DOI: 10.1016/0014-5793(96)00157-3. Multiple transduction pathways regulate the sodium‐extrusion gene <i>PMR2/ENA1</i> during salt stress in yeast

Multiple transduction pathways regulate the sodium‐extrusion gene PMR2/ENA1 during salt stress in yeast

10.1016/0014-5793(96)00157-3

Crossref journal-article

Wiley

FEBS Letters (311)

Abstract

The yeast PMR2/ENA1 gene encodes an ATPase involved in sodium extrusion and induced by NaCl. At low salt concentration (0.3 M) induction is mediated by the HOG‐MAP kinase pathway, a system activated by non‐specific osmotic stress. At high salt concentrations (0.8 M) induction is mediated by the protein phosphatase calcineurin and is specific for sodium. Protein kinase A and Sis2p/Hal3p modulate PMR2/ENA1 expression as negative and positive factors, respectively but Sis2p/Hal3p does not participate in the transduction of the salt signal. Salt stress decreases the level of cAMP and the resulting decrease in protein kinase A activity may contribute to HOG‐mediated induction.

Bibliography

MÃ¤rquez, J., & Serrano, R. (1996). Multiple transduction pathways regulate the sodiumâextrusion gene PMR2/ENA1 during salt stress in yeast. FEBS Letters, 382(1â2), 89â92. Portico.

Authors 2

JoséA Märquez (first)
Ramón Serrano (additional)

References 24 Referenced 112

{'key': 'e_1_2_1_2_1', 'first-page': '3', 'volume-title': 'Biochemical and Cellular Mechanisms of Stress Tolerance in Plants', 'author': 'Nover L', 'year': '1993'} / Biochemical and Cellular Mechanisms of Stress Tolerance in Plants by Nover L (1993)
10.1016/S0074-7696(08)62219-6
10.1126/science.218.4571.443
10.1016/0014-5793(91)81280-L
10.1128/MCB.14.6.4135
10.1126/science.7681220
10.1002/j.1460-2075.1994.tb06758.x
10.1016/S0021-9258(17)37038-2
10.1002/j.1460-2075.1993.tb06090.x
10.1128/MCB.15.10.5470
10.1002/yea.320101308
10.1016/0076-6879(91)94004-V
10.1101/gad.1.9.931
10.1016/0076-6879(91)94015-5
10.1016/0968-0004(93)90069-Y
10.1002/j.1460-2075.1992.tb05392.x
10.1111/j.1365-2958.1995.mmi_17040653.x
10.1104/pp.90.4.1271
10.1016/S0021-9258(19)47061-0
10.1016/S0021-9258(19)50037-0
10.1002/j.1460-2075.1994.tb06467.x
10.1128/MCB.13.1.248
10.1002/j.1460-2075.1993.tb05849.x
10.1002/j.1460-2075.1994.tb06720.x

Dates

Type	When
Created	23 years, 1 month ago (July 25, 2002, 1:55 p.m.)
Deposited	1 year, 11 months ago (Sept. 17, 2023, 3:58 a.m.)
Indexed	1 month ago (Aug. 1, 2025, 11:59 p.m.)
Issued	29 years, 5 months ago (March 11, 1996)
Published	29 years, 5 months ago (March 11, 1996)
Published Online	25 years, 9 months ago (Nov. 30, 1999)
Published Print	29 years, 5 months ago (March 11, 1996)

