DOI: 10.1016/0092-8674(93)90420-u. The protein product of the fragile X gene, FMR1, has characteristics of an RNA-binding protein

The protein product of the fragile X gene, FMR1, has characteristics of an RNA-binding protein

10.1016/0092-8674(93)90420-u

Crossref journal-article

Elsevier BV

Cell (78)

Bibliography

Siomi, H., Siomi, M. C., Nussbaum, R. L., & Dreyfuss, G. (1993). The protein product of the fragile X gene, FMR1, has characteristics of an RNA-binding protein. Cell, 74(2), 291â298.

Authors 4

Haruhiko Siomi (first)
Mikiko C. Siomi (additional)
Robert L. Nussbaum (additional)
Gideon Dreyfuss (additional)

References 56 Referenced 498

{'key': '10.1016/0092-8674(93)90420-U_BIB1', 'first-page': '931', 'article-title': 'cDNA cloning and sequencing of human fibrillarin, a conserved nucleolar protein recognized by autoimmune antisera', 'volume': '88', 'author': 'Aris', 'year': '1991'} / cDNA cloning and sequencing of human fibrillarin, a conserved nucleolar protein recognized by autoimmune antisera by Aris (1991)
10.1101/gad.3.4.431 / Genes Dev. / RNA-binding proteins as developmental regulators by Bandziulis (1989)
10.1016/0092-8674(91)90514-Y / Cell / Physical mapping across the fragile X: hypermethylation and clinical expression of the fragile X syndrome by Bell (1991)
10.1016/0014-5793(79)80531-1 / FEBS Lett. / The primary structure of protein S3 from the small ribosomal subunit of Escherichia coli by Brauer (1979)
10.1093/nar/16.9.3751 / Nucl. Acids Res. / cDNA cloning of human hnRNP protein A1 reveals the existence of multiple RNA isoforms by Buvoli (1988)
10.1126/science.1589758 / Science / Triplet repeat mutations in human disease by Caskey (1992)
{'key': '10.1016/0092-8674(93)90420-U_BIB7', 'first-page': '7471', 'article-title': 'Isolation of the heterogeneous nuclear RNA-ribonucleoprotein complex (hnRNP): a unique supramolecular assembly', 'volume': '81', 'author': 'Choi', 'year': '1984'} / Isolation of the heterogeneous nuclear RNA-ribonucleoprotein complex (hnRNP): a unique supramolecular assembly by Choi (1984)
10.1016/S0006-291X(88)81279-8 / Biochem. Biophys. Res. Commun. / The nucleolar protein, B-36, contains a glycine and dimethylarginine-rich sequence conserved in several other nuclear RNA-binding proteins by Christensen (1988)
10.1016/S0021-9258(19)35461-4 / J. Biol. Chem. / Mammalian heterogeneous nuclear ribonucleoprotein complex protein A1 by Cobianchi (1988)
10.1016/S0021-9258(19)76435-7 / J. Biol. Chem. / Cloning of full-length complementary DNA for an Artemia salina glycine protein by Cruz-Alvarez (1987)
10.1038/ng0193-31 / Nature Genet. / Point mutation in the FMR-1 gene associated with fragile X mental retardation by De Boulle (1993)
10.1093/nar/14.22.9213 / Nucl. Acids Res. / A yeast protein HX has homologies with the histone H2AF expressed in chicken embryo by Delahodde (1986)
10.1083/jcb.106.5.1419 / J. Cell Biol. / Ribonucleoprotein particles in cellular processes by Dreyfuss (1988)
10.1146/annurev.bi.62.070193.001445 / Annu. Rev. Biochem. / hnRNP proteins and the biogenesis of mRNA by Dreyfuss (1993)
10.1128/MCB.10.5.2379 / Mol. Cell. Biol. / MER1, a yeast gene required for chromosome pairing and genetic recombination, is induced in meiosis by Engebrecht (1990)
10.1016/0092-8674(91)90047-3 / Cell / Meiosis-specific RNA splicing in yeast by Engebrecht (1991)
10.1016/0092-8674(91)90282-4 / Cell / RNA-protein interactions by Frankel (1991)
