DOI: 10.1016/0014-5793(90)80452-o. Functional expression from cloned cDNAs of glutamate receptor species responsive to kainate and quisqualate

Functional expression from cloned cDNAs of glutamate receptor species responsive to kainate and quisqualate

10.1016/0014-5793(90)80452-o

Crossref journal-article

Wiley

FEBS Letters (311)

Abstract

The complete amino acid sequences of two mouse glutamate receptor subunits (GluR1 and GluR2) have been deduced by cloning and sequencing the cDNAs. Xenopus oocytes injected with mRNA derived from the GluR1 cDNA exhibit current responses both to kainate and to quisqualate as well as to glutamate, whereas oocytes injected with mRNA derived from the GluR2 cDNA show little response. Injection of oocytes with both the mRNAs produces current responses larger than those induced by the GluR1‐specific mRNA and the dose‐response relations indicate a positively cooperative interaction between the two subunits. These results suggest that kainate and quisqualate can activate a common glutamate receptor subtype and that glutamate‐gated ionic channels are hetero‐oligomers of different subunits.

Bibliography

Sakimura, K., Bujo, H., Kushiya, E., Araki, K., Yamazaki, M., Yamazaki, M., Meguro, H., Warashina, A., Numa, S., & Mishina, M. (1990). Functional expression from cloned cDNAs of glutamate receptor species responsive to kainate and quisqualate. FEBS Letters, 272(1â2), 73â80. Portico.

Authors 10

Kenji Sakimura (first)
Hideaki Bujo (additional)
Etsuko Kushiya (additional)
Kazuaki Araki (additional)
Makoto Yamazaki (additional)
Masatoshi Yamazaki (additional)
Hiroyuki Meguro (additional)
Akira Warashina (additional)
Shosaku Numa (additional)
Masayoshi Mishina (additional)

References 29 Referenced 146

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1978 National Biomedical Research Foundation Silver Springs MD M.O. Dayhoff R.M. Schwartz B.C. Orcutt M.O. Dayhoff Atlas of Protein Sequence and Structure 345 352
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{'key': 'e_1_2_1_29_1', 'first-page': '298', 'volume': '34', 'author': 'Verdoorn T.A.', 'year': '1988', 'journal-title': 'Mol. Pharmacol.'} / Mol. Pharmacol. by Verdoorn T.A. (1988)
10.1016/0304-3940(89)90469-2

Dates

Type	When
Created	23 years, 1 month ago (July 25, 2002, 5:10 a.m.)
Deposited	1 year, 11 months ago (Sept. 16, 2023, 1:43 p.m.)
Indexed	1 day, 3 hours ago (Sept. 4, 2025, 10:28 a.m.)
Issued	34 years, 10 months ago (Oct. 15, 1990)
Published	34 years, 10 months ago (Oct. 15, 1990)
Published Online	23 years, 9 months ago (Nov. 12, 2001)
Published Print	34 years, 10 months ago (Oct. 15, 1990)

Funders 0

None

BibTeX

@article{Sakimura_1990, title={Functional expression from cloned cDNAs of glutamate receptor species responsive to kainate and quisqualate}, volume={272}, ISSN={1873-3468}, url={http://dx.doi.org/10.1016/0014-5793(90)80452-o}, DOI={10.1016/0014-5793(90)80452-o}, number={1–2}, journal={FEBS Letters}, publisher={Wiley}, author={Sakimura, Kenji and Bujo, Hideaki and Kushiya, Etsuko and Araki, Kazuaki and Yamazaki, Makoto and Yamazaki, Masatoshi and Meguro, Hiroyuki and Warashina, Akira and Numa, Shosaku and Mishina, Masayoshi}, year={1990}, month=oct, pages={73–80} }

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