DOI: 10.1016/0014-5793(87)80446-5. Tight control of the amount of yeast plasma membrane ATPase during changes in growth conditions and gene dosage

Tight control of the amount of yeast plasma membrane ATPase during changes in growth conditions and gene dosage

10.1016/0014-5793(87)80446-5

Crossref journal-article

Wiley

FEBS Letters (311)

Abstract

The activity of the plasma membrane ATPase in growing yeast is increased by low pH and by glucose, conditions which result in a higher demand for proton pumping. The amount of enzyme is not significatively modified under these conditions. The amount of ATPase is only slightly increased by introducing extra copies of its gene in autonomous plasmids. In addition, the expression of the ATPase gene in a multi‐copy plasmid causes a reduction of the copy number of the plasmid and slows growth. Therefore, overexpression of the ATPase is detrimental for the cell, justifying a regulatory mechanism based on increasing the catalytic activity and not the amount of enzyme.

Bibliography

Eraso, P., Cid, A., & Serrano, R. (1987). Tight control of the amount of yeast plasma membrane ATPase during changes in growth conditions and gene dosage. FEBS Letters, 224(1), 193â197. Portico.

Authors 3

Pilar Eraso (first)
Angel Cid (additional)
Ramón Serrano (additional)

References 24 Referenced 59

1985 CRC Press Boca Raton FL R. Serrano Plasma Membrane ATPase of Plants and Fungi
10.1038/319689a0
10.1007/BF00434664
10.1016/0014-5793(83)80237-3
10.1016/0006-291X(85)91223-9
10.1111/j.1432-1033.1987.tb11067.x
10.1073/pnas.79.23.7410
10.1128/MCB.4.8.1440
10.1016/0076-6879(83)01024-1
10.1128/jb.153.1.163-168.1983
10.1016/0003-2697(76)90527-3
10.1073/pnas.81.6.1684
10.1016/0092-8674(82)90384-1
1985 IRL Press Oxford M.L.M. Anderson B.D. Young B.D. Hames S.J. Higgins Nucleic Acid Hybridisation: a Practical Approach 73 111
10.1016/0003-2697(83)90418-9
10.1016/0378-1119(79)90004-0
10.1016/0014-5793(87)80445-3
10.1016/S0021-9258(17)36138-0
10.1016/S0021-9258(18)67613-6
10.1073/pnas.80.22.6750
10.1016/0378-1119(84)90172-0
10.1128/MCB.2.8.977
10.1073/pnas.81.20.6276
10.1111/j.1432-1033.1980.tb04516.x

Dates

Type	When
Created	23 years, 1 month ago (July 25, 2002, 5:10 a.m.)
Deposited	1 year, 11 months ago (Sept. 16, 2023, 4:10 p.m.)
Indexed	2 months ago (July 2, 2025, 3:07 p.m.)
Issued	37 years, 9 months ago (Nov. 16, 1987)
Published	37 years, 9 months ago (Nov. 16, 1987)
Published Online	23 years, 10 months ago (Oct. 19, 2001)
Published Print	37 years, 9 months ago (Nov. 16, 1987)

Funders 0

None

BibTeX

@article{Eraso_1987, title={Tight control of the amount of yeast plasma membrane ATPase during changes in growth conditions and gene dosage}, volume={224}, ISSN={1873-3468}, url={http://dx.doi.org/10.1016/0014-5793(87)80446-5}, DOI={10.1016/0014-5793(87)80446-5}, number={1}, journal={FEBS Letters}, publisher={Wiley}, author={Eraso, Pilar and Cid, Angel and Serrano, Ramón}, year={1987}, month=nov, pages={193–197} }

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