DOI: 10.1016/0014-5793(94)01256-3. Is Zn<sup>2+</sup> transported by the mitochondrial calcium uniporter?

Is Zn2+ transported by the mitochondrial calcium uniporter?

10.1016/0014-5793(94)01256-3

Crossref journal-article

Wiley

FEBS Letters (311)

Abstract

Zinc ions were found to inhibit Ca2+ uptake by rat liver mitochondria driven by succinate respiration but not that by a valinomycin‐induced membrane potential. Zn2+ at 1 μM or higher concentrations induced a lowering of the membrane potential under the former but not the latter conditions. It is concluded that it is the lowered membrane potential in the presence of Zn2+ that reduces the rate of respiration‐driven Ca2+. Ruthenium red was found to inhibit the uptake of Zn2+ but had no influence on its action upon the membrane potential. Zn2+ did not affect the Ruthenium red‐insensitive Ca2+ efflux. Ca2+ stimulated the uptake of Zn2+. It is concluded that Zn2+ may be transported by the mitochondrial calcium uniporter but that it may have access to sites required for inhibition of respiration by other routes.

Bibliography

Saris, N.-E. L., & Niva, K. (1994). Is Zn2+ transported by the mitochondrial calcium uniporter? FEBS Letters, 356(2â3), 195â198. Portico.

Authors 2

Nils-Erik L. Saris (first)
Kaija Niva (additional)

References 22 Referenced 63

10.1248/cpb.29.2370
10.1016/0006-2952(82)90018-1
10.1016/0009-2797(89)90085-9
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10.1016/0014-5793(72)80802-0
10.1016/0003-9861(74)90148-9
10.1016/0006-291X(67)90242-2
10.1016/S0021-9258(18)99541-4
10.1021/bi00864a035
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10.1002/jcp.1040820213
10.1016/B978-0-12-152510-1.50010-9
{'key': 'e_1_2_1_15_1', 'volume-title': 'CRC Handbook of Chemistry and Physics', 'year': '1979'} / CRC Handbook of Chemistry and Physics (1979)
10.1016/0013-9351(80)90133-4
10.1016/0005-2728(85)90123-9
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10.1007/BF00762847

Dates

Type	When
Created	23 years, 1 month ago (July 25, 2002, 3:57 a.m.)
Deposited	1 year, 11 months ago (Sept. 15, 2023, 10:23 p.m.)
Indexed	1 year, 1 month ago (July 15, 2024, 7:18 a.m.)
Issued	30 years, 8 months ago (Dec. 19, 1994)
Published	30 years, 8 months ago (Dec. 19, 1994)
Published Online	23 years, 10 months ago (Oct. 19, 2001)
Published Print	30 years, 8 months ago (Dec. 19, 1994)

Funders 0

None

BibTeX

@article{Saris_1994, title={Is Zn2+ transported by the mitochondrial calcium uniporter?}, volume={356}, ISSN={1873-3468}, url={http://dx.doi.org/10.1016/0014-5793(94)01256-3}, DOI={10.1016/0014-5793(94)01256-3}, number={2–3}, journal={FEBS Letters}, publisher={Wiley}, author={Saris, Nils-Erik L. and Niva, Kaija}, year={1994}, month=dec, pages={195–198} }

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