DOI: 10.1016/0014-5793(96)00151-2. A calcium switch for the functional coupling between α (hslo) and β subunits (KV, Caβ) of maxi K channels

A calcium switch for the functional coupling between α (hslo) and β subunits (KV, Caβ) of maxi K channels

10.1016/0014-5793(96)00151-2

Crossref journal-article

Wiley

FEBS Letters (311)

Abstract

K V , Ca β subunit dramatically increases the apparent calcium sensitivity of the α subunit of MaxlK channels when probed in the micromolar [Ca2+]i range. Analysis in a wide range of [Ca2+]i revealed that this functional coupling is exquisitely modulated by [Ca2+]i. Ca2+ ions switch MaxiK α+β complex into a functionally coupled state at concentrations beyond resting [Ca2+]i. At [Ca2+] ≤ 100 nM, MaxiK activity becomes independent of Ca2+, is purely voltage‐activated, and its functional coupling with its β subunit is released. The functional switch develops at [Ca2+]i that occur during cellular excitation, providing the molecular basis of how MaxiK channels regulate smooth muscle excitability and neurotransmitter release.

Bibliography

Meera, P., Wallner, M., Jiang, Z., & Toro, L. (1996). A calcium switch for the functional coupling between Î± (hslo) and Î² subunits (KV, CaÎ²) of maxi K channels. FEBS Letters, 382(1â2), 84â88. Portico.

Authors 4

P Meera (first)
M Wallner (additional)
Z Jiang (additional)
L Toro (additional)

References 14 Referenced 183

10.1016/0896-6273(92)90160-F
10.1016/S0021-9258(17)32551-6
10.1016/0896-6273(95)90321-6
{'key': 'e_1_2_1_5_1', 'first-page': '185', 'volume': '3', 'author': 'Wallner M', 'year': '1995', 'journal-title': 'Receptors Channels'} / Receptors Channels by Wallner M (1995)
10.1038/369289a0
10.1016/0092-8674(95)90279-1
10.1016/0076-6879(88)57093-3
10.1016/S0021-9258(17)41720-0
10.1126/science.270.5236.633
10.1126/science.1350109
10.1242/jeb.124.1.5
10.1085/jgp.82.4.511
10.1113/jphysiol.1991.sp018861
10.1126/science.8211185

Dates

Type	When
Created	23 years, 1 month ago (July 25, 2002, 3:16 p.m.)
Deposited	1 year, 11 months ago (Sept. 17, 2023, 3:59 a.m.)
Indexed	1 month ago (Aug. 2, 2025, 12:27 a.m.)
Issued	29 years, 5 months ago (March 11, 1996)
Published	29 years, 5 months ago (March 11, 1996)
Published Online	25 years, 9 months ago (Nov. 30, 1999)
Published Print	29 years, 5 months ago (March 11, 1996)

Funders 0

None

BibTeX

@article{Meera_1996, title={A calcium switch for the functional coupling between α (hslo) and β subunits (KV, Caβ) of maxi K channels}, volume={382}, ISSN={1873-3468}, url={http://dx.doi.org/10.1016/0014-5793(96)00151-2}, DOI={10.1016/0014-5793(96)00151-2}, number={1–2}, journal={FEBS Letters}, publisher={Wiley}, author={Meera, P and Wallner, M and Jiang, Z and Toro, L}, year={1996}, month=mar, pages={84–88} }

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