DOI: 10.1016/0092-8674(93)90387-6. Targeting of SIR1 protein establishes transcriptional silencing at HM loci and telomeres in yeast

Targeting of SIR1 protein establishes transcriptional silencing at HM loci and telomeres in yeast

10.1016/0092-8674(93)90387-6

Crossref journal-article

Elsevier BV

Cell (78)

Bibliography

Chien, C., Buck, S., Sternglanz, R., & Shore, D. (1993). Targeting of SIR1 protein establishes transcriptional silencing at HM loci and telomeres in yeast. Cell, 75(3), 531â541.

Authors 4

Cheng-ting Chien (first)
Stephen Buck (additional)
Rolf Sternglanz (additional)
David Shore (additional)

References 62 Referenced 157

10.1016/0022-2836(84)90492-3 / J. Mol. Biol. / Regulation of mating-type information in yeast by Abraham (1984)
10.1016/0092-8674(91)90049-5 / Cell / Modifiers of position effect are shared between telomeric and silent mating-type loci in S. cerevisiae by Aparicio (1991)
10.1038/357128a0 / Nature / ATP-dependent recognition of eukaryotic origins of DNA replication by a multiprotein complex by Bell (1992)
10.1016/0076-6879(87)54076-9 / Meth. Enzymol. / 5-Fluoro-orotic acid as a selective agent in yeast molecular genetics by Boeke (1987)
10.1002/j.1460-2075.1986.tb04253.x / EMBO J. / A GAL family of upstream activation sequences in yeast: roles in both induction and repression of transcription by Bram (1986)
10.1016/0092-8674(85)90059-5 / Cell / Characterization of a “silencer” in yeast: a DNA sequence with properties opposite to those of a transcriptional enhancer by Brand (1985)
10.1016/0092-8674(87)90094-8 / Cell / A yeast silencer contains sequences that can promote autonomous plasmid replication and transcriptional activation by Brand (1987)
10.1016/0092-8674(88)90203-6 / Cell / Transcription-dependent DNA supercoiling in yeast DNA topoisomerase mutants by Brill (1988)
10.1128/MCB.10.3.887 / Mol. Cell. Biol. / A yeast ARS-binding protein activates transcription synergistically in combination with other weak activating factors by Buchman (1990)
10.1128/MCB.8.1.210 / Mol. Cell. Biol. / Two DNA-binding factors recognize specific sequences at silencers, upstream activating sequences, autonomously replicating sequences, and telomeres in Saccharomyces cerevisiae by Buchman (1988)
10.1128/MCB.8.12.5086 / Mol. Cell. Biol. / Connections between transcriptional activators, silencers, and telomeres as revealed by functional analysis of a yeast DNA-binding protein by Buchman (1988)
10.1128/MCB.9.12.5516 / Mol. Cell. Biol. / Transcriptional control of the Saccharomyces cerevisiae PGK gene by RAP1 by Chambers (1989)
10.1016/S0021-9258(18)54049-7 / J. Biol. Chem. / Nucleosome structural changes during derepression of silent mating-type loci in yeast by Chen-Cleland (1993)
{'key': '10.1016/0092-8674(93)90387-6_BIB14', 'first-page': '9578', 'article-title': 'The two-hybrid system: a method to identify and clone genes for proteins that interact with a protein of interest', 'volume': '88', 'author': 'Chien', 'year': '1991'} / The two-hybrid system: a method to identify and clone genes for proteins that interact with a protein of interest by Chien (1991)
10.1016/0092-8674(90)90140-A / Cell / RAP1 protein interacts with yeast telomeres in vivo: overproduction alters telomere structure and decreases chromosome stability by Conrad (1990)
10.1038/357169a0 / Nature / Protein-DNA interactions at a yeast replication origin by Diffley (1992)
10.1016/0022-2836(84)90313-9 / J. Mol. Biol. / Identification of sites required for repression of a silent mating-type locus in yeast by Feldman (1984)
10.1016/0092-8674(85)90336-8 / Cell / Specific DNA binding of GAL4, a positive regulatory protein of yeast by Giniger (1985)
10.1016/0092-8674(89)90681-8 / Cell / A new role for a yeast transcriptional silencer gene, SIR2, in regulation of recombination in ribosomal DNA by Gottlieb (1989)
