DOI: 10.1016/0378-1119(94)90366-2. Cloning and characterization of a yeast cytochrome b5-encoding gene which suppresses ketoconazole hypersensitivity in a NADPH-P-450 reductase-deficient strain

Cloning and characterization of a yeast cytochrome b5-encoding gene which suppresses ketoconazole hypersensitivity in a NADPH-P-450 reductase-deficient strain

10.1016/0378-1119(94)90366-2

Crossref journal-article

Elsevier BV

Gene (78)

Bibliography

Truan, G., Epinat, J.-C., Rougeulle, C., Cullin, C., & Pompon, D. (1994). Cloning and characterization of a yeast cytochrome b5-encoding gene which suppresses ketoconazole hypersensitivity in a NADPH-P-450 reductase-deficient strain. Gene, 142(1), 123â127.

Authors 5

Gilles Truan (first)
Jean-Charles Epinat (additional)
Claire Rougeulle (additional)
Christophe Cullin (additional)
Denis Pompon (additional)

References 22 Referenced 67

10.1016/0005-2760(81)90205-8 / Biochim. Biophys. Acta / Involvement of eytochrome b5, and a cyanide-sensitive monooxygenase in the 4-demethylation of 4,4-dimethyl-zymosterol by yeast microsomes by Aoyama (1981)
10.1002/yea.320070609 / Yeast / A family of low and high copy replicative, integrative and single-stranded S. cerevisiae/E. coli shuttle vectors by Bonneaud (1991)
10.1093/nar/12.1Part1.387 / Nucleic Acids Res. / A comprehensive set of sequence analysis program for the VAX by Devereux (1984)
10.1016/S0021-9258(18)99177-5 / J. Biol. Chem. / Reactions and significance of cytochrome-P-450 enzymes by Guengerich (1991)
10.1002/yea.320020304 / Yeast / Yeast/E. coli shuttle vectors with multiple unique restriction sites by Hill (1993)
10.1128/MCB.11.3.1326 / Mol. Cell. Biol. / p68 RNA helicase: identification of a nucleolar form and cloning of related genes containing a conserved intron in yeasts by Iggo (1991)
10.1089/dna.1987.6.529 / DNA / Primary structure of the P450 lanosterol demethylase gene from Saccharomyces cerevisiae by Kalb (1987)
{'key': '10.1016/0378-1119(94)90366-2_BIB8', 'first-page': '387', 'article-title': 'The structure of eytochrome b5 at 2.0 angstroms', 'volume': '36', 'author': 'Mathews', 'year': '1972'} / The structure of eytochrome b5 at 2.0 angstroms by Mathews (1972)
10.1002/j.1460-2075.1992.tb05513.x / EMBO J. / The C-terminal 10 amino acid residues of eytochrome 5 are necessary for its targeting to the endoplasmic reticulum by Mitoma (1992)
10.1006/abbi.1993.1100 / Arch. Biochem. Biophys. / The structural requirements of sterols for membrane functions in Saccharomyces cerevisiae by Nes (1993)
{'key': '10.1016/0378-1119(94)90366-2_BIB11', 'first-page': '2444', 'article-title': 'Improved tools for biological sequence comparison', 'volume': '85', 'author': 'Pearson', 'year': '1988'} / Improved tools for biological sequence comparison by Pearson (1988)
{'key': '10.1016/0378-1119(94)90366-2_BIB12', 'first-page': '712', 'article-title': 'Sterol synergism in yeast', 'volume': '80', 'author': 'Ramgopal', 'year': '1983'} / Sterol synergism in yeast by Ramgopal (1983)
10.1016/S0021-9258(17)40432-7 / J. Biol. Chem. / Mechanism of C-5 double bond introduction in the biosynthesis of cholesterol by rat liver microsomes by Reddy (1977)
10.1016/0005-2760(85)90057-8 / Biochim. Biophys. Acta / Multiple functions for sterols in Saccharomyces cerevisiae by Rodriguez (1985)
{'key': '10.1016/0378-1119(94)90366-2_BIB15', 'first-page': '4565', 'article-title': 'Purification and properties of rat liver microsomal stearyl coenzyme A desaturase', 'volume': '71', 'author': 'Strittmatter', 'year': '1974'} / Purification and properties of rat liver microsomal stearyl coenzyme A desaturase by Strittmatter (1974)
10.1016/S0006-291X(89)80139-1 / Biochem. Biophys. Res. Commun. / Disruption of the Saccharomyces cerevisiae gene for NADPH-cytochrome P450 reductase causes increased sensitivity to ketoconazole by Sutler (1989)
10.1016/0378-1119(93)90744-N / Gene / Enhanced in vivo monooxygenase activities of mammalian P450s in engineered yeast cells producing high levels of NADPH-P450 reductase and human eytochrome b5 by Truan (1993)
10.1042/bst0180056 / Biochem. Soc. Trans. / Mutation in eytochrome P-450-dependent 14 alpha-demethylase results in decreased affinity for azole antifungals by Vanden Bossche (1990)
10.1042/bst0180010 / Biochem. Soc. Trans. / From 14 alpha-demethylase inhibitors in fungal cells to androgen and oestrogen biosynthesis inhibitors in mammalian cells by Vanden Bossche (1990)
10.1016/S0021-9258(18)42317-4 / J. Biol. Chem. / Expression of eytochrome b5 in yeast and characterisation of mutants of the membrane anchoring domain by Vergéres (1992)
10.1016/0006-2952(87)90694-0 / Biochem. Pharmacol. / Interaction of azole antifungal agents with eytochrome P-450 14DM purified from Saccharomyces cerevisiae microsomes by Yoshida (1987)
10.1042/bst0190778 / Biochem. Soc. Trans. / Sterol 14 alpha-demethylase and its inhibition: structural considerations on interaction of azole antifungal agents with lanosterol 14 alpha-demethylase (P-450 14DM) of yeast by Yoshida (1991)

