DOI: 10.1016/0026-0495(78)90267-6. Nonsuppressible insulin-like activity (NSILA) from human serum: Recent accomplishments and their physiologic implications

Nonsuppressible insulin-like activity (NSILA) from human serum: Recent accomplishments and their physiologic implications

10.1016/0026-0495(78)90267-6

Crossref journal-article

Elsevier BV

Metabolism (78)

Bibliography

Zapf, J., Rinderknecht, E., Humbel, R. E., & Froesch, E. R. (1978). Nonsuppressible insulin-like activity (NSILA) from human serum: Recent accomplishments and their physiologic implications. Metabolism, 27(12), 1803â1828.

Authors 4

J. Zapf (first)
E. Rinderknecht (additional)
R.E. Humbel (additional)
E.R. Froesch (additional)

References 92 Referenced 158

10.1172/JCI104130 / J Clin Invest / Immunoassay of endogenous plasma insulin in men by Yalow (1960)
10.1172/JCI102583 / J Clin Invest / Evidence for the presence of insulin in blood serum. A method for the approximate determination of the insulin content of blood by Groen (1952)
10.1016/S0140-6736(58)91246-7 / Lancet / An assay for insulin-like activity using rat adipose tissue by Martin (1958)
10.1172/JCI104168 / J Clin Invest / Measurement of small quantities of insulin-like activity using rat adipose tissue. 1. A proposed procedure by Renold (1960)
{'key': '10.1016/0026-0495(78)90267-6_BIB5', 'first-page': '272', 'article-title': 'Insulin-like activity of blood, what is it?', 'volume': '18', 'author': 'Leonards', 'year': '1959'} / Insulin-like activity of blood, what is it? by Leonards (1959)
10.1172/JCI104866 / J Clin Invest / Antibody-suppressible and nonsuppressible insulin-like activities in human serum and their physiologic significance. An insulin assay with adipose tissue of increased precision and specificity by Froesch (1963)
10.1677/joe.0.0240263 / J Endocrinol / Further immunological studies on the form of circulating insulin by Samaan (1962)
{'key': '10.1016/0026-0495(78)90267-6_BIB8', 'article-title': 'Antibody-suppressible and nonsuppressible insulin-like activities', 'volume': 'I', 'author': 'Oelz', 'year': '1972'} / Antibody-suppressible and nonsuppressible insulin-like activities by Oelz (1972)
10.1016/0304-4165(66)90124-3 / Biochim Biophys Acta / Nonsuppressible insulin-like activity of human serum. I. Physicochemical properties, extraction and partial purification by Bürgi (1966)
{'key': '10.1016/0026-0495(78)90267-6_BIB10', 'first-page': '2365', 'article-title': 'Polypeptides with nonsuppressible insulin-like and cell-growth promoting activities in human serum: Isolation, chemical characterization, and some biological properties of forms I and II', 'volume': '73', 'author': 'Rinderknecht', 'year': '1976'} / Polypeptides with nonsuppressible insulin-like and cell-growth promoting activities in human serum: Isolation, chemical characterization, and some biological properties of forms I and II by Rinderknecht (1976)
{'key': '10.1016/0026-0495(78)90267-6_BIB11', 'first-page': '4379', 'article-title': 'Amino-terminal sequences of two polypeptides from human serum with nonsuppressible insulin-like and cell-growth-promoting activities: Evidence for structural homology with insulin B chain', 'volume': '73', 'author': 'Rinderknecht', 'year': '1976'} / Amino-terminal sequences of two polypeptides from human serum with nonsuppressible insulin-like and cell-growth-promoting activities: Evidence for structural homology with insulin B chain by Rinderknecht (1976)
10.1016/S0021-9258(17)40889-1 / J Biol Chem / The amino acid sequence of human insulin-like growth factor I and its structural homology with proinsulin by Rinderknecht (1978)
10.1016/0014-5793(78)80237-3 / FEBS Lett / Primary structure of human insulin-like growth factor II by Rinderknecht (1978)
{'key': '10.1016/0026-0495(78)90267-6_BIB14', 'first-page': '180', 'article-title': 'Insulin-like growth factor: A model for tertiary structure accounting for immuno-reactivity and receptor binding', 'volume': '75', 'author': 'Blundell', 'year': '1978'} / Insulin-like growth factor: A model for tertiary structure accounting for immuno-reactivity and receptor binding by Blundell (1978)
10.1016/0003-9861(75)90295-7 / Arch Biochem Biophys / Specific binding of nonsuppressible insulin-like activity to chicken embryo fibroblasts and to a solubilized fibroblast receptor by Zapf (1975)
10.1111/j.1432-1033.1978.tb12377.x / Eur J Biochem / Insulin-like growth factors I and II: Some biological actions and receptor binding characteristics of two purified constituents of nonsuppressible insulin-like activity of human serum by Zapf (1978)
10.1016/0014-5793(76)80360-2 / FEBS Lett / Binding of nonsuppressible insulin-like activity (NSILA) to isolated fat cells: Evidence for two separate membrane acceptor sites by Schoenle (1976)
10.1016/S0021-9258(19)40683-2 / J Biol Chem / The NSILA-S receptor in liver plasma membranes. Characterization and comparison with the insulin receptor by Megyesi (1975)
10.2337/diab.18.4.193 / Diabetes / Immunology conformation and biological activity of insulin by Arquilla (1969)
10.1016/0022-2836(76)90256-4 / J Mol Biol / The evolutionary origin of proinsulin. Amino acid sequence homology with the trypsin-related serine proteases detected and evaluated by new statistical methods by De Haën (1976)
{'key': '10.1016/0026-0495(78)90267-6_BIB21', 'first-page': '207', 'article-title': 'Proinsulin and the biosynthesis of insulin', 'volume': '25', 'author': 'Steiner', 'year': '1969', 'journal-title': 'Rec Prog Horm Res'} / Rec Prog Horm Res / Proinsulin and the biosynthesis of insulin by Steiner (1969)
10.1016/S0006-291X(74)80391-8 / Biochem Biophys Res Commun / Insulin and nonsuppressible insulin-like activity (NSILA-S): Evidence for separate plasma membrane receptor sites by Megyesi (1974)
10.1007/BF01219707 / Diabetologia / Effects of insulin and NSILA on adipocytes of normal and diabetic rats: Receptor binding, glucose transport and glucose metabolism by Schoenle (1977)
{'key': '10.1016/0026-0495(78)90267-6_BIB24', 'first-page': '384', 'article-title': 'Evidence for different membrane receptors at the fat cell mediating glucose transport and antilipolysis', 'volume': '10', 'author': 'Renner', 'year': '1974', 'journal-title': 'Diabetologia'} / Diabetologia / Evidence for different membrane receptors at the fat cell mediating glucose transport and antilipolysis by Renner (1974)
10.1055/s-0028-1093718 / Horm Metab Res / Studies of the biological activity of insulin, cyclic nucleotides and concanavalin A in the isolated fat cell by Solomon (1975)
{'key': '10.1016/0026-0495(78)90267-6_BIB26', 'first-page': '1264', 'article-title': 'Insulin receptor interactions in adipose tissue cells: Direct measurement and properties', 'volume': '68', 'author': 'Cuatrecasas', 'year': '1971'} / Insulin receptor interactions in adipose tissue cells: Direct measurement and properties by Cuatrecasas (1971)
10.1016/S0021-9258(18)61777-6 / J Biol Chem / The relationship between the insulin binding capacity of fat cells and the cellular response to insulin. Studies with intact and trypsin-treated fat cells by Kono (1971)
10.1111/j.1365-2362.1975.tb00433.x / Eur J Clin Invest / Effects of insulin and of NSILA-S on the perfused rat heart: Glucose uptake, lactate production and efflux of 3-0-methylglucose by Meuli (1975)
10.1016/0304-4165(66)90125-5 / Biochim Biophys Acta / Nonsuppressible insulin-like activity of human serum. II. Biological properties of plasma extracts with nonsuppressible insulin-like activity by Froesch (1966)
