6273(89)90050-0 / Neuron / The microtubule binding domain of tau protein by Lee (1989)
10.1126/science.1899488 / Science / A68: a major subunit of paired helical filaments and derivatized forms of normal tau by Lee (1991)
{'key': '10.1016/0896-6273(92)90117-V_BIB29', 'first-page': '5837', 'article-title': 'Difference between the tau protein of Alzheimer paired helical filament core and normal tau revealed by epitope analysis of mAbs 423 and 751', 'volume': '88', 'author': 'Novak', 'year': '1991'} / Difference between the tau protein of Alzheimer paired helical filament core and normal tau revealed by epitope analysis of mAbs 423 and 751 by Novak (1991)
10.1007/BF00688880 / Acta Neuropathol. / Senile dementia of Alzheimer type: astroglial reaction to extracellular neurofibrillary tangles in the hippocampus by Probst (1982)
10.1016/0006-8993(86)91460-5 / Brain Res. / Paired helical filaments associated with Alzheimer disease are readily soluble structures by Rubenstein (1986)
10.1002/j.1460-2075.1990.tb07563.x / EMBO J. / Phosphorylation of microtubule-associated protein tau: identification of the site for Ca2+/calmodulin dependent kinase and relationship with tau phosphorylation in Alzheimer tangles by Steiner (1990)
{'key': '10.1016/0896-6273(92)90117-V_BIB33', 'first-page': '337', 'article-title': 'Alterserkrankungen des Zentralnervensystems', 'volume': 'Vol. 1A', 'author': 'Von Braunmühl', 'year': '1957'} / Alterserkrankungen des Zentralnervensystems by Von Braunmühl (1957)
{'key': '10.1016/0896-6273(92)90117-V_BIB34', 'first-page': '4506', 'article-title': 'Isolation of a fragment of tau derived from the core of the Alzheimer paired helical filament', 'volume': '85', 'author': 'Wischik', 'year': '1988'} / Isolation of a fragment of tau derived from the core of the Alzheimer paired helical filament by Wischik (1988)
{'key': '10.1016/0896-6273(92)90117-V_BIB35', 'first-page': '4884', 'article-title': 'Structural characterization of the coreof the paired helical filament of Alzheimer disease', 'volume': '95', 'author': 'Wischik', 'year': '1988'} / Structural characterization of the coreof the paired helical filament of Alzheimer disease by Wischik (1988)
10.1126/science.3083509 / Science / A neuronal antigen in the brains of Alzheimer patients by Wolozin (1986)
{'key': '10.1016/0896-6273(92)90117-V_BIB37', 'first-page': '4040', 'article-title': 'Neurofibrillary tangles of Alzheimer disease share antigenic determinants with the axonal microtubule-associated protein tau', 'volume': '83', 'author': 'Wood', 'year': '1986'} / Neurofibrillary tangles of Alzheimer disease share antigenic determinants with the axonal microtubule-associated protein tau by Wood (1986)

Dates

Type	When
Created	20 years, 11 months ago (Sept. 8, 2004, 2:41 p.m.)
Deposited	4 years, 2 months ago (June 25, 2021, 11:36 a.m.)
Indexed	1 day, 7 hours ago (Sept. 4, 2025, 9:33 a.m.)
Issued	33 years, 8 months ago (Jan. 1, 1992)
Published	33 years, 8 months ago (Jan. 1, 1992)
Published Print	33 years, 8 months ago (Jan. 1, 1992)

Funders 0

None

BibTeX

@article{Goedert_1992, title={Tau proteins of alzheimer paired helical filaments: Abnormal phosphorylation of all six brain isoforms}, volume={8}, ISSN={0896-6273}, url={http://dx.doi.org/10.1016/0896-6273(92)90117-v}, DOI={10.1016/0896-6273(92)90117-v}, number={1}, journal={Neuron}, publisher={Elsevier BV}, author={Goedert, M. and Spillantini, M.G. and Cairns, N.J. and Crowther, R.A.}, year={1992}, month=jan, pages={159–168} }

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      "author": "Brion",
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      "author": "Flament",
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      "author": "Flament",
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      "journal-title": "Brain Res."
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      "volume": "9",
      "author": "Goedert",
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      "first-page": "4051",
      "article-title": "Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau",
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      "year": "1988"
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      "year": "1991",
      "journal-title": "Trends Neurosci."
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      "first-page": "5827",
      "article-title": "A preparation of Alzheimer paired helical filaments that displays distinct tau proteins by polyacrylamide gel electrophoresis",
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      "volume": "99",
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      "year": "1986",
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      "author": "Lee",
      "year": "1989",
      "journal-title": "Neuron"
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      "key": "10.1016/0896-6273(92)90117-V_BIB28",
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      "first-page": "675",
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      "volume": "251",
      "author": "Lee",
      "year": "1991",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/0896-6273(92)90117-V_BIB29",
      "first-page": "5837",
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      "first-page": "75",
      "DOI": "10.1007/BF00688880",
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      "volume": "57",
      "author": "Probst",
      "year": "1982",
      "journal-title": "Acta Neuropathol."
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