DOI: 10.1016/0014-5793(93)81750-t. Involvement of protein kinase in environmental stress‐induced activation of human multidrug resistance 1 (MDR1) gene promoter

Involvement of protein kinase in environmental stress‐induced activation of human multidrug resistance 1 (MDR1) gene promoter

10.1016/0014-5793(93)81750-t

Crossref journal-article

Wiley

FEBS Letters (311)

Abstract

The human MDR1 gene can be induced in response to various environmental stimuli. To examine whether such stress‐induced activation of the MDR1 gene can be modulated by protein kinase, we employed a stable human cancer KB cell line which contained the bacterial chloramphenicol acetyltransferase (CAT) gene directed by the MDR1 gene promoter. H‐7, a protein kinase C inhibitor, at more than 40 μM inhibited activation of the MDR1 promoter that was induced by ethylmethane sulfonate, 5‐fluorouracil or UV irradiation. DNA binding activity of nuclear factors recognizing the MDR1 promoter was augmented in KB cells treated with UV, but decreased in cells treated concomitantly with H‐7. Okadaic acid alone was able to induce the promoter activation, and this induction was dependent on specific promoter sequences. Okadaic acid also enhanced the DNA binding activity of nuclear factors recognizing the MDR1 promoter. The phosphorylation of transacting factors may modulate the MDR1 gene promoter activity.

Bibliography

Uchiumi, T., Kohno, K., Tanimura, H., Hidaka, K., Asakuno, K., Abe, H., Uchida, Y., & Kuwano, M. (1993). Involvement of protein kinase in environmental stressâinduced activation of human multidrug resistance 1 (MDR1) gene promoter. FEBS Letters, 326(1â3), 11â16. Portico.

Authors 8

Takeshi Uchiumi (first)
Kimitoshi Kohno (additional)
Hideyuki Tanimura (additional)
Katsuhiko Hidaka (additional)
Keizo Asakuno (additional)
Hiroko Abe (additional)
Yuzo Uchida (additional)
Michihiko Kuwano (additional)

References 31 Referenced 47

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Dates

Type	When
Created	23 years, 1 month ago (July 25, 2002, 3:41 a.m.)
Deposited	1 year, 11 months ago (Sept. 16, 2023, 10:28 a.m.)
Indexed	1 month, 2 weeks ago (July 14, 2025, 11:16 p.m.)
Issued	32 years, 2 months ago (July 1, 1993)
Published	32 years, 2 months ago (July 1, 1993)
Published Online	23 years, 8 months ago (Dec. 7, 2001)
Published Print	32 years, 2 months ago (July 1, 1993)

Funders 0

None

BibTeX

@article{Uchiumi_1993, title={Involvement of protein kinase in environmental stress‐induced activation of human multidrug resistance 1 (MDR1) gene promoter}, volume={326}, ISSN={1873-3468}, url={http://dx.doi.org/10.1016/0014-5793(93)81750-t}, DOI={10.1016/0014-5793(93)81750-t}, number={1–3}, journal={FEBS Letters}, publisher={Wiley}, author={Uchiumi, Takeshi and Kohno, Kimitoshi and Tanimura, Hideyuki and Hidaka, Katsuhiko and Asakuno, Keizo and Abe, Hiroko and Uchida, Yuzo and Kuwano, Michihiko}, year={1993}, month=jul, pages={11–16} }

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