DOI: 10.1016/0014-5793(94)00472-2. Sequential degradation of the neuropeptide gonadotropin‐releasing hormone by the 20 S granulosa cell proteasomes

Sequential degradation of the neuropeptide gonadotropin‐releasing hormone by the 20 S granulosa cell proteasomes

10.1016/0014-5793(94)00472-2

Crossref journal-article

Wiley

FEBS Letters (311)

Abstract

The decapeptide gonadotropin‐releasing hormone (GnRH) is degraded by the 20 S multicatalytic proteinase complex (proteasome EC 3.4.99.46), purified from ovarian granulosa cells, at the Tyr5 Gly6 bond and to a lesser extent at the Gly6 Leu7 bond, when incubated for 2 h at 37°C. Further cleavage, at Trp3 Ser4 and Ser4 Tyr5 bonds of the neurohormone occurs only subsequently to the appearance of the initial N‐terminal degradation products, (1–5)GnRH and (1–6)GnRH. Our results suggest that the sequential degradation of GnRH can serve as an important mechanism for the rapid termination of its biological activity in target cells.

Bibliography

Sequential degradation of the neuropeptide gonadotropinâreleasing hormone by the 20 S granulosa cell proteasomes. (1994). FEBS Letters, 346(2â3), 203â206. Portico.

Authors 0

None

References 38 Referenced 9

RivettA.J.Biochem. J.291 (1993) 1–10. (10.1042/bj2910001)
GoldbergA.L.RockK.L.Nature357 (1992) 375–379. (10.1038/357375a0)
TanakaK.TamuraT.YoshimuraT.IchiharaA.New Biologist4 (1992) 173–187. (10.1038/sj.bdj.4807991)
BrownM.G.DriscollJ.MonacoJ.J.Nature353 (1991) 355–357.
GlynneR.PowisS.H.BeckS.KellyA.KerrL.A.TrowsdaleJ.Nature353 (1991) 357–360.
DriscollJ.FinleyD.Cell68 (1992) 823–825. (10.1016/0092-8674(92)90024-7)
DahlmannB.KoppF.KuehnL.NiedelB.PfeiferG.HegerlR.BaumeisterW.FEBS Lett.251 (1989) 125–131. (10.1016/0014-5793(89)81441-3)
PuählerG.WeinkaufS.BachmannL.MuällerS.EngelA.HegeriR.BaumeisterW.EMBO J.11 (1992) 1607–1616. (10.1002/j.1460-2075.1992.tb05206.x)
ShauerT.M.NesperM.KehlM.LottspeichF.Muäller-TaubenbergerA.GerischG.BaumeisterW.J. Struct. Biol.111 (1993) 135–147.
{'key': 'e_1_2_1_11_1', 'first-page': '1349', 'volume-title': 'The physiology of Reproduction', 'author': 'Fink G.', 'year': '1988'} / The physiology of Reproduction by Fink G. (1988)
BurgusR.ButcherM.LingN.MonahanM.RivierJ.FellowsR.BlackwellR.ValeW.GuilleminR.Proc. Natl. Acad. Sci. USA69 (1972) 278–282. (10.1073/pnas.69.1.278)
SchallyA.VNairR.M.G.ReddingT.W.ArimuraA.J. Biol. Chem.246 (1971) 7230–7236. (10.1016/S0021-9258(19)45877-8)
