DOI: 10.1016/0014-5793(92)80067-q. Herbimycin A blocks IL‐1‐induced NF‐κB DNA‐binding activity in lymphoid cell lines

Herbimycin A blocks IL‐1‐induced NF‐κB DNA‐binding activity in lymphoid cell lines

10.1016/0014-5793(92)80067-q

Crossref journal-article

Wiley

FEBS Letters (311)

Abstract

The mechanism by which interleukin‐1α (IL‐1α) activates NF‐κB DNA‐binding activity is not completely understood. While it is well established that protein kinase C can activate NF‐κB, neither protein kinase C nor protein kinase A appears to be critical in the induction of NF‐κB by IL‐1α. Since a number of growth factors signal via protein tyrosine kinase, in this study we examined a possible involvement of protein tyrosine kinase in the IL‐1α‐induced NF‐κB. The results showed that in the murine pre‐B cell line 7OZ/3 and in the murine T cell line EL‐4 6.1 C10 IL‐1α‐induced NF‐κB was associated with transient increase in protein tyrosine kinase activity. Pre‐treatment of these cell lines with herbimycin A, an inhibitor of tyrosine kinase activity, blocked the IL‐1α‐enhanced protein tyrosine kinase activity and the IL‐1α‐induced NF‐κB DNA‐binding activity. Herbimycin A at concentrations sufficient to block IL‐1α‐induced NF‐κB did not block the phorbol 12‐myristate 13‐acetate(PMA)‐induced NF‐κB. The data suggest that IL‐1α and PMA activate NF‐κB by different pathways and that induction of NF‐κB DNA‐binding activity by IL‐1 might be dependent on protein tyrosine phosphorylation.

Bibliography

Iwasaki, T., Uehara, Y., Graves, L., Rachie, N., & Bomsztyk, K. (1992). Herbimycin A blocks ILâ1âinduced NFâÎºB DNAâbinding activity in lymphoid cell lines. FEBS Letters, 298(2â3), 240â244. Portico.

Authors 5

Takaaki Iwasaki (first)
Yoshimasa Uehara (additional)
Lee Graves (additional)
Nisa Rachie (additional)
Karol Bomsztyk (additional)

References 34 Referenced 49

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Dates

Type	When
Created	23 years, 1 month ago (July 25, 2002, 5:09 a.m.)
Deposited	1 year, 11 months ago (Sept. 16, 2023, 8:30 a.m.)
Indexed	1 year, 2 months ago (June 17, 2024, 4:36 p.m.)
Issued	33 years, 6 months ago (Feb. 24, 1992)
Published	33 years, 6 months ago (Feb. 24, 1992)
Published Online	23 years, 7 months ago (Jan. 16, 2002)
Published Print	33 years, 6 months ago (Feb. 24, 1992)

Funders 0

None

BibTeX

@article{Iwasaki_1992, title={Herbimycin A blocks IL‐1‐induced NF‐κB DNA‐binding activity in lymphoid cell lines}, volume={298}, ISSN={1873-3468}, url={http://dx.doi.org/10.1016/0014-5793(92)80067-q}, DOI={10.1016/0014-5793(92)80067-q}, number={2–3}, journal={FEBS Letters}, publisher={Wiley}, author={Iwasaki, Takaaki and Uehara, Yoshimasa and Graves, Lee and Rachie, Nisa and Bomsztyk, Karol}, year={1992}, month=feb, pages={240–244} }

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