{'key': '10.1016/0092-8674(93)90387-6_BIB20', 'first-page': '4062', 'article-title': 'Telomere-proximal DNA in Saccharomyces cerevisiae is refractory to methyltransferase activity in vivo', 'volume': '89', 'author': 'Gottschling', 'year': '1992'} / Telomere-proximal DNA in Saccharomyces cerevisiae is refractory to methyltransferase activity in vivo by Gottschling (1992)
10.1016/0092-8674(90)90141-Z / Cell / Position effect at S. cerevisiae telomeres: reversible repression of pol II transcription by Gottschling (1990)
10.1128/MCB.12.3.1209 / Mol. Cell. Biol. / Dissection of a carboxy-terminal region of the yeast regulatory protein RAP1 with effects on both transcriptional activation and silencing by Hardy (1992)
10.1128/MCB.6.2.688 / Mol. Cell. Biol. / Cloning and characterization of four SIR genes from Saccharomyces cerevisiae by Ivy (1986)
{'key': '10.1016/0092-8674(93)90387-6_BIB24', 'first-page': '6286', 'article-title': 'Genetic evidence for an interaction between SIR3 and histone H4 in the repression of the silent mating loci in Saccharomyces cerevisiae', 'volume': '87', 'author': 'Johnson', 'year': '1990'} / Genetic evidence for an interaction between SIR3 and histone H4 in the repression of the silent mating loci in Saccharomyces cerevisiae by Johnson (1990)
10.1016/0092-8674(88)90006-2 / Cell / Extremely conserved histone H4 N terminus is dispensable for growth but essential for repressing the silent mating loci in yeast by Kayne (1988)
10.1016/0092-8674(92)90146-4 / Cell / Ssn6-Tup1 is a general repressor of transcription in yeast by Keleher (1992)
10.1128/MCB.7.12.4225 / Mol. Cell. Biol. / Replication and segregation of plasmids containing cis-acting regulatory sites of silent mating-type genes in Saccharomyces cerevisiae are controlled by the SIR genes by Kimmerly (1987)
10.1002/j.1460-2075.1988.tb03064.x / EMBO J. / Roles of two DNA-binding factors in replication, segregation, and transcriptional repression mediated by a yeast silencer by Kimmerly (1988)
10.1101/gad.6.9.1707 / Genes Dev. / Yeast SNF2/SWI2, SNF5, and SNF6 proteins function coordinately with the gene-specific transcriptional activators GAL4 and Bicoid by Laurent (1992)
10.1007/BF00422108 / Curr. Genet. / A yeast telomere binding activity binds to two related telomere sequence motifs and is indistinguishable from RAP1 by Longtine (1989)
10.1126/science.2237406 / Science / Involvement of the silencer and UAS binding protein RAP1 in regulation of telomere length by Lustig (1990)
10.1016/0092-8674(87)90015-8 / Cell / A new class of yeast transcriptional activators by Ma (1987)
10.1101/gad.5.4.605 / Genes Dev. / Mutations in the HML E silencer of Saccharomyces cerevisiae yield metastable inheritance of transcriptional repression by Mahoney (1991)
10.1126/science.1536007 / Science / A yeast chromosomal origin of DNA replication defined by multiple functional elements by Marahrens (1992)
10.1016/0378-1119(84)90022-2 / Gene / The pIC plasmid and phage vectors with versatile cloning sites for recombinant selection by insertional inactivation by Marsh (1984)
10.1128/MCB.7.12.4441 / Mol. Cell. Biol. / Functional domains of SIR4, a gene required for position effect regulation in Saccharomyces cerevisiae by Marshall (1987)
10.1128/MCB.11.11.5648 / Mol. Cell. Biol. / A synthetic silencer mediates SIR-dependent functions in Saccharomyces cerevisiae by McNally (1991)
10.1126/science.2106160 / Science / Genetic analysis of histone H4: essential role of lysines subject to reversible acetylation by Megee (1990)
10.1038/312247a0 / Nature / Role of DNA replication in the repression of silent mating-type loci in yeast by Miller (1984)
10.1128/MCB.11.5.2723 / Mol. Cell. Biol. / Association of RAP1 binding sites with stringent control of ribosomal protein gene transcription in Saccharomyces cerevisiae by Moehle (1991)
10.1002/j.1460-2075.1989.tb03615.x / EMBO J. / Identification and characterization of genes and mutants for an N-terminal acetyltransferase from yeast by Mullen (1989)