10.1016/0092-8674(91)90283-5 / Cell / Variation of the CGG repeat at the fragile X site results in genetic instability: resolution of the Sherman paradox by Fu (1991)
10.1038/ng0892-341 / Nature Genet. / Fragile X syndrome without CCG amplification has an FMR1 deletion by Gedeon (1992)
10.1126/science.2006411 / Science / Isolation of sequences that span the fragile X and identification of a fragile X-related CpG island by Heitz (1991)
10.1016/S0021-9673(00)93969-4 / J. Chromat. / New metal chelate adsorbent selective for proteins and peptides containing neighbouring histidine residues by Hochuli (1987)
10.1016/0092-8674(80)90160-9 / Cell / Association of a 5S gene transcription factor with 5S RNA and altered levels of the factor during cell differentiation by Honda (1980)
10.1016/0092-8674(86)90070-X / Cell / Functional dissection of a eukaryotic transcriptional activator protein, GCN4 of yeast by Hope (1986)
10.1002/j.1460-2075.1992.tb05331.x / EMBO J. / Primary structure and binding activity of the hnRNP U protein: binding RNA through RGG box by Kiledjian (1992)
10.1126/science.1675488 / Science / Mapping of DNA instability at the fragile X to a trinucleotide repeat sequence p(CCG)n by Kremer (1991)
10.1016/S0021-9258(17)38718-5 / J. Biol. Chem. / Purification and partial characterization of a nucleolar scleroderma antigen (Mr = 34,000; pl, 8.5) rich in NG, NG-dimethylarginine by Lischwe (1985)
10.1128/MCB.12.1.164 / Mol. Cell. Biol. / Characterization and primary structure of the poly(C)-binding heterogeneous nuclear ribonucleoprotein complex K protein by Matunis (1992)
{'key': '10.1016/0092-8674(93)90420-U_BIB28', 'first-page': '11', 'article-title': 'Sequence analysis of cytoplasmic mRNA-binding proteins of Xenopus oocytes identifies a family of RNA-binding proteins', 'volume': '89', 'author': 'Murray', 'year': '1992'} / Sequence analysis of cytoplasmic mRNA-binding proteins of Xenopus oocytes identifies a family of RNA-binding proteins by Murray (1992)
10.1021/bi00225a034 / Biochemistry / Interactions of the A1 heterogeneous nuclear ribonucleoprotein and its proteolytic derivative, UP1, with RNA and DNA: evidence for multiple RNA binding domains and salt-dependent binding mode transitions by Nadler (1991)
10.1146/annurev.ge.20.120186.000545 / Annu. Rev. Genet. / Fragile-X syndrome: a unique mutation in man by Nussbaum (1986)
10.1126/science.252.5009.1097 / Science / Instability of a 550-base pair DNA segment and abnormal methylation in fragile X syndrome by Oberle (1991)
{'key': '10.1016/0092-8674(93)90420-U_BIB32', 'first-page': '4170', 'article-title': 'A specific transcription factor that can bind either the 5S RNA gene or 5S RNA', 'volume': '77', 'author': 'Pelham', 'year': '1980'} / A specific transcription factor that can bind either the 5S RNA gene or 5S RNA by Pelham (1980)
10.1016/0092-8674(91)90125-I / Cell / Absence of expression of the FMR-1 gene in fragile X syndrome by Pieretti (1991)
10.1101/gad.2.2.215 / Genes Dev. / Immunopurification of heterogeneous nuclear ribonucleoprotein particles reveals an assortment of RNA-binding proteins by Piñol-Roma (1988)
10.1016/S0021-9258(19)75888-8 / J. Biol. Chem. / Nucleotide sequence of the pnp gene of Escherichia coli encoding polynucleotide phosphorylase: homology of the primary structure of the protein with the RNA-binding domain of ribosomal protein S1 by Régnier (1987)
10.1016/0168-9525(92)90395-K / Trends Genet. / Fragile X syndrome: the molecular picture comes into focus by Richards (1992)