Dates

Type	When
Created	22 years, 6 months ago (Feb. 11, 2003, 9:08 p.m.)
Deposited	4 years, 3 months ago (June 4, 2021, 2:54 a.m.)
Indexed	4 months, 3 weeks ago (April 10, 2025, 12:07 p.m.)
Issued	31 years, 4 months ago (May 1, 1994)
Published	31 years, 4 months ago (May 1, 1994)
Published Print	31 years, 4 months ago (May 1, 1994)

Funders 0

None

BibTeX

@article{Truan_1994, title={Cloning and characterization of a yeast cytochrome b5-encoding gene which suppresses ketoconazole hypersensitivity in a NADPH-P-450 reductase-deficient strain}, volume={142}, ISSN={0378-1119}, url={http://dx.doi.org/10.1016/0378-1119(94)90366-2}, DOI={10.1016/0378-1119(94)90366-2}, number={1}, journal={Gene}, publisher={Elsevier BV}, author={Truan, Gilles and Epinat, Jean-Charles and Rougeulle, Claire and Cullin, Christophe and Pompon, Denis}, year={1994}, month=may, pages={123–127} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        4,
        10
      ]
    ],
    "date-time": "2025-04-10T16:07:26Z",
    "timestamp": 1744301246049
  },
  "reference-count": 22,
  "publisher": "Elsevier BV",
  "issue": "1",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            1994,
            5,
            1
          ]
        ],
        "date-time": "1994-05-01T00:00:00Z",
        "timestamp": 767750400000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://www.elsevier.com/tdm/userlicense/1.0/"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        1994,
        5
      ]
    ]
  },
  "DOI": "10.1016/0378-1119(94)90366-2",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2003,
        2,
        12
      ]
    ],
    "date-time": "2003-02-12T02:08:32Z",
    "timestamp": 1045015712000
  },
  "page": "123-127",
  "source": "Crossref",
  "is-referenced-by-count": 67,
  "title": "Cloning and characterization of a yeast cytochrome b5-encoding gene which suppresses ketoconazole hypersensitivity in a NADPH-P-450 reductase-deficient strain",
  "prefix": "10.1016",
  "volume": "142",
  "author": [
    {
      "given": "Gilles",
      "family": "Truan",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Jean-Charles",
      "family": "Epinat",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Claire",
      "family": "Rougeulle",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Christophe",
      "family": "Cullin",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Denis",
      "family": "Pompon",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "78",
  "reference": [
    {
      "key": "10.1016/0378-1119(94)90366-2_BIB1",
      "doi-asserted-by": "crossref",
      "first-page": "194",
      "DOI": "10.1016/0005-2760(81)90205-8",
      "article-title": "Involvement of eytochrome b5, and a cyanide-sensitive monooxygenase in the 4-demethylation of 4,4-dimethyl-zymosterol by yeast microsomes",
      "volume": "663",
      "author": "Aoyama",
      "year": "1981",
      "journal-title": "Biochim. Biophys. Acta"
    },
    {
      "key": "10.1016/0378-1119(94)90366-2_BIB2",
      "doi-asserted-by": "crossref",
      "first-page": "609",
      "DOI": "10.1002/yea.320070609",
      "article-title": "A family of low and high copy replicative, integrative and single-stranded S. cerevisiae/E. coli shuttle vectors",
      "volume": "7",
      "author": "Bonneaud",
      "year": "1991",
      "journal-title": "Yeast"
    },
    {
      "key": "10.1016/0378-1119(94)90366-2_BIB3",
      "doi-asserted-by": "crossref",
      "first-page": "387",
      "DOI": "10.1093/nar/12.1Part1.387",
      "article-title": "A comprehensive set of sequence analysis program for the VAX",
      "volume": "12",
      "author": "Devereux",
      "year": "1984",
      "journal-title": "Nucleic Acids Res."
    },
    {
      "key": "10.1016/0378-1119(94)90366-2_BIB4",
      "doi-asserted-by": "crossref",
      "first-page": "10019",
      "DOI": "10.1016/S0021-9258(18)99177-5",
      "article-title": "Reactions and significance of cytochrome-P-450 enzymes",
      "volume": "266",
      "author": "Guengerich",
