DOI: 10.1016/0014-5793(88)80064-4. Differential down‐regulation of protein kinase C subspecies in KM3 cells

Differential down‐regulation of protein kinase C subspecies in KM3 cells

10.1016/0014-5793(88)80064-4

Crossref journal-article

Wiley

FEBS Letters (311)

Abstract

The down‐regulation of protein kinase C (PKC) subspecies in KM3 cells (a pre‐B, pre‐T cell line) has been examined. The PKC from KM3 cells was resolved into two subspecies, type II (mainly βII) and type III (α), upon hydroxyapatite column chromatography. Biochemical and immunocytochemical analysis revealed that, when these cells were treated with 12‐O‐tetradecanoylphorbol 13‐acetate (TPA), the time course of down‐regulation of the PKC subspecies was different; type II PKC was translocated and depleted from the cell more quickly than type III enzyme. The results suggest that each PKC subspecies plays a different role in the cellular response to TPA and probably to other external stimuli.

Bibliography

Ase, K., Berry, N., Kikkawa, U., Kishimoto, A., & Nishizuka, Y. (1988). Differential downâregulation of protein kinase C subspecies in KM3 cells. FEBS Letters, 236(2), 396â400. Portico.

Authors 5

Katsuhiko Ase (first)
Nicola Berry (additional)
Ushio Kikkawa (additional)
Akira Kishimoto (additional)
Yasutomi Nishizuka (additional)

References 23 Referenced 89

10.1038/308693a0
10.1126/science.3014651
10.1016/S0021-9258(18)34459-4
10.1073/pnas.80.1.36
10.1038/301621a0
10.1016/S0006-291X(84)80213-2
10.1016/S0021-9258(18)33173-9
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{'key': 'e_1_2_1_19_1', 'author': 'Shearman M.S.', 'year': '1988', 'journal-title': 'FEBS Lett.'} / FEBS Lett. by Shearman M.S. (1988)
10.1016/0145-2126(84)90142-5
10.1016/0014-5793(88)80698-7
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10.1038/330767a0
10.1002/jcp.1041300116

Dates

Type	When
Created	23 years, 1 month ago (July 25, 2002, 3:45 a.m.)
Deposited	1 year, 11 months ago (Sept. 16, 2023, 7:16 a.m.)
Indexed	1 year, 2 months ago (June 17, 2024, 4:29 p.m.)
Issued	37 years ago (Aug. 29, 1988)
Published	37 years ago (Aug. 29, 1988)
Published Online	23 years, 10 months ago (Oct. 19, 2001)
Published Print	37 years ago (Aug. 29, 1988)

Funders 0

None

BibTeX

@article{Ase_1988, title={Differential down‐regulation of protein kinase C subspecies in KM3 cells}, volume={236}, ISSN={1873-3468}, url={http://dx.doi.org/10.1016/0014-5793(88)80064-4}, DOI={10.1016/0014-5793(88)80064-4}, number={2}, journal={FEBS Letters}, publisher={Wiley}, author={Ase, Katsuhiko and Berry, Nicola and Kikkawa, Ushio and Kishimoto, Akira and Nishizuka, Yasutomi}, year={1988}, month=aug, pages={396–400} }

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