OkonE.LivniN.KochY.Br. J. Exp. Pathol.61 (1980) 579–589. (10.1161/01.CIR.61.3.579)
OkonE.KochY.Nature263 (1976) 345–347.
HsuehA.J.W.JonesP.B.C.Endocr. Rev.2 (1981) 437–461. (10.1210/edrv-2-4-437)
AmsterdamA.RotmenschS.Endocr. Rev.8 (1987) 309–337. (10.1210/edrv-8-3-309)
Ben-Ze'evA.AmsterdamA.Endocrinology124 (1989) 2548–2594. (10.1210/endo-124-5-2584)
AmsterdamA.KnechtM.CattK.J.Proc. Natl. Acad. Sci. USA78 (1981) 300–3304.
KnechtM.AmsterdamA.CattK.J.Endocrinology110 (1982) 865–872. (10.1210/endo-110-3-865)
Ben-Ze'evA.AmsterdamA.J. Biol. Chem.262 (1987) 5366–5376. (10.1016/S0021-9258(18)61197-4)
LiscovitchM.AmsterdamA.J. Biol. Chem.264 (1989) 11762–11767. (10.1016/S0021-9258(18)80131-4)
LiscovitchM.DantesA.AmsterdamA.submitted to Endocrinology (1994)
SakumaY.PfaffD.W.Nature283 (1980) 566–567. (10.1038/283566a0)
KalcheinC.SzechtmanH.KochY.J. Comp. Physiol. Psychol.95 (1981) 36–44. (10.1037/h0077762)
KaiserU.B.JakubowiakA.SteinbergerA.ChinW.W.Endocrinology133 (1983) 931–934.
KochY.BaramT.ChobsiengP.FridkinM.Biochem. Biophys. Res. Commun.61 (1974) 95–103. (10.1016/0006-291X(74)90539-7)
ElkabesS.FridkinM.KochY.Biochem. Biophys. Res. Commun.103 (1981) 240–248. (10.1016/0006-291X(81)91685-5)
HazumE.KochY.LiscovitchM.AmsterdamA.Cell Tissue Res.239 (1985) 3–8. (10.1007/BF00214895)
{'key': 'e_1_2_1_30_1', 'first-page': '377', 'volume-title': 'Biorhythms and Stress in the Physiopathology of Reproduction', 'author': 'Koch Y.', 'year': '1988'} / Biorhythms and Stress in the Physiopathology of Reproduction by Koch Y. (1988)
AmsterdamA.PitzerF.BaumeisterW.Proc. Natl. Acad. Sci. USA90 (1993) 99–103. (10.1073/pnas.90.1.99)
{'key': 'e_1_2_1_32_1', 'first-page': '1', 'volume-title': 'The Peptides', 'author': 'Barany G.', 'year': '1979'} / The Peptides by Barany G. (1979)
BradfordM.M.Anal. Biochem.72 (1976) 248–254. (10.1016/0003-2697(76)90527-3)
LeibovitzD.BenAroya N.FridkinM.KochY.Proc. 75th Annu. Meeting American Endocr. Soc. (1993) Abstr. #1815
{'key': 'e_1_2_1_35_1', 'first-page': '1979', 'volume-title': 'Chemistry of the Amino Acids', 'author': 'Greenstein J.P.', 'year': '1961'} / Chemistry of the Amino Acids by Greenstein J.P. (1961)
OrlowskiM.CardozoC.MichaudC.Biochemistry32 (1993) 1563–1572.
WenzelT.BaumeisterW.FEBS Lett.326 (1993) 215–218. (10.1016/0014-5793(93)81793-Y)
DickL.R.MoomawC.R.DeMartinoG.N.SlaughterC.A.Biochemistry30 (1991) 2725–2734. (10.1021/bi00224a022)
BilligH.FurutaI.HsuehA.J.W.Endocrinology134 (1994) 245–252.

