DOI: 10.1016/0014-5793(96)00811-3. ROCK‐I and ROCK‐II, two isoforms of Rho‐associated coiled‐coil forming protein serine/threonine kinase in mice

ROCK‐I and ROCK‐II, two isoforms of Rho‐associated coiled‐coil forming protein serine/threonine kinase in mice

10.1016/0014-5793(96)00811-3

Crossref journal-article

Wiley

FEBS Letters (311)

Abstract

We recently identified a novel human protein kinase, p160 ROCK, as a putative downstream target of the small GTPase Rho. Using the human ROCK cDNA as a probe, we isolated cDNA of two distinct, highly related sequences from mouse libraries. One encoded a mouse counterpart of human ROCK (ROCK‐I), and the other encoded a novel ROCK‐related kinase (ROCK‐II). Like ROCK/ROCK‐I, ROCK‐II also bound to GTP‐Rho selectively. ROCK‐I mRNA was ubiquitously expressed except in the brain and muscle, whereas ROCK‐II mRNA was expressed abundantly in the brain, muscle, heart, lung and placenta. These results suggest that at least two ROCK isoforms are present in a single species and play distinct roles in Rho‐mediated signalling pathways.

Bibliography

Nakagawa, O., Fujisawa, K., Ishizaki, T., Saito, Y., Nakao, K., & Narumiya, S. (1996). ROCKâI and ROCKâII, two isoforms of Rhoâassociated coiledâcoil forming protein serine/threonine kinase in mice. FEBS Letters, 392(2), 189â193. Portico.

Authors 6

Osamu Nakagawa (first)
Kazuko Fujisawa (additional)
Toshimasa Ishizaki (additional)
Yuji Saito (additional)
Kazuwa Nakao (additional)
Shuh Narumiya (additional)

References 21 Referenced 663

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Dates

Type	When
Created	22 years, 4 months ago (April 30, 2003, 6:24 p.m.)
Deposited	1 year, 11 months ago (Sept. 16, 2023, 6:11 a.m.)
Indexed	13 hours, 27 minutes ago (Sept. 3, 2025, 7:05 a.m.)
Issued	29 years ago (Aug. 26, 1996)
Published	29 years ago (Aug. 26, 1996)
Published Online	25 years, 9 months ago (Nov. 30, 1999)
Published Print	29 years ago (Aug. 26, 1996)

Funders 0

None

BibTeX

@article{Nakagawa_1996, title={ROCK‐I and ROCK‐II, two isoforms of Rho‐associated coiled‐coil forming protein serine/threonine kinase in mice}, volume={392}, ISSN={1873-3468}, url={http://dx.doi.org/10.1016/0014-5793(96)00811-3}, DOI={10.1016/0014-5793(96)00811-3}, number={2}, journal={FEBS Letters}, publisher={Wiley}, author={Nakagawa, Osamu and Fujisawa, Kazuko and Ishizaki, Toshimasa and Saito, Yuji and Nakao, Kazuwa and Narumiya, Shuh}, year={1996}, month=aug, pages={189–193} }

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