DOI: 10.1016/0092-8674(90)90076-q. TGFα overexpression in transgenic mice induces liver neoplasia and abnormal development of the mammary gland and pancreas

TGFα overexpression in transgenic mice induces liver neoplasia and abnormal development of the mammary gland and pancreas

10.1016/0092-8674(90)90076-q

Crossref journal-article

Elsevier BV

Cell (78)

Bibliography

Jhappan, C., Stahle, C., Harkins, R. N., Fausto, N., Smith, G. H., & Merlino, G. T. (1990). TGFÎ± overexpression in transgenic mice induces liver neoplasia and abnormal development of the mammary gland and pancreas. Cell, 61(6), 1137â1146.

Authors 6

Chamelli Jhappan (first)
Cheryl Stahle (additional)
Richard N. Harkins (additional)
Nelson Fausto (additional)
Gilbert H. Smith (additional)
Glenn T. Merlino (additional)

References 58 Referenced 540

10.1002/1097-0142(19810315)47:6+<1528::AID-CNCR2820471415>3.0.CO;2-X / Cancer / Cells of origin of pancreatic cancer: experimental animal tumors related to human pancreas by Bockman (1981)
10.1016/0002-9610(82)90518-9 / Am. J. Surg. / Origin of tubular complexes in human chronic pancreatitis by Bockman (1982)
10.2307/3430734 / Environ. Health Perspect. / Growth control and differentiation in mammary epithelial cells by Borellini (1989)
{'key': '10.1016/0092-8674(90)90076-Q_BIB4', 'first-page': '4682', 'article-title': 'ras oncogenes in human cancer: a review', 'volume': '49', 'author': 'Bor', 'year': '1989', 'journal-title': 'Cancer Res.'} / Cancer Res. / ras oncogenes in human cancer: a review by Bor (1989)
10.1016/0092-8674(89)90591-6 / Cell / Transmembrane TGF-α precursors activate EGFTGF-α receptors by Brachmann (1989)
10.1016/0092-8674(89)90770-8 / Cell / Molecular pathogenesis of hepatocellular carcinoma in hepatitis B virus transgenic mice by Chisari (1989)
10.1016/0003-2697(87)90021-2 / Anal. Biochem. / Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction by Chomczynski (1987)
10.1016/0012-1606(90)90267-M / Dev. Biol. / Inhibition of mouse mammary ductal morphogenesis and down-regulation of the EGF receptor by epidermal growth factor by Coleman (1990)
10.1016/0012-1606(88)90317-X / Dev. Biol. / Ductal morphogenesis in the mouse mammary gland: evidence supporting a role for epidermal growth factor by Coleman (1988)
{'key': '10.1016/0092-8674(90)90076-Q_BIB10', 'first-page': '4001', 'article-title': 'Growth factors from murine sarcoma virus-transformed cells', 'volume': '75', 'author': 'DeLarco', 'year': '1978'} / Growth factors from murine sarcoma virus-transformed cells by DeLarco (1978)
10.1016/S0092-8674(88)80001-1 / Cell / Transforming growth factor α by Derynck (1988)
10.1016/0092-8674(84)90550-6 / Cell / Human transforming growth factor-α: precursor structure and expression in E. coli by Derynck (1984)
{'key': '10.1016/0092-8674(90)90076-Q_BIB13', 'first-page': '707', 'article-title': 'Synthesis of messenger RNAs for transforming growth factors α and β and the epidermal growth factor receptor by human tumors', 'volume': '47', 'author': 'Derynck', 'year': '1987', 'journal-title': 'Cancer Res.'} / Cancer Res. / Synthesis of messenger RNAs for transforming growth factors α and β and the epidermal growth factor receptor by human tumors by Derynck (1987)
{'key': '10.1016/0092-8674(90)90076-Q_BIB14', 'first-page': '831', 'article-title': 'Autocrine interaction between TGFα and the EGF receptor: quantitative requirements for induction of the malignant phenotype', 'volume': '4', 'author': 'Di Marco', 'year': '1989', 'journal-title': 'Oncogene'} / Oncogene / Autocrine interaction between TGFα and the EGF receptor: quantitative requirements for induction of the malignant phenotype by Di Marco (1989)
10.1083/jcb.98.6.2148 / J. Cell Biol. / Receptor-mediated endocytosis of epidermal growth factor by hepatocytes in the perfused rat liver: ligand and receptor dynamics by Dunn (1984)
{'key': '10.1016/0092-8674(90)90076-Q_BIB16', 'first-page': '4', 'article-title': 'Hepatocarcinogenesis: a dynamic cellular perspective', 'volume': '56', 'author': 'Farber', 'year': '1987', 'journal-title': 'Lab. Invest.'} / Lab. Invest. / Hepatocarcinogenesis: a dynamic cellular perspective by Farber (1987)
{'key': '10.1016/0092-8674(90)90076-Q_BIB17', 'first-page': '4', 'article-title': 'Regulation of liver growth: protooncogenes and transforming growth factors', 'volume': '60', 'author': 'Fausto', 'year': '1989', 'journal-title': 'Lab. Invest.'} / Lab. Invest. / Regulation of liver growth: protooncogenes and transforming growth factors by Fausto (1989)
10.1128/MCB.7.5.1585 / Mol. Cell. Biol. / Expression and characterization of transforming growth factor alpha precursor protein in transfected mammalian cells by Gentry (1987)
10.1016/S0021-9258(18)37739-1 / J. Biol. Chem. / Rapid constitutive internalization and externalization of epidermal growth factor receptors in isolated rat hepatocytes: monensin inhibits receptor externalization and reduces the capacity for continued endocytosis of epidermal growth factors by Gladhaug (1988)
10.1038/292267a0 / Nature / Structure of mouse metallothionein-1 gene and its mRNA by Glanville (1981)
{'key': '10.1016/0092-8674(90)90076-Q_BIB21', 'author': 'Hogan', 'year': '1986'} by Hogan (1986)
