DOI: 10.1016/0304-3959(77)90034-3. Reversal of morphine and stimulus-produced analgesia by subtotal spinal cord lesions

Reversal of morphine and stimulus-produced analgesia by subtotal spinal cord lesions

10.1016/0304-3959(77)90034-3

Crossref journal-article

Ovid Technologies (Wolters Kluwer Health)

Pain (276)

Bibliography

Basbaum, A. I., Marley, N. J. E., OÊ¼Keefe, J., & Clanton, C. H. (1977). Reversal of morphine and stimulus-produced analgesia by subtotal spinal cord lesions. Pain, 3(1), 43â56.

Authors 4

Allan I. Basbaum (first)
Nicholas J.E. Marley (additional)
John OʼKeefe (additional)
Charles H. Clanton (additional)

References 39 Referenced 256

10.1016/0006-8993(75)90062-1 / Brain Res. / Monoaminergic mechanisms of stimulation-produced analgesia by Akil (1975)
10.1016/0006-8993(72)90338-1 / Brain Res. / Antagonism of stimulation-produced analgesia by p-CPA ,a serotonin synthesis inhibitor by Akil (1972)
10.1016/0006-8993(73)90796-8 / Brain Res. / The analgesic effect of electrical stimulation of the diencephalon and mesencephalon by Balagura (1973)
10.1016/0014-4886(73)90105-2 / Exp. Neurol. / Conduction of the effects of noxious stimulation by short-fiber multi-synaptic systems of the spinal cord in the rat by Basbaum (1973)
{'key': '10.1016/0304-3959(77)90034-3_BIB5', 'series-title': 'An autoradiographic study, Paper presented at Cajal Club', 'article-title': 'Contrasting descending projections of the nucleus gigantocellularis (NGC) and nucleus raphe magnus (NRM) of the cat', 'author': 'Basbaum', 'year': '1976'} / An autoradiographic study, Paper presented at Cajal Club / Contrasting descending projections of the nucleus gigantocellularis (NGC) and nucleus raphe magnus (NRM) of the cat by Basbaum (1976)
Basbaum, A.I., Marley, N. and O'Keefe, J., Effects of spinal cord lesions on the analgesic properties of electrical brain stimulation, Advanc. in Pain Res., in press.
10.1038/260625a0 / Nature (Lond.) / Analgesia induced in vivo by central administration of enkephalin in rat by Belluzzi (1976)
10.1002/cne.901560205 / J. comp. Neurol. / Connections of the median and dorsal raphe nuclei in the rat: an autoradiographic and degeneration study by Conrad (1974)
10.1126/science.149.3681.323 / Science / Attenuation of aversive properties of peripheral shock by hypothalamic stimulation by Cox (1965)
{'issue': 'Suppl. 247', 'key': '10.1016/0304-3959(77)90034-3_BIB10', 'first-page': '5', 'article-title': 'Evidence for the existence of monoamine neurons in the central nervous system. II. Experimentally induced changes in the intraneuronal amine levels of bulbospinal neuron systems', 'volume': '64', 'author': 'Dahlström', 'year': '1965', 'journal-title': 'Acta physiol. scand.'} / Acta physiol. scand. / Evidence for the existence of monoamine neurons in the central nervous system. II. Experimentally induced changes in the intraneuronal amine levels of bulbospinal neuron systems by Dahlström (1965)
Fields, H.L., Anderson, S.D., Clanton, C.H. and Basbaum, A.I., Nucleus raphe magnus: a common mediator of opiate and stimulus produced analgesia, Trans. Amer. neurol. Ass., in press.
10.1016/0006-8993(73)90549-0 / Brain Res. / Suppression by LSD of the inhibitory effect exerted by dorsal raphe stimulation on certain spinal cord interneurons in the cat by Guilbaud (1973)
Hayes, R.L., Price, D.D., Bennett, G., Mayer, D. and Wilcox, G., In preparation.
10.1016/0006-8993(75)90391-1 / Brain Res. / Isolation of an endogenous compound from the brain with pharmacological properties similar to morphine by Hughes (1975)
{'key': '10.1016/0304-3959(77)90034-3_BIB15', 'series-title': 'Opiate Receptor Mechanisms', 'first-page': '55', 'article-title': 'Search for the endogenous ligand of the opiate receptor', 'author': 'Hughes', 'year': '1975'} / Opiate Receptor Mechanisms / Search for the endogenous ligand of the opiate receptor by Hughes (1975)
{'key': '10.1016/0304-3959(77)90034-3_BIB16', 'series-title': 'The Rat Brain. A Stereotaxic Atlas of the Forebrain and Lower Parts of the Brain Stem', 'author': 'König', 'year': '1963'} / The Rat Brain. A Stereotaxic Atlas of the Forebrain and Lower Parts of the Brain Stem by König (1963)
{'key': '10.1016/0304-3959(77)90034-3_BIB17', 'first-page': '1369', 'article-title': 'Comparaison chez le chat spinale et le chat décérébré des effets de la morphine sur les activités des interneurones de type V de la corne dorsale de la moelle', 'volume': '279', 'author': 'LeBars', 'year': '1974', 'journal-title': 'C.R. Acad. Sci. (Paris)'} / C.R. Acad. Sci. (Paris) / Comparaison chez le chat spinale et le chat décérébré des effets de la morphine sur les activités des interneurones de type V de la corne dorsale de la moelle by LeBars (1974)
