DOI: 10.1016/0014-5793(94)01328-x. Molecular cloning of an orphan transporter A new member of the neurotransmitter transporter family

Molecular cloning of an orphan transporter A new member of the neurotransmitter transporter family

10.1016/0014-5793(94)01328-x

Crossref journal-article

Wiley

FEBS Letters (311)

Abstract

A complementary DNA clone predicted to encode a novel transporter was isolated from rat brain and the localization of its mRNA was examined. The cDNA, designated rB21a, predicts a protein with 12 putative transmembrane domains that exhibits significant sequence homology with neurotransmitter transporters. Expression studies have not yet identified the endogenous substrate for this transporter, but the presence of rB21a mRNA within the leptomeninges of the brain suggests the transporter may regulate CSF levels of its substrate. The cloning of rB21a provides the means to determine its physiological functions and the potential to design novel, transporter‐based therapeutic agents for neurological and psychiatric disorders.

Bibliography

Smith, K. E., Fried, S. G., Durkin, M. M., Gustafson, E. L., Borden, L. A., Branchek, T. A., & Weinshank, R. L. (1995). Molecular cloning of an orphan transporter A new member of the neurotransmitter transporter family. FEBS Letters, 357(1), 86â92. Portico.

Authors 7

Kelli E. Smith (first)
Steven G. Fried (additional)
Margaret M. Durkin (additional)
Eric L. Gustafson (additional)
Laurence A. Borden (additional)
Theresa A. Branchek (additional)
Richard L. Weinshank (additional)

References 38 Referenced 30

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Dates

Type	When
Created	22 years, 3 months ago (May 19, 2003, 1:32 p.m.)
Deposited	1 year, 11 months ago (Sept. 15, 2023, 9:01 p.m.)
Indexed	1 year, 8 months ago (Dec. 23, 2023, 2:58 a.m.)
Issued	30 years, 8 months ago (Jan. 2, 1995)
Published	30 years, 8 months ago (Jan. 2, 1995)
Published Online	25 years, 6 months ago (Feb. 23, 2000)
Published Print	30 years, 8 months ago (Jan. 2, 1995)

Funders 0

None

BibTeX

@article{Smith_1995, title={Molecular cloning of an orphan transporter A new member of the neurotransmitter transporter family}, volume={357}, ISSN={1873-3468}, url={http://dx.doi.org/10.1016/0014-5793(94)01328-x}, DOI={10.1016/0014-5793(94)01328-x}, number={1}, journal={FEBS Letters}, publisher={Wiley}, author={Smith, Kelli E. and Fried, Steven G. and Durkin, Margaret M. and Gustafson, Eric L. and Borden, Laurence A. and Branchek, Theresa A. and Weinshank, Richard L.}, year={1995}, month=jan, pages={86–92} }

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