Funders 0

None

BibTeX

@article{M_rquez_1996, title={Multiple transduction pathways regulate the sodium‐extrusion gene PMR2/ENA1 during salt stress in yeast}, volume={382}, ISSN={1873-3468}, url={http://dx.doi.org/10.1016/0014-5793(96)00157-3}, DOI={10.1016/0014-5793(96)00157-3}, number={1–2}, journal={FEBS Letters}, publisher={Wiley}, author={Märquez, JoséA and Serrano, Ramón}, year={1996}, month=mar, pages={89–92} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        8,
        2
      ]
    ],
    "date-time": "2025-08-02T03:59:36Z",
    "timestamp": 1754107176176
  },
  "reference-count": 24,
  "publisher": "Wiley",
  "issue": "1-2",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            1999,
            11,
            30
          ]
        ],
        "date-time": "1999-11-30T00:00:00Z",
        "timestamp": 943920000000
      },
      "content-version": "vor",
      "delay-in-days": 1359,
      "URL": "http://onlinelibrary.wiley.com/termsAndConditions#vor"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        1996,
        3,
        11
      ]
    ]
  },
  "abstract": "<jats:p>The yeast <jats:italic>PMR2/ENA1</jats:italic> gene encodes an ATPase involved in sodium extrusion and induced by NaCl. At low salt concentration (0.3 M) induction is mediated by the HOG\u2010MAP kinase pathway, a system activated by non\u2010specific osmotic stress. At high salt concentrations (0.8 M) induction is mediated by the protein phosphatase calcineurin and is specific for sodium. Protein kinase A and Sis2p/Hal3p modulate <jats:italic>PMR2/ENA1</jats:italic> expression as negative and positive factors, respectively but Sis2p/Hal3p does not participate in the transduction of the salt signal. Salt stress decreases the level of cAMP and the resulting decrease in protein kinase A activity may contribute to HOG\u2010mediated induction.</jats:p>",
  "DOI": "10.1016/0014-5793(96)00157-3",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2002,
        7,
        25
      ]
    ],
    "date-time": "2002-07-25T17:55:22Z",
    "timestamp": 1027619722000
  },
  "page": "89-92",
  "source": "Crossref",
  "is-referenced-by-count": 112,
  "title": "Multiple transduction pathways regulate the sodium\u2010extrusion gene <i>PMR2/ENA1</i> during salt stress in yeast",
  "prefix": "10.1002",
  "volume": "382",
  "author": [
    {
      "given": "Jos\u00e9A",
      "family": "M\u00e4rquez",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Ram\u00f3n",
      "family": "Serrano",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "311",
  "published-online": {
    "date-parts": [
      [
        1999,
        11,
        30
      ]
    ]
  },
  "reference": [
    {
      "key": "e_1_2_1_2_1",
      "first-page": "3",
      "volume-title": "Biochemical and Cellular Mechanisms of Stress Tolerance in Plants",
      "author": "Nover L",
      "year": "1993"
    },
    {
      "key": "e_1_2_1_3_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0074-7696(08)62219-6"
    },
    {
      "key": "e_1_2_1_4_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.218.4571.443"
    },
    {
      "key": "e_1_2_1_5_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0014-5793(91)81280-L"
    },
    {
      "key": "e_1_2_1_6_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/MCB.14.6.4135"
    },
    {
      "key": "e_1_2_1_7_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.7681220"
    },
    {
      "key": "e_1_2_1_8_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/j.1460-2075.1994.tb06758.x"
    },
    {
      "key": "e_1_2_1_9_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0021-9258(17)37038-2"
    },
    {
      "key": "e_1_2_1_10_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/j.1460-2075.1993.tb06090.x"
    },
    {
      "key": "e_1_2_1_11_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/MCB.15.10.5470"
    },
    {
      "key": "e_1_2_1_12_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/yea.320101308"
    },
    {
      "key": "e_1_2_1_13_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0076-6879(91)94004-V"
    },
    {
      "key": "e_1_2_1_14_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1101/gad.1.9.931"
    },
    {
      "key": "e_1_2_1_15_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0076-6879(91)94015-5"
    },
    {
      "key": "e_1_2_1_16_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0968-0004(93)90069-Y"
    },
    {
      "key": "e_1_2_1_17_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/j.1460-2075.1992.tb05392.x"
    },
    {
      "key": "e_1_2_1_18_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1111/j.1365-2958.1995.mmi_17040653.x"
    },
    {
      "key": "e_1_2_1_19_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1104/pp.90.4.1271"
    },
    {
      "key": "e_1_2_1_20_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0021-9258(19)47061-0"
    },
    {
      "key": "e_1_2_1_21_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0021-9258(19)50037-0"
    },
    {
      "key": "e_1_2_1_22_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/j.1460-2075.1994.tb06467.x"
    },
    {
      "key": "e_1_2_1_23_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/MCB.13.1.248"
    },
    {
      "key": "e_1_2_1_24_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/j.1460-2075.1993.tb05849.x"
    },
    {
      "key": "e_1_2_1_25_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/j.1460-2075.1994.tb06720.x"
    }
  ],
  "container-title": "FEBS Letters",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1016%2F0014-5793%2896%2900157-3",
      "content-type": "application/pdf",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1016%2F0014-5793(96)00157-3",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://febs.onlinelibrary.wiley.com/doi/pdf/10.1016/0014-5793%2896%2900157-3",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2023,
        9,
        17
      ]
    ],
    "date-time": "2023-09-17T07:58:55Z",
    "timestamp": 1694937535000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://febs.onlinelibrary.wiley.com/doi/10.1016/0014-5793%2896%2900157-3"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1996,
        3,
        11
      ]
    ]
  },
  "references-count": 24,
  "journal-issue": {
    "issue": "1-2",
    "published-print": {
      "date-parts": [
        [
          1996,
          3,
          11
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1016/0014-5793(96)00157-3"
  ],
  "URL": "http://dx.doi.org/10.1016/0014-5793(96)00157-3",
  "relation": {},
  "ISSN": [
    "0014-5793",
    "1873-3468"
  ],
  "subject": [],
  "container-title-short": "FEBS Letters",
  "published": {
    "date-parts": [
      [
        1996,
        3,
        11
      ]
    ]
  }
}