Dates

Type	When
Created	23 years ago (July 25, 2002, 3:40 a.m.)
Deposited	1 year, 11 months ago (Sept. 16, 2023, 8:56 a.m.)
Indexed	1 year, 1 month ago (July 12, 2024, 8:34 a.m.)
Issued	31 years, 2 months ago (June 13, 1994)
Published	31 years, 2 months ago (June 13, 1994)
Published Online	23 years, 7 months ago (Jan. 9, 2002)
Published Print	31 years, 2 months ago (June 13, 1994)

Funders 0

None

BibTeX

@article{1994, volume={346}, ISSN={1873-3468}, url={http://dx.doi.org/10.1016/0014-5793(94)00472-2}, DOI={10.1016/0014-5793(94)00472-2}, number={2–3}, journal={FEBS Letters}, publisher={Wiley}, year={1994}, month=jun, pages={203–206} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2024,
        7,
        12
      ]
    ],
    "date-time": "2024-07-12T12:34:50Z",
    "timestamp": 1720787690671
  },
  "reference-count": 38,
  "publisher": "Wiley",
  "issue": "2-3",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2002,
            1,
            9
          ]
        ],
        "date-time": "2002-01-09T00:00:00Z",
        "timestamp": 1010534400000
      },
      "content-version": "vor",
      "delay-in-days": 2767,
      "URL": "http://onlinelibrary.wiley.com/termsAndConditions#vor"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        1994,
        6,
        13
      ]
    ]
  },
  "abstract": "<jats:p>The decapeptide gonadotropin\u2010releasing hormone (GnRH) is degraded by the 20 S multicatalytic proteinase complex (proteasome EC 3.4.99.46), purified from ovarian granulosa cells, at the Tyr<jats:sup>5</jats:sup>\nGly<jats:sup>6</jats:sup> bond and to a lesser extent at the Gly<jats:sup>6</jats:sup>\nLeu<jats:sup>7</jats:sup> bond, when incubated for 2 h at 37\u00b0C. Further cleavage, at Trp<jats:sup>3</jats:sup>\nSer<jats:sup>4</jats:sup> and Ser<jats:sup>4</jats:sup>\nTyr<jats:sup>5</jats:sup> bonds of the neurohormone occurs only subsequently to the appearance of the initial N\u2010terminal degradation products, (1\u20135)GnRH and (1\u20136)GnRH. Our results suggest that the sequential degradation of GnRH can serve as an important mechanism for the rapid termination of its biological activity in target cells.</jats:p>",
  "DOI": "10.1016/0014-5793(94)00472-2",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2002,
        7,
        25
      ]
    ],
    "date-time": "2002-07-25T07:40:55Z",
    "timestamp": 1027582855000
  },
  "page": "203-206",
  "source": "Crossref",
  "is-referenced-by-count": 9,
  "title": "Sequential degradation of the neuropeptide gonadotropin\u2010releasing hormone by the 20 S granulosa cell proteasomes",
  "prefix": "10.1002",
  "volume": "346",
  "member": "311",
  "published-online": {
    "date-parts": [
      [
        2002,
        1,
        9
      ]
    ]
  },
  "reference": [
    {
      "key": "e_1_2_1_2_1",
      "doi-asserted-by": "crossref",
      "unstructured": "RivettA.J.Biochem. J.291 (1993) 1\u201310.",
      "DOI": "10.1042/bj2910001"
    },
    {
      "key": "e_1_2_1_3_1",
      "doi-asserted-by": "crossref",
      "unstructured": "GoldbergA.L.RockK.L.Nature357 (1992) 375\u2013379.",
      "DOI": "10.1038/357375a0"
    },
    {
      "key": "e_1_2_1_4_1",
      "doi-asserted-by": "crossref",
      "unstructured": "TanakaK.TamuraT.YoshimuraT.IchiharaA.New Biologist4 (1992) 173\u2013187.",
      "DOI": "10.1038/sj.bdj.4807991"
    },
    {
      "key": "e_1_2_1_5_1",
      "unstructured": "BrownM.G.DriscollJ.MonacoJ.J.Nature353 (1991) 355\u2013357."
    },
    {
      "key": "e_1_2_1_6_1",
      "unstructured": "GlynneR.PowisS.H.BeckS.KellyA.KerrL.A.TrowsdaleJ.Nature353 (1991) 357\u2013360."
    },
    {
      "key": "e_1_2_1_7_1",
      "doi-asserted-by": "crossref",
      "unstructured": "DriscollJ.FinleyD.Cell68 (1992) 823\u2013825.",