10.1111/j.1365-2362.1970.tb00596.x / Eur J Clin Invest / Nonsuppressible insulin-like activity (NSILA) of human serum. V. Hypoglycemia and preferential metabolic stimulation of muscle by NSILA-S by Oelz (1970)
10.1016/0003-9861(76)90412-4 / Arch Biochem Biophys / Binding of insulin and nonsuppressible insulin-like activity to isolated perfused rat heart muscle. Evidence for two separate binding sites by Meuli (1976)
10.1016/0304-4165(73)90161-X / Biochim Biophys Acta / Binding and degradation of 125I-labelled insulin by isolated rat fat cells by Gammeltoft (1973)
{'key': '10.1016/0026-0495(78)90267-6_BIB33', 'first-page': '1833', 'article-title': 'Insulin receptors in the liver: Specific binding of 125I-insulin to the plasma membrane and its relation to insulin bioactivity', 'volume': '68', 'author': 'Freychet', 'year': '1971'} / Insulin receptors in the liver: Specific binding of 125I-insulin to the plasma membrane and its relation to insulin bioactivity by Freychet (1971)
10.1172/JCI107845 / J Clin Invest / The interactions of proinsulin with insulin receptors on the plasma membrane of the liver by Freychet (1974)
10.2337/diab.24.8.715 / Diabetes / Insulin receptors in the heart muscle: Demonstration of specific binding sites and impairment of insulin binding in the plasma membrane of the obese hyperglycemic mouse by Forgue (1975)
10.1016/0006-291X(77)91527-3 / Biochem Biophys Res Commun / Insulin and nonsuppressible insulin-like activity (NSILA-S) stimulate the same glucose transport system via two separate receptors in rat heart by Meuli (1977)
10.1111/j.1365-2362.1973.tb00338.x / Eur J Clin Invest / Fibroblasts as an experimental tool in metabolic and hormone studies. II. Effects of insulin and nonsuppressible insulin-like activity (NSILA-S) on fibroblasts in culture by Morell (1973)
10.1001/jama.1924.26520460003014d / J Am Med Assoc / Observations on the effects of insulin introduced into the medium of tissue cultures by Gey (1924)
{'key': '10.1016/0026-0495(78)90267-6_BIB39', 'first-page': '384', 'article-title': 'Receptor binding of nonsuppressible insulin-like activity (NSILA-S) to chicken embryo fibroblasts and its effect on DNA-, RNA- and protein synthesis', 'volume': '11', 'author': 'Zapf', 'year': '1975', 'journal-title': 'Diabetologia'} / Diabetologia / Receptor binding of nonsuppressible insulin-like activity (NSILA-S) to chicken embryo fibroblasts and its effect on DNA-, RNA- and protein synthesis by Zapf (1975)
10.1002/jcp.1040880213 / J Cell Physiol / Stimulation of ornithine decarboxylase activity in chick fibroblasts by nonsuppressible insulin-like activity, insulin and serum by Haselbacher (1976)
10.1210/jcem-39-3-512 / J Clin Endocrinol Metab / DNA synthesis in human fibroblasts: Stimulation by insulin and by nonsuppressible insulin-like activity (NSILA-S) by Rechler (1974)
10.1007/BF00461691 / Diabetologia / Effects of partially purified preparations with nonsuppressible insulin-like activity (NSILA-S) on sulfate incorporation into rat and chicken cartilage by Zingg (1973)
{'key': '10.1016/0026-0495(78)90267-6_BIB43', 'first-page': '2904', 'article-title': 'Nonsuppressible insulin-like activity and thyroid hormones: Major pituitary-dependent sulfation factors for chick embryo cartilage', 'volume': '73', 'author': 'Froesch', 'year': '1976'} / Nonsuppressible insulin-like activity and thyroid hormones: Major pituitary-dependent sulfation factors for chick embryo cartilage by Froesch (1976)
10.1210/endo-76-4-709 / Endocrinology / Studies on the state of insulin in blood: Properties of circulating “free” and “bound” insulin by Antoniades (1965)
10.2337/diab.18.2.75 / Diabetes / Insulin-like activity by fat pad assay and immunoreactive insulin. II. Their occurrence in fractions by gel filtration of serum by Kajinuma (1969)
10.2337/diab.12.4.339 / Diabetes / The “typical” and “atypical” forms of serum insulin by Samaan (1963)
10.1172/JCI105951 / J Clin Invest / Nonsuppressible insulin-like activity in human serum. III. Differentiation of two distinct molecules with nonsuppressible ILA by Jakob (1968)
{'key': '10.1016/0026-0495(78)90267-6_BIB48', 'series-title': 'Proc. of the 1973 Laurentian Hormone Conference, The Somatomedins', 'first-page': '303', 'volume': 'vol. 30', 'author': 'Froesch', 'year': '1974'} / Proc. of the 1973 Laurentian Hormone Conference, The Somatomedins by Froesch (1974)
10.1210/jcem-38-5-931 / J Clin Endocrinol Metab / Hypoglycemia associated with extrapancreatic tumours: Demonstration of elevated plasma NSILA-S by a new radioreceptor assay by Megyesi (1974)
10.1210/jcem-41-3-475 / J Clin Endocrinol Metab / Circulating NSILA-S in man: Preliminary studies of stimuli in vivo and of binding to plasma components by Megyesi (1975)
10.1530/acta.0.0810028 / Acta Endocrinol (Kbh) / Nonsuppressible insulin-like activity and sulphation activity in serum extracts of normal subjects, acromegalics and pituitary dwarfs by Schlumpf (1976)
10.1016/0003-9861(75)90296-9 / Arch Biochem Biophys / Binding of nonsuppressible insulin-like activity to human serum. Evidence for a carrier protein by Zapf (1975)
10.1016/0014-5793(78)80315-9 / FEBS Lett / Evidence for the existence in human serum of large molecular weight nonsuppressible insulin-like activity (NSILA) different from the small molecular weight form by Zapf (1978)
{'key': '10.1016/0026-0495(78)90267-6_BIB54', 'series-title': 'Proceedings of the Symposium on Somatomedins and Growth', 'article-title': 'Binding protein(s) for NSILA in serum, protein binding assay and serum NSILA levels in health and disease', 'author': 'Zapf', 'year': '1978'} / Proceedings of the Symposium on Somatomedins and Growth / Binding protein(s) for NSILA in serum, protein binding assay and serum NSILA levels in health and disease by Zapf (1978)
10.1210/jcem-44-1-160 / J Clin Endocrinol Metab / Demonstration of a specific serum carrier protein of nonsuppressible insulin-like activity in vivo by Kaufmann (1977)
10.1093/clinchem/23.4.677 / Clin Chem / Determination of nonsuppressible insulin-like activity in human serum by a sensitive protein binding assay by Zapf (1977)
10.1210/jcem-46-4-664 / J Clin Endocrinol Metab / Nonsuppressible insulin-like activity (NSILA). 1. Development of a new sensitive competitive protein binding assay for determination of serum levels by Schalch (1978)
10.1007/BF01219425 / Diabetologia / NSILA-carrier protein abolishes the action of nonsuppressible insulin-like activity (NSILA-S) on perfused rat heart by Meuli (1978)
10.1210/jcem-43-5-1164 / J Clin Endocrinol Metab / A bioassay for NSILA-S in individual serum samples and its relationship to somatotropin by Franklin (1976)
10.1530/acta.0.0870716 / Acta Endocrinol (Kbh) / Growth hormone dependence of nonsuppressible insulin-like activity (NSILA) and of NSILA-carrier protein in rats by Kaufmann (1978)
10.1038/263137a0 / Nature / Specific binding of a somatomedin-like polypeptide in rat serum depends on growth hormone by Moses (1976)
10.1530/acta.0.0860498 / Acta Endocrinol (Kbh) / The influence of hypophysectomy on NSILA concentrations in the dog: Evidence for partially pituitary-independent regulation by Eigenmann (1977)
10.1016/S0140-6736(62)90845-0 / Lancet / Abnormalities of serum insulin-like activity in liver disease by Samaan (1962)
10.1007/BF01338711 / Diabetologia / Bildung eines insulinartigen Wirkstoffes in der isolierten Rattenleber by Siess (1965)