10.1093/jnci/55.1.37 / J. Natl. Cancer Inst. / Aging changes in CD-1 HaM/ICR mice reared under standard laboratory conditions by Homburger (1975)
{'key': '10.1016/0092-8674(90)90076-Q_BIB23', 'first-page': '6307', 'article-title': 'Biologically active precursor for transforming growth factor type α, released by retrovirally transformed cells', 'volume': '83', 'author': 'Ignotz', 'year': '1986'} / Biologically active precursor for transforming growth factor type α, released by retrovirally transformed cells by Ignotz (1986)
10.1210/endo-122-5-1707 / Endocrinology / Sex differences in epidermal growth factor receptor levels in rat liver plasma membrane by Kashimata (1988)
{'key': '10.1016/0092-8674(90)90076-Q_BIB25', 'first-page': '3613', 'article-title': 'Distinct high-performance liquid chromatography pattern of transforming growth factor activity in urine of cancer patients as compared with that of normal individuals', 'volume': '44', 'author': 'Kimball', 'year': '1984', 'journal-title': 'Cancer Res.'} / Cancer Res. / Distinct high-performance liquid chromatography pattern of transforming growth factor activity in urine of cancer patients as compared with that of normal individuals by Kimball (1984)
{'key': '10.1016/0092-8674(90)90076-Q_BIB26', 'series-title': 'The Exocrine Pancreas: Biology, Pathology and Diseases', 'first-page': '649', 'article-title': 'Pathology of nonendocrine pancreatic tumors', 'author': 'Klöppel', 'year': '1986'} / The Exocrine Pancreas: Biology, Pathology and Diseases / Pathology of nonendocrine pancreatic tumors by Klöppel (1986)
10.1038/313489a0 / Nature / Cloning and sequence analysis of a cDNA for rat transforming growth factor-α by Lee (1985)
{'key': '10.1016/0092-8674(90)90076-Q_BIB28', 'first-page': '850', 'article-title': 'Transforming growth factors produced by normal and neoplastically transformed rat liver epithelial cells in culture', 'volume': '48', 'author': 'Liu', 'year': '1988', 'journal-title': 'Cancer Res.'} / Cancer Res. / Transforming growth factors produced by normal and neoplastically transformed rat liver epithelial cells in culture by Liu (1988)
10.1016/0092-8674(85)90075-3 / Cell / Tissue-specific posttranslational processing of pre-prosomatostatin encoded by a metallothionein-somatostatin fusion gene in transgenic mice by Low (1985)
10.1016/0092-8674(88)90390-X / Cell / Induction of transforming growth factor-α in activated human alveolar macrophages by Madtes (1988)
{'key': '10.1016/0092-8674(90)90076-Q_BIB31', 'author': 'Maniatis', 'year': '1982'} by Maniatis (1982)
{'key': '10.1016/0092-8674(90)90076-Q_BIB32', 'first-page': '4684', 'article-title': 'Transforming growth factors produced by retrovirus-transformed rodent fibroblasts and human melanoma cells: amino acid sequence homology with epidermal growth factor', 'volume': '80', 'author': 'Marquardt', 'year': '1983'} / Transforming growth factors produced by retrovirus-transformed rodent fibroblasts and human melanoma cells: amino acid sequence homology with epidermal growth factor by Marquardt (1983)
10.1126/science.6320373 / Science / Rat transforming growth factor type I: structure and relation to epidermal growth factor by Marquardt (1984)
10.1016/S0021-9258(17)43959-7 / J. Biol. Chem. / Epidermal growth factor-like transforming growth factor II. Interaction with epidermal growth factor receptors on human placenta membrane and A431 cells by Massagué (1983)
{'key': '10.1016/0092-8674(90)90076-Q_BIB35', 'first-page': '1375', 'article-title': 'Infection with a TGF-α retroviral vector transforms normal mouse mammary epithelial cells but not normal rat fibroblasts', 'volume': '4', 'author': 'McGeady', 'year': '1989', 'journal-title': 'Oncogene'} / Oncogene / Infection with a TGF-α retroviral vector transforms normal mouse mammary epithelial cells but not normal rat fibroblasts by McGeady (1989)
{'key': '10.1016/0092-8674(90)90076-Q_BIB36', 'first-page': '1558', 'article-title': 'Transforming growth factor α may be a physiological regulator of liver regeneration by means of an autocrine mechanism', 'volume': '86', 'author': 'Mead', 'year': '1989'} / Transforming growth factor α may be a physiological regulator of liver regeneration by means of an autocrine mechanism by Mead (1989)
{'key': '10.1016/0092-8674(90)90076-Q_BIB37', 'series-title': 'The Mammary Gland: Development, Regulation and Function', 'year': '1987'} / The Mammary Gland: Development, Regulation and Function (1987)
{'key': '10.1016/0092-8674(90)90076-Q_BIB38', 'first-page': '50', 'article-title': 'The pancreas: non-neoplastic alterations', 'volume': '13', 'author': 'Oertel', 'year': '1989', 'journal-title': 'Am. J. Surg. Pathol.'} / Am. J. Surg. Pathol. / The pancreas: non-neoplastic alterations by Oertel (1989)
{'key': '10.1016/0092-8674(90)90076-Q_BIB39', 'first-page': '103', 'article-title': 'Insulin-like growth factor I and transforming growth factor α as autocrine growth factors in human pancreatic cancer cell growth', 'volume': '50', 'author': 'Ohmura', 'year': '1990', 'journal-title': 'Cancer Res.'} / Cancer Res. / Insulin-like growth factor I and transforming growth factor α as autocrine growth factors in human pancreatic cancer cell growth by Ohmura (1990)