10.1016/0092-8674(82)90253-7 / Cell / The regulation of yeast mating-type chromatin structure by SIR, an action at a distance affecting both transcription and transposition by Nasmyth (1982)
10.1128/MCB.10.9.4932 / Mol. Cell. Biol. / Point mutations in the yeast histone H4 gene prevent silencing of the silent mating type locus HML by Park (1990)
10.1002/j.1460-2075.1992.tb05267.x / EMBO J. / ARD1 and NAT1 proteins form a complex that has N-terminal acetyltransferase activity by Park (1992)
10.1016/0092-8674(92)90192-F / Cell / Characterization of the yeast SWI1, SWI2, and SWI3 genes, which encode a global activator of transcription by Peterson (1992)
10.1016/0092-8674(89)90009-3 / Cell / Epigenetic inheritance of transcriptional states in S. cerevisiae by Pillus (1989)
10.1093/genetics/116.1.9 / Genetics / Four genes responsible for a position effect on expression from HML and HMR in Saccharomyces cerevisiae by Rine (1987)
10.1016/S0959-437X(05)80286-2 / Curr. Opin. Genet. Dev. / Silencing: the establishment and inheritance of stable, repressed transcription states by Rivier (1992)
10.1016/0076-6879(91)94012-2 / Meth. Enzymol. / Spore enrichment by Rockmill (1991)
{'key': '10.1016/0092-8674(93)90387-6_BIB50', 'author': 'Rose', 'year': '1990'} by Rose (1990)
10.1007/BF00340712 / Curr. Genet. / High efficiency transformation of intact yeast cells using single stranded nucleic acids as a carrier by Schiestl (1989)
10.1016/0092-8674(87)90095-X / Cell / Purification and cloning of a DNA binding protein from yeast that binds to both silencer and activator elements by Shore (1987)
10.1002/j.1460-2075.1984.tb02214.x / EMBO J. / Characterization of two genes required for position effect control of mating type by Shore (1984)
10.1002/j.1460-2075.1987.tb04776.x / EMBO J. / Identification of silencer binding proteins from yeast: possible roles in SIR control and DNA replication by Shore (1987)
10.1101/gad.6.2.186 / Genes Dev. / Active genes in budding yeast display enhanced in vivo accessibility to foreign DNA methylases: a novel in vivo probe for chromatin structure of yeast by Singh (1992)
{'key': '10.1016/0092-8674(93)90387-6_BIB56', 'series-title': 'PhD thesis', 'article-title': 'The SIR1 gene of Saccharomyces cerevisiae', 'author': 'Stone', 'year': '1991'} / PhD thesis / The SIR1 gene of Saccharomyces cerevisiae by Stone (1991)
10.1128/MCB.11.4.2253 / Mol. Cell. Biol. / The SIR1 gene of Saccharomyces cerevisiae and its role as an extragenic suppressor of several mating-defective mutants by Stone (1991)
{'key': '10.1016/0092-8674(93)90387-6_BIB58', 'first-page': '7749', 'article-title': 'Separation of transcriptional activation and silencing functions of the RAP1-encoded repressor/activator protein. I. Isolation of viable mutants affecting both silencing and telomere length', 'volume': '88', 'author': 'Sussel', 'year': '1991'} / Separation of transcriptional activation and silencing functions of the RAP1-encoded repressor/activator protein. I. Isolation of viable mutants affecting both silencing and telomere length by Sussel (1991)
10.1128/MCB.13.7.3919 / Mol. Cell. Biol. / Epigenetic switching of transcriptional states: cis- and trans-acting factors affecting establishment of silencing at the HMR locus in Saccharomyces cerevisiae by Sussel (1993)
10.1016/0092-8674(89)90584-9 / Cell / Elevated recombination rates in transcriptionally active DNA by Thomas (1989)
10.1016/0378-1119(90)90441-S / Gene / Efficient expression of the Saccharomyces cerevisiae glycolytic gene ADH1 is dependent upon a cis-acting regulatory element (UASRPG) found initially in genes encoding ribosomal proteins by Tornow (1990)
10.1128/MCB.7.10.3713 / Mol. Cell. Biol. / The yeast ARD1 gene product is required for repression of cryptic mating-type information at the HML locus by Whiteway (1987)