      "year": "1991",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/0378-1119(94)90366-2_BIB5",
      "doi-asserted-by": "crossref",
      "first-page": "163",
      "DOI": "10.1002/yea.320020304",
      "article-title": "Yeast/E. coli shuttle vectors with multiple unique restriction sites",
      "volume": "2",
      "author": "Hill",
      "year": "1993",
      "journal-title": "Yeast"
    },
    {
      "key": "10.1016/0378-1119(94)90366-2_BIB6",
      "doi-asserted-by": "crossref",
      "first-page": "1326",
      "DOI": "10.1128/MCB.11.3.1326",
      "article-title": "p68 RNA helicase: identification of a nucleolar form and cloning of related genes containing a conserved intron in yeasts",
      "volume": "11",
      "author": "Iggo",
      "year": "1991",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1016/0378-1119(94)90366-2_BIB7",
      "doi-asserted-by": "crossref",
      "first-page": "529",
      "DOI": "10.1089/dna.1987.6.529",
      "article-title": "Primary structure of the P450 lanosterol demethylase gene from Saccharomyces cerevisiae",
      "volume": "6",
      "author": "Kalb",
      "year": "1987",
      "journal-title": "DNA"
    },
    {
      "key": "10.1016/0378-1119(94)90366-2_BIB8",
      "first-page": "387",
      "article-title": "The structure of eytochrome b5 at 2.0 angstroms",
      "volume": "36",
      "author": "Mathews",
      "year": "1972"
    },
    {
      "key": "10.1016/0378-1119(94)90366-2_BIB9",
      "doi-asserted-by": "crossref",
      "first-page": "4197",
      "DOI": "10.1002/j.1460-2075.1992.tb05513.x",
      "article-title": "The C-terminal 10 amino acid residues of eytochrome 5 are necessary for its targeting to the endoplasmic reticulum",
      "volume": "11",
      "author": "Mitoma",
      "year": "1992",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/0378-1119(94)90366-2_BIB10",
      "doi-asserted-by": "crossref",
      "first-page": "724",
      "DOI": "10.1006/abbi.1993.1100",
      "article-title": "The structural requirements of sterols for membrane functions in Saccharomyces cerevisiae",
      "volume": "300",
      "author": "Nes",
      "year": "1993",
      "journal-title": "Arch. Biochem. Biophys."
    },
    {
      "key": "10.1016/0378-1119(94)90366-2_BIB11",
      "first-page": "2444",
      "article-title": "Improved tools for biological sequence comparison",
      "volume": "85",
      "author": "Pearson",
      "year": "1988"
    },
    {
      "key": "10.1016/0378-1119(94)90366-2_BIB12",
      "first-page": "712",
      "article-title": "Sterol synergism in yeast",
      "volume": "80",
      "author": "Ramgopal",
      "year": "1983"
    },
    {
      "key": "10.1016/0378-1119(94)90366-2_BIB13",
      "doi-asserted-by": "crossref",
      "first-page": "2797",
      "DOI": "10.1016/S0021-9258(17)40432-7",
      "article-title": "Mechanism of C-5 double bond introduction in the biosynthesis of cholesterol by rat liver microsomes",
      "volume": "252",
      "author": "Reddy",
      "year": "1977",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/0378-1119(94)90366-2_BIB14",
      "doi-asserted-by": "crossref",
      "first-page": "336",
      "DOI": "10.1016/0005-2760(85)90057-8",
      "article-title": "Multiple functions for sterols in Saccharomyces cerevisiae",
      "volume": "837",
      "author": "Rodriguez",
      "year": "1985",
      "journal-title": "Biochim. Biophys. Acta"
    },
    {
      "key": "10.1016/0378-1119(94)90366-2_BIB15",
      "first-page": "4565",
      "article-title": "Purification and properties of rat liver microsomal stearyl coenzyme A desaturase",
      "volume": "71",
      "author": "Strittmatter",
      "year": "1974"
    },
    {
      "key": "10.1016/0378-1119(94)90366-2_BIB16",
      "doi-asserted-by": "crossref",
      "first-page": "1257",
      "DOI": "10.1016/S0006-291X(89)80139-1",
      "article-title": "Disruption of the Saccharomyces cerevisiae gene for NADPH-cytochrome P450 reductase causes increased sensitivity to ketoconazole",