10.1002/j.1460-2075.1986.tb04494.x / EMBO J. / Mammalian single-stranded DNA binding protein UP1 is derived from the hnRNP core protein A1 by Riva (1986)
10.1126/science.3144044 / Science / The elav gene product of Drosophila, required in neurons, has three RNP consensus motifs by Robinow (1988)
10.1016/0378-1119(87)90165-X / Gene / Vectors for selective expression of cloned DNAs by T7 RNA polymerase by Rosenberg (1987)
10.1056/NEJM199112123252401 / N. Engl. J. Med. / Direct diagnosis by DNA analysis of the fragile X syndrome of mental retardation by Rousseau (1991)
10.1111/j.1432-1033.1992.tb16967.x / Eur. J. Biochem. / Complete cDNA sequence of chicken vigilin, a novel protein with amplified and evolutionary conserved domains by Schmidt (1992)
10.1093/nar/21.5.1193 / Nucl. Acids Res. / The pre-mRNA binding K protein contains a novel evolutionarily conserved motif by Siomi (1993)
10.1016/S0021-9258(18)68629-6 / J. Biol. Chem. / Chelating peptide-immobilized metal ion affinity chromatography: a new concept in affinity chromatography for recombinant proteins by Smith (1988)
10.1139/m89-023 / Can. J. Microbiol. / Ribosomal protein gene cluster of Halobacterium halobium: nucleotide sequence of the genes coding for S3 and L29 equivalent ribosomal proteins by Spiridonova (1989)
10.1016/0076-6879(90)85008-C / Meth. Enzymol. / Use of T7 RNA polymerase to direct expression of cloned genes by Studier (1990)
{'key': '10.1016/0092-8674(93)90420-U_BIB46', 'series-title': 'Fragile Sites on Human Chromosomes', 'author': 'Sutherland', 'year': '1985'} / Fragile Sites on Human Chromosomes by Sutherland (1985)
10.1128/MCB.8.5.2237 / Mol. Cell. Biol. / Classification and purification of proteins of heterogeneous nuclear ribonucleoprotein particles by RNA binding proteins by Swanson (1988)
10.1128/MCB.7.5.1731 / Mol. Cell. Biol. / Primary structure of the human ribonucleoprotein particle C proteins: conservation of sequence and domain structures in heterogeneous nuclear RNA, mRNA and pre-rRNA-binding proteins by Swanson (1987)
10.1002/j.1460-2075.1989.tb08463.x / EMBO J. / U3, U8 and U13 comprise a new class of mammalian snRNPs localized in the cell nucleolus by Tyc (1989)
10.1016/0092-8674(91)90397-H / Cell / Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome by Verkerk (1991)
10.1038/349624a0 / Nature / Abnormal pattern detected in fragile-X patients by pulsedfield gel electrophoresis by Vincent (1991)
10.1016/0092-8674(84)90412-4 / Cell / The structure of an antigenic determinant in a protein by Wilson (1984)
10.1172/JCI111047 / J. Clin. Invest. / Human hypoxanthine-guanine phosphoribosyl-transferase by Wilson (1983)
{'key': '10.1016/0092-8674(93)90420-U_BIB54', 'first-page': '299', 'article-title': 'A microdeletion of less than 250 kb, including the proximal part of the FMR-1 gene and the fragile-X site, in a male with the clinical phenotype of fragile-X syndrome', 'volume': '51', 'author': 'Wohrle', 'year': '1992', 'journal-title': 'Am. J. Hum. Genet.'} / Am. J. Hum. Genet. / A microdeletion of less than 250 kb, including the proximal part of the FMR-1 gene and the fragile-X site, in a male with the clinical phenotype of fragile-X syndrome by Wohrle (1992)
10.1016/0092-8674(92)90455-L / Cell / Molecular cloning and nucleic acid binding properties of the GAP-associated tyrosine phosphoprotein p62 by Wong (1992)
10.1126/science.252.5009.1179 / Science / Fragile-X genotype characterized by an unstable region of DNA by Yu (1991)

