DOI: 10.1016/0092-8674(94)90360-3. Nef induces CD4 endocytosis: Requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain

Nef induces CD4 endocytosis: Requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain

10.1016/0092-8674(94)90360-3

Crossref journal-article

Elsevier BV

Cell (78)

Bibliography

Aiken, C., Konner, J., Landau, N. R., Lenburg, M. E., & Trono, D. (1994). Nef induces CD4 endocytosis: Requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain. Cell, 76(5), 853â864.

Authors 5

Christopher Aiken (first)
Jason Konner (additional)
Nathaniel R. Landau (additional)
Marc E. Lenburg (additional)
Didier Trono (additional)

References 83 Referenced 577

10.1016/S0021-9258(18)66700-6 / J. Biol. Chem. / Rapid phosphorylation and modulation of the T4 antigen on cloned helper T cells induced by phorbol myristate acetate or antigen by Acres (1986)
10.1128/JVI.59.2.284-291.1986 / J. Virol. / Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone by Adachi (1986)
10.1126/science.3262235 / Science / Nef protein of HIV-1 is a transcriptional repressor of HIV-1 LTR by Ahmad (1988)
10.1126/science.2997921 / Science / A new HTLV-III/LAV-encoded antigen detected by antibodies from AIDS patients by Allan (1985)
10.1016/S0065-2776(08)60756-7 / Adv. Immunol. / Molecular events mediating T cell activation by Altman (1990)
10.1128/JVI.67.8.4923-4931.1993 / J. Virol. / Nef from primary isolates of human immunodeficiency virus type 1 suppresses surface CD4 expression in human and mouse T cells by Anderson (1993)
10.1126/science.2990040 / Science / Trans-activator gene of human T-lymphotropic virus type III (HTLV-III) by Arya (1985)
{'key': '10.1016/0092-8674(94)90360-3_BIB8', 'series-title': 'Current Protocols in Molecular Biology', 'author': 'Ausubel', 'year': '1987'} / Current Protocols in Molecular Biology by Ausubel (1987)
{'key': '10.1016/0092-8674(94)90360-3_BIB9', 'first-page': '1233', 'article-title': 'The cytoplasmic tail of CD4 targets chimeric molecules to a degradative pathway', 'volume': '3', 'author': 'Baenziger', 'year': '1991', 'journal-title': 'New Biol.'} / New Biol. / The cytoplasmic tail of CD4 targets chimeric molecules to a degradative pathway by Baenziger (1991)
{'key': '10.1016/0092-8674(94)90360-3_BIB10', 'first-page': '3277', 'article-title': 'The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complex', 'volume': '86', 'author': 'Barber', 'year': '1989'} / The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complex by Barber (1989)
10.1084/jem.177.6.1561 / J. Exp. Med. / Downregulation of cell-surface CD4 expression by simian immunodeficiency virus Nef prevents viral super infection by Benson (1993)
10.1002/j.1460-2075.1991.tb07959.x / EMBO J. / Autonomous roles for the cytoplasmic domains of the CD2 and CD4 T cell surface antigens by Beyers (1991)
10.4049/jimmunol.139.12.3949 / J. Immunol. / Phosphorylation of CD4 and CD8 molecules following T cell triggering by Blue (1987)
10.4049/jimmunol.142.2.374 / J. Immunol. / Regulation of CD4 and CD8 surface expression on human thymocyte subpopulations by triggering through CD2 and CD3-T cell receptor by Blue (1989)
10.1016/0092-8674(92)90598-7 / Cell / ZAP-70: a 70 kd protein-tyrosine kinase that associates with the TCR ζ chain by Chan (1992)
10.1016/S0021-9258(18)69070-2 / J. Biol. Chem. / Demonstration of epidermal growth factor-induced receptor dimerization in living cells using a chemical covalent cross-linking agent by Cochet (1988)
10.1128/JVI.64.11.5585-5593.1990 / J. Virol. / CD4 is retained in the endoplasmic reticulum by the human immunodeficiency virus type 1 glycoprotein precursor by Crise (1990)
10.1128/JVI.66.4.2296-2301.1992 / J. Virol. / Human immunodeficiency virus type 1 glycoprotein presursor retains a CD4-p56lck complex in the endoplasmic reticulum by Crise (1992)
10.1128/JVI.65.3.1053-1056.1991 / J. Virol. / Human immunodeficiency virus as a prototypic complex retrovirus by Cullen (1991)
{'key': '10.1016/0092-8674(94)90360-3_BIB20', 'first-page': '6460', 'article-title': 'Safe and efficient generation of recombinant retroviruses with amphotropic and ecotropic host ranges', 'volume': '85', 'author': 'Danos', 'year': '1988'} / Safe and efficient generation of recombinant retroviruses with amphotropic and ecotropic host ranges by Danos (1988)
{'key': '10.1016/0092-8674(94)90360-3_BIB21', 'first-page': '2644', 'article-title': 'Molecular mechanisms of mitogen action: processing of receptor induced by epidermal growth factor', 'volume': '75', 'author': 'Das', 'year': '1978'} / Molecular mechanisms of mitogen action: processing of receptor induced by epidermal growth factor by Das (1978)
10.1016/0042-6822(92)90772-H / Virology / Natural HIV-1 Nef accelerates virus replication in primary human lymphocytes by de Ronde (1992)
10.1038/330256a0 / Nature / Interaction between CD4 and class II MHC molecules mediates cell adhesion by Doyle (1987)
10.1096/fasebj.3.1.2783412 / FASEB J. / High-yield trapping of EGF-induced receptor dimers by chemical cross-linking by Fanger (1989)
10.1016/0042-6822(86)90219-9 / Virology / Cytoplasmic localization of the HTLV-III 3′orf protein in cultured T cells by Franchini (1986)
10.1038/350508a0 / Nature / Serine phosphorylation-independent downregulation of cell-surface CD4 by nef by Garcia (1991)
10.1128/JVI.67.3.1511-1516.1993 / J. Virol. / The negative effect of human immunodeficiency virus type 1 Nef on cell surface CD4 expression is not species specific and requires the cytoplasmic domain of CD4 by Garcia (1993)
10.1016/0092-8674(91)90235-Q / Cell / Requirement for association of p56lck with CD4 in antigen-specific signal transduction in T cells by Glaichenhaus (1991)
10.1038/330266a0 / Nature / HIV F/3′ orf encodes a phosphorylated GTP-binding protein resembling an oncogene product by Guy (1987)