10.1016/0006-8993(74)90534-4 / Brain Res. / Pain reduction by focal electrical stimulation of the brain: an anatomical and behavioral analysis by Mayer (1974)
10.1126/science.174.4016.1351 / Science / Analgesia from electrical stimulation in the brainstem of the rat by Mayer (1971)
10.1016/0014-4886(74)90178-2 / Exp. Neurol. / Analgesia produced by brain stimulation: evidence of prolonged onset period by Melzack (1974)
{'key': '10.1016/0304-3959(77)90034-3_BIB21', 'first-page': '338', 'article-title': 'Relationship of neural activity in the raphe nuclei of the rat to brain stimulation-produced analgesia', 'volume': '18', 'author': 'Oleson', 'year': '1975', 'journal-title': 'Physiologist'} / Physiologist / Relationship of neural activity in the raphe nuclei of the rat to brain stimulation-produced analgesia by Oleson (1975)
10.1007/BF00239016 / Exp. Brain Res. / Behavioral and electrophysiological evidence of pain inhibition from midbrain stimulation in the cat by Oliveras (1974)
10.1016/0304-3959(75)90098-6 / Pain / Analgesia induced by electrical stimulation of the inferior centralis nucleus of the raphe in the cat by Oliveras (1975)
10.1016/0006-8993(74)90731-8 / Brain Res. / Sites of morphine induced analgesia in the primate brain: relation to brain pathways by Pert (1974)
10.1126/science.179.4077.1011 / Science / Opiate receptor: demonstration in nervous tissue by Pert (1973)
10.1016/0006-8993(75)90380-7 / Brain Res. / Morphine analgesia: blockade by raphe magnus lesions by Proudfit (1975)
10.1126/science.164.3878.444 / Science / Surgery in the rat during electrical analgesia induced by focal brain stimulation by Reynolds (1969)
Richardson, D.E. and Akil, H., Stimulation-produced analgesia: chronic self-stimulation of periventricular gray in man, J. Neurosurg., in press.
{'key': '10.1016/0304-3959(77)90034-3_BIB29', 'article-title': 'Autoradiographic Examination of the Efferent Projections of the Midbrain Central Grey in the Cat', 'author': 'Ruda', 'year': '1976'} / Autoradiographic Examination of the Efferent Projections of the Midbrain Central Grey in the Cat by Ruda (1976)
10.1016/0014-2999(71)90122-1 / Europ. J. Pharmacol. / Enhancement by morphine of the central descending inhibitory influence on spinal sensory transmission by Satoh (1971)
10.3171/jns.1971.35.6.0715 / J. Neurosurg. / Pain threshold alterations by brain stimulation in the monkey by Schmidek (1971)
10.1038/257185a0 / Nature (Lond.) / Opiate receptor in normal and drug altered brain function by Snyder (1975)
10.1002/cne.901140205 / J. comp. Neurol. / The raphe nuclei of the brainstem in the cat. I. Normal topography and cytoarchitecture and general discussion by Taber (1960)
10.1016/0024-3205(75)90269-6 / Life Sci. / Morphine-like ligand for opiate receptors in human CSF by Terenius (1975)
10.1016/0028-3908(73)90082-8 / Neuropharmacology / Autoradiographic studies concerning the supraspinal site of the antinociceptive action of morphine when inhibiting the hindleg flexor reflex in rabbits by Teschemacher (1973)
10.1113/jphysiol.1974.sp010448 / J. Physiol. (Lond.) / The effect of lowering the 5-hydroxytryptamine content of the rat spinal cord on analgesia produced by morphine by Vogt (1974)
Yaksh, T.L. and Rudy, T.A., Analgesia mediated by a direct spinal action of narcotics, Science, in press.
10.1016/0006-8993(76)91009-X / Brain Res. / Systematic examination in the rat of brain sites sensitive to the direct application of morphine: observation of differential effects within the periaqueductal gray by Yaksh (1976)
10.1002/cne.901230302 / J. comp. Neurol. / An experimental study of the anatomical organization of the cortico-bulbar system in the albino rat by Zimmerman (1964)

Dates

Type	When
Created	22 years, 4 months ago (April 25, 2003, 4:06 a.m.)
Deposited	4 years, 3 months ago (May 13, 2021, 12:46 p.m.)
Indexed	11 minutes ago (Sept. 3, 2025, 12:59 a.m.)
Issued	48 years, 7 months ago (Feb. 1, 1977)
Published	48 years, 7 months ago (Feb. 1, 1977)
Published Print	48 years, 7 months ago (Feb. 1, 1977)

Funders 0

None

BibTeX

@article{Basbaum_1977, title={Reversal of morphine and stimulus-produced analgesia by subtotal spinal cord lesions}, volume={3}, ISSN={0304-3959}, url={http://dx.doi.org/10.1016/0304-3959(77)90034-3}, DOI={10.1016/0304-3959(77)90034-3}, number={1}, journal={Pain}, publisher={Ovid Technologies (Wolters Kluwer Health)}, author={Basbaum, Allan I. and Marley, Nicholas J.E. and OʼKeefe, John and Clanton, Charles H.}, year={1977}, month=feb, pages={43–56} }

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