Dates

Type	When
Created	21 years, 4 months ago (May 4, 2004, 6:14 a.m.)
Deposited	4 years, 2 months ago (June 17, 2021, 4:16 a.m.)
Indexed	3 days, 6 hours ago (Sept. 3, 2025, 6:35 a.m.)
Issued	32 years, 2 months ago (July 1, 1993)
Published	32 years, 2 months ago (July 1, 1993)
Published Print	32 years, 2 months ago (July 1, 1993)

Funders 0

None

BibTeX

@article{Siomi_1993, title={The protein product of the fragile X gene, FMR1, has characteristics of an RNA-binding protein}, volume={74}, ISSN={0092-8674}, url={http://dx.doi.org/10.1016/0092-8674(93)90420-u}, DOI={10.1016/0092-8674(93)90420-u}, number={2}, journal={Cell}, publisher={Elsevier BV}, author={Siomi, Haruhiko and Siomi, Mikiko C. and Nussbaum, Robert L. and Dreyfuss, Gideon}, year={1993}, month=jul, pages={291–298} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        9,
        3
      ]
    ],
    "date-time": "2025-09-03T10:35:48Z",
    "timestamp": 1756895748564
  },
  "reference-count": 56,
  "publisher": "Elsevier BV",
  "issue": "2",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            1993,
            7,
            1
          ]
        ],
        "date-time": "1993-07-01T00:00:00Z",
        "timestamp": 741484800000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://www.elsevier.com/tdm/userlicense/1.0/"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        1993,
        7
      ]
    ]
  },
  "DOI": "10.1016/0092-8674(93)90420-u",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2004,
        5,
        4
      ]
    ],
    "date-time": "2004-05-04T10:14:26Z",
    "timestamp": 1083665666000
  },
  "page": "291-298",
  "source": "Crossref",
  "is-referenced-by-count": 498,
  "title": "The protein product of the fragile X gene, FMR1, has characteristics of an RNA-binding protein",
  "prefix": "10.1016",
  "volume": "74",
  "author": [
    {
      "given": "Haruhiko",
      "family": "Siomi",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Mikiko C.",
      "family": "Siomi",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Robert L.",
      "family": "Nussbaum",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Gideon",
      "family": "Dreyfuss",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "78",
  "reference": [
    {
      "key": "10.1016/0092-8674(93)90420-U_BIB1",
      "first-page": "931",
      "article-title": "cDNA cloning and sequencing of human fibrillarin, a conserved nucleolar protein recognized by autoimmune antisera",
      "volume": "88",
      "author": "Aris",
      "year": "1991"
    },
    {
      "key": "10.1016/0092-8674(93)90420-U_BIB2",
      "doi-asserted-by": "crossref",
      "first-page": "431",
      "DOI": "10.1101/gad.3.4.431",
      "article-title": "RNA-binding proteins as developmental regulators",
      "volume": "3",
      "author": "Bandziulis",
      "year": "1989",
      "journal-title": "Genes Dev."
    },
    {
      "key": "10.1016/0092-8674(93)90420-U_BIB3",
      "doi-asserted-by": "crossref",
      "first-page": "861",
      "DOI": "10.1016/0092-8674(91)90514-Y",
      "article-title": "Physical mapping across the fragile X: hypermethylation and clinical expression of the fragile X syndrome",
      "volume": "64",
      "author": "Bell",
      "year": "1991",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/0092-8674(93)90420-U_BIB4",
      "doi-asserted-by": "crossref",
      "first-page": "352",
      "DOI": "10.1016/0014-5793(79)80531-1",
      "article-title": "The primary structure of protein S3 from the small ribosomal subunit of Escherichia coli",
      "volume": "106",
      "author": "Brauer",
      "year": "1979",
      "journal-title": "FEBS Lett."
    },
    {
      "key": "10.1016/0092-8674(93)90420-U_BIB5",
      "doi-asserted-by": "crossref",
      "first-page": "3751",
      "DOI": "10.1093/nar/16.9.3751",
      "article-title": "cDNA cloning of human hnRNP protein A1 reveals the existence of multiple RNA isoforms",
      "volume": "16",
      "author": "Buvoli",
      "year": "1988",
      "journal-title": "Nucl. Acids Res."
    },
    {
      "key": "10.1016/0092-8674(93)90420-U_BIB6",
      "doi-asserted-by": "crossref",
      "first-page": "784",
      "DOI": "10.1126/science.1589758",
      "article-title": "Triplet repeat mutations in human disease",
      "volume": "256",
      "author": "Caskey",
      "year": "1992",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/0092-8674(93)90420-U_BIB7",
      "first-page": "7471",
      "article-title": "Isolation of the heterogeneous nuclear RNA-ribonucleoprotein complex (hnRNP): a unique supramolecular assembly",
      "volume": "81",
      "author": "Choi",
      "year": "1984"
    },
    {
      "key": "10.1016/0092-8674(93)90420-U_BIB8",
      "doi-asserted-by": "crossref",
      "first-page": "1278",
      "DOI": "10.1016/S0006-291X(88)81279-8",