{'key': '10.1016/0092-8674(94)90360-3_BIB30', 'first-page': '3317', 'article-title': 'Visualization by fluorescence of the binding and internalization of epidermal growth factor in human carcinoma cells A431', 'volume': '75', 'author': 'Haigler', 'year': '1978'} / Visualization by fluorescence of the binding and internalization of epidermal growth factor in human carcinoma cells A431 by Haigler (1978)
{'key': '10.1016/0092-8674(94)90360-3_BIB31', 'first-page': '9549', 'article-title': 'Nef protein of human immunodeficiency virus type 1: evidence against its role as a transcriptional inhibitor', 'volume': '86', 'author': 'Hammes', 'year': '1989'} / Nef protein of human immunodeficiency virus type 1: evidence against its role as a transcriptional inhibitor by Hammes (1989)
10.1038/358328a0 / Nature / Association of tyrosine kinase p56lck with CD4 inhibits the induction of growth through the αβ T-cell receptor by Haughn (1992)
10.4049/jimmunol.137.4.1194 / J. Immunol. / Transient modulation and internalization of T4 antigen induced by phorbol esters by Hoxie (1986)
10.4049/jimmunol.140.3.786 / J. Immunol. / T4 endocytosis and phosphorylation induced by phorbol esters but not by mitogen or HIV infection by Hoxie (1988)
10.1128/JVI.64.12.6297-6304.1990 / J. Virol. / Intracellular interaction of human immunodeficiency virus type 1 (ARV-2) envelope glycoprotein gp160 with CD4 blocks the movement and maturation of CD4 to the plasma membrane by Jabbar (1990)
10.1016/0092-8674(91)90097-I / Cell / Importance of the nef gene for maintenance of high virus loads and for development of AIDS by Kestler (1991)
10.1128/JVI.63.9.3708-3713.1989 / J. Virol. / Temporal aspects of DNA and RNA synthesis during human immunodeficiency virus infection: evidence for differential gene expression by Kim (1989)
{'key': '10.1016/0092-8674(94)90360-3_BIB38', 'first-page': '9544', 'article-title': 'Lack of a negative influence on viral growth by the nef gene of human immunodeficiency virus type 1', 'volume': '86', 'author': 'Kim', 'year': '1989'} / Lack of a negative influence on viral growth by the nef gene of human immunodeficiency virus type 1 by Kim (1989)
{'key': '10.1016/0092-8674(94)90360-3_BIB39', 'first-page': '5011', 'article-title': 'Kinetics of expression of multiply spliced RNA in early human immunodeficiency virus type 1 infection of lymphocytes and monocytes', 'volume': '88', 'author': 'Klotman', 'year': '1991'} / Kinetics of expression of multiply spliced RNA in early human immunodeficiency virus type 1 infection of lymphocytes and monocytes by Klotman (1991)
10.1128/JVI.67.12.7238-7245.1993 / J. Virol. / Vpu-induced degradation of CD4: requirement for specific amino acid residues in the cytoplasmic domain of CD4 by Lenburg (1993)
10.1016/0092-8674(92)90636-Q / Cell / A novel di-leucine motif and a tyrosine-based motif independently mediate lysosomal targeting and endocytosis of CD3 chains by Letourneur (1992)
10.1126/science.6326261 / Science / Expression cloning of human EGF receptor complementary DNA: gene amplification and three related messenger RNA products in A431 cells by Lin (1984)
{'key': '10.1016/0092-8674(94)90360-3_BIB43', 'first-page': '1434', 'article-title': 'Mutational analysis of the human immunodeficiency virus: the orf-B region down-regulates virus replication', 'volume': '84', 'author': 'Luciw', 'year': '1987'} / Mutational analysis of the human immunodeficiency virus: the orf-B region down-regulates virus replication by Luciw (1987)
{'key': '10.1016/0092-8674(94)90360-3_BIB44', 'first-page': '5326', 'article-title': 'Expression of the type 1 human immunodeficiency virus Nef protein in T cells prevents antigen receptor-mediated induction of interleukin 2 mRNA', 'volume': '88', 'author': 'Luria', 'year': '1991'} / Expression of the type 1 human immunodeficiency virus Nef protein in T cells prevents antigen receptor-mediated induction of interleukin 2 mRNA by Luria (1991)
10.1016/0092-8674(86)90590-8 / Cell / The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain by Maddon (1986)
10.1016/S0092-8674(85)80105-7 / Cell / The isolation and nucleotide sequence of a cDNA encoding the T cell surface protein T4: a new member of the immunoglobulin gene family by Maddon (1985)
{'key': '10.1016/0092-8674(94)90360-3_BIB47', 'first-page': '5549', 'article-title': 'CD4 downregulation by nef alleles isolated from HIV-1-infected individuals', 'volume': '90', 'author': 'Mariani', 'year': '1993'} / CD4 downregulation by nef alleles isolated from HIV-1-infected individuals by Mariani (1993)
{'key': '10.1016/0092-8674(94)90360-3_BIB48', 'first-page': '133', 'article-title': 'The roles of CD4 and CD8 in T cell activation', 'volume': '3', 'author': 'Miceli', 'year': '1991', 'journal-title': 'Semin. Immunol.'} / Semin. Immunol. / The roles of CD4 and CD8 in T cell activation by Miceli (1991)
{'key': '10.1016/0092-8674(94)90360-3_BIB49', 'first-page': '1128', 'article-title': 'Human immunodeficiency virus type 1 negative factor is a transcriptional silencer', 'volume': '86', 'author': 'Niederman', 'year': '1989'} / Human immunodeficiency virus type 1 negative factor is a transcriptional silencer by Niederman (1989)
10.1016/S0065-2776(08)60644-6 / Adv. Immunol. / Molecular biology and function of CD4 and CD3 by Parnes (1989)
10.1002/j.1460-2075.1989.tb08538.x / EMBO J. / Internalization and recycling of CD4 transfected into HeLa and NIH3T3 cells by Pelchen-Matthews (1989)
10.1084/jem.173.3.575 / J. Exp. Med. / Differential endocytosis of CD4 in lymphocytic and nonlymphocytic cells by Pelchen-Matthews (1991)
10.1083/jcb.117.2.279 / J. Cell Biol. / The protein tyrosine kinase p56lck inhibits CD4 endocytosis by preventing entry of CD4 into coated pits by Pelchen-Matthews (1992)
10.1084/jem.178.4.1209 / J. Exp. Med. / Phorbol ester-induced downregulation of CD4 is a multistep process involving dissociation from p56lck, increased association with clathrin-coated pits, and altered endosomal sorting by Pelchen-Matthews (1993)
