DOI: 10.1016/0014-5793(92)80381-p. Glucose has to be phosphorylated to activate glycogen synthase, but not to inactivate glycogen phosphorylase in hepatocytes

Glucose has to be phosphorylated to activate glycogen synthase, but not to inactivate glycogen phosphorylase in hepatocytes

10.1016/0014-5793(92)80381-p

Crossref journal-article

Wiley

FEBS Letters (311)

Abstract

2‐Deoxyglucose and 5‐thioglucose, in the same fashion as glucose, cause the inactivation of the rat hepatocyte glycogen phosphorylase and the activation of glycogen synthase. However, 6‐deoxyglucose and 1,5‐anhydroglucitol inactivate phosphorylase without increasing the activation state of glycogen synthase. With 3‐O‐methylglucose no changes in the activity or these enzymes occurred. These results prove that while glucose is the molecule that triggers the inactivation of phosphorylase, glucose 6‐phosphate is the signal for glucose synthase activation and that a metabolite control of the activation state of glycogen synthase is operative in hepatocytes.

Bibliography

Carabaza, A., Ciudad, C. J., BaquÃ©, S., & Guinovart, J. J. (1992). Glucose has to be phosphorylated to activate glycogen synthase, but not to inactivate glycogen phosphorylase in hepatocytes. FEBS Letters, 296(2), 211â214. Portico.

Authors 4

Assumpta Carabaza (first)
Carlos J. Ciudad (additional)
Susanna Baqué (additional)
Joan J. Guinovart (additional)

References 15 Referenced 50

Dates

Type	When
Created	23 years, 1 month ago (July 25, 2002, 3:42 a.m.)
Deposited	1 year, 11 months ago (Sept. 16, 2023, 1:49 a.m.)
Indexed	1 year, 1 month ago (Aug. 5, 2024, 2:03 a.m.)
Issued	33 years, 7 months ago (Jan. 20, 1992)
Published	33 years, 7 months ago (Jan. 20, 1992)
Published Online	23 years, 7 months ago (Jan. 16, 2002)
Published Print	33 years, 7 months ago (Jan. 20, 1992)

Funders 0

None

BibTeX

@article{Carabaza_1992, title={Glucose has to be phosphorylated to activate glycogen synthase, but not to inactivate glycogen phosphorylase in hepatocytes}, volume={296}, ISSN={1873-3468}, url={http://dx.doi.org/10.1016/0014-5793(92)80381-p}, DOI={10.1016/0014-5793(92)80381-p}, number={2}, journal={FEBS Letters}, publisher={Wiley}, author={Carabaza, Assumpta and Ciudad, Carlos J. and Baqué, Susanna and Guinovart, Joan J.}, year={1992}, month=jan, pages={211–214} }

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