      "article-title": "The nucleolar protein, B-36, contains a glycine and dimethylarginine-rich sequence conserved in several other nuclear RNA-binding proteins",
      "volume": "155",
      "author": "Christensen",
      "year": "1988",
      "journal-title": "Biochem. Biophys. Res. Commun."
    },
    {
      "key": "10.1016/0092-8674(93)90420-U_BIB9",
      "doi-asserted-by": "crossref",
      "first-page": "1063",
      "DOI": "10.1016/S0021-9258(19)35461-4",
      "article-title": "Mammalian heterogeneous nuclear ribonucleoprotein complex protein A1",
      "volume": "263",
      "author": "Cobianchi",
      "year": "1988",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/0092-8674(93)90420-U_BIB10",
      "doi-asserted-by": "crossref",
      "first-page": "13377",
      "DOI": "10.1016/S0021-9258(19)76435-7",
      "article-title": "Cloning of full-length complementary DNA for an Artemia salina glycine protein",
      "volume": "262",
      "author": "Cruz-Alvarez",
      "year": "1987",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/0092-8674(93)90420-U_BIB11",
      "doi-asserted-by": "crossref",
      "first-page": "31",
      "DOI": "10.1038/ng0193-31",
      "article-title": "Point mutation in the FMR-1 gene associated with fragile X mental retardation",
      "volume": "3",
      "author": "De Boulle",
      "year": "1993",
      "journal-title": "Nature Genet."
    },
    {
      "key": "10.1016/0092-8674(93)90420-U_BIB12",
      "doi-asserted-by": "crossref",
      "first-page": "9213",
      "DOI": "10.1093/nar/14.22.9213",
      "article-title": "A yeast protein HX has homologies with the histone H2AF expressed in chicken embryo",
      "volume": "14",
      "author": "Delahodde",
      "year": "1986",
      "journal-title": "Nucl. Acids Res."
    },
    {
      "key": "10.1016/0092-8674(93)90420-U_BIB13",
      "doi-asserted-by": "crossref",
      "first-page": "1419",
      "DOI": "10.1083/jcb.106.5.1419",
      "article-title": "Ribonucleoprotein particles in cellular processes",
      "volume": "106",
      "author": "Dreyfuss",
      "year": "1988",
      "journal-title": "J. Cell Biol."
    },
    {
      "key": "10.1016/0092-8674(93)90420-U_BIB14",
      "doi-asserted-by": "crossref",
      "first-page": "289",
      "DOI": "10.1146/annurev.bi.62.070193.001445",
      "article-title": "hnRNP proteins and the biogenesis of mRNA",
      "volume": "62",
      "author": "Dreyfuss",
      "year": "1993",
      "journal-title": "Annu. Rev. Biochem."
    },
    {
      "key": "10.1016/0092-8674(93)90420-U_BIB15",
      "doi-asserted-by": "crossref",
      "first-page": "2379",
      "DOI": "10.1128/MCB.10.5.2379",
      "article-title": "MER1, a yeast gene required for chromosome pairing and genetic recombination, is induced in meiosis",
      "volume": "10",
      "author": "Engebrecht",
      "year": "1990",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1016/0092-8674(93)90420-U_BIB16",
      "doi-asserted-by": "crossref",
      "first-page": "1257",
      "DOI": "10.1016/0092-8674(91)90047-3",
      "article-title": "Meiosis-specific RNA splicing in yeast",
      "volume": "66",
      "author": "Engebrecht",
      "year": "1991",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/0092-8674(93)90420-U_BIB17",
      "doi-asserted-by": "crossref",
      "first-page": "1041",
      "DOI": "10.1016/0092-8674(91)90282-4",
      "article-title": "RNA-protein interactions",
      "volume": "67",
      "author": "Frankel",
      "year": "1991",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/0092-8674(93)90420-U_BIB18",
      "doi-asserted-by": "crossref",
      "first-page": "1047",
      "DOI": "10.1016/0092-8674(91)90283-5",
      "article-title": "Variation of the CGG repeat at the fragile X site results in genetic instability: resolution of the Sherman paradox",
      "volume": "67",
      "author": "Fu",
      "year": "1991",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/0092-8674(93)90420-U_BIB19",
      "doi-asserted-by": "crossref",
      "first-page": "341",
      "DOI": "10.1038/ng0892-341",
      "article-title": "Fragile X syndrome without CCG amplification has an FMR1 deletion",
      "volume": "1",
      "author": "Gedeon",
      "year": "1992",
      "journal-title": "Nature Genet."
    },
    {
      "key": "10.1016/0092-8674(93)90420-U_BIB20",
      "doi-asserted-by": "crossref",
      "first-page": "1236",
      "DOI": "10.1126/science.2006411",
      "article-title": "Isolation of sequences that span the fragile X and identification of a fragile X-related CpG island",
      "volume": "251",
      "author": "Heitz",
      "year": "1991",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/0092-8674(93)90420-U_BIB21",
      "doi-asserted-by": "crossref",
      "first-page": "177",
      "DOI": "10.1016/S0021-9673(00)93969-4",
      "article-title": "New metal chelate adsorbent selective for proteins and peptides containing neighbouring histidine residues",