10.1016/0092-8674(90)90691-7 / Cell / Cells nonproductively infected with HIV-1 exhibit an aberrant pattern of viral RNA expression: a molecular model for latency by Pomerantz (1990)
10.1128/JVI.66.3.1809-1813.1992 / J. Virol. / Efficient replication of human immunodeficiency virus type 1 requires a threshold level of Rev: potential implications for latency by Pomerantz (1992)
10.1016/0092-8674(90)90082-P / Cell / CD4: collaborator in immune recognition and HIV infection by Robey (1990)
{'key': '10.1016/0092-8674(94)90360-3_BIB58', 'first-page': '5190', 'article-title': 'The CD4 receptor is complexed in detergent lysates to a protein-tyrosine kinase (pp58) from human T lymphocytes', 'volume': '85', 'author': 'Rudd', 'year': '1988'} / The CD4 receptor is complexed in detergent lysates to a protein-tyrosine kinase (pp58) from human T lymphocytes by Rudd (1988)
10.1016/S0021-9258(19)37037-1 / J. Biol. Chem. / Degradation of CD4 following phorbol-induced internalization in human T lymphocytes by Ruegg (1992)
{'key': '10.1016/0092-8674(94)90360-3_BIB60', 'first-page': '2659', 'article-title': 'Direct visualization of binding, aggregation, and internalization of insulin and epidermal growth factor on living fibroblastic cells', 'volume': '75', 'author': 'Schlessinger', 'year': '1978'} / Direct visualization of binding, aggregation, and internalization of insulin and epidermal growth factor on living fibroblastic cells by Schlessinger (1978)
10.1128/JVI.67.6.3274-3280.1993 / J. Virol. / Reduced cell surface expression of processed human immunodeficiency virus type 1 envelope glycoprotein in the presence of Nef by Schwartz (1993)
10.1126/science.6095449 / Science / Molecular characterization of human T-cell leukemia (lymphotropic) virus type III in the acquired immune deficiency syndrome by Shaw (1984)
10.1016/0092-8674(89)90008-1 / Cell / The lck tyrosine protein kinase interacts with the cytoplasmic tail of the CD4 glycoprotein through its unique aminoterminal domain by Shaw (1989)
10.1002/j.1460-2075.1990.tb08127.x / EMBO J. / Structural features of the cytoplasmic region of CD4 required for internalization by Shin (1990)
10.1016/S0021-9258(18)99274-4 / J. Biol. Chem. / Phosphorylation-dependent down-modulation of CD4 requires a specific structure within the cytoplasmic domain of CD4 by Shin (1991)
10.1002/j.1460-2075.1993.tb05704.x / EMBO J. / Altered T cell activation and development in transgenic mice expressing the HIV-1 nef gene by Skowronski (1993)
10.1038/328351a0 / Nature / Expression and function of CD4 in a murine T-cell hybridoma by Sleckman (1987)
{'key': '10.1016/0092-8674(94)90360-3_BIB68', 'first-page': '7566', 'article-title': 'Disruption of the CD4-p56lck complex is required for rapid internalization of CD4', 'volume': '89', 'author': 'Sleckman', 'year': '1992'} / Disruption of the CD4-p56lck complex is required for rapid internalization of CD4 by Sleckman (1992)
10.1016/0092-8674(88)90168-7 / Cell / Envelope glycoprotein of HIV induces interference and cytolysis resistance in CD4+ cells: mechanism for persistance in AIDS by Stevenson (1988)
10.1083/jcb.98.3.1048 / J. Cell Biol. / “Down regulation” of EGF receptors: direct demonstration of receptor degradation in human fibroblasts by Stoscheck (1984)
10.1016/0092-8674(92)90428-F / Cell / Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor by Straus (1992)
{'key': '10.1016/0092-8674(94)90360-3_BIB72', 'first-page': '10971', 'article-title': 'Allelic variation in the effects of the nef gene on replication of human immunodeficiency virus type 1', 'volume': '88', 'author': 'Terwilliger', 'year': '1991'} / Allelic variation in the effects of the nef gene on replication of human immunodeficiency virus type 1 by Terwilliger (1991)
10.1002/j.1460-2075.1990.tb07638.x / EMBO J. / A human cell factor is essential for HIV-1 Rev action by Trono (1990)
10.1146/annurev.cb.09.110193.001021 / Annu. Rev. Cell Biol. / Signal-dependent membrane protein trafficking in the endocytic pathway by Trowbridge (1993)
10.1016/0092-8674(90)90090-2 / Cell / Interaction of the unique N-terminal region of tyrosine kinase p56lck with cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs by Turner (1990)
10.1038/309418a0 / Nature / Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells by Ullrich (1984)
10.1038/338257a0 / Nature / Signal transduction through the CD4 receptor involves the activation of the internal membrane tyrosine-protein kinase p56lck by Veillette (1989)
10.1128/JVI.67.9.5538-5549.1993 / J. Virol. / Human immunodeficiency virus type 1 Vpu protein induces degradation of chimeric envelope glycoproteins bearing the cytoplasmic and anchor domains of CD4: role of the cytoplasmic domain in Vpu-induced degradation in the endoplasmic reticulum by Vincent (1993)
10.1016/0092-8674(93)90221-B / Cell / T cell antigen receptor signal transduction: a tale of tails and cytoplasmic protein-tyrosine kinases by Weiss (1993)
10.4049/jimmunol.138.5.1351 / J. Immunol. / Modulation of CD4 by antigenic activation by Weyand (1987)
10.1128/JVI.66.12.7193-7200.1992 / J. Virol. / Human immunodeficiency virus type 1 Vpu protein induces rapid degradation of CD4 by Willey (1992)
{'key': '10.1016/0092-8674(94)90360-3_BIB82', 'first-page': '6634', 'article-title': 'Mutational analysis of the human immunodeficiency virus type 1 Eli Nef function', 'volume': '89', 'author': 'Zazopoulos', 'year': '1992'} / Mutational analysis of the human immunodeficiency virus type 1 Eli Nef function by Zazopoulos (1992)
{'key': '10.1016/0092-8674(94)90360-3_BIB83', 'first-page': '167', 'article-title': 'CD4 and CD8 act as co-receptors during thymic selection of the T cell repertoire', 'volume': '3', 'author': 'Zúñiga-Pflücker', 'year': '1991', 'journal-title': 'Semin. Immunol.'} / Semin. Immunol. / CD4 and CD8 act as co-receptors during thymic selection of the T cell repertoire by Zúñiga-Pflücker (1991)