10.1126/science.2821617 / Science / Pancreatic neoplasia induced by SV40 T-antigen expression in acinar cells of transgenic mice by Ornitz (1987)
10.1002/jcp.1041050118 / J. Cell. Physiol. / Kirsten murine sarcoma virus transformed cell lines and a spontaneously transformed rat cell line produce transforming factors by Ozanne (1980)
10.1016/0092-8674(87)90710-0 / Cell / Pancreatic neoplasia induced by ras expression in acinar cells of transgenic mice by Quaife (1987)
{'key': '10.1016/0092-8674(90)90076-Q_BIB43', 'first-page': '3608', 'article-title': 'Regulation of transforming growth factor α messenger RNA expression in a chemically transformed rat hepatic epithelial cell line by phorbol ester and hormones', 'volume': '49', 'author': 'Raymond', 'year': '1989', 'journal-title': 'Cancer Res.'} / Cancer Res. / Regulation of transforming growth factor α messenger RNA expression in a chemically transformed rat hepatic epithelial cell line by phorbol ester and hormones by Raymond (1989)
10.1016/0092-8674(86)90747-6 / Cell / Expression in rat fibroblasts of a human transforming growth factor-α cDNA results in transformation by Rosenthal (1986)
10.1002/jcp.1041300313 / J. Cell. Physiol. / Loss of growth responsiveness to epidermal growth factor and enhanced production of alpha-transforming growth factors in ras-transformed mouse mammary epithelial cells by Salomon (1987)
10.1007/978-3-642-83638-1_8 / Recent Results Cancer Res. / Modulation by estrogen and growth factors of transforming growth factor alpha (TGFα) expression in normal and malignant human mammary epithelial cells by Salomon (1989)
{'key': '10.1016/0092-8674(90)90076-Q_BIB47', 'first-page': '715', 'article-title': 'Oncogene-induced liver neoplasia in transgenic mice', 'volume': '4', 'author': 'Sandgren', 'year': '1989', 'journal-title': 'Oncogene'} / Oncogene / Oncogene-induced liver neoplasia in transgenic mice by Sandgren (1989)
{'key': '10.1016/0092-8674(90)90076-Q_BIB48', 'first-page': '6108', 'article-title': 'Development of a transgenic mouse system for the analysis of stages in liver carcinogenesis using tissue-specific expression of SV40 large T-antigen controlled by regulatory elements of the human α-1-antitrypsin gene', 'volume': '49', 'author': 'Sepulveda', 'year': '1989', 'journal-title': 'Cancer Res.'} / Cancer Res. / Development of a transgenic mouse system for the analysis of stages in liver carcinogenesis using tissue-specific expression of SV40 large T-antigen controlled by regulatory elements of the human α-1-antitrypsin gene by Sepulveda (1989)
10.1016/0041-008X(74)90258-0 / Toxicol. Appl. Pharmacol. / Tumors in mice, literature tabulation by Sher (1974)
{'key': '10.1016/0092-8674(90)90076-Q_BIB50', 'first-page': '7567', 'article-title': 'Production of transforming growth factor α in human pancreatic cancer cells: evidence for a superagonist autocrine cycle', 'volume': '84', 'author': 'Smith', 'year': '1987'} / Production of transforming growth factor α in human pancreatic cancer cells: evidence for a superagonist autocrine cycle by Smith (1987)
10.1056/NEJM198010093031511 / N. Engl. J. Med. / Autocrine secretion and malignant transformation of cells by Sporn (1980)
{'key': '10.1016/0092-8674(90)90076-Q_BIB52', 'first-page': '5201', 'article-title': 'Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose', 'volume': '77', 'author': 'Thomas', 'year': '1980'} / Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose by Thomas (1980)
10.1126/science.3500513 / Science / Epidermal growth factor-dependent transformation by a human EGF receptor proto-oncogene by Velu (1987)
10.1002/jcp.1041320324 / J. Cell. Physiol. / Local effects of EGF, α-TGF and EGF-like growth factors on lobuloalveolar development of the mouse mammary gland in vivo by Vonderhaar (1987)
{'key': '10.1016/0092-8674(90)90076-Q_BIB55', 'first-page': '439', 'article-title': 'Ultrastructure of the rat pancreas after experimental duct ligation. I. The role of apoptosis and intraepithelial macrophages in acinar cell deletion', 'volume': '126', 'author': 'Walker', 'year': '1987', 'journal-title': 'Am. J. Pathol.'} / Am. J. Pathol. / Ultrastructure of the rat pancreas after experimental duct ligation. I. The role of apoptosis and intraepithelial macrophages in acinar cell deletion by Walker (1987)
{'key': '10.1016/0092-8674(90)90076-Q_BIB56', 'first-page': '1258', 'article-title': 'Transformation of normal rat kidney (NRK) cells by an infectious retrovirus carrying a synthetic rat type α transforming growth factor gene', 'volume': '84', 'author': 'Watanabe', 'year': '1987'} / Transformation of normal rat kidney (NRK) cells by an infectious retrovirus carrying a synthetic rat type α transforming growth factor gene by Watanabe (1987)
10.1016/0092-8674(89)90252-3 / Cell / The TGF-α precursor expressed on the cell surface binds to the EGF receptor on adjacent cells, leading to signal transduction by Wong (1989)
10.1016/S0065-230X(08)60434-0 / Adv. Cancer Res. / Chemical carcinogenesis: from animal models to molecular models in one decade by Yuspa (1988)

