DOI: 10.1016/0014-5793(92)80438-m. The proteasome/multicatalytic—multifunctional proteinase In vivo function in the ubiquitin‐dependent N‐end rule pathway of protein degradation in eukaryotes

The proteasome/multicatalytic—multifunctional proteinase In vivo function in the ubiquitin‐dependent N‐end rule pathway of protein degradation in eukaryotes

10.1016/0014-5793(92)80438-m

Crossref journal-article

Wiley

FEBS Letters (311)

Abstract

Proteinase yscE, the proteasome/multicatalytic—multifunctional proteinase of yeast had been shown to function in stress response and in the degradation of ubiquitinated proteins [(1991) EMBO J. 10, 555–562]. A well‐defined set of proteins degraded via ubiquitin‐mediated proteolysis are the substrates of the N‐end rule pathway [(1986) Science 234, 179–186; (1989) Science 243, 1576–1583]. We show that mutants defective in the chymotryptic activity of proteinase yscE fail to degrade substrates of the N‐end rule pathway. This gives further proof of the proteasome being a central catalyst in ubiquitin‐mediated proteolysis.

Bibliography

Richter-Ruoff, B., Heinemeyer, W., & Wolf, D. H. (1992). The proteasome/multicatalyticâmultifunctional proteinase In vivo function in the ubiquitinâdependent Nâend rule pathway of protein degradation in eukaryotes. FEBS Letters, 302(2), 192â196. Portico.

Authors 3

Birgit Richter-Ruoff (first)
Wolfgang Heinemeyer (additional)
Dieter H. Wolf (additional)

References 35 Referenced 60

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Dates

Type	When
Created	23 years ago (July 25, 2002, 5:09 a.m.)
Deposited	1 year, 11 months ago (Sept. 16, 2023, 3:01 a.m.)
Indexed	1 year, 9 months ago (Nov. 22, 2023, 10:43 p.m.)
Issued	33 years, 3 months ago (May 11, 1992)
Published	33 years, 3 months ago (May 11, 1992)
Published Online	23 years, 7 months ago (Jan. 16, 2002)
Published Print	33 years, 3 months ago (May 11, 1992)

Funders 0

None

BibTeX

@article{Richter_Ruoff_1992, title={The proteasome/multicatalytic—multifunctional proteinase In vivo function in the ubiquitin‐dependent N‐end rule pathway of protein degradation in eukaryotes}, volume={302}, ISSN={1873-3468}, url={http://dx.doi.org/10.1016/0014-5793(92)80438-m}, DOI={10.1016/0014-5793(92)80438-m}, number={2}, journal={FEBS Letters}, publisher={Wiley}, author={Richter-Ruoff, Birgit and Heinemeyer, Wolfgang and Wolf, Dieter H.}, year={1992}, month=may, pages={192–196} }

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