Dates

Type	When
Created	21 years, 3 months ago (May 4, 2004, 6:14 a.m.)
Deposited	1 year, 7 months ago (Jan. 13, 2024, 4:13 a.m.)
Indexed	1 week, 4 days ago (Aug. 20, 2025, 9:13 a.m.)
Issued	31 years, 5 months ago (March 1, 1994)
Published	31 years, 5 months ago (March 1, 1994)
Published Print	31 years, 5 months ago (March 1, 1994)

Funders 0

None

BibTeX

@article{Aiken_1994, title={Nef induces CD4 endocytosis: Requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain}, volume={76}, ISSN={0092-8674}, url={http://dx.doi.org/10.1016/0092-8674(94)90360-3}, DOI={10.1016/0092-8674(94)90360-3}, number={5}, journal={Cell}, publisher={Elsevier BV}, author={Aiken, Christopher and Konner, Jason and Landau, Nathaniel R. and Lenburg, Marc E. and Trono, Didier}, year={1994}, month=mar, pages={853–864} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        8,
        20
      ]
    ],
    "date-time": "2025-08-20T13:13:42Z",
    "timestamp": 1755695622313
  },
  "reference-count": 83,
  "publisher": "Elsevier BV",
  "issue": "5",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            1994,
            3,
            1
          ]
        ],
        "date-time": "1994-03-01T00:00:00Z",
        "timestamp": 762480000000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://www.elsevier.com/tdm/userlicense/1.0/"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        1994,
        3
      ]
    ]
  },
  "DOI": "10.1016/0092-8674(94)90360-3",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2004,
        5,
        4
      ]
    ],
    "date-time": "2004-05-04T10:14:26Z",
    "timestamp": 1083665666000
  },
  "page": "853-864",
  "source": "Crossref",
  "is-referenced-by-count": 577,
  "title": "Nef induces CD4 endocytosis: Requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain",
  "prefix": "10.1016",
  "volume": "76",
  "author": [
    {
      "given": "Christopher",
      "family": "Aiken",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Jason",
      "family": "Konner",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Nathaniel R.",
      "family": "Landau",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Marc E.",
      "family": "Lenburg",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Didier",
      "family": "Trono",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "78",
  "reference": [
    {
      "key": "10.1016/0092-8674(94)90360-3_BIB1",
      "doi-asserted-by": "crossref",
      "first-page": "16210",
      "DOI": "10.1016/S0021-9258(18)66700-6",
      "article-title": "Rapid phosphorylation and modulation of the T4 antigen on cloned helper T cells induced by phorbol myristate acetate or antigen",
      "volume": "34",
      "author": "Acres",
      "year": "1986",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/0092-8674(94)90360-3_BIB2",
      "doi-asserted-by": "crossref",
      "first-page": "284",
      "DOI": "10.1128/JVI.59.2.284-291.1986",
      "article-title": "Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone",
      "volume": "59",
      "author": "Adachi",
      "year": "1986",
      "journal-title": "J. Virol."
    },
    {
      "key": "10.1016/0092-8674(94)90360-3_BIB3",
      "doi-asserted-by": "crossref",
      "first-page": "1481",
      "DOI": "10.1126/science.3262235",
      "article-title": "Nef protein of HIV-1 is a transcriptional repressor of HIV-1 LTR",
      "volume": "241",
      "author": "Ahmad",
      "year": "1988",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/0092-8674(94)90360-3_BIB4",
      "doi-asserted-by": "crossref",
      "first-page": "810",
      "DOI": "10.1126/science.2997921",
      "article-title": "A new HTLV-III/LAV-encoded antigen detected by antibodies from AIDS patients",
      "volume": "230",
      "author": "Allan",
      "year": "1985",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/0092-8674(94)90360-3_BIB5",
      "doi-asserted-by": "crossref",
      "first-page": "227",
      "DOI": "10.1016/S0065-2776(08)60756-7",
      "article-title": "Molecular events mediating T cell activation",
      "volume": "48",
      "author": "Altman",
      "year": "1990",
      "journal-title": "Adv. Immunol."
    },
    {
      "key": "10.1016/0092-8674(94)90360-3_BIB6",
      "doi-asserted-by": "crossref",
      "first-page": "4923",
      "DOI": "10.1128/JVI.67.8.4923-4931.1993",
      "article-title": "Nef from primary isolates of human immunodeficiency virus type 1 suppresses surface CD4 expression in human and mouse T cells",
      "volume": "67",
      "author": "Anderson",
      "year": "1993",
      "journal-title": "J. Virol."
    },
    {
      "key": "10.1016/0092-8674(94)90360-3_BIB7",
      "doi-asserted-by": "crossref",
      "first-page": "69",
      "DOI": "10.1126/science.2990040",
      "article-title": "Trans-activator gene of human T-lymphotropic virus type III (HTLV-III)",
      "volume": "229",
      "author": "Arya",
      "year": "1985",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/0092-8674(94)90360-3_BIB8",
      "series-title": "Current Protocols in Molecular Biology",
      "author": "Ausubel",
      "year": "1987"
    },
    {
      "key": "10.1016/0092-8674(94)90360-3_BIB9",
      "first-page": "1233",
      "article-title": "The cytoplasmic tail of CD4 targets chimeric molecules to a degradative pathway",
      "volume": "3",
      "author": "Baenziger",
      "year": "1991",
      "journal-title": "New Biol."
    },
    {
      "key": "10.1016/0092-8674(94)90360-3_BIB10",
      "first-page": "3277",
      "article-title": "The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complex",
      "volume": "86",
      "author": "Barber",
      "year": "1989"
    },
    {
      "key": "10.1016/0092-8674(94)90360-3_BIB11",
      "doi-asserted-by": "crossref",
      "first-page": "1561",
      "DOI": "10.1084/jem.177.6.1561",
      "article-title": "Downregulation of cell-surface CD4 expression by simian immunodeficiency virus Nef prevents viral super infection",
      "volume": "177",
      "author": "Benson",
      "year": "1993",
      "journal-title": "J. Exp. Med."
    },
    {
      "key": "10.1016/0092-8674(94)90360-3_BIB12",
      "doi-asserted-by": "crossref",
      "first-page": "377",
      "DOI": "10.1002/j.1460-2075.1991.tb07959.x",
      "article-title": "Autonomous roles for the cytoplasmic domains of the CD2 and CD4 T cell surface antigens",
      "volume": "10",
      "author": "Beyers",
      "year": "1991",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/0092-8674(94)90360-3_BIB13",
      "doi-asserted-by": "crossref",
      "first-page": "3949",
      "DOI": "10.4049/jimmunol.139.12.3949",
      "article-title": "Phosphorylation of CD4 and CD8 molecules following T cell triggering",
      "volume": "139",
      "author": "Blue",
      "year": "1987",