      "DOI": "10.1016/0092-8674(92)90024-7"
    },
    {
      "key": "e_1_2_1_8_1",
      "doi-asserted-by": "crossref",
      "unstructured": "DahlmannB.KoppF.KuehnL.NiedelB.PfeiferG.HegerlR.BaumeisterW.FEBS Lett.251 (1989) 125\u2013131.",
      "DOI": "10.1016/0014-5793(89)81441-3"
    },
    {
      "key": "e_1_2_1_9_1",
      "doi-asserted-by": "crossref",
      "unstructured": "Pu\u00e4hlerG.WeinkaufS.BachmannL.Mu\u00e4llerS.EngelA.HegeriR.BaumeisterW.EMBO J.11 (1992) 1607\u20131616.",
      "DOI": "10.1002/j.1460-2075.1992.tb05206.x"
    },
    {
      "key": "e_1_2_1_10_1",
      "unstructured": "ShauerT.M.NesperM.KehlM.LottspeichF.Mu\u00e4ller-TaubenbergerA.GerischG.BaumeisterW.J. Struct. Biol.111 (1993) 135\u2013147."
    },
    {
      "key": "e_1_2_1_11_1",
      "first-page": "1349",
      "volume-title": "The physiology of Reproduction",
      "author": "Fink G.",
      "year": "1988"
    },
    {
      "key": "e_1_2_1_12_1",
      "doi-asserted-by": "crossref",
      "unstructured": "BurgusR.ButcherM.LingN.MonahanM.RivierJ.FellowsR.BlackwellR.ValeW.GuilleminR.Proc. Natl. Acad. Sci. USA69 (1972) 278\u2013282.",
      "DOI": "10.1073/pnas.69.1.278"
    },
    {
      "key": "e_1_2_1_13_1",
      "doi-asserted-by": "crossref",
      "unstructured": "SchallyA.VNairR.M.G.ReddingT.W.ArimuraA.J. Biol. Chem.246 (1971) 7230\u20137236.",
      "DOI": "10.1016/S0021-9258(19)45877-8"
    },
    {
      "key": "e_1_2_1_14_1",
      "doi-asserted-by": "crossref",
      "unstructured": "OkonE.LivniN.KochY.Br. J. Exp. Pathol.61 (1980) 579\u2013589.",
      "DOI": "10.1161/01.CIR.61.3.579"
    },
    {
      "key": "e_1_2_1_15_1",
      "unstructured": "OkonE.KochY.Nature263 (1976) 345\u2013347."
    },
    {
      "key": "e_1_2_1_16_1",
      "doi-asserted-by": "crossref",
      "unstructured": "HsuehA.J.W.JonesP.B.C.Endocr. Rev.2 (1981) 437\u2013461.",
      "DOI": "10.1210/edrv-2-4-437"
    },
    {
      "key": "e_1_2_1_17_1",
      "doi-asserted-by": "crossref",
      "unstructured": "AmsterdamA.RotmenschS.Endocr. Rev.8 (1987) 309\u2013337.",
      "DOI": "10.1210/edrv-8-3-309"
    },
    {
      "key": "e_1_2_1_18_1",
      "doi-asserted-by": "crossref",
      "unstructured": "Ben-Ze'evA.AmsterdamA.Endocrinology124 (1989) 2548\u20132594.",
      "DOI": "10.1210/endo-124-5-2584"
    },
    {
      "key": "e_1_2_1_19_1",
      "unstructured": "AmsterdamA.KnechtM.CattK.J.Proc. Natl. Acad. Sci. USA78 (1981) 300\u20133304."
    },
    {
      "key": "e_1_2_1_20_1",
      "doi-asserted-by": "crossref",
      "unstructured": "KnechtM.AmsterdamA.CattK.J.Endocrinology110 (1982) 865\u2013872.",
      "DOI": "10.1210/endo-110-3-865"
    },
    {
      "key": "e_1_2_1_21_1",
      "doi-asserted-by": "crossref",
      "unstructured": "Ben-Ze'evA.AmsterdamA.J. Biol. Chem.262 (1987) 5366\u20135376.",
      "DOI": "10.1016/S0021-9258(18)61197-4"
    },
    {
      "key": "e_1_2_1_22_1",
      "doi-asserted-by": "crossref",
      "unstructured": "LiscovitchM.AmsterdamA.J. Biol. Chem.264 (1989) 11762\u201311767.",
      "DOI": "10.1016/S0021-9258(18)80131-4"
    },
    {
      "key": "e_1_2_1_23_1",
      "unstructured": "LiscovitchM.DantesA.AmsterdamA.submitted to Endocrinology (1994)"
    },
    {
      "key": "e_1_2_1_24_1",
      "doi-asserted-by": "crossref",
      "unstructured": "SakumaY.PfaffD.W.Nature283 (1980) 566\u2013567.",
      "DOI": "10.1038/283566a0"
    },
    {
      "key": "e_1_2_1_25_1",
      "doi-asserted-by": "crossref",
      "unstructured": "KalcheinC.SzechtmanH.KochY.J. Comp. Physiol. Psychol.95 (1981) 36\u201344.",
      "DOI": "10.1037/h0077762"
    },
    {
      "key": "e_1_2_1_26_1",
      "unstructured": "KaiserU.B.JakubowiakA.SteinbergerA.ChinW.W.Endocrinology133 (1983) 931\u2013934."
    },
    {
