DOI: 10.1016/0166-3542(92)90056-b. Use of a standardized cell culture assay to assess activities of nucleoside analogs against hepatitis B virus replication

Use of a standardized cell culture assay to assess activities of nucleoside analogs against hepatitis B virus replication

10.1016/0166-3542(92)90056-b

Crossref journal-article

Elsevier BV

Antiviral Research (78)

Bibliography

Korba, B. E., & Gerin, J. L. (1992). Use of a standardized cell culture assay to assess activities of nucleoside analogs against hepatitis B virus replication. Antiviral Research, 19(1), 55â70.

Authors 2

Brent E. Korba (first)
John L. Gerin (additional)

References 26 Referenced 156

{'key': '10.1016/0166-3542(92)90056-B_BIB1', 'series-title': 'Viral Hepatitis and Liver Disease', 'first-page': '209', 'article-title': 'Epidemiology of hepatocellular carcinoma', 'author': 'Beasley', 'year': '1984'} / Viral Hepatitis and Liver Disease / Epidemiology of hepatocellular carcinoma by Beasley (1984)
{'key': '10.1016/0166-3542(92)90056-B_BIB2', 'first-page': '253', 'article-title': 'Antiviral strategies in chronic hepatitis B virus infection: I. Inhibition of duck hepatitis B virus in vitro using conventional antiviral agents and supercoiled-DNA active compounds', 'volume': '30', 'author': 'Civitico', 'year': '1990', 'journal-title': 'J. Med. Virol.'} / J. Med. Virol. / Antiviral strategies in chronic hepatitis B virus infection: I. Inhibition of duck hepatitis B virus in vitro using conventional antiviral agents and supercoiled-DNA active compounds by Civitico (1990)
10.1128/AAC.31.9.1355 / Antimicrob. Agents Chemother. / Synthesis and biological effects of 2′-fluoro-5-ethyl-1-B-D-arabinofuranouracil by Chou (1987)
10.1099/0022-1317-5-3-419 / J. Gen. Virol. / Dye uptake methods for assessing viral cytopathogenicity and their application to interferon assays by Finter (1969)
10.1128/AAC.34.3.473 / Antimicrob. Agents Chemother. / Inhibitory effects of 2′-fluorinated arabinosyl-pyrimidine nucleosides on woodchuck hepatitis virus replication in chronically infected woodchucks by Fourel (1990)
{'key': '10.1016/0166-3542(92)90056-B_BIB6', 'first-page': '227', 'article-title': 'Hepadnavirus-induced liver cancer in woodchucks', 'volume': '14', 'author': 'Gerin', 'year': '1989', 'journal-title': 'Cancer Prevention and Detection'} / Cancer Prevention and Detection / Hepadnavirus-induced liver cancer in woodchucks by Gerin (1989)
{'key': '10.1016/0166-3542(92)90056-B_BIB7', 'series-title': 'Viral Hepatitis and Liver Disease', 'first-page': '632', 'article-title': 'Current status and future directions in the treatment of chronic viral hepatitis', 'author': 'Hoofnagle', 'year': '1991'} / Viral Hepatitis and Liver Disease / Current status and future directions in the treatment of chronic viral hepatitis by Hoofnagle (1991)
10.1128/AAC.33.3.336 / Antimicrob. Agents Chemother. / In vitro and in vivo comparison of the abilities of purine and pyrimidine 2′,3′-dideoxynucleosides to inhibit duck hepadnavirus by Lee (1989)