Dates

Type	When
Created	21 years, 4 months ago (May 4, 2004, 6:14 a.m.)
Deposited	4 years, 2 months ago (June 17, 2021, 4:02 a.m.)
Indexed	1 day, 11 hours ago (Sept. 4, 2025, 9:24 a.m.)
Issued	35 years, 3 months ago (June 1, 1990)
Published	35 years, 3 months ago (June 1, 1990)
Published Print	35 years, 3 months ago (June 1, 1990)

Funders 0

None

BibTeX

@article{Jhappan_1990, title={TGFα overexpression in transgenic mice induces liver neoplasia and abnormal development of the mammary gland and pancreas}, volume={61}, ISSN={0092-8674}, url={http://dx.doi.org/10.1016/0092-8674(90)90076-q}, DOI={10.1016/0092-8674(90)90076-q}, number={6}, journal={Cell}, publisher={Elsevier BV}, author={Jhappan, Chamelli and Stahle, Cheryl and Harkins, Richard N. and Fausto, Nelson and Smith, Gilbert H. and Merlino, Glenn T.}, year={1990}, month=jun, pages={1137–1146} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        9,
        4
      ]
    ],
    "date-time": "2025-09-04T13:24:25Z",
    "timestamp": 1756992265206
  },
  "reference-count": 58,
  "publisher": "Elsevier BV",
  "issue": "6",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            1990,
            6,
            1
          ]
        ],
        "date-time": "1990-06-01T00:00:00Z",
        "timestamp": 644198400000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://www.elsevier.com/tdm/userlicense/1.0/"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        1990,
        6
      ]
    ]
  },
  "DOI": "10.1016/0092-8674(90)90076-q",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2004,
        5,
        4
      ]
    ],
    "date-time": "2004-05-04T10:14:38Z",
    "timestamp": 1083665678000
  },
  "page": "1137-1146",
  "source": "Crossref",
  "is-referenced-by-count": 540,
  "title": "TGF\u03b1 overexpression in transgenic mice induces liver neoplasia and abnormal development of the mammary gland and pancreas",
  "prefix": "10.1016",
  "volume": "61",
  "author": [
    {
      "given": "Chamelli",
      "family": "Jhappan",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Cheryl",
      "family": "Stahle",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Richard N.",
      "family": "Harkins",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Nelson",
      "family": "Fausto",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Gilbert H.",
      "family": "Smith",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Glenn T.",
      "family": "Merlino",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "78",
  "reference": [
    {
      "key": "10.1016/0092-8674(90)90076-Q_BIB1",
      "doi-asserted-by": "crossref",
      "first-page": "1528",
      "DOI": "10.1002/1097-0142(19810315)47:6+<1528::AID-CNCR2820471415>3.0.CO;2-X",
      "article-title": "Cells of origin of pancreatic cancer: experimental animal tumors related to human pancreas",
      "volume": "47",
      "author": "Bockman",
      "year": "1981",
      "journal-title": "Cancer"
    },
    {
      "key": "10.1016/0092-8674(90)90076-Q_BIB2",
      "doi-asserted-by": "crossref",
      "first-page": "243",
      "DOI": "10.1016/0002-9610(82)90518-9",
      "article-title": "Origin of tubular complexes in human chronic pancreatitis",
      "volume": "144",
      "author": "Bockman",
      "year": "1982",
      "journal-title": "Am. J. Surg."
    },
    {
      "key": "10.1016/0092-8674(90)90076-Q_BIB3",
      "doi-asserted-by": "crossref",
      "first-page": "85",
      "DOI": "10.2307/3430734",
      "article-title": "Growth control and differentiation in mammary epithelial cells",
      "volume": "80",
      "author": "Borellini",
      "year": "1989",
      "journal-title": "Environ. Health Perspect."
    },
    {
      "key": "10.1016/0092-8674(90)90076-Q_BIB4",
      "first-page": "4682",
      "article-title": "ras oncogenes in human cancer: a review",
      "volume": "49",
      "author": "Bor",
      "year": "1989",
      "journal-title": "Cancer Res."
    },
    {
      "key": "10.1016/0092-8674(90)90076-Q_BIB5",
      "doi-asserted-by": "crossref",
      "first-page": "691",
      "DOI": "10.1016/0092-8674(89)90591-6",
      "article-title": "Transmembrane TGF-\u03b1 precursors activate EGFTGF-\u03b1 receptors",
      "volume": "56",
      "author": "Brachmann",
      "year": "1989",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/0092-8674(90)90076-Q_BIB6",
      "doi-asserted-by": "crossref",
      "first-page": "1145",
      "DOI": "10.1016/0092-8674(89)90770-8",
      "article-title": "Molecular pathogenesis of hepatocellular carcinoma in hepatitis B virus transgenic mice",
      "volume": "59",
      "author": "Chisari",
      "year": "1989",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/0092-8674(90)90076-Q_BIB7",
      "doi-asserted-by": "crossref",
      "first-page": "156",
      "DOI": "10.1016/0003-2697(87)90021-2",
