DOI: 10.1016/0014-5793(94)00615-6. Mitochondrial calcium spiking: A transduction mechanism based on calcium‐induced permeability transition involved in cell calcium signalling

Mitochondrial calcium spiking: A transduction mechanism based on calcium‐induced permeability transition involved in cell calcium signalling

10.1016/0014-5793(94)00615-6

Crossref journal-article

Wiley

FEBS Letters (311)

Abstract

We report reversible Ca2+‐induced Ca2+ release from mitochondria, which takes the form of Ca2+ spikes. Mitochondrial Ca2+ spiking is an all‐or‐none process with a threshold dependence on both the frequency and the amplitude of the Ca2+ pulses used as stimuli. This spiking relies on the transient operation of the mitochondrial permeability transition pore, and is initiated — in a threshold‐dependent manner — with inositol‐triphosphate‐mediated Ca2+ responses in permeabilized cells. Evidence that mitochondrial Ca2+‐induced Ca2+ release contributes to inositol‐triphosphate‐mediated Ca2+ responses in intact cells is also reported.

Bibliography

Ichas, F., Jouaville, L. S., Sidash, S. S., Mazat, J.-P., & Holmuhamedov, E. L. (1994). Mitochondrial calcium spiking: A transduction mechanism based on calciumâinduced permeability transition involved in cell calcium signalling. FEBS Letters, 348(2), 211â215. Portico.

Authors 5

François Ichas (first)
Laurence S. Jouaville (additional)
Sergueï S. Sidash (additional)
Jean-Pierre Mazat (additional)
Ekhson L. Holmuhamedov (additional)

References 13 Referenced 126

10.1038/341197a0
10.1038/361315a0
10.1016/0092-8674(92)90409-6
10.1152/ajpcell.1990.258.5.C755
10.1126/science.8235595
{'key': 'e_1_2_1_7_1', 'first-page': '612', 'volume': '6', 'author': 'Holmuhamedov E.L.', 'year': '1991', 'journal-title': 'Biologicheskie Membrany'} / Biologicheskie Membrany by Holmuhamedov E.L. (1991)
10.1016/0143-4160(94)90053-1
10.1016/S0021-9258(18)51025-5
10.1016/0003-9861(86)90192-X
10.1042/bj2920019
10.1016/S0021-9258(18)54034-5
10.1007/BF00769537
10.1016/S0021-9258(18)89421-2

Dates

Type	When
Created	23 years, 1 month ago (July 25, 2002, 3:40 a.m.)
Deposited	1 year, 11 months ago (Sept. 16, 2023, 1:58 p.m.)
Indexed	2 months ago (June 27, 2025, 6:35 a.m.)
Issued	31 years, 1 month ago (July 11, 1994)
Published	31 years, 1 month ago (July 11, 1994)
Published Online	23 years, 10 months ago (Oct. 18, 2001)
Published Print	31 years, 1 month ago (July 11, 1994)

Funders 0

None

BibTeX

@article{Ichas_1994, title={Mitochondrial calcium spiking: A transduction mechanism based on calcium‐induced permeability transition involved in cell calcium signalling}, volume={348}, ISSN={1873-3468}, url={http://dx.doi.org/10.1016/0014-5793(94)00615-6}, DOI={10.1016/0014-5793(94)00615-6}, number={2}, journal={FEBS Letters}, publisher={Wiley}, author={Ichas, François and Jouaville, Laurence S. and Sidash, Sergueï S. and Mazat, Jean-Pierre and Holmuhamedov, Ekhson L.}, year={1994}, month=jul, pages={211–215} }

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