DOI: 10.1016/0014-5793(88)80285-0. Amino acid sequence of rat liver cathepsin L

Amino acid sequence of rat liver cathepsin L

10.1016/0014-5793(88)80285-0

Crossref journal-article

Wiley

FEBS Letters (311)

Abstract

The complete amino acid sequences of the heavy and light chains of rat liver cathepsin L (EC 3.4.22.15) were determined at the protein level. The heavy and light chains consisted of 175 and 44 amino acid residues, respectively, and their M r values without glycosyl groups calculated from these sequences were 18941 and 5056, respectively. The amino acid sequence was also determined from the N‐terminal sequences of the heavy and light chains, and the sequences of cleavage fragments of the heavy chain with lysylendopeptidase and cyanogen bromide. The fragments were aligned by comparison with the amino acid sequence deduced from the sequence of cDNA of rat preprocathepsin L. The sequence of rat liver cathepsin L determined at the protein level was identical with that deduced from the cDNA sequence except that in the heavy chain, residues 176–177 (Asp‐Ser) were not present at the C‐terminus and alanine was replaced by proline at residue 125. Asn‐108 in the heavy chain is modified with carbohydrate.

Bibliography

Towatari, T., & Katunuma, N. (1988). Amino acid sequence of rat liver cathepsin L. FEBS Letters, 236(1), 57â61. Portico.

Authors 2

Takae Towatari (first)
Nobuhiko Katunuma (additional)

References 20 Referenced 31

10.1016/B978-0-08-027377-8.50013-0
10.1016/S0076-6879(81)80043-2
10.1111/j.1432-1033.1977.tb11393.x
10.1016/0014-5793(76)80548-0
10.1093/oxfordjournals.jbchem.a132171
10.1042/bj2170209
{'key': 'e_1_2_1_8_1', 'first-page': '33', 'volume': '87', 'author': 'Okitani A.', 'year': '1980', 'journal-title': 'J. Biochem. (Tokyo)'} / J. Biochem. (Tokyo) by Okitani A. (1980)
10.1093/oxfordjournals.jbchem.a121703
10.1016/0014-5793(86)81137-1
10.1111/j.1432-1033.1987.tb13298.x
10.1021/bi00392a017
10.1016/0014-5793(88)80028-0
10.1016/S0021-9258(18)66927-3
10.1016/0014-5793(87)80511-2
10.1016/S0065-3233(08)60279-X
10.1016/S0006-291X(80)80173-2
10.1093/oxfordjournals.jbchem.a121882
10.1016/S0021-9258(19)73948-9
{'key': 'e_1_2_1_20_1', 'author': 'Hara K.', 'year': '1988', 'journal-title': 'FEBS Lett.'} / FEBS Lett. by Hara K. (1988)
10.1073/pnas.80.12.3666

Dates

Type	When
Created	23 years, 1 month ago (July 25, 2002, 3:45 a.m.)
Deposited	1 year, 11 months ago (Sept. 16, 2023, 7:54 p.m.)
Indexed	1 year, 2 months ago (June 19, 2024, 7:58 a.m.)
Issued	37 years ago (Aug. 15, 1988)
Published	37 years ago (Aug. 15, 1988)
Published Online	23 years, 10 months ago (Oct. 19, 2001)
Published Print	37 years ago (Aug. 15, 1988)

Funders 0

None

BibTeX

@article{Towatari_1988, title={Amino acid sequence of rat liver cathepsin L}, volume={236}, ISSN={1873-3468}, url={http://dx.doi.org/10.1016/0014-5793(88)80285-0}, DOI={10.1016/0014-5793(88)80285-0}, number={1}, journal={FEBS Letters}, publisher={Wiley}, author={Towatari, Takae and Katunuma, Nobuhiko}, year={1988}, month=aug, pages={57–61} }

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