DOI: 10.1016/0092-8674(94)90253-4. The latch region of calcineurin B is involved in both immunosuppressant-immunophilin complex docking and phosphatase activation

The latch region of calcineurin B is involved in both immunosuppressant-immunophilin complex docking and phosphatase activation

10.1016/0092-8674(94)90253-4

Crossref journal-article

Elsevier BV

Cell (78)

Bibliography

Milan, D., Griffith, J., Su, M., Price, E. R., & McKeon, F. (1994). The latch region of calcineurin B is involved in both immunosuppressant-immunophilin complex docking and phosphatase activation. Cell, 79(3), 437â447.

Authors 5

David Milan (first)
Jim Griffith (additional)
Michael Su (additional)
E.Roydon Price (additional)
Frank McKeon (additional)

References 44 Referenced 82

10.1016/S0021-9258(18)41958-8 / J. Biol. Chem. / Charged surface residues of FKBP12 participate in formation of the FKBP-FK506-Calcineurin complex by Aldape (1992)
10.1021/bi00178a010 / Biochemistry / 1H, 13C, 15N, nuclear magnetic resonance backbone assignments and secondary structure of human calcineurin B by Anglister (1994)
{'key': '10.1016/0092-8674(94)90253-4_BIB3', 'series-title': 'Current Protocols in Molecular Biology', 'author': 'Ausubel', 'year': '1987'} / Current Protocols in Molecular Biology by Ausubel (1987)
10.1016/0022-2836(88)90608-0 / J. Mol. Biol. / Structure of calmodulin refined at 2.2 Å resolution by Babu (1988)
10.1021/bi00138a005 / Biochemistry / Backbone dynamics of calmodulin studied by ISN relaxation using inverse detected two dimensional NMR spectroscopy: the central helix is flexible by Barbato (1992)
10.1021/bi00539a017 / Biochemistry / Effects of pH, ionic strength, and temperature on activation by calmodulin on catalytic activity of myosin light chain kinase by Blumenthal (1982)
10.1016/S0021-9258(19)83888-7 / J. Biol. Chem. / Dephosphorylation of cAMP-dependent protein kinase regulatory subunit (type II) by calmodulin-dependent protein phosphatase by Blumenthal (1986)
10.1016/0022-2836(92)90324-D / J. Mol. Biol. / Calmodulin structure refined at 1.7 Å resolution by Chattopadhyaya (1992)
10.1038/357695a0 / Nature / Identification of calcineurin as a key signaling enzyme in T-lymphocyte activation by Clipstone (1992)
10.1016/S0021-9258(20)88197-6 / J. Biol. Chem. / Protein phosphatases come of age by Cohen (1989)
10.1126/science.2595372 / Science / Cyclosporin A specifically inhibits function of nuclear proteins involved in T-cell activation by Emmel (1989)
10.1038/352803a0 / Nature / Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A by Flanagan (1991)
10.1002/j.1460-2075.1994.tb06329.x / EMBO J. / Calcineurin acts in synergy with PMA to inactivate Iκ-B/MAD3, an inhibitor of NF-κ B by Frantz (1994)
10.1016/0092-8674(91)90123-G / Cell / Two cytoplasmic candidates for immunophilin action are revealed by affinity for a new cyclophilin: one in the presence and one in the absence of CsA by Friedman (1991)
{'key': '10.1016/0092-8674(94)90253-4_BIB15', 'first-page': '3686', 'article-title': 'Calcineurin phosphatase activity in T lymphocytes is inhibited by FK506 and cyclospoin A', 'volume': '89', 'author': 'Fruman', 'year': '1992'} / Calcineurin phosphatase activity in T lymphocytes is inhibited by FK506 and cyclospoin A by Fruman (1992)
10.1016/S0021-9258(19)38836-2 / J. Biol. Chem. / Chimeric calmodulin-cardiac troponin C proteins differentially activate calmodulin target enzymes by George (1990)
{'key': '10.1016/0092-8674(94)90253-4_BIB17', 'first-page': '9183', 'article-title': 'Cloning of human calcineurin A: evidence for two isozymes and identification of a polyproline structural domain', 'volume': '86', 'author': 'Guerini', 'year': '1989'} / Cloning of human calcineurin A: evidence for two isozymes and identification of a polyproline structural domain by Guerini (1989)
10.1089/dna.1.1989.8.675 / DNA / Isolation and sequence of a cDNA clone for human calcineurin B, the Ca2+-binding subunit of the Ca2+calmodulin-stimulated protein phosphatase by Guerini (1989)
10.1016/0014-5793(92)81456-V / FEBS Lett. / Inhibition of calcineurin by cyclosporin A-cyclophilin requires calcineurin B by Haddy (1992)