      "article-title": "Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction",
      "volume": "162",
      "author": "Chomczynski",
      "year": "1987",
      "journal-title": "Anal. Biochem."
    },
    {
      "key": "10.1016/0092-8674(90)90076-Q_BIB8",
      "doi-asserted-by": "crossref",
      "first-page": "425",
      "DOI": "10.1016/0012-1606(90)90267-M",
      "article-title": "Inhibition of mouse mammary ductal morphogenesis and down-regulation of the EGF receptor by epidermal growth factor",
      "volume": "137",
      "author": "Coleman",
      "year": "1990",
      "journal-title": "Dev. Biol."
    },
    {
      "key": "10.1016/0092-8674(90)90076-Q_BIB9",
      "doi-asserted-by": "crossref",
      "first-page": "304",
      "DOI": "10.1016/0012-1606(88)90317-X",
      "article-title": "Ductal morphogenesis in the mouse mammary gland: evidence supporting a role for epidermal growth factor",
      "volume": "127",
      "author": "Coleman",
      "year": "1988",
      "journal-title": "Dev. Biol."
    },
    {
      "key": "10.1016/0092-8674(90)90076-Q_BIB10",
      "first-page": "4001",
      "article-title": "Growth factors from murine sarcoma virus-transformed cells",
      "volume": "75",
      "author": "DeLarco",
      "year": "1978"
    },
    {
      "key": "10.1016/0092-8674(90)90076-Q_BIB11",
      "doi-asserted-by": "crossref",
      "first-page": "593",
      "DOI": "10.1016/S0092-8674(88)80001-1",
      "article-title": "Transforming growth factor \u03b1",
      "volume": "54",
      "author": "Derynck",
      "year": "1988",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/0092-8674(90)90076-Q_BIB12",
      "doi-asserted-by": "crossref",
      "first-page": "287",
      "DOI": "10.1016/0092-8674(84)90550-6",
      "article-title": "Human transforming growth factor-\u03b1: precursor structure and expression in E. coli",
      "volume": "38",
      "author": "Derynck",
      "year": "1984",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/0092-8674(90)90076-Q_BIB13",
      "first-page": "707",
      "article-title": "Synthesis of messenger RNAs for transforming growth factors \u03b1 and \u03b2 and the epidermal growth factor receptor by human tumors",
      "volume": "47",
      "author": "Derynck",
      "year": "1987",
      "journal-title": "Cancer Res."
    },
    {
      "key": "10.1016/0092-8674(90)90076-Q_BIB14",
      "first-page": "831",
      "article-title": "Autocrine interaction between TGF\u03b1 and the EGF receptor: quantitative requirements for induction of the malignant phenotype",
      "volume": "4",
      "author": "Di Marco",
      "year": "1989",
      "journal-title": "Oncogene"
    },
    {
      "key": "10.1016/0092-8674(90)90076-Q_BIB15",
      "doi-asserted-by": "crossref",
      "first-page": "2148",
      "DOI": "10.1083/jcb.98.6.2148",
      "article-title": "Receptor-mediated endocytosis of epidermal growth factor by hepatocytes in the perfused rat liver: ligand and receptor dynamics",
      "volume": "98",
      "author": "Dunn",
      "year": "1984",
      "journal-title": "J. Cell Biol."
    },
    {
      "key": "10.1016/0092-8674(90)90076-Q_BIB16",
      "first-page": "4",
      "article-title": "Hepatocarcinogenesis: a dynamic cellular perspective",
      "volume": "56",
      "author": "Farber",
      "year": "1987",
      "journal-title": "Lab. Invest."
    },
    {
      "key": "10.1016/0092-8674(90)90076-Q_BIB17",
      "first-page": "4",
      "article-title": "Regulation of liver growth: protooncogenes and transforming growth factors",
      "volume": "60",
      "author": "Fausto",
      "year": "1989",
      "journal-title": "Lab. Invest."
    },
    {
      "key": "10.1016/0092-8674(90)90076-Q_BIB18",
      "doi-asserted-by": "crossref",
      "first-page": "1585",
      "DOI": "10.1128/MCB.7.5.1585",
      "article-title": "Expression and characterization of transforming growth factor alpha precursor protein in transfected mammalian cells",
      "volume": "7",
      "author": "Gentry",
      "year": "1987",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1016/0092-8674(90)90076-Q_BIB19",
      "doi-asserted-by": "crossref",
      "first-page": "12199",
      "DOI": "10.1016/S0021-9258(18)37739-1",
      "article-title": "Rapid constitutive internalization and externalization of epidermal growth factor receptors in isolated rat hepatocytes: monensin inhibits receptor externalization and reduces the capacity for continued endocytosis of epidermal growth factors",
      "volume": "263",
      "author": "Gladhaug",
      "year": "1988",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/0092-8674(90)90076-Q_BIB20",
      "doi-asserted-by": "crossref",
      "first-page": "267",
      "DOI": "10.1038/292267a0",
      "article-title": "Structure of mouse metallothionein-1 gene and its mRNA",
      "volume": "292",
      "author": "Glanville",