      "volume": "411",
      "author": "Hochuli",
      "year": "1987",
      "journal-title": "J. Chromat."
    },
    {
      "key": "10.1016/0092-8674(93)90420-U_BIB22",
      "doi-asserted-by": "crossref",
      "first-page": "119",
      "DOI": "10.1016/0092-8674(80)90160-9",
      "article-title": "Association of a 5S gene transcription factor with 5S RNA and altered levels of the factor during cell differentiation",
      "volume": "22",
      "author": "Honda",
      "year": "1980",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/0092-8674(93)90420-U_BIB23",
      "doi-asserted-by": "crossref",
      "first-page": "885",
      "DOI": "10.1016/0092-8674(86)90070-X",
      "article-title": "Functional dissection of a eukaryotic transcriptional activator protein, GCN4 of yeast",
      "volume": "46",
      "author": "Hope",
      "year": "1986",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/0092-8674(93)90420-U_BIB24",
      "doi-asserted-by": "crossref",
      "first-page": "2655",
      "DOI": "10.1002/j.1460-2075.1992.tb05331.x",
      "article-title": "Primary structure and binding activity of the hnRNP U protein: binding RNA through RGG box",
      "volume": "11",
      "author": "Kiledjian",
      "year": "1992",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/0092-8674(93)90420-U_BIB25",
      "doi-asserted-by": "crossref",
      "first-page": "1711",
      "DOI": "10.1126/science.1675488",
      "article-title": "Mapping of DNA instability at the fragile X to a trinucleotide repeat sequence p(CCG)n",
      "volume": "252",
      "author": "Kremer",
      "year": "1991",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/0092-8674(93)90420-U_BIB26",
      "doi-asserted-by": "crossref",
      "first-page": "14304",
      "DOI": "10.1016/S0021-9258(17)38718-5",
      "article-title": "Purification and partial characterization of a nucleolar scleroderma antigen (Mr = 34,000; pl, 8.5) rich in NG, NG-dimethylarginine",
      "volume": "260",
      "author": "Lischwe",
      "year": "1985",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/0092-8674(93)90420-U_BIB27",
      "doi-asserted-by": "crossref",
      "first-page": "164",
      "DOI": "10.1128/MCB.12.1.164",
      "article-title": "Characterization and primary structure of the poly(C)-binding heterogeneous nuclear ribonucleoprotein complex K protein",
      "volume": "12",
      "author": "Matunis",
      "year": "1992",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1016/0092-8674(93)90420-U_BIB28",
      "first-page": "11",
      "article-title": "Sequence analysis of cytoplasmic mRNA-binding proteins of Xenopus oocytes identifies a family of RNA-binding proteins",
      "volume": "89",
      "author": "Murray",
      "year": "1992"
    },
    {
      "key": "10.1016/0092-8674(93)90420-U_BIB29",
      "doi-asserted-by": "crossref",
      "first-page": "2968",
      "DOI": "10.1021/bi00225a034",
      "article-title": "Interactions of the A1 heterogeneous nuclear ribonucleoprotein and its proteolytic derivative, UP1, with RNA and DNA: evidence for multiple RNA binding domains and salt-dependent binding mode transitions",
      "volume": "30",
      "author": "Nadler",
      "year": "1991",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1016/0092-8674(93)90420-U_BIB30",
      "doi-asserted-by": "crossref",
      "first-page": "109",
      "DOI": "10.1146/annurev.ge.20.120186.000545",
      "article-title": "Fragile-X syndrome: a unique mutation in man",
      "volume": "20",
      "author": "Nussbaum",
      "year": "1986",
      "journal-title": "Annu. Rev. Genet."
    },
    {
      "key": "10.1016/0092-8674(93)90420-U_BIB31",
      "doi-asserted-by": "crossref",
      "first-page": "1097",
      "DOI": "10.1126/science.252.5009.1097",
      "article-title": "Instability of a 550-base pair DNA segment and abnormal methylation in fragile X syndrome",
      "volume": "252",
      "author": "Oberle",
      "year": "1991",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/0092-8674(93)90420-U_BIB32",
      "first-page": "4170",
      "article-title": "A specific transcription factor that can bind either the 5S RNA gene or 5S RNA",
      "volume": "77",
      "author": "Pelham",
      "year": "1980"
    },
    {
      "key": "10.1016/0092-8674(93)90420-U_BIB33",
      "doi-asserted-by": "crossref",
      "first-page": "817",
      "DOI": "10.1016/0092-8674(91)90125-I",
      "article-title": "Absence of expression of the FMR-1 gene in fragile X syndrome",
      "volume": "66",
      "author": "Pieretti",
      "year": "1991",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/0092-8674(93)90420-U_BIB34",
      "doi-asserted-by": "crossref",
      "first-page": "215",
      "DOI": "10.1101/gad.2.2.215",
      "article-title": "Immunopurification of heterogeneous nuclear ribonucleoprotein particles reveals an assortment of RNA-binding proteins",