      "key": "e_1_2_1_27_1",
      "doi-asserted-by": "crossref",
      "unstructured": "KochY.BaramT.ChobsiengP.FridkinM.Biochem. Biophys. Res. Commun.61 (1974) 95\u2013103.",
      "DOI": "10.1016/0006-291X(74)90539-7"
    },
    {
      "key": "e_1_2_1_28_1",
      "doi-asserted-by": "crossref",
      "unstructured": "ElkabesS.FridkinM.KochY.Biochem. Biophys. Res. Commun.103 (1981) 240\u2013248.",
      "DOI": "10.1016/0006-291X(81)91685-5"
    },
    {
      "key": "e_1_2_1_29_1",
      "doi-asserted-by": "crossref",
      "unstructured": "HazumE.KochY.LiscovitchM.AmsterdamA.Cell Tissue Res.239 (1985) 3\u20138.",
      "DOI": "10.1007/BF00214895"
    },
    {
      "key": "e_1_2_1_30_1",
      "first-page": "377",
      "volume-title": "Biorhythms and Stress in the Physiopathology of Reproduction",
      "author": "Koch Y.",
      "year": "1988"
    },
    {
      "key": "e_1_2_1_31_1",
      "doi-asserted-by": "crossref",
      "unstructured": "AmsterdamA.PitzerF.BaumeisterW.Proc. Natl. Acad. Sci. USA90 (1993) 99\u2013103.",
      "DOI": "10.1073/pnas.90.1.99"
    },
    {
      "key": "e_1_2_1_32_1",
      "first-page": "1",
      "volume-title": "The Peptides",
      "author": "Barany G.",
      "year": "1979"
    },
    {
      "key": "e_1_2_1_33_1",
      "doi-asserted-by": "crossref",
      "unstructured": "BradfordM.M.Anal. Biochem.72 (1976) 248\u2013254.",
      "DOI": "10.1016/0003-2697(76)90527-3"
    },
    {
      "key": "e_1_2_1_34_1",
      "unstructured": "LeibovitzD.BenAroya N.FridkinM.KochY.Proc. 75th Annu. Meeting American Endocr. Soc. (1993) Abstr. #1815"
    },
    {
      "key": "e_1_2_1_35_1",
      "first-page": "1979",
      "volume-title": "Chemistry of the Amino Acids",
      "author": "Greenstein J.P.",
      "year": "1961"
    },
    {
      "key": "e_1_2_1_36_1",
      "unstructured": "OrlowskiM.CardozoC.MichaudC.Biochemistry32 (1993) 1563\u20131572."
    },
    {
      "key": "e_1_2_1_37_1",
      "doi-asserted-by": "crossref",
      "unstructured": "WenzelT.BaumeisterW.FEBS Lett.326 (1993) 215\u2013218.",
      "DOI": "10.1016/0014-5793(93)81793-Y"
    },
    {
      "key": "e_1_2_1_38_1",
      "doi-asserted-by": "crossref",
      "unstructured": "DickL.R.MoomawC.R.DeMartinoG.N.SlaughterC.A.Biochemistry30 (1991) 2725\u20132734.",
      "DOI": "10.1021/bi00224a022"
    },
    {
      "key": "e_1_2_1_39_1",
      "unstructured": "BilligH.FurutaI.HsuehA.J.W.Endocrinology134 (1994) 245\u2013252."
    }
  ],
  "container-title": "FEBS Letters",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1016%2F0014-5793%2894%2900472-2",
      "content-type": "application/pdf",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1016%2F0014-5793(94)00472-2",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://febs.onlinelibrary.wiley.com/doi/pdf/10.1016/0014-5793%2894%2900472-2",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2023,
        9,
        16
      ]
    ],
    "date-time": "2023-09-16T12:56:37Z",
    "timestamp": 1694868997000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://febs.onlinelibrary.wiley.com/doi/10.1016/0014-5793%2894%2900472-2"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1994,
        6,
        13
      ]
    ]
  },
  "references-count": 38,
  "journal-issue": {
    "issue": "2-3",
    "published-print": {
      "date-parts": [
        [
          1994,
          6,
          13
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1016/0014-5793(94)00472-2"
  ],
  "URL": "http://dx.doi.org/10.1016/0014-5793(94)00472-2",
  "relation": {},
  "ISSN": [
    "0014-5793",
    "1873-3468"
  ],
  "subject": [],
  "container-title-short": "FEBS Letters",
  "published": {
    "date-parts": [
      [
        1994,
        6,
        13
      ]
    ]
  }
}