Dates

Type	When
Created	21 years, 3 months ago (May 4, 2004, 6:14 a.m.)
Deposited	4 years, 2 months ago (June 17, 2021, 4:14 a.m.)
Indexed	3 weeks ago (Aug. 6, 2025, 9:25 a.m.)
Issued	31 years, 9 months ago (Nov. 1, 1993)
Published	31 years, 9 months ago (Nov. 1, 1993)
Published Print	31 years, 9 months ago (Nov. 1, 1993)

Funders 0

None

BibTeX

@article{Chien_1993, title={Targeting of SIR1 protein establishes transcriptional silencing at HM loci and telomeres in yeast}, volume={75}, ISSN={0092-8674}, url={http://dx.doi.org/10.1016/0092-8674(93)90387-6}, DOI={10.1016/0092-8674(93)90387-6}, number={3}, journal={Cell}, publisher={Elsevier BV}, author={Chien, Cheng-ting and Buck, Stephen and Sternglanz, Rolf and Shore, David}, year={1993}, month=nov, pages={531–541} }

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      "article-title": "Extremely conserved histone H4 N terminus is dispensable for growth but essential for repressing the silent mating loci in yeast",
      "volume": "55",
      "author": "Kayne",
      "year": "1988",
      "journal-title": "Cell"
    },
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      "key": "10.1016/0092-8674(93)90387-6_BIB26",
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      "DOI": "10.1016/0092-8674(92)90146-4",
      "article-title": "Ssn6-Tup1 is a general repressor of transcription in yeast",
      "volume": "68",
      "author": "Keleher",
      "year": "1992",
      "journal-title": "Cell"
    },
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      "key": "10.1016/0092-8674(93)90387-6_BIB27",
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      "volume": "7",
      "author": "Kimmerly",
      "year": "1987",
      "journal-title": "Mol. Cell. Biol."
    },
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      "key": "10.1016/0092-8674(93)90387-6_BIB28",
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      "first-page": "2241",
      "DOI": "10.1002/j.1460-2075.1988.tb03064.x",
      "article-title": "Roles of two DNA-binding factors in replication, segregation, and transcriptional repression mediated by a yeast silencer",
      "volume": "7",
      "author": "Kimmerly",
      "year": "1988",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/0092-8674(93)90387-6_BIB29",
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      "first-page": "1707",
      "DOI": "10.1101/gad.6.9.1707",
      "article-title": "Yeast SNF2/SWI2, SNF5, and SNF6 proteins function coordinately with the gene-specific transcriptional activators GAL4 and Bicoid",
      "volume": "6",
      "author": "Laurent",
      "year": "1992",
      "journal-title": "Genes Dev."
    },
    {
      "key": "10.1016/0092-8674(93)90387-6_BIB30",
      "doi-asserted-by": "crossref",
      "first-page": "225",
      "DOI": "10.1007/BF00422108",
      "article-title": "A yeast telomere binding activity binds to two related telomere sequence motifs and is indistinguishable from RAP1",
      "volume": "16",
      "author": "Longtine",
      "year": "1989",
      "journal-title": "Curr. Genet."
    },
    {
      "key": "10.1016/0092-8674(93)90387-6_BIB31",
      "doi-asserted-by": "crossref",
      "first-page": "549",
      "DOI": "10.1126/science.2237406",
      "article-title": "Involvement of the silencer and UAS binding protein RAP1 in regulation of telomere length",
      "volume": "250",
      "author": "Lustig",
      "year": "1990",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/0092-8674(93)90387-6_BIB32",
      "doi-asserted-by": "crossref",
      "first-page": "113",
      "DOI": "10.1016/0092-8674(87)90015-8",
      "article-title": "A new class of yeast transcriptional activators",
      "volume": "51",
      "author": "Ma",
      "year": "1987",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/0092-8674(93)90387-6_BIB33",
      "doi-asserted-by": "crossref",
      "first-page": "605",
      "DOI": "10.1101/gad.5.4.605",
      "article-title": "Mutations in the HML E silencer of Saccharomyces cerevisiae yield metastable inheritance of transcriptional repression",
      "volume": "5",
      "author": "Mahoney",
      "year": "1991",
      "journal-title": "Genes Dev."
    },
    {
      "key": "10.1016/0092-8674(93)90387-6_BIB34",