      "volume": "2",
      "author": "Pi\u00f1ol-Roma",
      "year": "1988",
      "journal-title": "Genes Dev."
    },
    {
      "key": "10.1016/0092-8674(93)90420-U_BIB35",
      "doi-asserted-by": "crossref",
      "first-page": "63",
      "DOI": "10.1016/S0021-9258(19)75888-8",
      "article-title": "Nucleotide sequence of the pnp gene of Escherichia coli encoding polynucleotide phosphorylase: homology of the primary structure of the protein with the RNA-binding domain of ribosomal protein S1",
      "volume": "262",
      "author": "R\u00e9gnier",
      "year": "1987",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/0092-8674(93)90420-U_BIB36",
      "doi-asserted-by": "crossref",
      "first-page": "249",
      "DOI": "10.1016/0168-9525(92)90395-K",
      "article-title": "Fragile X syndrome: the molecular picture comes into focus",
      "volume": "8",
      "author": "Richards",
      "year": "1992",
      "journal-title": "Trends Genet."
    },
    {
      "key": "10.1016/0092-8674(93)90420-U_BIB37",
      "doi-asserted-by": "crossref",
      "first-page": "2267",
      "DOI": "10.1002/j.1460-2075.1986.tb04494.x",
      "article-title": "Mammalian single-stranded DNA binding protein UP1 is derived from the hnRNP core protein A1",
      "volume": "5",
      "author": "Riva",
      "year": "1986",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/0092-8674(93)90420-U_BIB38",
      "doi-asserted-by": "crossref",
      "first-page": "1570",
      "DOI": "10.1126/science.3144044",
      "article-title": "The elav gene product of Drosophila, required in neurons, has three RNP consensus motifs",
      "volume": "242",
      "author": "Robinow",
      "year": "1988",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/0092-8674(93)90420-U_BIB39",
      "doi-asserted-by": "crossref",
      "first-page": "125",
      "DOI": "10.1016/0378-1119(87)90165-X",
      "article-title": "Vectors for selective expression of cloned DNAs by T7 RNA polymerase",
      "volume": "56",
      "author": "Rosenberg",
      "year": "1987",
      "journal-title": "Gene"
    },
    {
      "key": "10.1016/0092-8674(93)90420-U_BIB40",
      "doi-asserted-by": "crossref",
      "first-page": "1673",
      "DOI": "10.1056/NEJM199112123252401",
      "article-title": "Direct diagnosis by DNA analysis of the fragile X syndrome of mental retardation",
      "volume": "325",
      "author": "Rousseau",
      "year": "1991",
      "journal-title": "N. Engl. J. Med."
    },
    {
      "key": "10.1016/0092-8674(93)90420-U_BIB41",
      "doi-asserted-by": "crossref",
      "first-page": "625",
      "DOI": "10.1111/j.1432-1033.1992.tb16967.x",
      "article-title": "Complete cDNA sequence of chicken vigilin, a novel protein with amplified and evolutionary conserved domains",
      "volume": "206",
      "author": "Schmidt",
      "year": "1992",
      "journal-title": "Eur. J. Biochem."
    },
    {
      "key": "10.1016/0092-8674(93)90420-U_BIB42",
      "doi-asserted-by": "crossref",
      "first-page": "1193",
      "DOI": "10.1093/nar/21.5.1193",
      "article-title": "The pre-mRNA binding K protein contains a novel evolutionarily conserved motif",
      "volume": "21",
      "author": "Siomi",
      "year": "1993",
      "journal-title": "Nucl. Acids Res."
    },
    {
      "key": "10.1016/0092-8674(93)90420-U_BIB43",
      "doi-asserted-by": "crossref",
      "first-page": "7211",
      "DOI": "10.1016/S0021-9258(18)68629-6",
      "article-title": "Chelating peptide-immobilized metal ion affinity chromatography: a new concept in affinity chromatography for recombinant proteins",
      "volume": "263",
      "author": "Smith",
      "year": "1988",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/0092-8674(93)90420-U_BIB44",
      "doi-asserted-by": "crossref",
      "first-page": "153",
      "DOI": "10.1139/m89-023",
      "article-title": "Ribosomal protein gene cluster of Halobacterium halobium: nucleotide sequence of the genes coding for S3 and L29 equivalent ribosomal proteins",
      "volume": "35",
      "author": "Spiridonova",
      "year": "1989",
      "journal-title": "Can. J. Microbiol."
    },
    {
      "key": "10.1016/0092-8674(93)90420-U_BIB45",
      "doi-asserted-by": "crossref",
      "first-page": "60",
      "DOI": "10.1016/0076-6879(90)85008-C",
      "article-title": "Use of T7 RNA polymerase to direct expression of cloned genes",
      "volume": "185",
      "author": "Studier",
      "year": "1990",
      "journal-title": "Meth. Enzymol."
    },
    {
      "key": "10.1016/0092-8674(93)90420-U_BIB46",
      "series-title": "Fragile Sites on Human Chromosomes",
      "author": "Sutherland",
      "year": "1985"
    },
    {
      "key": "10.1016/0092-8674(93)90420-U_BIB47",
      "doi-asserted-by": "crossref",
      "first-page": "2237",
      "DOI": "10.1128/MCB.8.5.2237",