      "year": "1981",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/0092-8674(90)90076-Q_BIB21",
      "author": "Hogan",
      "year": "1986"
    },
    {
      "key": "10.1016/0092-8674(90)90076-Q_BIB22",
      "doi-asserted-by": "crossref",
      "first-page": "37",
      "DOI": "10.1093/jnci/55.1.37",
      "article-title": "Aging changes in CD-1 HaM/ICR mice reared under standard laboratory conditions",
      "volume": "55",
      "author": "Homburger",
      "year": "1975",
      "journal-title": "J. Natl. Cancer Inst."
    },
    {
      "key": "10.1016/0092-8674(90)90076-Q_BIB23",
      "first-page": "6307",
      "article-title": "Biologically active precursor for transforming growth factor type \u03b1, released by retrovirally transformed cells",
      "volume": "83",
      "author": "Ignotz",
      "year": "1986"
    },
    {
      "key": "10.1016/0092-8674(90)90076-Q_BIB24",
      "doi-asserted-by": "crossref",
      "first-page": "1707",
      "DOI": "10.1210/endo-122-5-1707",
      "article-title": "Sex differences in epidermal growth factor receptor levels in rat liver plasma membrane",
      "volume": "122",
      "author": "Kashimata",
      "year": "1988",
      "journal-title": "Endocrinology"
    },
    {
      "key": "10.1016/0092-8674(90)90076-Q_BIB25",
      "first-page": "3613",
      "article-title": "Distinct high-performance liquid chromatography pattern of transforming growth factor activity in urine of cancer patients as compared with that of normal individuals",
      "volume": "44",
      "author": "Kimball",
      "year": "1984",
      "journal-title": "Cancer Res."
    },
    {
      "key": "10.1016/0092-8674(90)90076-Q_BIB26",
      "series-title": "The Exocrine Pancreas: Biology, Pathology and Diseases",
      "first-page": "649",
      "article-title": "Pathology of nonendocrine pancreatic tumors",
      "author": "Kl\u00f6ppel",
      "year": "1986"
    },
    {
      "key": "10.1016/0092-8674(90)90076-Q_BIB27",
      "doi-asserted-by": "crossref",
      "first-page": "489",
      "DOI": "10.1038/313489a0",
      "article-title": "Cloning and sequence analysis of a cDNA for rat transforming growth factor-\u03b1",
      "volume": "313",
      "author": "Lee",
      "year": "1985",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/0092-8674(90)90076-Q_BIB28",
      "first-page": "850",
      "article-title": "Transforming growth factors produced by normal and neoplastically transformed rat liver epithelial cells in culture",
      "volume": "48",
      "author": "Liu",
      "year": "1988",
      "journal-title": "Cancer Res."
    },
    {
      "key": "10.1016/0092-8674(90)90076-Q_BIB29",
      "doi-asserted-by": "crossref",
      "first-page": "211",
      "DOI": "10.1016/0092-8674(85)90075-3",
      "article-title": "Tissue-specific posttranslational processing of pre-prosomatostatin encoded by a metallothionein-somatostatin fusion gene in transgenic mice",
      "volume": "41",
      "author": "Low",
      "year": "1985",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/0092-8674(90)90076-Q_BIB30",
      "doi-asserted-by": "crossref",
      "first-page": "285",
      "DOI": "10.1016/0092-8674(88)90390-X",
      "article-title": "Induction of transforming growth factor-\u03b1 in activated human alveolar macrophages",
      "volume": "53",
      "author": "Madtes",
      "year": "1988",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/0092-8674(90)90076-Q_BIB31",
      "author": "Maniatis",
      "year": "1982"
    },
    {
      "key": "10.1016/0092-8674(90)90076-Q_BIB32",
      "first-page": "4684",
      "article-title": "Transforming growth factors produced by retrovirus-transformed rodent fibroblasts and human melanoma cells: amino acid sequence homology with epidermal growth factor",
      "volume": "80",
      "author": "Marquardt",
      "year": "1983"
    },
    {
      "key": "10.1016/0092-8674(90)90076-Q_BIB33",
      "doi-asserted-by": "crossref",
      "first-page": "1079",
      "DOI": "10.1126/science.6320373",
      "article-title": "Rat transforming growth factor type I: structure and relation to epidermal growth factor",
      "volume": "223",
      "author": "Marquardt",
      "year": "1984",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/0092-8674(90)90076-Q_BIB34",
      "doi-asserted-by": "crossref",
      "first-page": "13614",
      "DOI": "10.1016/S0021-9258(17)43959-7",
      "article-title": "Epidermal growth factor-like transforming growth factor II. Interaction with epidermal growth factor receptors on human placenta membrane and A431 cells",
      "volume": "258",
      "author": "Massagu\u00e9",
      "year": "1983",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/0092-8674(90)90076-Q_BIB35",
      "first-page": "1375",
      "article-title": "Infection with a TGF-\u03b1 retroviral vector transforms normal mouse mammary epithelial cells but not normal rat fibroblasts",