{'issue': 'Suppl 212', 'key': '10.1016/0026-0495(78)90267-6_BIB65', 'first-page': '100', 'article-title': 'Hormonal regulation of NSILA release from the isolated perfused rat liver', 'volume': '85', 'author': 'Heinrich', 'year': '1977', 'journal-title': 'Acta Endocrinol (Kbh)'} / Acta Endocrinol (Kbh) / Hormonal regulation of NSILA release from the isolated perfused rat liver by Heinrich (1977)
10.1210/jcem-44-6-1175 / J Clin Endocrinol Metab / Adrenocortical carcinoma and hypoglycemia: Evidence for production of nonsuppressible insulin-like activity by the tumor by Hyodo (1977)
10.1210/jcem-45-2-330 / J Clin Endocrinol Metab / Lack of a simple relationship between endogenous growth hormone and NSILA-S related peptides by Megyesi (1977)
{'key': '10.1016/0026-0495(78)90267-6_BIB68', 'first-page': '152', 'article-title': 'Genetic pituitary dwarfism with high serum concentration of growth hormone: A new inborn error of metabolism?', 'volume': '2', 'author': 'Laron', 'year': '1966', 'journal-title': 'Isr J Med Sci'} / Isr J Med Sci / Genetic pituitary dwarfism with high serum concentration of growth hormone: A new inborn error of metabolism? by Laron (1966)
{'key': '10.1016/0026-0495(78)90267-6_BIB69', 'first-page': '1247', 'article-title': 'Syndrome of familial dwarfism and high plasma immunoreactive growth hormone', 'volume': '10', 'author': 'Laron', 'year': '1974', 'journal-title': 'Isr J Med Sci'} / Isr J Med Sci / Syndrome of familial dwarfism and high plasma immunoreactive growth hormone by Laron (1974)
10.1210/jcem-42-2-403 / J Clin Endocrinol Metab / Receptor-active growth hormone in Laron dwarfism by Jacobs (1976)
10.1038/235107a0 / Nature / Somatomedin: Proposed designation for sulfation factor by Daughaday (1972)
{'key': '10.1016/0026-0495(78)90267-6_BIB72', 'first-page': '129', 'article-title': 'Defective sulfation factor generation: A possible etiological link in dwarfism', 'volume': '82', 'author': 'Daughaday', 'year': '1969', 'journal-title': 'Trans Assoc Am Physicians'} / Trans Assoc Am Physicians / Defective sulfation factor generation: A possible etiological link in dwarfism by Daughaday (1969)
10.1111/j.1651-2227.1975.tb03891.x / Acta Paediatr Scand / Increased immunoreactive plasma and urinary growth hormone in growth retardation with defective generation of somatomedin A. (Laron's syndrome) by Kastrup (1975)
10.1159/000178730 / Horm Res / Radioimmunoassay for nonsuppressible insulin-like activity by Reber (1976)
10.1172/JCI108816 / J Clin Invest / Estimation of somatomedin-C levels in normals and patients with pituitary disease by radioimmunoassay by Furlanetto (1977)
10.1016/0304-4165(71)90050-X / Biochim Biophys Acta / Nonsuppressible insulin-like activity of human serum. VI. Difference between the action of insulin and that of precipitated nonsuppressible insulin-like activity on glycogen synthesis of rat adipose tissue and muscle by Oelz (1971)
10.1172/JCI108226 / J Clin Invest / The purification and partial characterization of an insulin-like protein from human serum by Poffenbarger (1975)
10.2337/diab.25.10.994 / Diabetes / Current concepts of somatomedin and other biologically related growth factors by Cochinov (1976)
10.1038/270665a0 / Nature / Somatomedins and related growth factors by Rechler (1977)
{'key': '10.1016/0026-0495(78)90267-6_BIB80', 'first-page': '733', 'article-title': 'Sulfation factor, a serum component mediating the action of growth hormone in stimulating incorporation of sulfate into cartilage', 'volume': '35', 'author': 'Salmon', 'year': '1956', 'journal-title': 'J Clin Invest'} / J Clin Invest / Sulfation factor, a serum component mediating the action of growth hormone in stimulating incorporation of sulfate into cartilage by Salmon (1956)
{'key': '10.1016/0026-0495(78)90267-6_BIB81', 'first-page': '825', 'article-title': 'A hormonally controlled serum factor which stimulates sulfate incorporation by cartilage in vitro', 'volume': '49', 'author': 'Salmon', 'year': '1957', 'journal-title': 'J Lab Clin Med'} / J Lab Clin Med / A hormonally controlled serum factor which stimulates sulfate incorporation by cartilage in vitro by Salmon (1957)
{'key': '10.1016/0026-0495(78)90267-6_BIB82', 'first-page': '357', 'article-title': 'Synchronous activation of DNA synthesis in hypophysectomized rat cartilage by growth hormone', 'volume': '68', 'author': 'Daughaday', 'year': '1966', 'journal-title': 'J Lab Clin Med'} / J Lab Clin Med / Synchronous activation of DNA synthesis in hypophysectomized rat cartilage by growth hormone by Daughaday (1966)
10.1210/endo-87-6-1168 / Endocrinology / In vitro stimulation of leucine incorporation into muscle and cartilage protein by a serum fraction with sulfation factor activity: Differentiation of effects from those of growth hormone and insulin by Salmon (1970)
{'key': '10.1016/0026-0495(78)90267-6_BIB84', 'first-page': '22', 'article-title': 'Human somatomedin. Biological properties of somatomedin with special emphasis on the influence of somatomedin on glucose uptake', 'volume': '163', 'author': 'Hall', 'year': '1972', 'journal-title': 'Acta Endocrinol (Kbh)'} / Acta Endocrinol (Kbh) / Human somatomedin. Biological properties of somatomedin with special emphasis on the influence of somatomedin on glucose uptake by Hall (1972)
10.1210/jcem-35-2-194 / J Clin Endocrinol Metab / Human somatomedin, the growth hormone-dependent sulfation factor, is antilipolytic by Underwood (1972)
10.1210/jcem-45-5-988 / J Clin Endocrinol Metab / Demonstration of specific plasma protein binding sites for somatomedin by Hintz (1977)
{'key': '10.1016/0026-0495(78)90267-6_BIB87', 'first-page': '65', 'article-title': 'Chemistry and biology of the somatomedins', 'volume': 'vol 48', 'author': 'Fryklund', 'year': '1977'} / Chemistry and biology of the somatomedins by Fryklund (1977)
{'key': '10.1016/0026-0495(78)90267-6_BIB88', 'first-page': '45', 'article-title': 'Biological effects and receptor binding of nonsuppressible insulin-like activity (NSILA)', 'volume': 'vol. 48', 'author': 'Zapf', 'year': '1977'} / Biological effects and receptor binding of nonsuppressible insulin-like activity (NSILA) by Zapf (1977)
{'key': '10.1016/0026-0495(78)90267-6_BIB89', 'first-page': '59', 'article-title': 'Receptor binding and biological effects of somatomedin A in vitro', 'volume': 'vol. 48', 'author': 'Hall', 'year': '1977'} / Receptor binding and biological effects of somatomedin A in vitro by Hall (1977)
10.1016/B978-0-12-027308-9.50015-9 / Adv Metab Disord / Explorations of the insulin-like and growth-promoting properties of somatomedin by membrane receptor assays by Van Wyk (1975)
{'key': '10.1016/0026-0495(78)90267-6_BIB91', 'series-title': 'Research Conference', 'article-title': 'Multiplication stimulating activity (MSA): A somatomedin-like peptide from cultured rat liver cells', 'author': 'Nissley', 'year': '1976'} / Research Conference / Multiplication stimulating activity (MSA): A somatomedin-like peptide from cultured rat liver cells by Nissley (1976)
{'key': '10.1016/0026-0495(78)90267-6_BIB92', 'series-title': '60th Meeting of the American Endocrine Society', 'article-title': 'Demonstration by radioimmunoassay of multiplication stimulating activity (MSA) in rat serum', 'author': 'Moses', 'year': '1978'} / 60th Meeting of the American Endocrine Society / Demonstration by radioimmunoassay of multiplication stimulating activity (MSA) in rat serum by Moses (1978)

