DOI: 10.1016/0014-5793(94)00958-9. The sevenmaker gain‐of‐function mutation in p42 MAP kinase leads to enhanced signalling and reduced sensitivity to dual specificity phosphatase action

The sevenmaker gain‐of‐function mutation in p42 MAP kinase leads to enhanced signalling and reduced sensitivity to dual specificity phosphatase action

10.1016/0014-5793(94)00958-9

Crossref journal-article

Wiley

FEBS Letters (311)

Abstract

A mammalian mutant MAP kinase, D319N ERK2, analogous to Drosophila melanogaster sevenmaker (rlsem) gain‐of‐function mutation was shown to have an increased sensitivity to low levels of signalling in vivo. However, the mutation does not lead to an elevated basal kinase activity and still requires activation by MAP kinase kinase (MAPKK) as does wild type ERK2. This increased responsiveness seen in vivo is not due to an increased ability to phosphorylate substrates but appears to reflect a reduced sensitivity to a MAP kinase phosphatase CL100.

Bibliography

Bott, C. M., Thorneycroft, S. G., & Marshall, C. J. (1994). The sevenmaker gainâofâfunction mutation in p42 MAP kinase leads to enhanced signalling and reduced sensitivity to dual specificity phosphatase action. FEBS Letters, 352(2), 201â205. Portico.

Authors 3

Cynthia M. Bott (first)
Simon G. Thorneycroft (additional)
Christopher J. Marshall (additional)

References 43 Referenced 87

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Dates

Type	When
Created	23 years, 1 month ago (July 25, 2002, 5:09 a.m.)
Deposited	1 year, 11 months ago (Sept. 17, 2023, 1:48 a.m.)
Indexed	1 month, 4 weeks ago (July 2, 2025, 11:57 a.m.)
Issued	30 years, 11 months ago (Sept. 26, 1994)
Published	30 years, 11 months ago (Sept. 26, 1994)
Published Online	23 years, 10 months ago (Oct. 19, 2001)
Published Print	30 years, 11 months ago (Sept. 26, 1994)

Funders 0

None

BibTeX

@article{Bott_1994, title={The sevenmaker gain‐of‐function mutation in p42 MAP kinase leads to enhanced signalling and reduced sensitivity to dual specificity phosphatase action}, volume={352}, ISSN={1873-3468}, url={http://dx.doi.org/10.1016/0014-5793(94)00958-9}, DOI={10.1016/0014-5793(94)00958-9}, number={2}, journal={FEBS Letters}, publisher={Wiley}, author={Bott, Cynthia M. and Thorneycroft, Simon G. and Marshall, Christopher J.}, year={1994}, month=sep, pages={201–205} }

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