      "journal-title": "J. Immunol."
    },
    {
      "key": "10.1016/0092-8674(94)90360-3_BIB14",
      "doi-asserted-by": "crossref",
      "first-page": "374",
      "DOI": "10.4049/jimmunol.142.2.374",
      "article-title": "Regulation of CD4 and CD8 surface expression on human thymocyte subpopulations by triggering through CD2 and CD3-T cell receptor",
      "volume": "142",
      "author": "Blue",
      "year": "1989",
      "journal-title": "J. Immunol."
    },
    {
      "key": "10.1016/0092-8674(94)90360-3_BIB15",
      "doi-asserted-by": "crossref",
      "first-page": "649",
      "DOI": "10.1016/0092-8674(92)90598-7",
      "article-title": "ZAP-70: a 70 kd protein-tyrosine kinase that associates with the TCR \u03b6 chain",
      "volume": "71",
      "author": "Chan",
      "year": "1992",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/0092-8674(94)90360-3_BIB16",
      "doi-asserted-by": "crossref",
      "first-page": "3290",
      "DOI": "10.1016/S0021-9258(18)69070-2",
      "article-title": "Demonstration of epidermal growth factor-induced receptor dimerization in living cells using a chemical covalent cross-linking agent",
      "volume": "263",
      "author": "Cochet",
      "year": "1988",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/0092-8674(94)90360-3_BIB17",
      "doi-asserted-by": "crossref",
      "first-page": "5585",
      "DOI": "10.1128/JVI.64.11.5585-5593.1990",
      "article-title": "CD4 is retained in the endoplasmic reticulum by the human immunodeficiency virus type 1 glycoprotein precursor",
      "volume": "64",
      "author": "Crise",
      "year": "1990",
      "journal-title": "J. Virol."
    },
    {
      "key": "10.1016/0092-8674(94)90360-3_BIB18",
      "doi-asserted-by": "crossref",
      "first-page": "2296",
      "DOI": "10.1128/JVI.66.4.2296-2301.1992",
      "article-title": "Human immunodeficiency virus type 1 glycoprotein presursor retains a CD4-p56lck complex in the endoplasmic reticulum",
      "volume": "66",
      "author": "Crise",
      "year": "1992",
      "journal-title": "J. Virol."
    },
    {
      "key": "10.1016/0092-8674(94)90360-3_BIB19",
      "doi-asserted-by": "crossref",
      "first-page": "1053",
      "DOI": "10.1128/JVI.65.3.1053-1056.1991",
      "article-title": "Human immunodeficiency virus as a prototypic complex retrovirus",
      "volume": "65",
      "author": "Cullen",
      "year": "1991",
      "journal-title": "J. Virol."
    },
    {
      "key": "10.1016/0092-8674(94)90360-3_BIB20",
      "first-page": "6460",
      "article-title": "Safe and efficient generation of recombinant retroviruses with amphotropic and ecotropic host ranges",
      "volume": "85",
      "author": "Danos",
      "year": "1988"
    },
    {
      "key": "10.1016/0092-8674(94)90360-3_BIB21",
      "first-page": "2644",
      "article-title": "Molecular mechanisms of mitogen action: processing of receptor induced by epidermal growth factor",
      "volume": "75",
      "author": "Das",
      "year": "1978"
    },
    {
      "key": "10.1016/0092-8674(94)90360-3_BIB22",
      "doi-asserted-by": "crossref",
      "first-page": "391",
      "DOI": "10.1016/0042-6822(92)90772-H",
      "article-title": "Natural HIV-1 Nef accelerates virus replication in primary human lymphocytes",
      "volume": "188",
      "author": "de Ronde",
      "year": "1992",
      "journal-title": "Virology"
    },
    {
      "key": "10.1016/0092-8674(94)90360-3_BIB23",
      "doi-asserted-by": "crossref",
      "first-page": "254",
      "DOI": "10.1038/330256a0",
      "article-title": "Interaction between CD4 and class II MHC molecules mediates cell adhesion",
      "volume": "330",
      "author": "Doyle",
      "year": "1987",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/0092-8674(94)90360-3_BIB24",
      "doi-asserted-by": "crossref",
      "first-page": "71",
      "DOI": "10.1096/fasebj.3.1.2783412",
      "article-title": "High-yield trapping of EGF-induced receptor dimers by chemical cross-linking",
      "volume": "3",
      "author": "Fanger",
      "year": "1989",
      "journal-title": "FASEB J."
    },
    {
      "key": "10.1016/0092-8674(94)90360-3_BIB25",
      "doi-asserted-by": "crossref",
      "first-page": "593",
      "DOI": "10.1016/0042-6822(86)90219-9",
      "article-title": "Cytoplasmic localization of the HTLV-III 3\u2032orf protein in cultured T cells",
      "volume": "155",
      "author": "Franchini",
      "year": "1986",
      "journal-title": "Virology"
    },
    {
      "key": "10.1016/0092-8674(94)90360-3_BIB26",
      "doi-asserted-by": "crossref",
      "first-page": "508",
      "DOI": "10.1038/350508a0",
      "article-title": "Serine phosphorylation-independent downregulation of cell-surface CD4 by nef",
      "volume": "350",
      "author": "Garcia",
      "year": "1991",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/0092-8674(94)90360-3_BIB27",
      "doi-asserted-by": "crossref",
      "first-page": "1511",
      "DOI": "10.1128/JVI.67.3.1511-1516.1993",
      "article-title": "The negative effect of human immunodeficiency virus type 1 Nef on cell surface CD4 expression is not species specific and requires the cytoplasmic domain of CD4",
      "volume": "67",
      "author": "Garcia",
      "year": "1993",
      "journal-title": "J. Virol."
    },
    {
      "key": "10.1016/0092-8674(94)90360-3_BIB28",
      "doi-asserted-by": "crossref",
      "first-page": "511",
      "DOI": "10.1016/0092-8674(91)90235-Q",
      "article-title": "Requirement for association of p56lck with CD4 in antigen-specific signal transduction in T cells",
      "volume": "64",
      "author": "Glaichenhaus",
      "year": "1991",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/0092-8674(94)90360-3_BIB29",
      "doi-asserted-by": "crossref",
      "first-page": "266",
      "DOI": "10.1038/330266a0",
      "article-title": "HIV F/3\u2032 orf encodes a phosphorylated GTP-binding protein resembling an oncogene product",
      "volume": "330",
      "author": "Guy",
      "year": "1987",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/0092-8674(94)90360-3_BIB30",
      "first-page": "3317",
      "article-title": "Visualization by fluorescence of the binding and internalization of epidermal growth factor in human carcinoma cells A431",
      "volume": "75",
      "author": "Haigler",
      "year": "1978"
    },
    {
      "key": "10.1016/0092-8674(94)90360-3_BIB31",
      "first-page": "9549",
      "article-title": "Nef protein of human immunodeficiency virus type 1: evidence against its role as a transcriptional inhibitor",
      "volume": "86",
      "author": "Hammes",
      "year": "1989"
    },
    {
      "key": "10.1016/0092-8674(94)90360-3_BIB32",
      "doi-asserted-by": "crossref",
      "first-page": "328",
