DOI: 10.1016/0014-5793(93)80891-w. Uteroglobin, an apically secreted protein of the uterine epithelium, is secreted non‐polarized from MDCK cells and mainly basolaterally from Caco‐2 cell

Uteroglobin, an apically secreted protein of the uterine epithelium, is secreted non‐polarized from MDCK cells and mainly basolaterally from Caco‐2 cell

10.1016/0014-5793(93)80891-w

Crossref journal-article

Wiley

FEBS Letters (311)

Abstract

A complete cDNA encoding rabbit Uteroglobin was constructed and expressed in MDCK and Caco‐2 cells. The MDCK cells secrete Uteroglobin in approximately equal amounts to the apical and the basolateral side, whereas the Caco‐2 cells secrete Uteroglobin mainly to the basolateral side. Both MDCK and Caco‐2 cells thus secrete Uteroglobin in a non‐sorted manner. It has, however, previously been shown that Uteroglobin is secreted exclusively at the apical membrane in primary cell culture of endometrial epithelial cells [S.K. Mani et al. (1991) Endocrinology 128, 1563‐1573]. This suggests that either the endometrial epithelium has an apical default pathway or recognises a sorting signal not recognised by MDCK cells and Caco‐2 cells. Our data thus show that a soluble molecule can be secreted at the apical, the basolateral or both membranes depending on the cell type.

Bibliography

Vogel, L. K., Suske, G., Beato, M., NorÃ©n, O., & SjÃ¶strÃ¶m, H. (1993). Uteroglobin, an apically secreted protein of the uterine epithelium, is secreted nonâpolarized from MDCK cells and mainly basolaterally from Cacoâ2 cell. FEBS Letters, 330(3), 293â296. Portico.

Authors 5

Lotte Katrine Vogel (first)
Guntram Suske (additional)
Miguel Beato (additional)
Ove Norén (additional)
Hans Sjöström (additional)

References 32 Referenced 8

10.1083/jcb.105.6.2735
10.1016/S0021-9258(19)67826-9
10.1016/0167-4889(92)90002-S
10.1038/329632a0
10.1016/0092-8674(85)90035-2
10.1073/pnas.83.7.2100
10.1016/S0021-9258(18)45948-0
10.1016/S0021-9258(18)45949-2
10.1016/S0021-9258(18)41667-5
10.1210/endo-128-3-1563
10.1007/BF00318977
10.1007/BF00509202
10.1007/BF00496819
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10.1007/BF00217880
10.1016/0022-2836(80)90166-7
{'key': 'e_1_2_1_18_1', 'volume-title': 'Molecular Cloning: A laboratory Manual', 'author': 'Sambrook J.', 'year': '1989'} / Molecular Cloning: A laboratory Manual by Sambrook J. (1989)
10.1093/protein/3.1.61
10.1093/nar/11.8.2257
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10.1016/0014-5793(92)81039-O
{'key': 'e_1_2_1_23_1', 'first-page': '327', 'volume': '1', 'author': 'Southern P.J.', 'year': '1982', 'journal-title': 'Mol. Appl. Genet.'} / Mol. Appl. Genet. by Southern P.J. (1982)
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10.1083/jcb.107.2.471
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Omitted
10.1007/BF02400976
10.1083/jcb.111.6.2923
10.1083/jcb.109.6.3291
10.1083/jcb.111.2.347
10.1083/jcb.117.3.551

Dates

Type	When
Created	23 years ago (July 25, 2002, 3:41 a.m.)
Deposited	1 year, 11 months ago (Sept. 16, 2023, 3:18 p.m.)
Indexed	3 weeks ago (Aug. 2, 2025, 12:42 a.m.)
Issued	31 years, 11 months ago (Sept. 20, 1993)
Published	31 years, 11 months ago (Sept. 20, 1993)
Published Online	23 years, 9 months ago (Nov. 12, 2001)
Published Print	31 years, 11 months ago (Sept. 20, 1993)

Funders 0

None

BibTeX

@article{Vogel_1993, title={Uteroglobin, an apically secreted protein of the uterine epithelium, is secreted non‐polarized from MDCK cells and mainly basolaterally from Caco‐2 cell}, volume={330}, ISSN={1873-3468}, url={http://dx.doi.org/10.1016/0014-5793(93)80891-w}, DOI={10.1016/0014-5793(93)80891-w}, number={3}, journal={FEBS Letters}, publisher={Wiley}, author={Vogel, Lotte Katrine and Suske, Guntram and Beato, Miguel and Norén, Ove and Sjöström, Hans}, year={1993}, month=sep, pages={293–296} }

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