      "article-title": "Classification and purification of proteins of heterogeneous nuclear ribonucleoprotein particles by RNA binding proteins",
      "volume": "3",
      "author": "Swanson",
      "year": "1988",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1016/0092-8674(93)90420-U_BIB48",
      "doi-asserted-by": "crossref",
      "first-page": "1731",
      "DOI": "10.1128/MCB.7.5.1731",
      "article-title": "Primary structure of the human ribonucleoprotein particle C proteins: conservation of sequence and domain structures in heterogeneous nuclear RNA, mRNA and pre-rRNA-binding proteins",
      "volume": "7",
      "author": "Swanson",
      "year": "1987",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1016/0092-8674(93)90420-U_BIB49",
      "doi-asserted-by": "crossref",
      "first-page": "3113",
      "DOI": "10.1002/j.1460-2075.1989.tb08463.x",
      "article-title": "U3, U8 and U13 comprise a new class of mammalian snRNPs localized in the cell nucleolus",
      "volume": "8",
      "author": "Tyc",
      "year": "1989",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/0092-8674(93)90420-U_BIB50",
      "doi-asserted-by": "crossref",
      "first-page": "905",
      "DOI": "10.1016/0092-8674(91)90397-H",
      "article-title": "Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome",
      "volume": "65",
      "author": "Verkerk",
      "year": "1991",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/0092-8674(93)90420-U_BIB51",
      "doi-asserted-by": "crossref",
      "first-page": "624",
      "DOI": "10.1038/349624a0",
      "article-title": "Abnormal pattern detected in fragile-X patients by pulsedfield gel electrophoresis",
      "volume": "349",
      "author": "Vincent",
      "year": "1991",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/0092-8674(93)90420-U_BIB52",
      "doi-asserted-by": "crossref",
      "first-page": "767",
      "DOI": "10.1016/0092-8674(84)90412-4",
      "article-title": "The structure of an antigenic determinant in a protein",
      "volume": "37",
      "author": "Wilson",
      "year": "1984",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/0092-8674(93)90420-U_BIB53",
      "doi-asserted-by": "crossref",
      "first-page": "767",
      "DOI": "10.1172/JCI111047",
      "article-title": "Human hypoxanthine-guanine phosphoribosyl-transferase",
      "volume": "72",
      "author": "Wilson",
      "year": "1983",
      "journal-title": "J. Clin. Invest."
    },
    {
      "key": "10.1016/0092-8674(93)90420-U_BIB54",
      "first-page": "299",
      "article-title": "A microdeletion of less than 250 kb, including the proximal part of the FMR-1 gene and the fragile-X site, in a male with the clinical phenotype of fragile-X syndrome",
      "volume": "51",
      "author": "Wohrle",
      "year": "1992",
      "journal-title": "Am. J. Hum. Genet."
    },
    {
      "key": "10.1016/0092-8674(93)90420-U_BIB55",
      "doi-asserted-by": "crossref",
      "first-page": "551",
      "DOI": "10.1016/0092-8674(92)90455-L",
      "article-title": "Molecular cloning and nucleic acid binding properties of the GAP-associated tyrosine phosphoprotein p62",
      "volume": "69",
      "author": "Wong",
      "year": "1992",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/0092-8674(93)90420-U_BIB56",
      "doi-asserted-by": "crossref",
      "first-page": "1179",
      "DOI": "10.1126/science.252.5009.1179",
      "article-title": "Fragile-X genotype characterized by an unstable region of DNA",
      "volume": "252",
      "author": "Yu",
      "year": "1991",
      "journal-title": "Science"
    }
  ],
  "container-title": "Cell",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.elsevier.com/content/article/PII:009286749390420U?httpAccept=text/xml",
      "content-type": "text/xml",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://api.elsevier.com/content/article/PII:009286749390420U?httpAccept=text/plain",
      "content-type": "text/plain",
      "content-version": "vor",
      "intended-application": "text-mining"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2021,
        6,
        17
      ]
    ],
    "date-time": "2021-06-17T08:16:05Z",
    "timestamp": 1623917765000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://linkinghub.elsevier.com/retrieve/pii/009286749390420U"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1993,
        7
      ]
    ]
  },
  "references-count": 56,
  "journal-issue": {
    "issue": "2",
    "published-print": {
      "date-parts": [
        [
          1993,
          7
        ]
      ]
    }
  },
  "alternative-id": [
    "009286749390420U"
  ],
  "URL": "http://dx.doi.org/10.1016/0092-8674(93)90420-U",
  "relation": {},
  "ISSN": [
    "0092-8674"
  ],
  "subject": [],
  "container-title-short": "Cell",
  "published": {
    "date-parts": [
      [
        1993,
        7
      ]
    ]
  }
}