Dates

Type	When
Created	21 years, 4 months ago (April 19, 2004, 1:37 a.m.)
Deposited	3 years, 2 months ago (June 21, 2022, 2:29 p.m.)
Indexed	2 days, 3 hours ago (Sept. 4, 2025, 9:39 a.m.)
Issued	46 years, 9 months ago (Dec. 1, 1978)
Published	46 years, 9 months ago (Dec. 1, 1978)
Published Print	46 years, 9 months ago (Dec. 1, 1978)

Funders 2

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 10.13039/501100001711
Region: Europe
pri (Trusts, charities, foundations (both public and private))
Labels10
1. Schweizerischer Nationalfonds
2. Swiss National Science Foundation
3. Fonds National Suisse de la Recherche Scientifique
4. Fondo Nazionale Svizzero per la Ricerca Scientifica
5. Fonds National Suisse
6. Fondo Nazionale Svizzero
7. Schweizerische Nationalfonds
8. SNF
9. SNSF
10. FNS
Universität Zürich 10.13039/501100006447
Region: Europe
gov (Universities (academic only))
Labels3
1. University of Zurich, Switzerland
2. University of Zurich
3. UZH
Awards3
1. 3.280.-0.78
2. 08.-0.76
3. 3.595.-0.75

BibTeX

@article{Zapf_1978, title={Nonsuppressible insulin-like activity (NSILA) from human serum: Recent accomplishments and their physiologic implications}, volume={27}, ISSN={0026-0495}, url={http://dx.doi.org/10.1016/0026-0495(78)90267-6}, DOI={10.1016/0026-0495(78)90267-6}, number={12}, journal={Metabolism}, publisher={Elsevier BV}, author={Zapf, J. and Rinderknecht, E. and Humbel, R.E. and Froesch, E.R.}, year={1978}, month=dec, pages={1803–1828} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        9,
        4
      ]
    ],
    "date-time": "2025-09-04T13:39:53Z",
    "timestamp": 1756993193601,
    "version": "3.37.3"
  },
  "reference-count": 92,
  "publisher": "Elsevier BV",
  "issue": "12",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            1978,
            12,
            1
          ]
        ],
        "date-time": "1978-12-01T00:00:00Z",
        "timestamp": 281318400000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://www.elsevier.com/tdm/userlicense/1.0/"
    }
  ],
  "funder": [
    {
      "DOI": "10.13039/501100001711",
      "name": "Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung",
      "doi-asserted-by": "publisher",
      "id": [
        {
          "id": "10.13039/501100001711",
          "id-type": "DOI",
          "asserted-by": "publisher"
        }
      ]
    },
    {
      "DOI": "10.13039/501100006447",
      "name": "Universit\u00e4t Z\u00fcrich",
      "doi-asserted-by": "publisher",
      "award": [
        "08.-0.76",
        "3.280.-0.78",
        "3.595.-0.75"
      ],
      "id": [
        {
          "id": "10.13039/501100006447",
          "id-type": "DOI",
          "asserted-by": "publisher"
        }
      ]
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        1978,
        12
      ]
    ]
  },
  "DOI": "10.1016/0026-0495(78)90267-6",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2004,
        4,
        19
      ]
    ],
    "date-time": "2004-04-19T05:37:56Z",
    "timestamp": 1082353076000
  },
  "page": "1803-1828",
  "source": "Crossref",
  "is-referenced-by-count": 158,
  "title": "Nonsuppressible insulin-like activity (NSILA) from human serum: Recent accomplishments and their physiologic implications",
  "prefix": "10.1016",
  "volume": "27",
  "author": [
    {
      "given": "J.",
      "family": "Zapf",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "E.",
      "family": "Rinderknecht",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "R.E.",
      "family": "Humbel",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "E.R.",
      "family": "Froesch",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "78",
  "reference": [
    {
      "key": "10.1016/0026-0495(78)90267-6_BIB1",
      "doi-asserted-by": "crossref",
      "first-page": "1157",
      "DOI": "10.1172/JCI104130",
      "article-title": "Immunoassay of endogenous plasma insulin in men",
      "volume": "39",
      "author": "Yalow",
      "year": "1960",
      "journal-title": "J Clin Invest"
    },
    {
      "key": "10.1016/0026-0495(78)90267-6_BIB2",
      "doi-asserted-by": "crossref",
      "first-page": "97",
      "DOI": "10.1172/JCI102583",
      "article-title": "Evidence for the presence of insulin in blood serum. A method for the approximate determination of the insulin content of blood",
      "volume": "31",
      "author": "Groen",
      "year": "1952",
      "journal-title": "J Clin Invest"
    },
    {
      "key": "10.1016/0026-0495(78)90267-6_BIB3",
      "doi-asserted-by": "crossref",
      "first-page": "76",
      "DOI": "10.1016/S0140-6736(58)91246-7",
      "article-title": "An assay for insulin-like activity using rat adipose tissue",
      "volume": "2",
      "author": "Martin",
      "year": "1958",
      "journal-title": "Lancet"
    },
    {
      "key": "10.1016/0026-0495(78)90267-6_BIB4",
      "doi-asserted-by": "crossref",
      "first-page": "1487",
      "DOI": "10.1172/JCI104168",
      "article-title": "Measurement of small quantities of insulin-like activity using rat adipose tissue. 1. A proposed procedure",
      "volume": "39",
      "author": "Renold",
      "year": "1960",
      "journal-title": "J Clin Invest"
    },
    {
      "key": "10.1016/0026-0495(78)90267-6_BIB5",
      "first-page": "272",
      "article-title": "Insulin-like activity of blood, what is it?",
      "volume": "18",
      "author": "Leonards",
      "year": "1959"
    },
    {
      "key": "10.1016/0026-0495(78)90267-6_BIB6",
      "doi-asserted-by": "crossref",
      "first-page": "1816",
      "DOI": "10.1172/JCI104866",
      "article-title": "Antibody-suppressible and nonsuppressible insulin-like activities in human serum and their physiologic significance. An insulin assay with adipose tissue of increased precision and specificity",
      "volume": "42",
      "author": "Froesch",
      "year": "1963",
      "journal-title": "J Clin Invest"
    },
    {
      "key": "10.1016/0026-0495(78)90267-6_BIB7",
      "doi-asserted-by": "crossref",
      "first-page": "263",
      "DOI": "10.1677/joe.0.0240263",
      "article-title": "Further immunological studies on the form of circulating insulin",
      "volume": "24",
      "author": "Samaan",
      "year": "1962",
      "journal-title": "J Endocrinol"
    },
    {
      "key": "10.1016/0026-0495(78)90267-6_BIB8",
      "article-title": "Antibody-suppressible and nonsuppressible insulin-like activities",
      "volume": "I",
      "author": "Oelz",
      "year": "1972"
    },
    {
      "key": "10.1016/0026-0495(78)90267-6_BIB9",
      "doi-asserted-by": "crossref",
      "first-page": "349",
      "DOI": "10.1016/0304-4165(66)90124-3",
      "article-title": "Nonsuppressible insulin-like activity of human serum. I. Physicochemical properties, extraction and partial purification",
      "volume": "121",
      "author": "B\u00fcrgi",
      "year": "1966",
      "journal-title": "Biochim Biophys Acta"
    },
    {
      "key": "10.1016/0026-0495(78)90267-6_BIB10",
      "first-page": "2365",
      "article-title": "Polypeptides with nonsuppressible insulin-like and cell-growth promoting activities in human serum: Isolation, chemical characterization, and some biological properties of forms I and II",
      "volume": "73",
      "author": "Rinderknecht",
      "year": "1976"
    },
    {
      "key": "10.1016/0026-0495(78)90267-6_BIB11",
      "first-page": "4379",
      "article-title": "Amino-terminal sequences of two polypeptides from human serum with nonsuppressible insulin-like and cell-growth-promoting activities: Evidence for structural homology with insulin B chain",
      "volume": "73",
      "author": "Rinderknecht",
      "year": "1976"
    },
    {
      "key": "10.1016/0026-0495(78)90267-6_BIB12",
      "doi-asserted-by": "crossref",
      "first-page": "2769",
      "DOI": "10.1016/S0021-9258(17)40889-1",
      "article-title": "The amino acid sequence of human insulin-like growth factor I and its structural homology with proinsulin",
      "volume": "253",
      "author": "Rinderknecht",
      "year": "1978",
