DOI: 10.1016/0014-5793(91)80319-x. Novel epoxysuccinyl peptides A selective inhibitor of cathepsin B, in vivo

Novel epoxysuccinyl peptides A selective inhibitor of cathepsin B, in vivo

10.1016/0014-5793(91)80319-x

Crossref journal-article

Wiley

FEBS Letters (311)

Abstract

New derivatives of E‐64 (compound CA‐030 and CA‐074) were tested in vitro and in vivo for selective inhibition of cathepsin B. They exhibited 10000–30000 times greater inhibitory effects on purified rat cathepsin B than on cathepsin H and L; their initial K 1 values for cathepsin B were about 2–5 nM, like that of E‐64‐c, whereas their initial K 1 values for cathepsins H and L were about 40–200 μM. In in vivo conditions, such us intraperitoneal injection of compound CA‐030 or CA‐074 into rats, compound CA‐074 is an especially potent selective inhibitor of cathepsin B, whereas compound CA‐030 does not show selectivity for cathepsin B, although both compounds CA‐030 and CA‐074 show complete selectivity for cathepsin B in vitro.

Bibliography

Towatari, T., Nikawa, T., Murata, M., Yokoo, C., Tamai, M., Hanada, K., & Katunuma, N. (1991). Novel epoxysuccinyl peptides A selective inhibitor of cathepsin B, in vivo. FEBS Letters, 280(2), 311â315. Portico.

Authors 7

Takae Towatari (first)
Takeshi Nikawa (additional)
Mitsuo Murata (additional)
Chihiro Yokoo (additional)
Masaharu Tamai (additional)
Kazunori Hanada (additional)
Nobuhiko Katunuma (additional)

References 24 Referenced 182

1989 Springer-Verlag Berlin N. Katunuma E. Knecht S. Grisolia RBC - Cell Biology Reviews 35 61
1987 Academic Press London H. Kirschke A.J. Barrett H. Glaumann F.J. Ballard Lysosomes - Their Role in Protein Breakdown 193 283
{'key': 'e_1_2_1_4_1', 'first-page': '193', 'volume': '122', 'author': 'Ii K.', 'year': '1986', 'journal-title': 'Am. J. Pathol.'} / Am. J. Pathol. by Ii K. (1986)
{'key': 'e_1_2_1_5_1', 'first-page': '461', 'volume': '127', 'author': 'Kominami E.', 'year': '1987', 'journal-title': 'Am. J. Pathol.'} / Am. J. Pathol. by Kominami E. (1987)
10.1007/BFb0034070
10.1016/0006-291X(84)90560-6
{'key': 'e_1_2_1_8_1', 'first-page': '579', 'volume': '111', 'author': 'Harris J.O.', 'year': '1975', 'journal-title': 'Am. Rev. Respir. Dis.'} / Am. Rev. Respir. Dis. by Harris J.O. (1975)
10.1042/bj1630639
{'key': 'e_1_2_1_10_1', 'first-page': '55', 'volume': '2', 'author': 'Denhardt D.', 'year': '1997', 'journal-title': 'Oncogene'} / Oncogene by Denhardt D. (1997)
10.1271/bbb1961.42.523
10.1093/oxfordjournals.jbchem.a132171
10.1016/0005-2744(80)90174-6
10.1093/oxfordjournals.jbchem.a132742
10.1093/oxfordjournals.jbchem.a133155
10.1093/oxfordjournals.jbchem.a133825
{'journal-title': 'FEBS Lett.', 'year': '1991', 'author': 'Murata M.', 'key': 'e_1_2_1_17_1'} / FEBS Lett. by Murata M. (1991)
10.1016/0006-291X(78)91020-3
{'key': 'e_1_2_1_19_1', 'first-page': '185', 'volume': '36', 'author': 'Kirschke H.', 'year': '1977', 'journal-title': 'Acta Biol. Med. Germ.'} / Acta Biol. Med. Germ. by Kirschke H. (1977)
10.1016/S0076-6879(81)80043-2
10.1042/bj2010189
{'key': 'e_1_2_1_22_1', 'first-page': '953', 'volume': '62', 'author': 'Nikawa T.', 'year': '1990', 'journal-title': 'SEIKAQ (Japan)'} / SEIKAQ (Japan) by Nikawa T. (1990)
10.1016/S0006-291X(88)81267-1
10.1042/bj2630861
10.1042/bj2620063

Dates

Type	When
Created	23 years, 1 month ago (July 24, 2002, 11:43 p.m.)
Deposited	1 year, 11 months ago (Sept. 16, 2023, 11:30 a.m.)
Indexed	1 month, 1 week ago (July 25, 2025, 6:48 a.m.)
Issued	34 years, 5 months ago (March 25, 1991)
Published	34 years, 5 months ago (March 25, 1991)
Published Online	23 years, 9 months ago (Dec. 7, 2001)
Published Print	34 years, 5 months ago (March 25, 1991)

Funders 0

None

BibTeX

@article{Towatari_1991, title={Novel epoxysuccinyl peptides A selective inhibitor of cathepsin B, in vivo}, volume={280}, ISSN={1873-3468}, url={http://dx.doi.org/10.1016/0014-5793(91)80319-x}, DOI={10.1016/0014-5793(91)80319-x}, number={2}, journal={FEBS Letters}, publisher={Wiley}, author={Towatari, Takae and Nikawa, Takeshi and Murata, Mitsuo and Yokoo, Chihiro and Tamai, Masaharu and Hanada, Kazunori and Katunuma, Nobuhiko}, year={1991}, month=mar, pages={311–315} }

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