10.1016/0092-8674(93)80048-J / Cell / Human Wee1 maintains mitotic timing by protecting the nucleus from cytoplasmically activated cdc2 kinase by Heald (1993)
10.1021/bi00430a066 / Biochemistry / Functional domain structure of calcineurin A: mapping by limited proteolysis by Hubbard (1989)
10.1016/0006-291X(89)91148-0 / Biochem. Biophys. Res. Commun. / The complete primary structure of calcineurin A, a calmodulin binding protein homologous with protein phosphatases 1 and 2A by Ito (1989)
10.1038/356801a0 / Nature / The T cell transcription factor NFATp is a substrate for calcineurin and interacts with the DNA-binding domains of Fos and Jun by Jain (1993)
10.1016/0092-8674(92)90108-O / Cell / Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties by Kaelin (1992)
{'key': '10.1016/0092-8674(94)90253-4_BIB25', 'first-page': '225', 'article-title': 'The calmodulin-regulated protein phosphatase', 'volume': 'Volume Five', 'author': 'Klee', 'year': '1988'} / The calmodulin-regulated protein phosphatase by Klee (1988)
10.1016/S0021-9258(19)85206-7 / J. Biol. Chem. / Specific interaction of the cyclophilin-cyclosporin complex with the B subunit of calcineurin by Li (1993)
10.1021/bi00131a002 / Biochemistry / Inhibition of T cell signaling by immunophilin-ligand complexes correlates with loss of calcineurin phosphatase activity by Liu (1992)
10.1016/0092-8674(91)90124-H / Cell / Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes by Liu (1991)
10.1016/S0021-9258(18)53757-1 / J. Biol. Chem. / NF-ATp, a T lymphocyte DNA-binding protein that is a target for calcineurin and immunosuppressive drugs by McCaffrey (1993)
10.1126/science.1519061 / Science / Target enzyme recognition by calmodulin: 2.4 Å structure of a calmodulin-peptide complex by Meador (1992)
10.1038/351248a0 / Nature / Solution structure of the major binding protein for the immunosuppressant FK506 by Moore (1991)
10.1038/357692a0 / Nature / FK506 and CsA-sensitive activation of the interleukin-2 promoter by calcineurin by O'Keefe (1992)
10.1016/0968-0004(90)90177-D / Trends Biochem. Sci. / How calmodulin binds its targets: sequence independent recognition of amphiphilic α-helices by O'Neil (1990)
10.1016/S0021-9258(19)49628-2 / J. Biol. Chem. / Characterization of the phosphatase activity of a baculovirus-expressed calcineurin A isoform by Perrino (1992)
10.1038/361091a0 / Nature / X-ray structure of the cyclophilin-cyclosporin crystal structure by Pflugl (1993)
{'key': '10.1016/0092-8674(94)90253-4_BIB36', 'first-page': '1903', 'article-title': 'Human cyclophilin B: a second cyclophilin gene encodes a peptidyl-prolyl isomerase with a signal sequence', 'volume': '88', 'author': 'Price', 'year': '1991'} / Human cyclophilin B: a second cyclophilin gene encodes a peptidyl-prolyl isomerase with a signal sequence by Price (1991)
10.1016/0092-8674(92)90158-9 / Cell / Immunophilin-sensitive protein phosphatase action in cell signaling pathways by Schreiber (1992)
10.1007/BF01877227 / J. Biomol. NMR / Measurement of the exchange rates of rapidly exchanging amide protons: application of the study of calmodulin and its complex with a myosin light chain kinase fragment by Spera (1991)
{'key': '10.1016/0092-8674(94)90253-4_BIB39', 'first-page': '3741', 'article-title': 'Cyclosporin-mediated inhibition of bovine calcineurin by cyclophilin A and B', 'volume': '89', 'author': 'Swanson', 'year': '1992'} / Cyclosporin-mediated inhibition of bovine calcineurin by cyclophilin A and B by Swanson (1992)
10.1038/361088a0 / Nature / Solution structure of the cyclosporin A/cyclophilin complex by NMR by Theriault (1993)
10.1016/S0021-9258(18)54665-2 / J. Biol. Chem. / Three amino acid substitutions in Domain 1 of calmodulin prevent the activation of chicken smooth muscle myosin light chain kinase by VanBerkum (1991)
10.1126/science.1709302 / Science / Atomic structure of FKBP-FK506, an immunophilin-immunosuppressant complex by VanDuyne (1991)
10.1021/bi00489a001 / Biochemistry / Additivity of mutational effects in proteins by Wells (1990)
10.1089/dna.1.1984.3.479 / DNA / Oligonucleotide-directed mutagenesis: a simple method using two oligonucleotide primers and a single-stranded DNA template by Zoller (1984)

