DOI: 10.1016/0014-5793(92)81216-9. Identification of MAPKAP kinase 2 as a major enzyme responsible for the phosphorylation of the small mammalian heat shock proteins

Identification of MAPKAP kinase 2 as a major enzyme responsible for the phosphorylation of the small mammalian heat shock proteins

10.1016/0014-5793(92)81216-9

Crossref journal-article

Wiley

FEBS Letters (311)

Abstract

MAP kinase‐activated protein kinase‐2 (MAPKAP kinase‐2) phosphorylates the serine residues in murine heat shock protein 25 (hsp25) and human heat shock protein 27 (hsp27) which are phosphorylated in vivo in response to growth factors and heat shock, namely Ser15 and Ser40 (hsp25) and Ser15, Ser78 and Ser82 (hsp27). Se86 of hsp25 and the equivalent residue in hsp27 (Ser82) are phosphorylated preferentially in vitro. The small heat shock protein is present in rabbit skeletal muscle and hsp25 kinase activity in skeletal muscle extracts co‐purifies with MAPKAP kinase‐2 activity throughout the purification of the latter enzyme. These results suggest that MAPKAP kinase‐2 is the enzyme responsible for the phosphorylation of these small heat shock proteins in mammalian cells.

Bibliography

Stokoe, D., Engel, K., Campbell, D. G., Cohen, P., & Gaestel, M. (1992). Identification of MAPKAP kinase 2 as a major enzyme responsible for the phosphorylation of the small mammalian heat shock proteins. FEBS Letters, 313(3), 307â313. Portico.

Authors 5

David Stokoe (first)
Katrin Engel (additional)
David G. Campbell (additional)
Philip Cohen (additional)
Matthias Gaestel (additional)

References 30 Referenced 463

10.1002/j.1460-2075.1992.tb05492.x
10.1038/334715a0
10.1038/348302a0
10.1016/S0021-9258(17)42478-1
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{'key': 'e_1_2_1_13_1', 'first-page': '219', 'volume': '49', 'author': 'Oesterreich S.', 'year': '1990', 'journal-title': 'Biomed. Biochim. Acta'} / Biomed. Biochim. Acta by Oesterreich S. (1990)
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{'journal-title': 'J. Biol. Chem.', 'year': '1992', 'author': 'Jacob U.', 'key': 'e_1_2_1_23_1'} / J. Biol. Chem. by Jacob U. (1992)
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{'key': 'e_1_2_1_26_1', 'first-page': '1065', 'volume': '50', 'author': 'Engel K.', 'year': '1991', 'journal-title': 'Biomed. Biophys. Acta.'} / Biomed. Biophys. Acta. by Engel K. (1991)
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{'journal-title': 'J. Biol. Chem.', 'year': '1992', 'author': 'Gaestel M.', 'key': 'e_1_2_1_30_1'} / J. Biol. Chem. by Gaestel M. (1992)
10.1016/0003-2697(76)90527-3

Dates

Type	When
Created	23 years ago (July 24, 2002, 11:42 p.m.)
Deposited	1 year, 11 months ago (Sept. 16, 2023, 7:57 p.m.)
Indexed	2 weeks ago (Aug. 7, 2025, 4:49 p.m.)
Issued	32 years, 8 months ago (Nov. 30, 1992)
Published	32 years, 8 months ago (Nov. 30, 1992)
Published Online	23 years, 8 months ago (Dec. 17, 2001)
Published Print	32 years, 8 months ago (Nov. 30, 1992)

Funders 0

None

BibTeX

@article{Stokoe_1992, title={Identification of MAPKAP kinase 2 as a major enzyme responsible for the phosphorylation of the small mammalian heat shock proteins}, volume={313}, ISSN={1873-3468}, url={http://dx.doi.org/10.1016/0014-5793(92)81216-9}, DOI={10.1016/0014-5793(92)81216-9}, number={3}, journal={FEBS Letters}, publisher={Wiley}, author={Stokoe, David and Engel, Katrin and Campbell, David G. and Cohen, Philip and Gaestel, Matthias}, year={1992}, month=nov, pages={307–313} }

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