      "DOI": "10.1038/358328a0",
      "article-title": "Association of tyrosine kinase p56lck with CD4 inhibits the induction of growth through the \u03b1\u03b2 T-cell receptor",
      "volume": "358",
      "author": "Haughn",
      "year": "1992",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/0092-8674(94)90360-3_BIB33",
      "doi-asserted-by": "crossref",
      "first-page": "1194",
      "DOI": "10.4049/jimmunol.137.4.1194",
      "article-title": "Transient modulation and internalization of T4 antigen induced by phorbol esters",
      "volume": "137",
      "author": "Hoxie",
      "year": "1986",
      "journal-title": "J. Immunol."
    },
    {
      "key": "10.1016/0092-8674(94)90360-3_BIB34",
      "doi-asserted-by": "crossref",
      "first-page": "786",
      "DOI": "10.4049/jimmunol.140.3.786",
      "article-title": "T4 endocytosis and phosphorylation induced by phorbol esters but not by mitogen or HIV infection",
      "volume": "140",
      "author": "Hoxie",
      "year": "1988",
      "journal-title": "J. Immunol."
    },
    {
      "key": "10.1016/0092-8674(94)90360-3_BIB35",
      "doi-asserted-by": "crossref",
      "first-page": "6297",
      "DOI": "10.1128/JVI.64.12.6297-6304.1990",
      "article-title": "Intracellular interaction of human immunodeficiency virus type 1 (ARV-2) envelope glycoprotein gp160 with CD4 blocks the movement and maturation of CD4 to the plasma membrane",
      "volume": "64",
      "author": "Jabbar",
      "year": "1990",
      "journal-title": "J. Virol."
    },
    {
      "key": "10.1016/0092-8674(94)90360-3_BIB36",
      "doi-asserted-by": "crossref",
      "first-page": "651",
      "DOI": "10.1016/0092-8674(91)90097-I",
      "article-title": "Importance of the nef gene for maintenance of high virus loads and for development of AIDS",
      "volume": "65",
      "author": "Kestler",
      "year": "1991",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/0092-8674(94)90360-3_BIB37",
      "doi-asserted-by": "crossref",
      "first-page": "3708",
      "DOI": "10.1128/JVI.63.9.3708-3713.1989",
      "article-title": "Temporal aspects of DNA and RNA synthesis during human immunodeficiency virus infection: evidence for differential gene expression",
      "volume": "63",
      "author": "Kim",
      "year": "1989",
      "journal-title": "J. Virol."
    },
    {
      "key": "10.1016/0092-8674(94)90360-3_BIB38",
      "first-page": "9544",
      "article-title": "Lack of a negative influence on viral growth by the nef gene of human immunodeficiency virus type 1",
      "volume": "86",
      "author": "Kim",
      "year": "1989"
    },
    {
      "key": "10.1016/0092-8674(94)90360-3_BIB39",
      "first-page": "5011",
      "article-title": "Kinetics of expression of multiply spliced RNA in early human immunodeficiency virus type 1 infection of lymphocytes and monocytes",
      "volume": "88",
      "author": "Klotman",
      "year": "1991"
    },
    {
      "key": "10.1016/0092-8674(94)90360-3_BIB40",
      "doi-asserted-by": "crossref",
      "first-page": "7238",
      "DOI": "10.1128/JVI.67.12.7238-7245.1993",
      "article-title": "Vpu-induced degradation of CD4: requirement for specific amino acid residues in the cytoplasmic domain of CD4",
      "volume": "67",
      "author": "Lenburg",
      "year": "1993",
      "journal-title": "J. Virol."
    },
    {
      "key": "10.1016/0092-8674(94)90360-3_BIB41",
      "doi-asserted-by": "crossref",
      "first-page": "1143",
      "DOI": "10.1016/0092-8674(92)90636-Q",
      "article-title": "A novel di-leucine motif and a tyrosine-based motif independently mediate lysosomal targeting and endocytosis of CD3 chains",
      "volume": "69",
      "author": "Letourneur",
      "year": "1992",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/0092-8674(94)90360-3_BIB42",
      "doi-asserted-by": "crossref",
      "first-page": "843",
      "DOI": "10.1126/science.6326261",
      "article-title": "Expression cloning of human EGF receptor complementary DNA: gene amplification and three related messenger RNA products in A431 cells",
      "volume": "224",
      "author": "Lin",
      "year": "1984",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/0092-8674(94)90360-3_BIB43",
      "first-page": "1434",
      "article-title": "Mutational analysis of the human immunodeficiency virus: the orf-B region down-regulates virus replication",
      "volume": "84",
      "author": "Luciw",
      "year": "1987"
    },
    {
      "key": "10.1016/0092-8674(94)90360-3_BIB44",
      "first-page": "5326",
      "article-title": "Expression of the type 1 human immunodeficiency virus Nef protein in T cells prevents antigen receptor-mediated induction of interleukin 2 mRNA",
      "volume": "88",
      "author": "Luria",
      "year": "1991"
    },
    {
      "key": "10.1016/0092-8674(94)90360-3_BIB45",
      "doi-asserted-by": "crossref",
      "first-page": "333",
      "DOI": "10.1016/0092-8674(86)90590-8",
      "article-title": "The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain",
      "volume": "47",
      "author": "Maddon",
      "year": "1986",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/0092-8674(94)90360-3_BIB46",
      "doi-asserted-by": "crossref",
      "first-page": "94",
      "DOI": "10.1016/S0092-8674(85)80105-7",
      "article-title": "The isolation and nucleotide sequence of a cDNA encoding the T cell surface protein T4: a new member of the immunoglobulin gene family",
      "volume": "42",
      "author": "Maddon",
      "year": "1985",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/0092-8674(94)90360-3_BIB47",
      "first-page": "5549",
      "article-title": "CD4 downregulation by nef alleles isolated from HIV-1-infected individuals",
      "volume": "90",
      "author": "Mariani",
      "year": "1993"
    },
    {
      "key": "10.1016/0092-8674(94)90360-3_BIB48",
      "first-page": "133",
      "article-title": "The roles of CD4 and CD8 in T cell activation",
      "volume": "3",
      "author": "Miceli",
      "year": "1991",
      "journal-title": "Semin. Immunol."
    },
    {
      "key": "10.1016/0092-8674(94)90360-3_BIB49",
      "first-page": "1128",
      "article-title": "Human immunodeficiency virus type 1 negative factor is a transcriptional silencer",
      "volume": "86",
      "author": "Niederman",
      "year": "1989"
    },
    {
      "key": "10.1016/0092-8674(94)90360-3_BIB50",
      "doi-asserted-by": "crossref",
      "first-page": "265",
      "DOI": "10.1016/S0065-2776(08)60644-6",
      "article-title": "Molecular biology and function of CD4 and CD3",
      "volume": "44",
      "author": "Parnes",
      "year": "1989",
      "journal-title": "Adv. Immunol."
    },
    {
      "key": "10.1016/0092-8674(94)90360-3_BIB51",
      "doi-asserted-by": "crossref",