      "volume": "160",
      "author": "Sutler",
      "year": "1989",
      "journal-title": "Biochem. Biophys. Res. Commun."
    },
    {
      "key": "10.1016/0378-1119(94)90366-2_BIB17",
      "doi-asserted-by": "crossref",
      "first-page": "49",
      "DOI": "10.1016/0378-1119(93)90744-N",
      "article-title": "Enhanced in vivo monooxygenase activities of mammalian P450s in engineered yeast cells producing high levels of NADPH-P450 reductase and human eytochrome b5",
      "volume": "125",
      "author": "Truan",
      "year": "1993",
      "journal-title": "Gene"
    },
    {
      "key": "10.1016/0378-1119(94)90366-2_BIB18",
      "doi-asserted-by": "crossref",
      "first-page": "56",
      "DOI": "10.1042/bst0180056",
      "article-title": "Mutation in eytochrome P-450-dependent 14 alpha-demethylase results in decreased affinity for azole antifungals",
      "volume": "18",
      "author": "Vanden Bossche",
      "year": "1990",
      "journal-title": "Biochem. Soc. Trans."
    },
    {
      "key": "10.1016/0378-1119(94)90366-2_BIB19",
      "doi-asserted-by": "crossref",
      "first-page": "10",
      "DOI": "10.1042/bst0180010",
      "article-title": "From 14 alpha-demethylase inhibitors in fungal cells to androgen and oestrogen biosynthesis inhibitors in mammalian cells",
      "volume": "18",
      "author": "Vanden Bossche",
      "year": "1990",
      "journal-title": "Biochem. Soc. Trans."
    },
    {
      "key": "10.1016/0378-1119(94)90366-2_BIB20",
      "doi-asserted-by": "crossref",
      "first-page": "12583",
      "DOI": "10.1016/S0021-9258(18)42317-4",
      "article-title": "Expression of eytochrome b5 in yeast and characterisation of mutants of the membrane anchoring domain",
      "volume": "267",
      "author": "Verg\u00e9res",
      "year": "1992",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/0378-1119(94)90366-2_BIB21",
      "doi-asserted-by": "crossref",
      "first-page": "229",
      "DOI": "10.1016/0006-2952(87)90694-0",
      "article-title": "Interaction of azole antifungal agents with eytochrome P-450 14DM purified from Saccharomyces cerevisiae microsomes",
      "volume": "36",
      "author": "Yoshida",
      "year": "1987",
      "journal-title": "Biochem. Pharmacol."
    },
    {
      "key": "10.1016/0378-1119(94)90366-2_BIB22",
      "doi-asserted-by": "crossref",
      "first-page": "778",
      "DOI": "10.1042/bst0190778",
      "article-title": "Sterol 14 alpha-demethylase and its inhibition: structural considerations on interaction of azole antifungal agents with lanosterol 14 alpha-demethylase (P-450 14DM) of yeast",
      "volume": "19",
      "author": "Yoshida",
      "year": "1991",
      "journal-title": "Biochem. Soc. Trans."
    }
  ],
  "container-title": "Gene",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.elsevier.com/content/article/PII:0378111994903662?httpAccept=text/xml",
      "content-type": "text/xml",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://api.elsevier.com/content/article/PII:0378111994903662?httpAccept=text/plain",
      "content-type": "text/plain",
      "content-version": "vor",
      "intended-application": "text-mining"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2021,
        6,
        4
      ]
    ],
    "date-time": "2021-06-04T06:54:31Z",
    "timestamp": 1622789671000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://linkinghub.elsevier.com/retrieve/pii/0378111994903662"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1994,
        5
      ]
    ]
  },
  "references-count": 22,
  "journal-issue": {
    "issue": "1",
    "published-print": {
      "date-parts": [
        [
          1994,
          5
        ]
      ]
    }
  },
  "alternative-id": [
    "0378111994903662"
  ],
  "URL": "http://dx.doi.org/10.1016/0378-1119(94)90366-2",
  "relation": {},
  "ISSN": [
    "0378-1119"
  ],
  "subject": [],
  "container-title-short": "Gene",
  "published": {
    "date-parts": [
      [
        1994,
        5
      ]
    ]
  }
}