      "volume": "4",
      "author": "McGeady",
      "year": "1989",
      "journal-title": "Oncogene"
    },
    {
      "key": "10.1016/0092-8674(90)90076-Q_BIB36",
      "first-page": "1558",
      "article-title": "Transforming growth factor \u03b1 may be a physiological regulator of liver regeneration by means of an autocrine mechanism",
      "volume": "86",
      "author": "Mead",
      "year": "1989"
    },
    {
      "key": "10.1016/0092-8674(90)90076-Q_BIB37",
      "series-title": "The Mammary Gland: Development, Regulation and Function",
      "year": "1987"
    },
    {
      "key": "10.1016/0092-8674(90)90076-Q_BIB38",
      "first-page": "50",
      "article-title": "The pancreas: non-neoplastic alterations",
      "volume": "13",
      "author": "Oertel",
      "year": "1989",
      "journal-title": "Am. J. Surg. Pathol."
    },
    {
      "key": "10.1016/0092-8674(90)90076-Q_BIB39",
      "first-page": "103",
      "article-title": "Insulin-like growth factor I and transforming growth factor \u03b1 as autocrine growth factors in human pancreatic cancer cell growth",
      "volume": "50",
      "author": "Ohmura",
      "year": "1990",
      "journal-title": "Cancer Res."
    },
    {
      "key": "10.1016/0092-8674(90)90076-Q_BIB40",
      "doi-asserted-by": "crossref",
      "first-page": "188",
      "DOI": "10.1126/science.2821617",
      "article-title": "Pancreatic neoplasia induced by SV40 T-antigen expression in acinar cells of transgenic mice",
      "volume": "238",
      "author": "Ornitz",
      "year": "1987",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/0092-8674(90)90076-Q_BIB41",
      "doi-asserted-by": "crossref",
      "first-page": "163",
      "DOI": "10.1002/jcp.1041050118",
      "article-title": "Kirsten murine sarcoma virus transformed cell lines and a spontaneously transformed rat cell line produce transforming factors",
      "volume": "105",
      "author": "Ozanne",
      "year": "1980",
      "journal-title": "J. Cell. Physiol."
    },
    {
      "key": "10.1016/0092-8674(90)90076-Q_BIB42",
      "doi-asserted-by": "crossref",
      "first-page": "1023",
      "DOI": "10.1016/0092-8674(87)90710-0",
      "article-title": "Pancreatic neoplasia induced by ras expression in acinar cells of transgenic mice",
      "volume": "48",
      "author": "Quaife",
      "year": "1987",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/0092-8674(90)90076-Q_BIB43",
      "first-page": "3608",
      "article-title": "Regulation of transforming growth factor \u03b1 messenger RNA expression in a chemically transformed rat hepatic epithelial cell line by phorbol ester and hormones",
      "volume": "49",
      "author": "Raymond",
      "year": "1989",
      "journal-title": "Cancer Res."
    },
    {
      "key": "10.1016/0092-8674(90)90076-Q_BIB44",
      "doi-asserted-by": "crossref",
      "first-page": "301",
      "DOI": "10.1016/0092-8674(86)90747-6",
      "article-title": "Expression in rat fibroblasts of a human transforming growth factor-\u03b1 cDNA results in transformation",
      "volume": "46",
      "author": "Rosenthal",
      "year": "1986",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/0092-8674(90)90076-Q_BIB45",
      "doi-asserted-by": "crossref",
      "first-page": "397",
      "DOI": "10.1002/jcp.1041300313",
      "article-title": "Loss of growth responsiveness to epidermal growth factor and enhanced production of alpha-transforming growth factors in ras-transformed mouse mammary epithelial cells",
      "volume": "130",
      "author": "Salomon",
      "year": "1987",
      "journal-title": "J. Cell. Physiol."
    },
    {
      "key": "10.1016/0092-8674(90)90076-Q_BIB46",
      "doi-asserted-by": "crossref",
      "first-page": "57",
      "DOI": "10.1007/978-3-642-83638-1_8",
      "article-title": "Modulation by estrogen and growth factors of transforming growth factor alpha (TGF\u03b1) expression in normal and malignant human mammary epithelial cells",
      "volume": "113",
      "author": "Salomon",
      "year": "1989",
      "journal-title": "Recent Results Cancer Res."
    },
    {
      "key": "10.1016/0092-8674(90)90076-Q_BIB47",
      "first-page": "715",
      "article-title": "Oncogene-induced liver neoplasia in transgenic mice",
      "volume": "4",
      "author": "Sandgren",
      "year": "1989",
      "journal-title": "Oncogene"
    },
    {
      "key": "10.1016/0092-8674(90)90076-Q_BIB48",
      "first-page": "6108",
      "article-title": "Development of a transgenic mouse system for the analysis of stages in liver carcinogenesis using tissue-specific expression of SV40 large T-antigen controlled by regulatory elements of the human \u03b1-1-antitrypsin gene",
      "volume": "49",
      "author": "Sepulveda",
      "year": "1989",
      "journal-title": "Cancer Res."