      "first-page": "3641",
      "DOI": "10.1002/j.1460-2075.1989.tb08538.x",
      "article-title": "Internalization and recycling of CD4 transfected into HeLa and NIH3T3 cells",
      "volume": "8",
      "author": "Pelchen-Matthews",
      "year": "1989",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/0092-8674(94)90360-3_BIB52",
      "doi-asserted-by": "crossref",
      "first-page": "575",
      "DOI": "10.1084/jem.173.3.575",
      "article-title": "Differential endocytosis of CD4 in lymphocytic and nonlymphocytic cells",
      "volume": "173",
      "author": "Pelchen-Matthews",
      "year": "1991",
      "journal-title": "J. Exp. Med."
    },
    {
      "key": "10.1016/0092-8674(94)90360-3_BIB53",
      "doi-asserted-by": "crossref",
      "first-page": "279",
      "DOI": "10.1083/jcb.117.2.279",
      "article-title": "The protein tyrosine kinase p56lck inhibits CD4 endocytosis by preventing entry of CD4 into coated pits",
      "volume": "117",
      "author": "Pelchen-Matthews",
      "year": "1992",
      "journal-title": "J. Cell Biol."
    },
    {
      "key": "10.1016/0092-8674(94)90360-3_BIB54",
      "doi-asserted-by": "crossref",
      "first-page": "1209",
      "DOI": "10.1084/jem.178.4.1209",
      "article-title": "Phorbol ester-induced downregulation of CD4 is a multistep process involving dissociation from p56lck, increased association with clathrin-coated pits, and altered endosomal sorting",
      "volume": "178",
      "author": "Pelchen-Matthews",
      "year": "1993",
      "journal-title": "J. Exp. Med."
    },
    {
      "key": "10.1016/0092-8674(94)90360-3_BIB55",
      "doi-asserted-by": "crossref",
      "first-page": "1271",
      "DOI": "10.1016/0092-8674(90)90691-7",
      "article-title": "Cells nonproductively infected with HIV-1 exhibit an aberrant pattern of viral RNA expression: a molecular model for latency",
      "volume": "61",
      "author": "Pomerantz",
      "year": "1990",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/0092-8674(94)90360-3_BIB56",
      "doi-asserted-by": "crossref",
      "first-page": "1809",
      "DOI": "10.1128/JVI.66.3.1809-1813.1992",
      "article-title": "Efficient replication of human immunodeficiency virus type 1 requires a threshold level of Rev: potential implications for latency",
      "volume": "66",
      "author": "Pomerantz",
      "year": "1992",
      "journal-title": "J. Virol."
    },
    {
      "key": "10.1016/0092-8674(94)90360-3_BIB57",
      "doi-asserted-by": "crossref",
      "first-page": "697",
      "DOI": "10.1016/0092-8674(90)90082-P",
      "article-title": "CD4: collaborator in immune recognition and HIV infection",
      "volume": "60",
      "author": "Robey",
      "year": "1990",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/0092-8674(94)90360-3_BIB58",
      "first-page": "5190",
      "article-title": "The CD4 receptor is complexed in detergent lysates to a protein-tyrosine kinase (pp58) from human T lymphocytes",
      "volume": "85",
      "author": "Rudd",
      "year": "1988"
    },
    {
      "key": "10.1016/0092-8674(94)90360-3_BIB59",
      "doi-asserted-by": "crossref",
      "first-page": "18837",
      "DOI": "10.1016/S0021-9258(19)37037-1",
      "article-title": "Degradation of CD4 following phorbol-induced internalization in human T lymphocytes",
      "volume": "267",
      "author": "Ruegg",
      "year": "1992",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/0092-8674(94)90360-3_BIB60",
      "first-page": "2659",
      "article-title": "Direct visualization of binding, aggregation, and internalization of insulin and epidermal growth factor on living fibroblastic cells",
      "volume": "75",
      "author": "Schlessinger",
      "year": "1978"
    },
    {
      "key": "10.1016/0092-8674(94)90360-3_BIB61",
      "doi-asserted-by": "crossref",
      "first-page": "3274",
      "DOI": "10.1128/JVI.67.6.3274-3280.1993",
      "article-title": "Reduced cell surface expression of processed human immunodeficiency virus type 1 envelope glycoprotein in the presence of Nef",
      "volume": "67",
      "author": "Schwartz",
      "year": "1993",
      "journal-title": "J. Virol."
    },
    {
      "key": "10.1016/0092-8674(94)90360-3_BIB62",
      "doi-asserted-by": "crossref",
      "first-page": "1165",
      "DOI": "10.1126/science.6095449",
      "article-title": "Molecular characterization of human T-cell leukemia (lymphotropic) virus type III in the acquired immune deficiency syndrome",
      "volume": "226",
      "author": "Shaw",
      "year": "1984",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/0092-8674(94)90360-3_BIB63",
      "doi-asserted-by": "crossref",
      "first-page": "627",
      "DOI": "10.1016/0092-8674(89)90008-1",
      "article-title": "The lck tyrosine protein kinase interacts with the cytoplasmic tail of the CD4 glycoprotein through its unique aminoterminal domain",
      "volume": "59",
      "author": "Shaw",
      "year": "1989",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/0092-8674(94)90360-3_BIB64",
      "doi-asserted-by": "crossref",
      "first-page": "425",
      "DOI": "10.1002/j.1460-2075.1990.tb08127.x",
      "article-title": "Structural features of the cytoplasmic region of CD4 required for internalization",
      "volume": "9",
      "author": "Shin",
      "year": "1990",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/0092-8674(94)90360-3_BIB65",
      "doi-asserted-by": "crossref",
      "first-page": "10658",
      "DOI": "10.1016/S0021-9258(18)99274-4",
      "article-title": "Phosphorylation-dependent down-modulation of CD4 requires a specific structure within the cytoplasmic domain of CD4",
      "volume": "266",
      "author": "Shin",
      "year": "1991",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/0092-8674(94)90360-3_BIB66",
      "doi-asserted-by": "crossref",
      "first-page": "703",
      "DOI": "10.1002/j.1460-2075.1993.tb05704.x",
      "article-title": "Altered T cell activation and development in transgenic mice expressing the HIV-1 nef gene",
      "volume": "12",
      "author": "Skowronski",
      "year": "1993",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/0092-8674(94)90360-3_BIB67",
      "doi-asserted-by": "crossref",
      "first-page": "351",
      "DOI": "10.1038/328351a0",
      "article-title": "Expression and function of CD4 in a murine T-cell hybridoma",
      "volume": "328",
      "author": "Sleckman",
      "year": "1987",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/0092-8674(94)90360-3_BIB68",
      "first-page": "7566",
      "article-title": "Disruption of the CD4-p56lck complex is required for rapid internalization of CD4",
      "volume": "89",
      "author": "Sleckman",
      "year": "1992"
    },
    {