{'key': '10.1016/0166-3542(92)90056-B_BIB9', 'series-title': 'Viral Hepatitis and Liver Disease', 'first-page': '663', 'article-title': 'Woodchuck hepatitis virus infection as a model for the development of antiviral therapies against HBV', 'author': 'Korba', 'year': '1991'} / Viral Hepatitis and Liver Disease / Woodchuck hepatitis virus infection as a model for the development of antiviral therapies against HBV by Korba (1991)
10.1016/0166-3542(91)90068-3 / Antiviral Res. / A cell culture assay for compounds which inhibit hepatitis B virus replication by Korba (1991)
10.1002/hep.1840090321 / Hepatology / Hepatocellular carcinoma in woodchuck hepatitis virus-infected woodchucks: presence of viral DNA in tumor tissue from chronic carriers and animals serologically recovered from acute infections by Korba (1989)
10.1128/JVI.58.1.1-8.1986 / J. Virol. / Hepadnavirus infection of peripheral blood lymphocytes in vivo: Woodchuck and chimpanzee models of viral hepatitis by Korba (1986)
10.1002/hep.1840130307 / Hepatology / Development and application of an in vitro model for screening anti-hepatitis B virus therapeutics by Lampertico (1991)
10.1128/AAC.34.10.1986 / Antimicrob. Agents Chemother. / Potent inhibition of hepatitis B virus production in vitro by modified pyrimidine nucleosides by Matthes (1990)
10.1002/hep.1840070425 / Hepatology / Relation of the hepatitis B virus carrier state to hepatocellular carcinoma by Popper (1987)
{'key': '10.1016/0166-3542(92)90056-B_BIB16', 'first-page': '806', 'article-title': 'Inhibition of the replication of hepatitis B virus by the carbocyclic analogue of 2′-deoxyguanosine', 'volume': '86', 'author': 'Price', 'year': '1989'} / Inhibition of the replication of hepatitis B virus by the carbocyclic analogue of 2′-deoxyguanosine by Price (1989)
{'key': '10.1016/0166-3542(92)90056-B_BIB17', 'series-title': 'Viral Hepatitis and Liver Disease', 'first-page': '817', 'article-title': 'Treatment of hepatitis B viral infection', 'author': 'Thomas', 'year': '1987'} / Viral Hepatitis and Liver Disease / Treatment of hepatitis B viral infection by Thomas (1987)
10.1038/317489a0 / Nature / The Hepatitis B virus by Tiollais (1985)
10.1021/jm00297a026 / J. Med. Chem. / Structure-activity relationships in adenosine deaminase inhibitors by Schaeffer (1970)
10.1126/science.3961490 / Science / Biochemical and genetic evidence for the hepatitis B virus replication strategy by Seeger (1986)
10.1128/JVI.62.8.2836-2844.1988 / J. Virol. / Replication intermediates of hepatitis B virus in HepG2 cells that produce infectious virions by Sells (1988)
10.1016/0092-8674(82)90157-X / Cell / Replication of the genome of a hepatitis-B-like virus by reverse transcription of an RNA intermediate by Summers (1982)
10.1016/S0006-291X(88)80752-6 / Biochem. Biophys. Res. Commun. / Inhibition of duck hepatitis B virus replication by purine 2′,3′-dideoxynucleosides by Suzuki (1988)
10.1016/0042-6822(89)90057-3 / Virology / An in vitro system for screening antihepatitis B virus drugs by Ueda (1989)
10.1021/jm00168a046 / J. Med. Chem. / Synthesis and anti-HIV evaluation of 2′,3′-dieoxyribochloropyrimidine analogues: Reduced toxicity of 5-chlorinated 2′,3′-dideoxynucleosides by Van Aerschot (1990)
10.1128/AAC.35.2.394 / Antimicrob. Agents Chemother. / Inhibitory effects of selected antiviral compounds on human hepatitis B virus DNA synthesis by Yokota (1991)