      "journal-title": "J Biol Chem"
    },
    {
      "key": "10.1016/0026-0495(78)90267-6_BIB13",
      "doi-asserted-by": "crossref",
      "first-page": "283",
      "DOI": "10.1016/0014-5793(78)80237-3",
      "article-title": "Primary structure of human insulin-like growth factor II",
      "volume": "89",
      "author": "Rinderknecht",
      "year": "1978",
      "journal-title": "FEBS Lett"
    },
    {
      "key": "10.1016/0026-0495(78)90267-6_BIB14",
      "first-page": "180",
      "article-title": "Insulin-like growth factor: A model for tertiary structure accounting for immuno-reactivity and receptor binding",
      "volume": "75",
      "author": "Blundell",
      "year": "1978"
    },
    {
      "key": "10.1016/0026-0495(78)90267-6_BIB15",
      "doi-asserted-by": "crossref",
      "first-page": "630",
      "DOI": "10.1016/0003-9861(75)90295-7",
      "article-title": "Specific binding of nonsuppressible insulin-like activity to chicken embryo fibroblasts and to a solubilized fibroblast receptor",
      "volume": "168",
      "author": "Zapf",
      "year": "1975",
      "journal-title": "Arch Biochem Biophys"
    },
    {
      "key": "10.1016/0026-0495(78)90267-6_BIB16",
      "doi-asserted-by": "crossref",
      "first-page": "285",
      "DOI": "10.1111/j.1432-1033.1978.tb12377.x",
      "article-title": "Insulin-like growth factors I and II: Some biological actions and receptor binding characteristics of two purified constituents of nonsuppressible insulin-like activity of human serum",
      "volume": "87",
      "author": "Zapf",
      "year": "1978",
      "journal-title": "Eur J Biochem"
    },
    {
      "key": "10.1016/0026-0495(78)90267-6_BIB17",
      "doi-asserted-by": "crossref",
      "first-page": "175",
      "DOI": "10.1016/0014-5793(76)80360-2",
      "article-title": "Binding of nonsuppressible insulin-like activity (NSILA) to isolated fat cells: Evidence for two separate membrane acceptor sites",
      "volume": "67",
      "author": "Schoenle",
      "year": "1976",
      "journal-title": "FEBS Lett"
    },
    {
      "key": "10.1016/0026-0495(78)90267-6_BIB18",
      "doi-asserted-by": "crossref",
      "first-page": "8990",
      "DOI": "10.1016/S0021-9258(19)40683-2",
      "article-title": "The NSILA-S receptor in liver plasma membranes. Characterization and comparison with the insulin receptor",
      "volume": "250",
      "author": "Megyesi",
      "year": "1975",
      "journal-title": "J Biol Chem"
    },
    {
      "key": "10.1016/0026-0495(78)90267-6_BIB19",
      "doi-asserted-by": "crossref",
      "first-page": "193",
      "DOI": "10.2337/diab.18.4.193",
      "article-title": "Immunology conformation and biological activity of insulin",
      "volume": "18",
      "author": "Arquilla",
      "year": "1969",
      "journal-title": "Diabetes"
    },
    {
      "key": "10.1016/0026-0495(78)90267-6_BIB20",
      "doi-asserted-by": "crossref",
      "first-page": "639",
      "DOI": "10.1016/0022-2836(76)90256-4",
      "article-title": "The evolutionary origin of proinsulin. Amino acid sequence homology with the trypsin-related serine proteases detected and evaluated by new statistical methods",
      "volume": "106",
      "author": "De Ha\u00ebn",
      "year": "1976",
      "journal-title": "J Mol Biol"
    },
    {
      "key": "10.1016/0026-0495(78)90267-6_BIB21",
      "first-page": "207",
      "article-title": "Proinsulin and the biosynthesis of insulin",
      "volume": "25",
      "author": "Steiner",
      "year": "1969",
      "journal-title": "Rec Prog Horm Res"
    },
    {
      "key": "10.1016/0026-0495(78)90267-6_BIB22",
      "doi-asserted-by": "crossref",
      "first-page": "307",
      "DOI": "10.1016/S0006-291X(74)80391-8",
      "article-title": "Insulin and nonsuppressible insulin-like activity (NSILA-S): Evidence for separate plasma membrane receptor sites",
      "volume": "57",
      "author": "Megyesi",
      "year": "1974",
      "journal-title": "Biochem Biophys Res Commun"
    },
    {
      "key": "10.1016/0026-0495(78)90267-6_BIB23",
      "doi-asserted-by": "crossref",
      "first-page": "243",
      "DOI": "10.1007/BF01219707",
      "article-title": "Effects of insulin and NSILA on adipocytes of normal and diabetic rats: Receptor binding, glucose transport and glucose metabolism",
      "volume": "13",
      "author": "Schoenle",
      "year": "1977",
      "journal-title": "Diabetologia"
    },
    {
      "key": "10.1016/0026-0495(78)90267-6_BIB24",
      "first-page": "384",
      "article-title": "Evidence for different membrane receptors at the fat cell mediating glucose transport and antilipolysis",
      "volume": "10",
      "author": "Renner",
      "year": "1974",
      "journal-title": "Diabetologia"
    },
    {
      "key": "10.1016/0026-0495(78)90267-6_BIB25",
      "doi-asserted-by": "crossref",
      "first-page": "297",
      "DOI": "10.1055/s-0028-1093718",
      "article-title": "Studies of the biological activity of insulin, cyclic nucleotides and concanavalin A in the isolated fat cell",
      "volume": "7",
      "author": "Solomon",
      "year": "1975",
      "journal-title": "Horm Metab Res"
    },
    {
      "key": "10.1016/0026-0495(78)90267-6_BIB26",
      "first-page": "1264",
      "article-title": "Insulin receptor interactions in adipose tissue cells: Direct measurement and properties",
      "volume": "68",
      "author": "Cuatrecasas",
      "year": "1971"
    },
    {
      "key": "10.1016/0026-0495(78)90267-6_BIB27",
      "doi-asserted-by": "crossref",
      "first-page": "6210",
      "DOI": "10.1016/S0021-9258(18)61777-6",
      "article-title": "The relationship between the insulin binding capacity of fat cells and the cellular response to insulin. Studies with intact and trypsin-treated fat cells",
      "volume": "246",
      "author": "Kono",
      "year": "1971",
      "journal-title": "J Biol Chem"
    },
    {
      "key": "10.1016/0026-0495(78)90267-6_BIB28",
      "doi-asserted-by": "crossref",
      "first-page": "93",
      "DOI": "10.1111/j.1365-2362.1975.tb00433.x",
      "article-title": "Effects of insulin and of NSILA-S on the perfused rat heart: Glucose uptake, lactate production and efflux of 3-0-methylglucose",
      "volume": "5",
      "author": "Meuli",
      "year": "1975",
      "journal-title": "Eur J Clin Invest"
    },
    {
      "key": "10.1016/0026-0495(78)90267-6_BIB29",
      "doi-asserted-by": "crossref",
      "first-page": "360",
      "DOI": "10.1016/0304-4165(66)90125-5",
      "article-title": "Nonsuppressible insulin-like activity of human serum. II. Biological properties of plasma extracts with nonsuppressible insulin-like activity",
      "volume": "121",
      "author": "Froesch",
      "year": "1966",
      "journal-title": "Biochim Biophys Acta"
    },
    {
      "key": "10.1016/0026-0495(78)90267-6_BIB30",
      "doi-asserted-by": "crossref",
      "first-page": "48",
      "DOI": "10.1111/j.1365-2362.1970.tb00596.x",
      "article-title": "Nonsuppressible insulin-like activity (NSILA) of human serum. V. Hypoglycemia and preferential metabolic stimulation of muscle by NSILA-S",
      "volume": "1",
      "author": "Oelz",
      "year": "1970",
      "journal-title": "Eur J Clin Invest"
    },
    {
      "key": "10.1016/0026-0495(78)90267-6_BIB31",
      "doi-asserted-by": "crossref",
      "first-page": "31",
      "DOI": "10.1016/0003-9861(76)90412-4",
      "article-title": "Binding of insulin and nonsuppressible insulin-like activity to isolated perfused rat heart muscle. Evidence for two separate binding sites",
      "volume": "177",
      "author": "Meuli",
      "year": "1976",
      "journal-title": "Arch Biochem Biophys"
    },
    {
      "key": "10.1016/0026-0495(78)90267-6_BIB32",
      "doi-asserted-by": "crossref",
      "first-page": "16",
      "DOI": "10.1016/0304-4165(73)90161-X",
      "article-title": "Binding and degradation of 125I-labelled insulin by isolated rat fat cells",
      "volume": "320",
      "author": "Gammeltoft",
      "year": "1973",
