DOI: 10.1016/0014-5793(89)80948-2. Inhibition of poly(ADP‐ribosyl)ation does not prevent lymphocyte entry into the cell cycle

Inhibition of poly(ADP‐ribosyl)ation does not prevent lymphocyte entry into the cell cycle

10.1016/0014-5793(89)80948-2

Crossref journal-article

Wiley

FEBS Letters (311)

Abstract

The enzyme poly(ADP‐ribosyl)transferase (ADPRT) becomes activated soon after a mitogenic stimulus is applied to lymphocyte cultures. It has also been reported that ADPRT inhibitors prevent cell proliferation when added to cultures at the same time as the mitogen. While this has been ascribed to the need to seal physiologically present DNA strand breaks before cells enter S phase, the presence of DNA strand breaks in quiescent human lymphocytes has been recently questioned. We demonstrate here that non‐toxic concentrations of ADPRT inhibitors do not affect lymphocyte blastization and proliferation, as measured by thymidine incorporation and cytofluorimetry. We therefore suggest that ADPRT activation is required for late functions which are not needed for cell cycle progression.

Bibliography

Marini, M., Zunica, G., Monti, D., Cossarizza, A., Ortolani, C., & Franceschi, C. (1989). Inhibition of poly(ADPâribosyl)ation does not prevent lymphocyte entry into the cell cycle. FEBS Letters, 253(1â2), 146â150. Portico.

Authors 6

Marina Marini (first)
Giovanna Zunica (additional)
Daniela Monti (additional)
Andrea Cossarizza (additional)
Claudio Ortolani (additional)
Claudio Franceschi (additional)

References 36 Referenced 10

10.1016/0163-7258(85)90026-9
10.2307/3576299
10.2307/3576301
10.1111/j.1749-6632.1988.tb22377.x
10.1016/0014-5793(80)81033-7
{'key': 'e_1_2_1_7_1', 'first-page': '685', 'volume': '55', 'author': 'Johnstone A.P.', 'year': '1985', 'journal-title': 'Immunology'} / Immunology by Johnstone A.P. (1985)
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10.1016/0006-291X(83)90541-7
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10.1016/0014-4827(86)90486-6
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10.2307/3576300
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{'key': 'e_1_2_1_27_1', 'first-page': '40', 'author': 'Hoshino J.', 'year': '1989', 'journal-title': 'Fourth European Meeting on ADP-Ribosylation of Proteins, Acta'} / Fourth European Meeting on ADP-Ribosylation of Proteins, Acta by Hoshino J. (1989)
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{'key': 'e_1_2_1_37_1', 'volume-title': 'The Biology of Cell Reproduction', 'author': 'Baserga R.', 'year': '1985'} / The Biology of Cell Reproduction by Baserga R. (1985)

Dates

Type	When
Created	23 years, 1 month ago (July 25, 2002, 3:45 a.m.)
Deposited	1 year, 11 months ago (Sept. 16, 2023, 3:27 a.m.)
Indexed	1 year, 2 months ago (June 14, 2024, 8:32 p.m.)
Issued	36 years ago (Aug. 14, 1989)
Published	36 years ago (Aug. 14, 1989)
Published Online	23 years, 10 months ago (Oct. 19, 2001)
Published Print	36 years ago (Aug. 14, 1989)

Funders 0

None

BibTeX

@article{Marini_1989, title={Inhibition of poly(ADP‐ribosyl)ation does not prevent lymphocyte entry into the cell cycle}, volume={253}, ISSN={1873-3468}, url={http://dx.doi.org/10.1016/0014-5793(89)80948-2}, DOI={10.1016/0014-5793(89)80948-2}, number={1–2}, journal={FEBS Letters}, publisher={Wiley}, author={Marini, Marina and Zunica, Giovanna and Monti, Daniela and Cossarizza, Andrea and Ortolani, Claudio and Franceschi, Claudio}, year={1989}, month=aug, pages={146–150} }

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