Dates

Type	When
Created	22 years, 8 months ago (Dec. 27, 2002, 5:31 p.m.)
Deposited	8 months, 3 weeks ago (Dec. 11, 2024, 11:34 a.m.)
Indexed	17 hours, 50 minutes ago (Sept. 3, 2025, 6:15 a.m.)
Issued	33 years, 2 months ago (July 1, 1992)
Published	33 years, 2 months ago (July 1, 1992)
Published Print	33 years, 2 months ago (July 1, 1992)

Funders 0

None

BibTeX

@article{Korba_1992, title={Use of a standardized cell culture assay to assess activities of nucleoside analogs against hepatitis B virus replication}, volume={19}, ISSN={0166-3542}, url={http://dx.doi.org/10.1016/0166-3542(92)90056-b}, DOI={10.1016/0166-3542(92)90056-b}, number={1}, journal={Antiviral Research}, publisher={Elsevier BV}, author={Korba, Brent E. and Gerin, John L.}, year={1992}, month=jul, pages={55–70} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        9,
        3
      ]
    ],
    "date-time": "2025-09-03T10:15:54Z",
    "timestamp": 1756894554282,
    "version": "3.30.2"
  },
  "reference-count": 26,
  "publisher": "Elsevier BV",
  "issue": "1",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            1992,
            7,
            1
          ]
        ],
        "date-time": "1992-07-01T00:00:00Z",
        "timestamp": 709948800000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://www.elsevier.com/tdm/userlicense/1.0/"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        1992,
        7
      ]
    ]
  },
  "DOI": "10.1016/0166-3542(92)90056-b",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2002,
        12,
        27
      ]
    ],
    "date-time": "2002-12-27T22:31:36Z",
    "timestamp": 1041028296000
  },
  "page": "55-70",
  "source": "Crossref",
  "is-referenced-by-count": 156,
  "title": "Use of a standardized cell culture assay to assess activities of nucleoside analogs against hepatitis B virus replication",
  "prefix": "10.1016",
  "volume": "19",
  "author": [
    {
      "given": "Brent E.",
      "family": "Korba",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "John L.",
      "family": "Gerin",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "78",
  "reference": [
    {
      "key": "10.1016/0166-3542(92)90056-B_BIB1",
      "series-title": "Viral Hepatitis and Liver Disease",
      "first-page": "209",
      "article-title": "Epidemiology of hepatocellular carcinoma",
      "author": "Beasley",
      "year": "1984"
    },
    {
      "key": "10.1016/0166-3542(92)90056-B_BIB2",
      "first-page": "253",
      "article-title": "Antiviral strategies in chronic hepatitis B virus infection: I. Inhibition of duck hepatitis B virus in vitro using conventional antiviral agents and supercoiled-DNA active compounds",
      "volume": "30",
      "author": "Civitico",
      "year": "1990",
      "journal-title": "J. Med. Virol."
    },
    {
      "key": "10.1016/0166-3542(92)90056-B_BIB3",
      "doi-asserted-by": "crossref",
      "first-page": "1355",
      "DOI": "10.1128/AAC.31.9.1355",
      "article-title": "Synthesis and biological effects of 2\u2032-fluoro-5-ethyl-1-B-D-arabinofuranouracil",
      "volume": "31",
      "author": "Chou",
      "year": "1987",
      "journal-title": "Antimicrob. Agents Chemother."
    },
    {
      "key": "10.1016/0166-3542(92)90056-B_BIB4",
      "doi-asserted-by": "crossref",
      "first-page": "419",
      "DOI": "10.1099/0022-1317-5-3-419",
      "article-title": "Dye uptake methods for assessing viral cytopathogenicity and their application to interferon assays",
      "volume": "5",
      "author": "Finter",
      "year": "1969",
      "journal-title": "J. Gen. Virol."
    },
    {
      "key": "10.1016/0166-3542(92)90056-B_BIB5",
      "doi-asserted-by": "crossref",
      "first-page": "473",
      "DOI": "10.1128/AAC.34.3.473",
      "article-title": "Inhibitory effects of 2\u2032-fluorinated arabinosyl-pyrimidine nucleosides on woodchuck hepatitis virus replication in chronically infected woodchucks",
      "volume": "34",
      "author": "Fourel",
      "year": "1990",
      "journal-title": "Antimicrob. Agents Chemother."
    },
    {
      "key": "10.1016/0166-3542(92)90056-B_BIB6",
      "first-page": "227",
      "article-title": "Hepadnavirus-induced liver cancer in woodchucks",
      "volume": "14",
      "author": "Gerin",
      "year": "1989",
      "journal-title": "Cancer Prevention and Detection"
    },
    {
      "key": "10.1016/0166-3542(92)90056-B_BIB7",