      "journal-title": "Biochim Biophys Acta"
    },
    {
      "key": "10.1016/0026-0495(78)90267-6_BIB33",
      "first-page": "1833",
      "article-title": "Insulin receptors in the liver: Specific binding of 125I-insulin to the plasma membrane and its relation to insulin bioactivity",
      "volume": "68",
      "author": "Freychet",
      "year": "1971"
    },
    {
      "key": "10.1016/0026-0495(78)90267-6_BIB34",
      "doi-asserted-by": "crossref",
      "first-page": "1020",
      "DOI": "10.1172/JCI107845",
      "article-title": "The interactions of proinsulin with insulin receptors on the plasma membrane of the liver",
      "volume": "54",
      "author": "Freychet",
      "year": "1974",
      "journal-title": "J Clin Invest"
    },
    {
      "key": "10.1016/0026-0495(78)90267-6_BIB35",
      "doi-asserted-by": "crossref",
      "first-page": "715",
      "DOI": "10.2337/diab.24.8.715",
      "article-title": "Insulin receptors in the heart muscle: Demonstration of specific binding sites and impairment of insulin binding in the plasma membrane of the obese hyperglycemic mouse",
      "volume": "24",
      "author": "Forgue",
      "year": "1975",
      "journal-title": "Diabetes"
    },
    {
      "key": "10.1016/0026-0495(78)90267-6_BIB36",
      "doi-asserted-by": "crossref",
      "first-page": "689",
      "DOI": "10.1016/0006-291X(77)91527-3",
      "article-title": "Insulin and nonsuppressible insulin-like activity (NSILA-S) stimulate the same glucose transport system via two separate receptors in rat heart",
      "volume": "75",
      "author": "Meuli",
      "year": "1977",
      "journal-title": "Biochem Biophys Res Commun"
    },
    {
      "key": "10.1016/0026-0495(78)90267-6_BIB37",
      "doi-asserted-by": "crossref",
      "first-page": "119",
      "DOI": "10.1111/j.1365-2362.1973.tb00338.x",
      "article-title": "Fibroblasts as an experimental tool in metabolic and hormone studies. II. Effects of insulin and nonsuppressible insulin-like activity (NSILA-S) on fibroblasts in culture",
      "volume": "3",
      "author": "Morell",
      "year": "1973",
      "journal-title": "Eur J Clin Invest"
    },
    {
      "key": "10.1016/0026-0495(78)90267-6_BIB38",
      "doi-asserted-by": "crossref",
      "first-page": "1609",
      "DOI": "10.1001/jama.1924.26520460003014d",
      "article-title": "Observations on the effects of insulin introduced into the medium of tissue cultures",
      "volume": "82",
      "author": "Gey",
      "year": "1924",
      "journal-title": "J Am Med Assoc"
    },
    {
      "key": "10.1016/0026-0495(78)90267-6_BIB39",
      "first-page": "384",
      "article-title": "Receptor binding of nonsuppressible insulin-like activity (NSILA-S) to chicken embryo fibroblasts and its effect on DNA-, RNA- and protein synthesis",
      "volume": "11",
      "author": "Zapf",
      "year": "1975",
      "journal-title": "Diabetologia"
    },
    {
      "key": "10.1016/0026-0495(78)90267-6_BIB40",
      "doi-asserted-by": "crossref",
      "first-page": "239",
      "DOI": "10.1002/jcp.1040880213",
      "article-title": "Stimulation of ornithine decarboxylase activity in chick fibroblasts by nonsuppressible insulin-like activity, insulin and serum",
      "volume": "88",
      "author": "Haselbacher",
      "year": "1976",
      "journal-title": "J Cell Physiol"
    },
    {
      "key": "10.1016/0026-0495(78)90267-6_BIB41",
      "doi-asserted-by": "crossref",
      "first-page": "512",
      "DOI": "10.1210/jcem-39-3-512",
      "article-title": "DNA synthesis in human fibroblasts: Stimulation by insulin and by nonsuppressible insulin-like activity (NSILA-S)",
      "volume": "39",
      "author": "Rechler",
      "year": "1974",
      "journal-title": "J Clin Endocrinol Metab"
    },
    {
      "key": "10.1016/0026-0495(78)90267-6_BIB42",
      "doi-asserted-by": "crossref",
      "first-page": "472",
      "DOI": "10.1007/BF00461691",
      "article-title": "Effects of partially purified preparations with nonsuppressible insulin-like activity (NSILA-S) on sulfate incorporation into rat and chicken cartilage",
      "volume": "9",
      "author": "Zingg",
      "year": "1973",
      "journal-title": "Diabetologia"
    },
    {
      "key": "10.1016/0026-0495(78)90267-6_BIB43",
      "first-page": "2904",
      "article-title": "Nonsuppressible insulin-like activity and thyroid hormones: Major pituitary-dependent sulfation factors for chick embryo cartilage",
      "volume": "73",
      "author": "Froesch",
      "year": "1976"
    },
    {
      "key": "10.1016/0026-0495(78)90267-6_BIB44",
      "doi-asserted-by": "crossref",
      "first-page": "709",
      "DOI": "10.1210/endo-76-4-709",
      "article-title": "Studies on the state of insulin in blood: Properties of circulating \u201cfree\u201d and \u201cbound\u201d insulin",
      "volume": "76",
      "author": "Antoniades",
      "year": "1965",
      "journal-title": "Endocrinology"
    },
    {
      "key": "10.1016/0026-0495(78)90267-6_BIB45",
      "doi-asserted-by": "crossref",
      "first-page": "75",
      "DOI": "10.2337/diab.18.2.75",
      "article-title": "Insulin-like activity by fat pad assay and immunoreactive insulin. II. Their occurrence in fractions by gel filtration of serum",
      "volume": "18",
      "author": "Kajinuma",
      "year": "1969",
      "journal-title": "Diabetes"
    },
    {
      "key": "10.1016/0026-0495(78)90267-6_BIB46",
      "doi-asserted-by": "crossref",
      "first-page": "339",
      "DOI": "10.2337/diab.12.4.339",
      "article-title": "The \u201ctypical\u201d and \u201catypical\u201d forms of serum insulin",
      "volume": "12",
      "author": "Samaan",
      "year": "1963",
      "journal-title": "Diabetes"
    },
    {
      "key": "10.1016/0026-0495(78)90267-6_BIB47",
      "doi-asserted-by": "crossref",
      "first-page": "2678",
      "DOI": "10.1172/JCI105951",
      "article-title": "Nonsuppressible insulin-like activity in human serum. III. Differentiation of two distinct molecules with nonsuppressible ILA",
      "volume": "47",
      "author": "Jakob",
      "year": "1968",
      "journal-title": "J Clin Invest"
    },
    {
      "key": "10.1016/0026-0495(78)90267-6_BIB48",
      "series-title": "Proc. of the 1973 Laurentian Hormone Conference, The Somatomedins",
      "first-page": "303",
      "volume": "vol. 30",
      "author": "Froesch",
      "year": "1974"
    },
    {
      "key": "10.1016/0026-0495(78)90267-6_BIB49",
      "doi-asserted-by": "crossref",
      "first-page": "931",
      "DOI": "10.1210/jcem-38-5-931",
      "article-title": "Hypoglycemia associated with extrapancreatic tumours: Demonstration of elevated plasma NSILA-S by a new radioreceptor assay",
      "volume": "38",
      "author": "Megyesi",
      "year": "1974",
      "journal-title": "J Clin Endocrinol Metab"
    },
    {
      "key": "10.1016/0026-0495(78)90267-6_BIB50",
      "doi-asserted-by": "crossref",
      "first-page": "475",
      "DOI": "10.1210/jcem-41-3-475",
      "article-title": "Circulating NSILA-S in man: Preliminary studies of stimuli in vivo and of binding to plasma components",
      "volume": "41",
      "author": "Megyesi",
      "year": "1975",
      "journal-title": "J Clin Endocrinol Metab"
    },
    {
      "key": "10.1016/0026-0495(78)90267-6_BIB51",
      "doi-asserted-by": "crossref",
      "first-page": "28",
      "DOI": "10.1530/acta.0.0810028",
      "article-title": "Nonsuppressible insulin-like activity and sulphation activity in serum extracts of normal subjects, acromegalics and pituitary dwarfs",
      "volume": "81",
      "author": "Schlumpf",
      "year": "1976",
      "journal-title": "Acta Endocrinol (Kbh)"
    },
    {
      "key": "10.1016/0026-0495(78)90267-6_BIB52",
      "doi-asserted-by": "crossref",
      "first-page": "638",
      "DOI": "10.1016/0003-9861(75)90296-9",
      "article-title": "Binding of nonsuppressible insulin-like activity to human serum. Evidence for a carrier protein",
      "volume": "168",
      "author": "Zapf",
      "year": "1975",