      "doi-asserted-by": "crossref",
      "first-page": "817",
      "DOI": "10.1126/science.1536007",
      "article-title": "A yeast chromosomal origin of DNA replication defined by multiple functional elements",
      "volume": "255",
      "author": "Marahrens",
      "year": "1992",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/0092-8674(93)90387-6_BIB35",
      "doi-asserted-by": "crossref",
      "first-page": "481",
      "DOI": "10.1016/0378-1119(84)90022-2",
      "article-title": "The pIC plasmid and phage vectors with versatile cloning sites for recombinant selection by insertional inactivation",
      "volume": "32",
      "author": "Marsh",
      "year": "1984",
      "journal-title": "Gene"
    },
    {
      "key": "10.1016/0092-8674(93)90387-6_BIB36",
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      "first-page": "4441",
      "DOI": "10.1128/MCB.7.12.4441",
      "article-title": "Functional domains of SIR4, a gene required for position effect regulation in Saccharomyces cerevisiae",
      "volume": "7",
      "author": "Marshall",
      "year": "1987",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1016/0092-8674(93)90387-6_BIB37",
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      "first-page": "5648",
      "DOI": "10.1128/MCB.11.11.5648",
      "article-title": "A synthetic silencer mediates SIR-dependent functions in Saccharomyces cerevisiae",
      "volume": "11",
      "author": "McNally",
      "year": "1991",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1016/0092-8674(93)90387-6_BIB38",
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      "first-page": "841",
      "DOI": "10.1126/science.2106160",
      "article-title": "Genetic analysis of histone H4: essential role of lysines subject to reversible acetylation",
      "volume": "247",
      "author": "Megee",
      "year": "1990",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/0092-8674(93)90387-6_BIB39",
      "doi-asserted-by": "crossref",
      "first-page": "247",
      "DOI": "10.1038/312247a0",
      "article-title": "Role of DNA replication in the repression of silent mating-type loci in yeast",
      "volume": "312",
      "author": "Miller",
      "year": "1984",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/0092-8674(93)90387-6_BIB40",
      "doi-asserted-by": "crossref",
      "first-page": "2723",
      "DOI": "10.1128/MCB.11.5.2723",
      "article-title": "Association of RAP1 binding sites with stringent control of ribosomal protein gene transcription in Saccharomyces cerevisiae",
      "volume": "11",
      "author": "Moehle",
      "year": "1991",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1016/0092-8674(93)90387-6_BIB41",
      "doi-asserted-by": "crossref",
      "first-page": "2067",
      "DOI": "10.1002/j.1460-2075.1989.tb03615.x",
      "article-title": "Identification and characterization of genes and mutants for an N-terminal acetyltransferase from yeast",
      "volume": "8",
      "author": "Mullen",
      "year": "1989",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/0092-8674(93)90387-6_BIB42",
      "doi-asserted-by": "crossref",
      "first-page": "567",
      "DOI": "10.1016/0092-8674(82)90253-7",
      "article-title": "The regulation of yeast mating-type chromatin structure by SIR, an action at a distance affecting both transcription and transposition",
      "volume": "30",
      "author": "Nasmyth",
      "year": "1982",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/0092-8674(93)90387-6_BIB43",
      "doi-asserted-by": "crossref",
      "first-page": "4932",
      "DOI": "10.1128/MCB.10.9.4932",
      "article-title": "Point mutations in the yeast histone H4 gene prevent silencing of the silent mating type locus HML",
      "volume": "10",
      "author": "Park",
      "year": "1990",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1016/0092-8674(93)90387-6_BIB44",
      "doi-asserted-by": "crossref",
      "first-page": "2087",
      "DOI": "10.1002/j.1460-2075.1992.tb05267.x",
      "article-title": "ARD1 and NAT1 proteins form a complex that has N-terminal acetyltransferase activity",
      "volume": "11",
      "author": "Park",
      "year": "1992",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/0092-8674(93)90387-6_BIB45",
