DOI: 10.1016/0014-5793(94)80501-6. Identification of the 23 kDa subunit of tau protein kinase II as a putative activator of cdk5 in bovine brain

Identification of the 23 kDa subunit of tau protein kinase II as a putative activator of cdk5 in bovine brain

10.1016/0014-5793(94)80501-6

Crossref journal-article

Wiley

FEBS Letters (311)

Abstract

Tau protein kinase II (TPKII) was reported previously to be composed of a neuron‐rich cdc2‐related kinase (PSSALRE/cdk5) and 23 kDa subunit. Here we show that the 23 kDa subunit is a putative activator for the kinase activity. Amino acid sequence analysis revealed that the protein was novel and included a partial similarity of amino acids to a cyclin box important for the interaction with cdc2‐related kinase. These results suggest that the 23 kDa subunit, but not cyclin, activates cdk5 in neuronal cells, which no longer exhibit cell cycling but are terminally differentiated cells.

Bibliography

Ishiguro, K., Kobayashi, S., Onion, A., Takamatsu, M., Yonekura, S., Anzai, K., Imahori, K., & Uchida, T. (1994). Identification of the 23 kDa subunit of tau protein kinase II as a putative activator of cdk5 in bovine brain. FEBS Letters, 342(2), 203â208. Portico.

Authors 8

Koichi Ishiguro (first)
Shunsuke Kobayashi (additional)
Akira Onion (additional)
Masako Takamatsu (additional)
Sayuri Yonekura (additional)
Kaijiro Anzai (additional)
Kazutomo Imahori (additional)
Tsuneko Uchida (additional)

References 35 Referenced 120

Dates

Type	When
Created	23 years, 1 month ago (July 25, 2002, 5:09 a.m.)
Deposited	1 year, 11 months ago (Sept. 16, 2023, 8:14 a.m.)
Indexed	1 month, 4 weeks ago (July 7, 2025, 2:27 a.m.)
Issued	31 years, 5 months ago (April 4, 1994)
Published	31 years, 5 months ago (April 4, 1994)
Published Online	23 years, 8 months ago (Dec. 5, 2001)
Published Print	31 years, 5 months ago (April 4, 1994)

Funders 0

None

BibTeX

@article{Ishiguro_1994, title={Identification of the 23 kDa subunit of tau protein kinase II as a putative activator of cdk5 in bovine brain}, volume={342}, ISSN={1873-3468}, url={http://dx.doi.org/10.1016/0014-5793(94)80501-6}, DOI={10.1016/0014-5793(94)80501-6}, number={2}, journal={FEBS Letters}, publisher={Wiley}, author={Ishiguro, Koichi and Kobayashi, Shunsuke and Onion, Akira and Takamatsu, Masako and Yonekura, Sayuri and Anzai, Kaijiro and Imahori, Kazutomo and Uchida, Tsuneko}, year={1994}, month=apr, pages={203–208} }

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