      "journal-title": "Arch Biochem Biophys"
    },
    {
      "key": "10.1016/0026-0495(78)90267-6_BIB53",
      "doi-asserted-by": "crossref",
      "first-page": "135",
      "DOI": "10.1016/0014-5793(78)80315-9",
      "article-title": "Evidence for the existence in human serum of large molecular weight nonsuppressible insulin-like activity (NSILA) different from the small molecular weight form",
      "volume": "90",
      "author": "Zapf",
      "year": "1978",
      "journal-title": "FEBS Lett"
    },
    {
      "key": "10.1016/0026-0495(78)90267-6_BIB54",
      "series-title": "Proceedings of the Symposium on Somatomedins and Growth",
      "article-title": "Binding protein(s) for NSILA in serum, protein binding assay and serum NSILA levels in health and disease",
      "author": "Zapf",
      "year": "1978"
    },
    {
      "key": "10.1016/0026-0495(78)90267-6_BIB55",
      "doi-asserted-by": "crossref",
      "first-page": "160",
      "DOI": "10.1210/jcem-44-1-160",
      "article-title": "Demonstration of a specific serum carrier protein of nonsuppressible insulin-like activity in vivo",
      "volume": "44",
      "author": "Kaufmann",
      "year": "1977",
      "journal-title": "J Clin Endocrinol Metab"
    },
    {
      "key": "10.1016/0026-0495(78)90267-6_BIB56",
      "doi-asserted-by": "crossref",
      "first-page": "677",
      "DOI": "10.1093/clinchem/23.4.677",
      "article-title": "Determination of nonsuppressible insulin-like activity in human serum by a sensitive protein binding assay",
      "volume": "23",
      "author": "Zapf",
      "year": "1977",
      "journal-title": "Clin Chem"
    },
    {
      "key": "10.1016/0026-0495(78)90267-6_BIB57",
      "doi-asserted-by": "crossref",
      "first-page": "664",
      "DOI": "10.1210/jcem-46-4-664",
      "article-title": "Nonsuppressible insulin-like activity (NSILA). 1. Development of a new sensitive competitive protein binding assay for determination of serum levels",
      "volume": "46",
      "author": "Schalch",
      "year": "1978",
      "journal-title": "J Clin Endocrinol Metab"
    },
    {
      "key": "10.1016/0026-0495(78)90267-6_BIB58",
      "doi-asserted-by": "crossref",
      "first-page": "255",
      "DOI": "10.1007/BF01219425",
      "article-title": "NSILA-carrier protein abolishes the action of nonsuppressible insulin-like activity (NSILA-S) on perfused rat heart",
      "volume": "14",
      "author": "Meuli",
      "year": "1978",
      "journal-title": "Diabetologia"
    },
    {
      "key": "10.1016/0026-0495(78)90267-6_BIB59",
      "doi-asserted-by": "crossref",
      "first-page": "1164",
      "DOI": "10.1210/jcem-43-5-1164",
      "article-title": "A bioassay for NSILA-S in individual serum samples and its relationship to somatotropin",
      "volume": "43",
      "author": "Franklin",
      "year": "1976",
      "journal-title": "J Clin Endocrinol Metab"
    },
    {
      "key": "10.1016/0026-0495(78)90267-6_BIB60",
      "doi-asserted-by": "crossref",
      "first-page": "716",
      "DOI": "10.1530/acta.0.0870716",
      "article-title": "Growth hormone dependence of nonsuppressible insulin-like activity (NSILA) and of NSILA-carrier protein in rats",
      "volume": "87",
      "author": "Kaufmann",
      "year": "1978",
      "journal-title": "Acta Endocrinol (Kbh)"
    },
    {
      "key": "10.1016/0026-0495(78)90267-6_BIB61",
      "doi-asserted-by": "crossref",
      "first-page": "137",
      "DOI": "10.1038/263137a0",
      "article-title": "Specific binding of a somatomedin-like polypeptide in rat serum depends on growth hormone",
      "volume": "263",
      "author": "Moses",
      "year": "1976",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/0026-0495(78)90267-6_BIB62",
      "doi-asserted-by": "crossref",
      "first-page": "498",
      "DOI": "10.1530/acta.0.0860498",
      "article-title": "The influence of hypophysectomy on NSILA concentrations in the dog: Evidence for partially pituitary-independent regulation",
      "volume": "86",
      "author": "Eigenmann",
      "year": "1977",
      "journal-title": "Acta Endocrinol (Kbh)"
    },
    {
      "key": "10.1016/0026-0495(78)90267-6_BIB63",
      "doi-asserted-by": "crossref",
      "first-page": "1287",
      "DOI": "10.1016/S0140-6736(62)90845-0",
      "article-title": "Abnormalities of serum insulin-like activity in liver disease",
      "volume": "2",
      "author": "Samaan",
      "year": "1962",
      "journal-title": "Lancet"
    },
    {
      "key": "10.1016/0026-0495(78)90267-6_BIB64",
      "doi-asserted-by": "crossref",
      "first-page": "21",
      "DOI": "10.1007/BF01338711",
      "article-title": "Bildung eines insulinartigen Wirkstoffes in der isolierten Rattenleber",
      "volume": "1",
      "author": "Siess",
      "year": "1965",
      "journal-title": "Diabetologia"
    },
    {
      "issue": "Suppl 212",
      "key": "10.1016/0026-0495(78)90267-6_BIB65",
      "first-page": "100",
      "article-title": "Hormonal regulation of NSILA release from the isolated perfused rat liver",
      "volume": "85",
      "author": "Heinrich",
      "year": "1977",
      "journal-title": "Acta Endocrinol (Kbh)"
    },
    {
      "key": "10.1016/0026-0495(78)90267-6_BIB66",
      "doi-asserted-by": "crossref",
      "first-page": "1175",
      "DOI": "10.1210/jcem-44-6-1175",
      "article-title": "Adrenocortical carcinoma and hypoglycemia: Evidence for production of nonsuppressible insulin-like activity by the tumor",
      "volume": "44",
      "author": "Hyodo",
      "year": "1977",
      "journal-title": "J Clin Endocrinol Metab"
    },
    {
      "key": "10.1016/0026-0495(78)90267-6_BIB67",
      "doi-asserted-by": "crossref",
      "first-page": "330",
      "DOI": "10.1210/jcem-45-2-330",
      "article-title": "Lack of a simple relationship between endogenous growth hormone and NSILA-S related peptides",
      "volume": "45",
      "author": "Megyesi",
      "year": "1977",
      "journal-title": "J Clin Endocrinol Metab"
    },
    {
      "key": "10.1016/0026-0495(78)90267-6_BIB68",
      "first-page": "152",
      "article-title": "Genetic pituitary dwarfism with high serum concentration of growth hormone: A new inborn error of metabolism?",
      "volume": "2",
      "author": "Laron",
      "year": "1966",
      "journal-title": "Isr J Med Sci"
    },
    {
      "key": "10.1016/0026-0495(78)90267-6_BIB69",
      "first-page": "1247",
      "article-title": "Syndrome of familial dwarfism and high plasma immunoreactive growth hormone",
      "volume": "10",
      "author": "Laron",
      "year": "1974",
      "journal-title": "Isr J Med Sci"
    },
    {
      "key": "10.1016/0026-0495(78)90267-6_BIB70",
      "doi-asserted-by": "crossref",
      "first-page": "403",
      "DOI": "10.1210/jcem-42-2-403",
      "article-title": "Receptor-active growth hormone in Laron dwarfism",
      "volume": "42",
      "author": "Jacobs",
      "year": "1976",
      "journal-title": "J Clin Endocrinol Metab"
    },
    {
      "key": "10.1016/0026-0495(78)90267-6_BIB71",
      "doi-asserted-by": "crossref",
      "first-page": "107",
      "DOI": "10.1038/235107a0",
      "article-title": "Somatomedin: Proposed designation for sulfation factor",
      "volume": "235",
      "author": "Daughaday",
      "year": "1972",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/0026-0495(78)90267-6_BIB72",
      "first-page": "129",
      "article-title": "Defective sulfation factor generation: A possible etiological link in dwarfism",
      "volume": "82",
      "author": "Daughaday",
      "year": "1969",
      "journal-title": "Trans Assoc Am Physicians"
    },
    {
      "key": "10.1016/0026-0495(78)90267-6_BIB73",
      "doi-asserted-by": "crossref",
      "first-page": "613",
      "DOI": "10.1111/j.1651-2227.1975.tb03891.x",
      "article-title": "Increased immunoreactive plasma and urinary growth hormone in growth retardation with defective generation of somatomedin A. (Laron's syndrome)",
      "volume": "64",
      "author": "Kastrup",
      "year": "1975",