      "series-title": "Viral Hepatitis and Liver Disease",
      "first-page": "632",
      "article-title": "Current status and future directions in the treatment of chronic viral hepatitis",
      "author": "Hoofnagle",
      "year": "1991"
    },
    {
      "key": "10.1016/0166-3542(92)90056-B_BIB8",
      "doi-asserted-by": "crossref",
      "first-page": "336",
      "DOI": "10.1128/AAC.33.3.336",
      "article-title": "In vitro and in vivo comparison of the abilities of purine and pyrimidine 2\u2032,3\u2032-dideoxynucleosides to inhibit duck hepadnavirus",
      "volume": "33",
      "author": "Lee",
      "year": "1989",
      "journal-title": "Antimicrob. Agents Chemother."
    },
    {
      "key": "10.1016/0166-3542(92)90056-B_BIB9",
      "series-title": "Viral Hepatitis and Liver Disease",
      "first-page": "663",
      "article-title": "Woodchuck hepatitis virus infection as a model for the development of antiviral therapies against HBV",
      "author": "Korba",
      "year": "1991"
    },
    {
      "key": "10.1016/0166-3542(92)90056-B_BIB10",
      "doi-asserted-by": "crossref",
      "first-page": "217",
      "DOI": "10.1016/0166-3542(91)90068-3",
      "article-title": "A cell culture assay for compounds which inhibit hepatitis B virus replication",
      "volume": "15",
      "author": "Korba",
      "year": "1991",
      "journal-title": "Antiviral Res."
    },
    {
      "key": "10.1016/0166-3542(92)90056-B_BIB11",
      "doi-asserted-by": "crossref",
      "first-page": "461",
      "DOI": "10.1002/hep.1840090321",
      "article-title": "Hepatocellular carcinoma in woodchuck hepatitis virus-infected woodchucks: presence of viral DNA in tumor tissue from chronic carriers and animals serologically recovered from acute infections",
      "volume": "9",
      "author": "Korba",
      "year": "1989",
      "journal-title": "Hepatology"
    },
    {
      "key": "10.1016/0166-3542(92)90056-B_BIB12",
      "doi-asserted-by": "crossref",
      "first-page": "1",
      "DOI": "10.1128/JVI.58.1.1-8.1986",
      "article-title": "Hepadnavirus infection of peripheral blood lymphocytes in vivo: Woodchuck and chimpanzee models of viral hepatitis",
      "volume": "58",
      "author": "Korba",
      "year": "1986",
      "journal-title": "J. Virol."
    },
    {
      "key": "10.1016/0166-3542(92)90056-B_BIB13",
      "doi-asserted-by": "crossref",
      "first-page": "422",
      "DOI": "10.1002/hep.1840130307",
      "article-title": "Development and application of an in vitro model for screening anti-hepatitis B virus therapeutics",
      "volume": "13",
      "author": "Lampertico",
      "year": "1991",
      "journal-title": "Hepatology"
    },
    {
      "key": "10.1016/0166-3542(92)90056-B_BIB14",
      "doi-asserted-by": "crossref",
      "first-page": "1986",
      "DOI": "10.1128/AAC.34.10.1986",
      "article-title": "Potent inhibition of hepatitis B virus production in vitro by modified pyrimidine nucleosides",
      "volume": "34",
      "author": "Matthes",
      "year": "1990",
      "journal-title": "Antimicrob. Agents Chemother."
    },
    {
      "key": "10.1016/0166-3542(92)90056-B_BIB15",
      "doi-asserted-by": "crossref",
      "first-page": "764",
      "DOI": "10.1002/hep.1840070425",
      "article-title": "Relation of the hepatitis B virus carrier state to hepatocellular carcinoma",
      "volume": "7",
      "author": "Popper",
      "year": "1987",
      "journal-title": "Hepatology"
    },
    {
      "key": "10.1016/0166-3542(92)90056-B_BIB16",
      "first-page": "806",
      "article-title": "Inhibition of the replication of hepatitis B virus by the carbocyclic analogue of 2\u2032-deoxyguanosine",
      "volume": "86",
      "author": "Price",
      "year": "1989"
    },
    {
      "key": "10.1016/0166-3542(92)90056-B_BIB17",
      "series-title": "Viral Hepatitis and Liver Disease",
      "first-page": "817",
      "article-title": "Treatment of hepatitis B viral infection",
      "author": "Thomas",
      "year": "1987"
    },
    {
      "key": "10.1016/0166-3542(92)90056-B_BIB18",
      "doi-asserted-by": "crossref",
      "first-page": "489",
      "DOI": "10.1038/317489a0",
      "article-title": "The Hepatitis B virus",
      "volume": "317",
      "author": "Tiollais",
      "year": "1985",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/0166-3542(92)90056-B_BIB19",
