DOI: 10.1016/0014-5793(89)80279-0. Nonmuscle actin ADP‐ribosylated by botulinum C2 toxin caps actin filaments

Nonmuscle actin ADP‐ribosylated by botulinum C2 toxin caps actin filaments

10.1016/0014-5793(89)80279-0

Crossref journal-article

Wiley

FEBS Letters (311)

Abstract

The effect of nonmuscle actin ADP‐ribosylated by botulinum C2 toxin on the polymerization of nonmuscle actin was investigated in order to clarify whether nonmuscle actin is converted into a capping protein by ADP‐ribosylation. ADP‐ribosylated actin was found to decrease the rate of polymerization of actin filaments which are free at both ends. ADP‐ribosylated actin turned out to have no effect on the rate or extent of polymerization at the pointed ends of actin filaments the barbed ends of which were capped by gelsolin. The monomer concentration reached at the final stage of polymerization was similar to the critical concentration of the pointed ends of actin filaments. The results suggest that nonmuscle actin ADP‐ribosylated by botulinum C2 toxin acts as a capping protein which binds to the barbed ends to inhibit polymerization.

Bibliography

Weigt, C., Just, I., Wegner, A., & Aktories, K. (1989). Nonmuscle actin ADPâribosylated by botulinum C2 toxin caps actin filaments. FEBS Letters, 246(1â2), 181â184. Portico.

Authors 4

Christiane Weigt (first)
Ingo Just (additional)
Albrecht Wegner (additional)
Klaus Aktories (additional)

References 24 Referenced 53

10.1007/978-3-642-71399-6_2
10.1016/0165-6147(87)90153-2
10.1128/iai.30.3.668-673.1980
10.1128/iai.40.2.691-695.1983
{'key': 'e_1_2_1_6_1', 'first-page': '665', 'volume': '230', 'author': 'Simpson L.L.', 'year': '1984', 'journal-title': 'J. Pharmacol. Exp. Ther.'} / J. Pharmacol. Exp. Ther. by Simpson L.L. (1984)
10.1038/322390a0
10.1111/j.1432-1033.1986.tb10136.x
{'key': 'e_1_2_1_9_1', 'first-page': '695', 'volume': '223', 'author': 'Simpson L.L.', 'year': '1982', 'journal-title': 'J. Pharmacol. Exp. Ther.'} / J. Pharmacol. Exp. Ther. by Simpson L.L. (1982)
{'key': 'e_1_2_1_10_1', 'first-page': '134', 'volume': '43', 'author': 'Reuner K.H.', 'year': '1987', 'journal-title': 'Eur. J. Cell Biol.'} / Eur. J. Cell Biol. by Reuner K.H. (1987)
10.1111/j.1574-6968.1984.tb01078.x
10.1016/S0021-9258(18)68303-6
10.1111/j.1432-0436.1979.tb01021.x
10.1515/znc-1983-9-1025
10.1016/S0022-2836(76)80100-3
10.1016/S0021-9258(19)70103-3
10.1111/j.1432-1033.1988.tb13780.x
10.1016/0005-2736(73)90475-6
10.1172/JCI110578
10.1016/0022-2836(86)90341-4
10.1021/bi00325a035
10.1016/S0006-291X(88)80435-2
10.1128/iai.56.9.2299-2306.1988
10.1016/S0021-9258(19)35408-0
10.1016/0014-5793(87)81129-8

Dates

Type	When
Created	23 years, 1 month ago (July 24, 2002, 11:45 p.m.)
Deposited	1 year, 11 months ago (Sept. 15, 2023, 4:30 p.m.)
Indexed	11 months, 2 weeks ago (Sept. 15, 2024, 9 p.m.)
Issued	36 years, 5 months ago (March 27, 1989)
Published	36 years, 5 months ago (March 27, 1989)
Published Online	23 years, 10 months ago (Oct. 23, 2001)
Published Print	36 years, 5 months ago (March 27, 1989)

Funders 0

None

BibTeX

@article{Weigt_1989, title={Nonmuscle actin ADP‐ribosylated by botulinum C2 toxin caps actin filaments}, volume={246}, ISSN={1873-3468}, url={http://dx.doi.org/10.1016/0014-5793(89)80279-0}, DOI={10.1016/0014-5793(89)80279-0}, number={1–2}, journal={FEBS Letters}, publisher={Wiley}, author={Weigt, Christiane and Just, Ingo and Wegner, Albrecht and Aktories, Klaus}, year={1989}, month=mar, pages={181–184} }

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