DOI: 10.1016/0014-5793(87)80670-1. Protein kinase C phosphorylates tau and induces its functional alterations

Protein kinase C phosphorylates tau and induces its functional alterations

10.1016/0014-5793(87)80670-1

Crossref journal-article

Wiley

FEBS Letters (311)

Abstract

We found that tau, one of the major microtubule‐associated proteins, is a good substrate for protein kinase C. The phosphorylation occurred mainly on serine residues and the sites phosphorylated by protein kinase C were largely different from those phosphorylated by cAMP‐dependent protein kinase as analyzed by phosphopeptide mapping. The protein kinase C‐mediated phosphorylation of tau reduced its abilities to promote tubulin polymerization and to cross‐link actin filaments. The reduction in its abilities was in proportion to the number of phosphates incorporated into tau.

Bibliography

Hoshi, M., Nishida, E., Miyata, Y., Sakai, H., Miyoshi, T., Ogawara, H., & Akiyama, T. (1987). Protein kinase C phosphorylates tau and induces its functional alterations. FEBS Letters, 217(2), 237â241. Portico.

Authors 7

Minako Hoshi (first)
Eisuke Nishida (additional)
Yoshihiko Miyata (additional)
Hikoichi Sakai (additional)
Tomoko Miyoshi (additional)
Hiroshi Ogawara (additional)
Tetsu Akiyama (additional)

References 22 Referenced 60

10.1038/308693a0
10.1016/S0021-9258(18)66765-1
10.1016/0092-8674(79)90055-2
10.1083/jcb.99.3.1045
10.1073/pnas.72.5.1858
10.1016/0022-2836(77)90213-3
10.1016/0022-2836(77)90214-5
10.1083/jcb.103.6.2739
10.1016/B978-0-12-615080-3.50033-1
10.1016/S0021-9258(18)69265-8
10.1016/S0021-9258(19)85149-9
10.1016/S0021-9258(18)90743-X
{'key': 'e_1_2_1_14_1', 'first-page': '1257', 'volume': '85', 'author': 'Nishida E.', 'year': '1979', 'journal-title': 'J. Biochem.'} / J. Biochem. by Nishida E. (1979)
10.1016/S0021-9258(18)62016-2
10.1021/bi00317a032
10.1038/227680a0
10.1083/jcb.85.2.414
10.1016/0006-291X(83)90991-9
10.1111/j.1471-4159.1985.tb12880.x
10.1093/oxfordjournals.jbchem.a135662
10.1073/pnas.83.13.4913
10.1097/00005072-198205000-00079

Dates

Type	When
Created	23 years, 1 month ago (July 25, 2002, 3:57 a.m.)
Deposited	1 year, 11 months ago (Sept. 16, 2023, 11:13 p.m.)
Indexed	1 year ago (Aug. 8, 2024, 5:54 p.m.)
Issued	38 years, 2 months ago (June 15, 1987)
Published	38 years, 2 months ago (June 15, 1987)
Published Online	23 years, 10 months ago (Oct. 19, 2001)
Published Print	38 years, 2 months ago (June 15, 1987)

Funders 0

None

BibTeX

@article{Hoshi_1987, title={Protein kinase C phosphorylates tau and induces its functional alterations}, volume={217}, ISSN={1873-3468}, url={http://dx.doi.org/10.1016/0014-5793(87)80670-1}, DOI={10.1016/0014-5793(87)80670-1}, number={2}, journal={FEBS Letters}, publisher={Wiley}, author={Hoshi, Minako and Nishida, Eisuke and Miyata, Yoshihiko and Sakai, Hikoichi and Miyoshi, Tomoko and Ogawara, Hiroshi and Akiyama, Tetsu}, year={1987}, month=jun, pages={237–241} }

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