      "doi-asserted-by": "crossref",
      "first-page": "452",
      "DOI": "10.1021/jm00297a026",
      "article-title": "Structure-activity relationships in adenosine deaminase inhibitors",
      "volume": "13",
      "author": "Schaeffer",
      "year": "1970",
      "journal-title": "J. Med. Chem."
    },
    {
      "key": "10.1016/0166-3542(92)90056-B_BIB20",
      "doi-asserted-by": "crossref",
      "first-page": "477",
      "DOI": "10.1126/science.3961490",
      "article-title": "Biochemical and genetic evidence for the hepatitis B virus replication strategy",
      "volume": "232",
      "author": "Seeger",
      "year": "1986",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/0166-3542(92)90056-B_BIB21",
      "doi-asserted-by": "crossref",
      "first-page": "2836",
      "DOI": "10.1128/JVI.62.8.2836-2844.1988",
      "article-title": "Replication intermediates of hepatitis B virus in HepG2 cells that produce infectious virions",
      "volume": "62",
      "author": "Sells",
      "year": "1988",
      "journal-title": "J. Virol."
    },
    {
      "key": "10.1016/0166-3542(92)90056-B_BIB22",
      "doi-asserted-by": "crossref",
      "first-page": "403",
      "DOI": "10.1016/0092-8674(82)90157-X",
      "article-title": "Replication of the genome of a hepatitis-B-like virus by reverse transcription of an RNA intermediate",
      "volume": "29",
      "author": "Summers",
      "year": "1982",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/0166-3542(92)90056-B_BIB23",
      "doi-asserted-by": "crossref",
      "first-page": "1144",
      "DOI": "10.1016/S0006-291X(88)80752-6",
      "article-title": "Inhibition of duck hepatitis B virus replication by purine 2\u2032,3\u2032-dideoxynucleosides",
      "volume": "156",
      "author": "Suzuki",
      "year": "1988",
      "journal-title": "Biochem. Biophys. Res. Commun."
    },
    {
      "key": "10.1016/0166-3542(92)90056-B_BIB24",
      "doi-asserted-by": "crossref",
      "first-page": "213",
      "DOI": "10.1016/0042-6822(89)90057-3",
      "article-title": "An in vitro system for screening antihepatitis B virus drugs",
      "volume": "169",
      "author": "Ueda",
      "year": "1989",
      "journal-title": "Virology"
    },
    {
      "key": "10.1016/0166-3542(92)90056-B_BIB25",
      "doi-asserted-by": "crossref",
      "first-page": "1833",
      "DOI": "10.1021/jm00168a046",
      "article-title": "Synthesis and anti-HIV evaluation of 2\u2032,3\u2032-dieoxyribochloropyrimidine analogues: Reduced toxicity of 5-chlorinated 2\u2032,3\u2032-dideoxynucleosides",
      "volume": "33",
      "author": "Van Aerschot",
      "year": "1990",
      "journal-title": "J. Med. Chem."
    },
    {
      "key": "10.1016/0166-3542(92)90056-B_BIB26",
      "doi-asserted-by": "crossref",
      "first-page": "394",
      "DOI": "10.1128/AAC.35.2.394",
      "article-title": "Inhibitory effects of selected antiviral compounds on human hepatitis B virus DNA synthesis",
      "volume": "35",
      "author": "Yokota",
      "year": "1991",
      "journal-title": "Antimicrob. Agents Chemother."
    }
  ],
  "container-title": "Antiviral Research",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.elsevier.com/content/article/PII:016635429290056B?httpAccept=text/xml",
      "content-type": "text/xml",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://api.elsevier.com/content/article/PII:016635429290056B?httpAccept=text/plain",
      "content-type": "text/plain",
      "content-version": "vor",
      "intended-application": "text-mining"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2024,
        12,
        11
      ]
    ],
    "date-time": "2024-12-11T16:34:49Z",
    "timestamp": 1733934889000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://linkinghub.elsevier.com/retrieve/pii/016635429290056B"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1992,
        7
      ]
    ]
  },
  "references-count": 26,
  "journal-issue": {
    "issue": "1",
    "published-print": {
      "date-parts": [
        [
          1992,
          7
        ]
      ]
    }
  },
  "alternative-id": [
    "016635429290056B"
  ],
  "URL": "http://dx.doi.org/10.1016/0166-3542(92)90056-B",
  "relation": {},
  "ISSN": [
    "0166-3542"
  ],
  "subject": [],
  "container-title-short": "Antiviral Research",
  "published": {
    "date-parts": [
      [
        1992,
        7
      ]
    ]
  }
}