DOI: 10.1016/0014-5793(94)01161-3. p53 expression in nitric oxide‐induced apoptosis

p53 expression in nitric oxide‐induced apoptosis

10.1016/0014-5793(94)01161-3

Crossref journal-article

Wiley

FEBS Letters (311)

Abstract

Nitric oxide (NO) is a diffusible messenger involved in several patho‐physiological processes including immune‐mediated cytotoxicity and neural cell killing. NO or the products of its redox chemistry can cause DNA damage and activate subsequent lethal reactions including energy depletion and cell necrosis. However, regardless of whether it is endogenously produced in response to cytokines, or generated by chemical breakdown of donor molecules, NO can also induce apoptosis in different systems. Here, we report that NO generation in response to a cytokine induced NO‐synthase or by NO donors stimulates the expression of the tumor suppressor gene, p53, in RAW 264.7 macrophages or pancreatic RINm5F cells prior to apoptosis. NO‐synthase inhibitors such as N G‐monomethyl‐l‐arginine prevent the inducible NO generation as well as p53 expression and apoptosis. Since p53 expression is linked to apoptosis in some cells exposed to DNA damaging agents, we suggest that NO‐induced apoptosis in these cell systems is the consequence of DNA damage and subsequent expression of this tumor suppressor gene.

Bibliography

MeÃmer, U. K., Ankarcrona, M., Nicotera, P., & BrÃ¼ne, B. (1994). p53 expression in nitric oxideâinduced apoptosis. FEBS Letters, 355(1), 23â26. Portico.

Authors 4

Udo K. Meßmer (first)
Maria Ankarcrona (additional)
Pierluigi Nicotera (additional)
Bernhard Brüne (additional)

References 30 Referenced 319

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Dates

Type	When
Created	23 years, 1 month ago (July 25, 2002, 3:57 a.m.)
Deposited	1 year, 11 months ago (Sept. 16, 2023, 8:21 p.m.)
Indexed	1 month, 2 weeks ago (July 11, 2025, 6:13 a.m.)
Issued	30 years, 9 months ago (Nov. 21, 1994)
Published	30 years, 9 months ago (Nov. 21, 1994)
Published Online	23 years, 10 months ago (Oct. 18, 2001)
Published Print	30 years, 9 months ago (Nov. 21, 1994)

Funders 0

None

BibTeX

@article{Me_mer_1994, title={p53 expression in nitric oxide‐induced apoptosis}, volume={355}, ISSN={1873-3468}, url={http://dx.doi.org/10.1016/0014-5793(94)01161-3}, DOI={10.1016/0014-5793(94)01161-3}, number={1}, journal={FEBS Letters}, publisher={Wiley}, author={Meßmer, Udo K. and Ankarcrona, Maria and Nicotera, Pierluigi and Brüne, Bernhard}, year={1994}, month=nov, pages={23–26} }

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