      "key": "10.1016/0092-8674(94)90360-3_BIB69",
      "doi-asserted-by": "crossref",
      "first-page": "483",
      "DOI": "10.1016/0092-8674(88)90168-7",
      "article-title": "Envelope glycoprotein of HIV induces interference and cytolysis resistance in CD4+ cells: mechanism for persistance in AIDS",
      "volume": "53",
      "author": "Stevenson",
      "year": "1988",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/0092-8674(94)90360-3_BIB70",
      "doi-asserted-by": "crossref",
      "first-page": "1048",
      "DOI": "10.1083/jcb.98.3.1048",
      "article-title": "\u201cDown regulation\u201d of EGF receptors: direct demonstration of receptor degradation in human fibroblasts",
      "volume": "98",
      "author": "Stoscheck",
      "year": "1984",
      "journal-title": "J. Cell Biol."
    },
    {
      "key": "10.1016/0092-8674(94)90360-3_BIB71",
      "doi-asserted-by": "crossref",
      "first-page": "585",
      "DOI": "10.1016/0092-8674(92)90428-F",
      "article-title": "Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor",
      "volume": "70",
      "author": "Straus",
      "year": "1992",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/0092-8674(94)90360-3_BIB72",
      "first-page": "10971",
      "article-title": "Allelic variation in the effects of the nef gene on replication of human immunodeficiency virus type 1",
      "volume": "88",
      "author": "Terwilliger",
      "year": "1991"
    },
    {
      "key": "10.1016/0092-8674(94)90360-3_BIB73",
      "doi-asserted-by": "crossref",
      "first-page": "4155",
      "DOI": "10.1002/j.1460-2075.1990.tb07638.x",
      "article-title": "A human cell factor is essential for HIV-1 Rev action",
      "volume": "9",
      "author": "Trono",
      "year": "1990",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/0092-8674(94)90360-3_BIB74",
      "doi-asserted-by": "crossref",
      "DOI": "10.1146/annurev.cb.09.110193.001021",
      "article-title": "Signal-dependent membrane protein trafficking in the endocytic pathway",
      "author": "Trowbridge",
      "year": "1993",
      "journal-title": "Annu. Rev. Cell Biol."
    },
    {
      "key": "10.1016/0092-8674(94)90360-3_BIB75",
      "doi-asserted-by": "crossref",
      "first-page": "755",
      "DOI": "10.1016/0092-8674(90)90090-2",
      "article-title": "Interaction of the unique N-terminal region of tyrosine kinase p56lck with cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs",
      "volume": "60",
      "author": "Turner",
      "year": "1990",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/0092-8674(94)90360-3_BIB76",
      "doi-asserted-by": "crossref",
      "first-page": "418",
      "DOI": "10.1038/309418a0",
      "article-title": "Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells",
      "volume": "309",
      "author": "Ullrich",
      "year": "1984",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/0092-8674(94)90360-3_BIB77",
      "doi-asserted-by": "crossref",
      "first-page": "257",
      "DOI": "10.1038/338257a0",
      "article-title": "Signal transduction through the CD4 receptor involves the activation of the internal membrane tyrosine-protein kinase p56lck",
      "volume": "338",
      "author": "Veillette",
      "year": "1989",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/0092-8674(94)90360-3_BIB78",
      "doi-asserted-by": "crossref",
      "first-page": "5538",
      "DOI": "10.1128/JVI.67.9.5538-5549.1993",
      "article-title": "Human immunodeficiency virus type 1 Vpu protein induces degradation of chimeric envelope glycoproteins bearing the cytoplasmic and anchor domains of CD4: role of the cytoplasmic domain in Vpu-induced degradation in the endoplasmic reticulum",
      "volume": "67",
      "author": "Vincent",
      "year": "1993",
      "journal-title": "J. Virol."
    },
    {
      "key": "10.1016/0092-8674(94)90360-3_BIB79",
      "doi-asserted-by": "crossref",
      "first-page": "209",
      "DOI": "10.1016/0092-8674(93)90221-B",
      "article-title": "T cell antigen receptor signal transduction: a tale of tails and cytoplasmic protein-tyrosine kinases",
      "volume": "73",
      "author": "Weiss",
      "year": "1993",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/0092-8674(94)90360-3_BIB80",
      "doi-asserted-by": "crossref",
      "first-page": "1351",
      "DOI": "10.4049/jimmunol.138.5.1351",
      "article-title": "Modulation of CD4 by antigenic activation",
      "volume": "138",
      "author": "Weyand",
      "year": "1987",
      "journal-title": "J. Immunol."
    },
    {
      "key": "10.1016/0092-8674(94)90360-3_BIB81",
      "doi-asserted-by": "crossref",
      "first-page": "7193",
      "DOI": "10.1128/JVI.66.12.7193-7200.1992",
      "article-title": "Human immunodeficiency virus type 1 Vpu protein induces rapid degradation of CD4",
      "volume": "66",
      "author": "Willey",
      "year": "1992",
      "journal-title": "J. Virol."
    },
    {
      "key": "10.1016/0092-8674(94)90360-3_BIB82",
      "first-page": "6634",
      "article-title": "Mutational analysis of the human immunodeficiency virus type 1 Eli Nef function",
      "volume": "89",
      "author": "Zazopoulos",
      "year": "1992"
    },
    {
      "key": "10.1016/0092-8674(94)90360-3_BIB83",
      "first-page": "167",
      "article-title": "CD4 and CD8 act as co-receptors during thymic selection of the T cell repertoire",
      "volume": "3",
      "author": "Z\u00fa\u00f1iga-Pfl\u00fccker",
      "year": "1991",
      "journal-title": "Semin. Immunol."
    }
  ],
  "container-title": "Cell",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.elsevier.com/content/article/PII:0092867494903603?httpAccept=text/xml",
      "content-type": "text/xml",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://api.elsevier.com/content/article/PII:0092867494903603?httpAccept=text/plain",
      "content-type": "text/plain",
      "content-version": "vor",
      "intended-application": "text-mining"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2024,
        1,
        13
      ]
    ],
    "date-time": "2024-01-13T09:13:14Z",
    "timestamp": 1705137194000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://linkinghub.elsevier.com/retrieve/pii/0092867494903603"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1994,
        3
      ]
    ]
  },
  "references-count": 83,
  "journal-issue": {
    "issue": "5",
    "published-print": {
      "date-parts": [
        [
          1994,
          3
        ]
      ]
    }
  },
  "alternative-id": [
    "0092867494903603"
  ],
  "URL": "http://dx.doi.org/10.1016/0092-8674(94)90360-3",
  "relation": {},
  "ISSN": [
    "0092-8674"
  ],
  "subject": [],
  "container-title-short": "Cell",
  "published": {
    "date-parts": [
      [
        1994,
        3
      ]
    ]
  }
}