DOI: 10.1016/0014-5793(89)80961-5. Inhibition of the aspartic proteinase from HIV‐2

Inhibition of the aspartic proteinase from HIV‐2

10.1016/0014-5793(89)80961-5

Crossref journal-article

Wiley

FEBS Letters (311)

Abstract

Kinetic constants were determined for the interaction of the HIV‐2 aspartic proteinase with a synthetic substrate and a number of inhibitors at several pH values. Acetyl‐pepstatin was more effective towards HIV‐2 proteinase than the renin inhibitor, H‐261; this effect is exactly the opposite from that observed previously for the proteinase from the HIV‐1 AIDS virus.

Bibliography

Richards, A. D., Broadhurst, A. V., Ritchie, A. J., Dunn, B. M., & Kay, J. (1989). Inhibition of the aspartic proteinase from HIVâ2. FEBS Letters, 253(1â2), 214â216. Portico.

Authors 5

Anthony D. Richards (first)
Anne V. Broadhurst (additional)
Alison J. Ritchie (additional)
Ben M. Dunn (additional)
John Kay (additional)

References 6 Referenced 26

10.1126/science.2420008
10.1038/337615a0
10.1126/science.2537531
10.1016/0014-5793(89)81251-7
10.1038/326662a0
{'journal-title': 'J. Biol. Chem.', 'year': '1989', 'author': 'Le Grice S.F.J.', 'key': 'e_1_2_1_7_1'} / J. Biol. Chem. by Le Grice S.F.J. (1989)

Dates

Type	When
Created	23 years, 1 month ago (July 25, 2002, 3:45 a.m.)
Deposited	1 year, 11 months ago (Sept. 16, 2023, 3:25 a.m.)
Indexed	11 months, 2 weeks ago (Sept. 15, 2024, 9 p.m.)
Issued	36 years ago (Aug. 14, 1989)
Published	36 years ago (Aug. 14, 1989)
Published Online	23 years, 10 months ago (Oct. 19, 2001)
Published Print	36 years ago (Aug. 14, 1989)

Funders 0

None

BibTeX

@article{Richards_1989, title={Inhibition of the aspartic proteinase from HIV‐2}, volume={253}, ISSN={1873-3468}, url={http://dx.doi.org/10.1016/0014-5793(89)80961-5}, DOI={10.1016/0014-5793(89)80961-5}, number={1–2}, journal={FEBS Letters}, publisher={Wiley}, author={Richards, Anthony D. and Broadhurst, Anne V. and Ritchie, Alison J. and Dunn, Ben M. and Kay, John}, year={1989}, month=aug, pages={214–216} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2024,
        9,
        16
      ]
    ],
    "date-time": "2024-09-16T01:00:59Z",
    "timestamp": 1726448459893
  },
  "reference-count": 6,
  "publisher": "Wiley",
  "issue": "1-2",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2001,
            10,
            19
          ]
        ],
        "date-time": "2001-10-19T00:00:00Z",
        "timestamp": 1003449600000
      },
      "content-version": "vor",
      "delay-in-days": 4449,
      "URL": "http://onlinelibrary.wiley.com/termsAndConditions#vor"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        1989,
        8,
        14
      ]
    ]
  },
  "abstract": "<jats:p>Kinetic constants were determined for the interaction of the HIV\u20102 aspartic proteinase with a synthetic substrate and a number of inhibitors at several pH values. Acetyl\u2010pepstatin was more effective towards HIV\u20102 proteinase than the renin inhibitor, H\u2010261; this effect is exactly the opposite from that observed previously for the proteinase from the HIV\u20101 AIDS virus.</jats:p>",
  "DOI": "10.1016/0014-5793(89)80961-5",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2002,
        7,
        25
      ]
    ],
    "date-time": "2002-07-25T07:45:01Z",
    "timestamp": 1027583101000
  },
  "page": "214-216",
  "source": "Crossref",
  "is-referenced-by-count": 26,
  "title": "Inhibition of the aspartic proteinase from HIV\u20102",
  "prefix": "10.1002",
  "volume": "253",
  "author": [
    {
      "given": "Anthony D.",
      "family": "Richards",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Anne V.",
      "family": "Broadhurst",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Alison J.",
      "family": "Ritchie",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Ben M.",
      "family": "Dunn",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "John",
      "family": "Kay",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "311",
  "published-online": {
    "date-parts": [
      [
        2001,
        10,
        19
      ]
    ]
  },
  "reference": [
    {
      "key": "e_1_2_1_2_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.2420008"
    },
    {
      "key": "e_1_2_1_3_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/337615a0"
    },
    {
      "key": "e_1_2_1_4_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.2537531"
    },
    {
      "key": "e_1_2_1_5_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0014-5793(89)81251-7"
    },
    {
      "key": "e_1_2_1_6_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/326662a0"
    },
    {
      "journal-title": "J. Biol. Chem.",
      "year": "1989",
      "author": "Le Grice S.F.J.",
      "key": "e_1_2_1_7_1"
    }
  ],
  "container-title": "FEBS Letters",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1016%2F0014-5793%2889%2980961-5",
      "content-type": "application/pdf",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1016%2F0014-5793(89)80961-5",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://febs.onlinelibrary.wiley.com/doi/pdf/10.1016/0014-5793%2889%2980961-5",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2023,
        9,
        16
      ]
    ],
    "date-time": "2023-09-16T07:25:44Z",
    "timestamp": 1694849144000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://febs.onlinelibrary.wiley.com/doi/10.1016/0014-5793%2889%2980961-5"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1989,
        8,
        14
      ]
    ]
  },
  "references-count": 6,
  "journal-issue": {
    "issue": "1-2",
    "published-print": {
      "date-parts": [
        [
          1989,
          8,
          14
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1016/0014-5793(89)80961-5"
  ],
  "URL": "http://dx.doi.org/10.1016/0014-5793(89)80961-5",
  "relation": {},
  "ISSN": [
    "0014-5793",
    "1873-3468"
  ],
  "subject": [],
  "container-title-short": "FEBS Letters",
  "published": {
    "date-parts": [
      [
        1989,
        8,
        14
      ]
    ]
  }
}