    },
    {
      "key": "10.1016/0092-8674(90)90076-Q_BIB49",
      "doi-asserted-by": "crossref",
      "first-page": "337",
      "DOI": "10.1016/0041-008X(74)90258-0",
      "article-title": "Tumors in mice, literature tabulation",
      "volume": "30",
      "author": "Sher",
      "year": "1974",
      "journal-title": "Toxicol. Appl. Pharmacol."
    },
    {
      "key": "10.1016/0092-8674(90)90076-Q_BIB50",
      "first-page": "7567",
      "article-title": "Production of transforming growth factor \u03b1 in human pancreatic cancer cells: evidence for a superagonist autocrine cycle",
      "volume": "84",
      "author": "Smith",
      "year": "1987"
    },
    {
      "key": "10.1016/0092-8674(90)90076-Q_BIB51",
      "doi-asserted-by": "crossref",
      "first-page": "878",
      "DOI": "10.1056/NEJM198010093031511",
      "article-title": "Autocrine secretion and malignant transformation of cells",
      "volume": "303",
      "author": "Sporn",
      "year": "1980",
      "journal-title": "N. Engl. J. Med."
    },
    {
      "key": "10.1016/0092-8674(90)90076-Q_BIB52",
      "first-page": "5201",
      "article-title": "Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose",
      "volume": "77",
      "author": "Thomas",
      "year": "1980"
    },
    {
      "key": "10.1016/0092-8674(90)90076-Q_BIB53",
      "doi-asserted-by": "crossref",
      "first-page": "1408",
      "DOI": "10.1126/science.3500513",
      "article-title": "Epidermal growth factor-dependent transformation by a human EGF receptor proto-oncogene",
      "volume": "238",
      "author": "Velu",
      "year": "1987",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/0092-8674(90)90076-Q_BIB54",
      "doi-asserted-by": "crossref",
      "first-page": "581",
      "DOI": "10.1002/jcp.1041320324",
      "article-title": "Local effects of EGF, \u03b1-TGF and EGF-like growth factors on lobuloalveolar development of the mouse mammary gland in vivo",
      "volume": "132",
      "author": "Vonderhaar",
      "year": "1987",
      "journal-title": "J. Cell. Physiol."
    },
    {
      "key": "10.1016/0092-8674(90)90076-Q_BIB55",
      "first-page": "439",
      "article-title": "Ultrastructure of the rat pancreas after experimental duct ligation. I. The role of apoptosis and intraepithelial macrophages in acinar cell deletion",
      "volume": "126",
      "author": "Walker",
      "year": "1987",
      "journal-title": "Am. J. Pathol."
    },
    {
      "key": "10.1016/0092-8674(90)90076-Q_BIB56",
      "first-page": "1258",
      "article-title": "Transformation of normal rat kidney (NRK) cells by an infectious retrovirus carrying a synthetic rat type \u03b1 transforming growth factor gene",
      "volume": "84",
      "author": "Watanabe",
      "year": "1987"
    },
    {
      "key": "10.1016/0092-8674(90)90076-Q_BIB57",
      "doi-asserted-by": "crossref",
      "first-page": "495",
      "DOI": "10.1016/0092-8674(89)90252-3",
      "article-title": "The TGF-\u03b1 precursor expressed on the cell surface binds to the EGF receptor on adjacent cells, leading to signal transduction",
      "volume": "56",
      "author": "Wong",
      "year": "1989",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/0092-8674(90)90076-Q_BIB58",
      "doi-asserted-by": "crossref",
      "first-page": "25",
      "DOI": "10.1016/S0065-230X(08)60434-0",
      "article-title": "Chemical carcinogenesis: from animal models to molecular models in one decade",
      "volume": "50",
      "author": "Yuspa",
      "year": "1988",
      "journal-title": "Adv. Cancer Res."
    }
  ],
  "container-title": "Cell",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.elsevier.com/content/article/PII:009286749090076Q?httpAccept=text/xml",
      "content-type": "text/xml",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://api.elsevier.com/content/article/PII:009286749090076Q?httpAccept=text/plain",
      "content-type": "text/plain",
      "content-version": "vor",
      "intended-application": "text-mining"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2021,
        6,
        17
      ]
    ],
    "date-time": "2021-06-17T08:02:17Z",
    "timestamp": 1623916937000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://linkinghub.elsevier.com/retrieve/pii/009286749090076Q"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1990,
        6
      ]
    ]
  },
  "references-count": 58,
  "journal-issue": {
    "issue": "6",
    "published-print": {
      "date-parts": [
        [
          1990,
          6
        ]
      ]
    }
  },
  "alternative-id": [
    "009286749090076Q"
  ],
  "URL": "http://dx.doi.org/10.1016/0092-8674(90)90076-Q",
  "relation": {},
  "ISSN": [
    "0092-8674"
  ],
  "subject": [],
  "container-title-short": "Cell",
  "published": {
    "date-parts": [
      [
        1990,
        6
      ]
    ]
  }
}