      "journal-title": "Acta Paediatr Scand"
    },
    {
      "key": "10.1016/0026-0495(78)90267-6_BIB74",
      "doi-asserted-by": "crossref",
      "first-page": "201",
      "DOI": "10.1159/000178730",
      "article-title": "Radioimmunoassay for nonsuppressible insulin-like activity",
      "volume": "7",
      "author": "Reber",
      "year": "1976",
      "journal-title": "Horm Res"
    },
    {
      "key": "10.1016/0026-0495(78)90267-6_BIB75",
      "doi-asserted-by": "crossref",
      "first-page": "648",
      "DOI": "10.1172/JCI108816",
      "article-title": "Estimation of somatomedin-C levels in normals and patients with pituitary disease by radioimmunoassay",
      "volume": "60",
      "author": "Furlanetto",
      "year": "1977",
      "journal-title": "J Clin Invest"
    },
    {
      "key": "10.1016/0026-0495(78)90267-6_BIB76",
      "doi-asserted-by": "crossref",
      "first-page": "20",
      "DOI": "10.1016/0304-4165(71)90050-X",
      "article-title": "Nonsuppressible insulin-like activity of human serum. VI. Difference between the action of insulin and that of precipitated nonsuppressible insulin-like activity on glycogen synthesis of rat adipose tissue and muscle",
      "volume": "230",
      "author": "Oelz",
      "year": "1971",
      "journal-title": "Biochim Biophys Acta"
    },
    {
      "key": "10.1016/0026-0495(78)90267-6_BIB77",
      "doi-asserted-by": "crossref",
      "first-page": "1455",
      "DOI": "10.1172/JCI108226",
      "article-title": "The purification and partial characterization of an insulin-like protein from human serum",
      "volume": "56",
      "author": "Poffenbarger",
      "year": "1975",
      "journal-title": "J Clin Invest"
    },
    {
      "key": "10.1016/0026-0495(78)90267-6_BIB78",
      "doi-asserted-by": "crossref",
      "first-page": "994",
      "DOI": "10.2337/diab.25.10.994",
      "article-title": "Current concepts of somatomedin and other biologically related growth factors",
      "volume": "25",
      "author": "Cochinov",
      "year": "1976",
      "journal-title": "Diabetes"
    },
    {
      "key": "10.1016/0026-0495(78)90267-6_BIB79",
      "doi-asserted-by": "crossref",
      "first-page": "665",
      "DOI": "10.1038/270665a0",
      "article-title": "Somatomedins and related growth factors",
      "volume": "270",
      "author": "Rechler",
      "year": "1977",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/0026-0495(78)90267-6_BIB80",
      "first-page": "733",
      "article-title": "Sulfation factor, a serum component mediating the action of growth hormone in stimulating incorporation of sulfate into cartilage",
      "volume": "35",
      "author": "Salmon",
      "year": "1956",
      "journal-title": "J Clin Invest"
    },
    {
      "key": "10.1016/0026-0495(78)90267-6_BIB81",
      "first-page": "825",
      "article-title": "A hormonally controlled serum factor which stimulates sulfate incorporation by cartilage in vitro",
      "volume": "49",
      "author": "Salmon",
      "year": "1957",
      "journal-title": "J Lab Clin Med"
    },
    {
      "key": "10.1016/0026-0495(78)90267-6_BIB82",
      "first-page": "357",
      "article-title": "Synchronous activation of DNA synthesis in hypophysectomized rat cartilage by growth hormone",
      "volume": "68",
      "author": "Daughaday",
      "year": "1966",
      "journal-title": "J Lab Clin Med"
    },
    {
      "key": "10.1016/0026-0495(78)90267-6_BIB83",
      "doi-asserted-by": "crossref",
      "first-page": "1168",
      "DOI": "10.1210/endo-87-6-1168",
      "article-title": "In vitro stimulation of leucine incorporation into muscle and cartilage protein by a serum fraction with sulfation factor activity: Differentiation of effects from those of growth hormone and insulin",
      "volume": "87",
      "author": "Salmon",
      "year": "1970",
      "journal-title": "Endocrinology"
    },
    {
      "key": "10.1016/0026-0495(78)90267-6_BIB84",
      "first-page": "22",
      "article-title": "Human somatomedin. Biological properties of somatomedin with special emphasis on the influence of somatomedin on glucose uptake",
      "volume": "163",
      "author": "Hall",
      "year": "1972",
      "journal-title": "Acta Endocrinol (Kbh)"
    },
    {
      "key": "10.1016/0026-0495(78)90267-6_BIB85",
      "doi-asserted-by": "crossref",
      "first-page": "194",
      "DOI": "10.1210/jcem-35-2-194",
      "article-title": "Human somatomedin, the growth hormone-dependent sulfation factor, is antilipolytic",
      "volume": "35",
      "author": "Underwood",
      "year": "1972",
      "journal-title": "J Clin Endocrinol Metab"
    },
    {
      "key": "10.1016/0026-0495(78)90267-6_BIB86",
      "doi-asserted-by": "crossref",
      "first-page": "988",
      "DOI": "10.1210/jcem-45-5-988",
      "article-title": "Demonstration of specific plasma protein binding sites for somatomedin",
      "volume": "45",
      "author": "Hintz",
      "year": "1977",
      "journal-title": "J Clin Endocrinol Metab"
    },
    {
      "key": "10.1016/0026-0495(78)90267-6_BIB87",
      "first-page": "65",
      "article-title": "Chemistry and biology of the somatomedins",
      "volume": "vol 48",
      "author": "Fryklund",
      "year": "1977"
    },
    {
      "key": "10.1016/0026-0495(78)90267-6_BIB88",
      "first-page": "45",
      "article-title": "Biological effects and receptor binding of nonsuppressible insulin-like activity (NSILA)",
      "volume": "vol. 48",
      "author": "Zapf",
      "year": "1977"
    },
    {
      "key": "10.1016/0026-0495(78)90267-6_BIB89",
      "first-page": "59",
      "article-title": "Receptor binding and biological effects of somatomedin A in vitro",
      "volume": "vol. 48",
      "author": "Hall",
      "year": "1977"
    },
    {
      "key": "10.1016/0026-0495(78)90267-6_BIB90",
      "doi-asserted-by": "crossref",
      "first-page": "127",
      "DOI": "10.1016/B978-0-12-027308-9.50015-9",
      "article-title": "Explorations of the insulin-like and growth-promoting properties of somatomedin by membrane receptor assays",
      "volume": "8",
      "author": "Van Wyk",
      "year": "1975",
      "journal-title": "Adv Metab Disord"
    },
    {
      "key": "10.1016/0026-0495(78)90267-6_BIB91",
      "series-title": "Research Conference",
      "article-title": "Multiplication stimulating activity (MSA): A somatomedin-like peptide from cultured rat liver cells",
      "author": "Nissley",
      "year": "1976"
    },
    {
      "key": "10.1016/0026-0495(78)90267-6_BIB92",
      "series-title": "60th Meeting of the American Endocrine Society",
      "article-title": "Demonstration by radioimmunoassay of multiplication stimulating activity (MSA) in rat serum",
      "author": "Moses",
      "year": "1978"
    }
  ],
  "container-title": "Metabolism",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.elsevier.com/content/article/PII:0026049578902676?httpAccept=text/xml",
      "content-type": "text/xml",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://api.elsevier.com/content/article/PII:0026049578902676?httpAccept=text/plain",
      "content-type": "text/plain",
      "content-version": "vor",
      "intended-application": "text-mining"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2022,
        6,
        21
      ]
    ],
    "date-time": "2022-06-21T18:29:41Z",
    "timestamp": 1655836181000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://linkinghub.elsevier.com/retrieve/pii/0026049578902676"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1978,
        12
      ]
    ]
  },
  "references-count": 92,
  "journal-issue": {
    "issue": "12",
    "published-print": {
      "date-parts": [
        [
          1978,
          12
        ]
      ]
    }
  },
  "alternative-id": [
    "0026049578902676"
  ],
  "URL": "http://dx.doi.org/10.1016/0026-0495(78)90267-6",
  "relation": {},
  "ISSN": [
    "0026-0495"
  ],
  "subject": [],
  "container-title-short": "Metabolism",
  "published": {
    "date-parts": [
      [
        1978,
        12
      ]
    ]
  }
}