Dates

Type	When
Created	21 years, 3 months ago (May 4, 2004, 6:14 a.m.)
Deposited	4 years, 2 months ago (June 17, 2021, 4:07 a.m.)
Indexed	5 months ago (March 31, 2025, 5:23 a.m.)
Issued	30 years, 10 months ago (Nov. 1, 1994)
Published	30 years, 10 months ago (Nov. 1, 1994)
Published Print	30 years, 10 months ago (Nov. 1, 1994)

Funders 0

None

BibTeX

@article{Milan_1994, title={The latch region of calcineurin B is involved in both immunosuppressant-immunophilin complex docking and phosphatase activation}, volume={79}, ISSN={0092-8674}, url={http://dx.doi.org/10.1016/0092-8674(94)90253-4}, DOI={10.1016/0092-8674(94)90253-4}, number={3}, journal={Cell}, publisher={Elsevier BV}, author={Milan, David and Griffith, Jim and Su, Michael and Price, E.Roydon and McKeon, Frank}, year={1994}, month=nov, pages={437–447} }

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      "volume": "31",
      "author": "Barbato",
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      "author": "Frantz",
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      "author": "Moore",
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      "author": "O'Keefe",
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      "article-title": "How calmodulin binds its targets: sequence independent recognition of amphiphilic \u03b1-helices",
      "volume": "15",
      "author": "O'Neil",
      "year": "1990",
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      "volume": "267",
      "author": "Perrino",
      "year": "1992",
      "journal-title": "J. Biol. Chem."
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      "article-title": "Human cyclophilin B: a second cyclophilin gene encodes a peptidyl-prolyl isomerase with a signal sequence",
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      "author": "Price",
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      "volume": "70",
      "author": "Schreiber",
      "year": "1992",
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      "DOI": "10.1007/BF01877227",
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      "volume": "1",
      "author": "Spera",
      "year": "1991",
      "journal-title": "J. Biomol. NMR"
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      "first-page": "3741",
      "article-title": "Cyclosporin-mediated inhibition of bovine calcineurin by cyclophilin A and B",
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      "author": "Theriault",
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      "article-title": "Three amino acid substitutions in Domain 1 of calmodulin prevent the activation of chicken smooth muscle myosin light chain kinase",
      "volume": "266",
      "author": "VanBerkum",
      "year": "1991",
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      "volume": "251",
      "author": "VanDuyne",
      "year": "1991",
      "journal-title": "Science"
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      "first-page": "8517",
      "DOI": "10.1021/bi00489a001",
      "article-title": "Additivity of mutational effects in proteins",
      "volume": "29",
      "author": "Wells",
      "year": "1990",
      "journal-title": "Biochemistry"
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      "DOI": "10.1089/dna.1.1984.3.479",
      "article-title": "Oligonucleotide-directed mutagenesis: a simple method using two oligonucleotide primers and a single-stranded DNA template",
      "volume": "3",
      "author": "Zoller",
      "year": "1984",
      "journal-title": "DNA"
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