DOI: 10.1016/0014-5793(87)80828-1. Calcium‐activated neutral protease and its endogenous inhibitor Activation at the cell membrane and biological function

Calcium‐activated neutral protease and its endogenous inhibitor Activation at the cell membrane and biological function

10.1016/0014-5793(87)80828-1

Crossref journal-article

Wiley

FEBS Letters (311)

Abstract

The structures of calcium‐activated neutral protease (CANP) and its endogenous inhibitor elucidated recently have revealed novel features with respect to their structure‐function relationship and enzyme activity regulation. The protease is regarded as a proenzyme which can be activated at the cell membrane in the presence of Ca2+ and phospholipid, and presumably regulates the functions of proteins, especially membrane‐associated proteins, by limited proteolysis. Protein kinase C is hydrolysed and activated by CANP at the cell membrane to a cofactor‐independent form. These results are reviewed and the possible involvement of CANP in signal transduction is discussed.

Bibliography

Suzuki, K., Imajoh, S., Emori, Y., Kawasaki, H., Minami, Y., & Ohno, S. (1987). Calciumâactivated neutral protease and its endogenous inhibitor Activation at the cell membrane and biological function. FEBS Letters, 220(2), 271â277. Portico.

Authors 6

Koichi Suzuki (first)
Shinobu Imajoh (additional)
Yasufumi Emori (additional)
Hiroshi Kawasaki (additional)
Yasufumi Minami (additional)
Shigeo Ohno (additional)

References 49 Referenced 227

1983 Academic Press New York T. Murachi W.Y. Cheung Calcium and Cell Function 377 410
1984 Academic Press New York K. Suzuki S. Kawashima K. Imahori S. Ebashi Calcium Regulation in Biological Systems 213 226
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10.1146/annurev.bi.55.070186.002323
10.1016/0968-0004(87)90048-X
{'key': 'e_1_2_1_7_1', 'volume': '5', 'author': 'Suzuki K.', 'year': '1987', 'journal-title': 'Prog. Clin. Biochem. Med.'} / Prog. Clin. Biochem. Med. by Suzuki K. (1987)
10.1042/bj2300509
10.1515/bchm3.1986.367.2.1147
10.1016/S0021-9258(18)90773-8
10.1093/oxfordjournals.jbchem.a135622
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10.1073/pnas.82.18.6075
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10.1016/0167-4838(85)90116-5
10.1016/S0021-9258(18)66963-7
1986 Elsevier Amsterdam New York C. Parkes A.J. Barrett G. Salvessen Proteinase Inhibitors 571 587
10.1016/0006-291X(87)91517-8
10.1042/bj2350097
10.1073/pnas.84.11.3590
{'key': 'e_1_2_1_32_1', 'author': 'Imajoh S.', 'year': '1987', 'journal-title': 'Biochem. Biophys. Res. Commun.'} / Biochem. Biophys. Res. Commun. by Imajoh S. (1987)
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10.1042/bj2340429
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10.1126/science.3014651
10.1073/pnas.82.19.6435
10.1111/j.1432-1033.1985.tb09118.x
10.1016/S0021-9258(17)35629-6
10.1016/0006-291X(86)90954-X
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10.1038/325161a0
10.1126/science.3755547
10.1016/0092-8674(86)90874-3
10.1038/325107a0
{'key': 'e_1_2_1_50_1', 'first-page': '3000', 'volume': '46', 'author': 'Hoshijima M.', 'year': '1986', 'journal-title': 'Cancer Res.'} / Cancer Res. by Hoshijima M. (1986)

Dates

Type	When
Created	23 years, 1 month ago (July 25, 2002, 3:57 a.m.)
Deposited	1 year, 11 months ago (Sept. 16, 2023, 11:07 p.m.)
Indexed	1 month, 3 weeks ago (July 11, 2025, 6:22 a.m.)
Issued	38 years ago (Aug. 17, 1987)
Published	38 years ago (Aug. 17, 1987)
Published Online	23 years, 10 months ago (Oct. 19, 2001)
Published Print	38 years ago (Aug. 17, 1987)

Funders 0

None

BibTeX

@article{Suzuki_1987, title={Calcium‐activated neutral protease and its endogenous inhibitor Activation at the cell membrane and biological function}, volume={220}, ISSN={1873-3468}, url={http://dx.doi.org/10.1016/0014-5793(87)80828-1}, DOI={10.1016/0014-5793(87)80828-1}, number={2}, journal={FEBS Letters}, publisher={Wiley}, author={Suzuki, Koichi and Imajoh, Shinobu and Emori, Yasufumi and Kawasaki, Hiroshi and Minami, Yasufumi and Ohno, Shigeo}, year={1987}, month=aug, pages={271–277} }

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