      "doi-asserted-by": "crossref",
      "first-page": "573",
      "DOI": "10.1016/0092-8674(92)90192-F",
      "article-title": "Characterization of the yeast SWI1, SWI2, and SWI3 genes, which encode a global activator of transcription",
      "volume": "68",
      "author": "Peterson",
      "year": "1992",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/0092-8674(93)90387-6_BIB46",
      "doi-asserted-by": "crossref",
      "first-page": "637",
      "DOI": "10.1016/0092-8674(89)90009-3",
      "article-title": "Epigenetic inheritance of transcriptional states in S. cerevisiae",
      "volume": "59",
      "author": "Pillus",
      "year": "1989",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/0092-8674(93)90387-6_BIB47",
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      "first-page": "9",
      "DOI": "10.1093/genetics/116.1.9",
      "article-title": "Four genes responsible for a position effect on expression from HML and HMR in Saccharomyces cerevisiae",
      "volume": "116",
      "author": "Rine",
      "year": "1987",
      "journal-title": "Genetics"
    },
    {
      "key": "10.1016/0092-8674(93)90387-6_BIB48",
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      "first-page": "286",
      "DOI": "10.1016/S0959-437X(05)80286-2",
      "article-title": "Silencing: the establishment and inheritance of stable, repressed transcription states",
      "volume": "2",
      "author": "Rivier",
      "year": "1992",
      "journal-title": "Curr. Opin. Genet. Dev."
    },
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      "key": "10.1016/0092-8674(93)90387-6_BIB49",
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      "first-page": "146",
      "DOI": "10.1016/0076-6879(91)94012-2",
      "article-title": "Spore enrichment",
      "volume": "194",
      "author": "Rockmill",
      "year": "1991",
      "journal-title": "Meth. Enzymol."
    },
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      "key": "10.1016/0092-8674(93)90387-6_BIB50",
      "author": "Rose",
      "year": "1990"
    },
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      "first-page": "339",
      "DOI": "10.1007/BF00340712",
      "article-title": "High efficiency transformation of intact yeast cells using single stranded nucleic acids as a carrier",
      "volume": "16",
      "author": "Schiestl",
      "year": "1989",
      "journal-title": "Curr. Genet."
    },
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      "DOI": "10.1016/0092-8674(87)90095-X",
      "article-title": "Purification and cloning of a DNA binding protein from yeast that binds to both silencer and activator elements",
      "volume": "51",
      "author": "Shore",
      "year": "1987",
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      "volume": "3",
      "author": "Shore",
      "year": "1984",
      "journal-title": "EMBO J."
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      "volume": "6",
      "author": "Shore",
      "year": "1987",
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      "volume": "6",
      "author": "Singh",
      "year": "1992",
      "journal-title": "Genes Dev."
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      "series-title": "PhD thesis",
      "article-title": "The SIR1 gene of Saccharomyces cerevisiae",
      "author": "Stone",
      "year": "1991"
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      "volume": "11",
      "author": "Stone",
      "year": "1991",
      "journal-title": "Mol. Cell. Biol."
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      "first-page": "7749",
      "article-title": "Separation of transcriptional activation and silencing functions of the RAP1-encoded repressor/activator protein. I. Isolation of viable mutants affecting both silencing and telomere length",
      "volume": "88",
      "author": "Sussel",
      "year": "1991"
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      "volume": "13",
      "author": "Sussel",
      "year": "1993",
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      "author": "Thomas",
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      "author": "Tornow",
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