DOI: 10.1016/0014-5793(90)80367-r. Possible mechanism of nuclear translocation of proteasomes

Possible mechanism of nuclear translocation of proteasomes

10.1016/0014-5793(90)80367-r

Crossref journal-article

Wiley

FEBS Letters (311)

Abstract

Proteasomes (multicatalytic proteinase complexes), which are identical to the ubiquitous eukaryotic 20S particles, are localized in both the cytoplasm and the nucleus, but the mechanism of their co‐localization in the two compartments is unknown. On examination of the primary structures of subunits of proteasomes, a consensus sequence for nuclear translocation of proteins, X‐X‐K‐K(R)‐X‐K(R) (where X is any residue), was found to be present in some subunits and to be highly conserved in the subunits of a wide range of eukaryotes. In addition, proteasomal subunits were found to bear a cluster of acidic amino acid residues and also a potential tyrosine phosphorylation site that was located in the same polypeptide chain as the nuclear location signal. These structural properties suggest that two sets of clusters with positive and negative charges serve to regulate the translocation of proteasomes from the cytoplasm to the nucleus, and that phosphorylation of tyrosine in certain subunits may play an additional role in transfer of proteasomes into the nucleus.

Bibliography

Tanaka, K., Yoshimura, T., Tamura, T., Fujiwara, T., Kumatori, A., & Ichihara, A. (1990). Possible mechanism of nuclear translocation of proteasomes. FEBS Letters, 271(1â2), 41â46. Portico.

Authors 6

Keiji Tanaka (first)
Tetsuro Yoshimura (additional)
Tomohiro Tamura (additional)
Tsutomu Fujiwara (additional)
Atsushi Kumatori (additional)
Akira Ichihara (additional)

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Dates

Type	When
Created	23 years ago (July 25, 2002, 3:44 a.m.)
Deposited	1 year, 11 months ago (Sept. 16, 2023, 6:06 a.m.)
Indexed	2 weeks, 4 days ago (Aug. 5, 2025, 8:50 a.m.)
Issued	34 years, 10 months ago (Oct. 1, 1990)
Published	34 years, 10 months ago (Oct. 1, 1990)
Published Online	23 years, 9 months ago (Nov. 12, 2001)
Published Print	34 years, 10 months ago (Oct. 1, 1990)

Funders 0

None

BibTeX

@article{Tanaka_1990, title={Possible mechanism of nuclear translocation of proteasomes}, volume={271}, ISSN={1873-3468}, url={http://dx.doi.org/10.1016/0014-5793(90)80367-r}, DOI={10.1016/0014-5793(90)80367-r}, number={1–2}, journal={FEBS Letters}, publisher={Wiley}, author={Tanaka, Keiji and Yoshimura, Tetsuro and Tamura, Tomohiro and Fujiwara, Tsutomu and Kumatori, Atsushi and Ichihara, Akira}, year={1990}, month=oct, pages={41–46} }

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