DOI: 10.1016/0014-5793(89)80641-6. Structure of the 5′‐external transcribed spacer of the human ribosomal RNA gene

Structure of the 5′‐external transcribed spacer of the human ribosomal RNA gene

10.1016/0014-5793(89)80641-6

Crossref journal-article

Wiley

FEBS Letters (311)

Abstract

We report the complete nucleotide sequence of the 3627 bp long 5′‐external transcribed spacer (ETS) of a human ribosomal RNA gene. This sequence exhibits only very limited homologies with its mouse counterpart, the only other mammalian specimen analyzed so far. It has very peculiar compositional characteristics, with a highly biased base content (very rich in G+C, very poor in A) and also some very strong dinucleotide preferences. Interestingly, these specific features are shared by the mouse sequence, despite the extensive sequence divergence, and also apply to the other transcribed spacers of mammals indicating that a common and strong structural constraint is exerted on all these regions of the ribosomal gene. An outstanding secondary structure can be formed within the human ETS RNA, which could have a significant role in preribosome assembly.

Bibliography

Renalier, M.-H., Mazan, S., Joseph, N., Michot, B., & Bachellerie, J.-P. (1989). Structure of the 5â²âexternal transcribed spacer of the human ribosomal RNA gene. FEBS Letters, 249(2), 279â284. Portico.

Authors 5

Marie-Hélène Renalier (first)
Sylvie Mazan (additional)
Nicole Joseph (additional)
Bernard Michot (additional)
Jean-Pierre Bachellerie (additional)

References 26 Referenced 14

10.1146/annurev.bi.45.070176.003133
{'key': 'e_1_2_1_3_1', 'first-page': '47', 'volume-title': 'Ribosomal RNA processing sites. In: DNA systematics', 'author': 'Crouch R.J.', 'year': '1986'} / Ribosomal RNA processing sites. In: DNA systematics by Crouch R.J. (1986)
10.1093/nar/13.13.4905
10.1128/MCB.7.8.2891
10.1073/pnas.84.3.629
10.1093/nar/8.24.5993
10.1002/j.1460-2075.1983.tb01442.x
10.1093/nar/11.10.3375
10.1093/nar/10.7.2387
10.1093/nar/11.23.8183
10.1089/dna.1988.7.181
{'key': 'e_1_2_1_13_1', 'author': 'Rénalier M.H.', 'year': '1989', 'journal-title': 'FEBS Lett.'} / FEBS Lett. by Rénalier M.H. (1989)
10.1073/pnas.80.17.5225
10.1093/nar/9.2.309
10.1073/pnas.74.12.5463
10.1073/pnas.79.10.3092
10.1093/nar/9.1.133
10.1093/nar/12.1Part1.387
{'key': 'e_1_2_1_20_1', 'first-page': '203', 'volume': '4', 'author': 'Levinson G.', 'year': '1987', 'journal-title': 'Mol. Biol. Evol.'} / Mol. Biol. Evol. by Levinson G. (1987)
10.1093/nar/10.17.5303
10.1089/dna.1987.6.13
10.1093/nar/12.3.1749
10.1016/0092-8674(88)90471-0
10.1016/0022-2836(74)90527-0
10.1016/0022-2836(75)90217-X
10.1016/0014-5793(84)80139-8

Dates

Type	When
Created	23 years, 1 month ago (July 25, 2002, 3:45 a.m.)
Deposited	1 year, 11 months ago (Sept. 17, 2023, 1:50 a.m.)
Indexed	1 year, 7 months ago (Jan. 3, 2024, 7:20 p.m.)
Issued	36 years, 2 months ago (June 5, 1989)
Published	36 years, 2 months ago (June 5, 1989)
Published Online	23 years, 10 months ago (Oct. 19, 2001)
Published Print	36 years, 2 months ago (June 5, 1989)

Funders 0

None

BibTeX

@article{Renalier_1989, title={Structure of the 5′‐external transcribed spacer of the human ribosomal RNA gene}, volume={249}, ISSN={1873-3468}, url={http://dx.doi.org/10.1016/0014-5793(89)80641-6}, DOI={10.1016/0014-5793(89)80641-6}, number={2}, journal={FEBS Letters}, publisher={Wiley}, author={Renalier, Marie-Hélène and Mazan, Sylvie and Joseph, Nicole and Michot, Bernard and Bachellerie, Jean-Pierre}, year={1989}, month=jun, pages={279–284} }

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