DOI: 10.1016/0014-5793(85)80289-1. α‐MSH and neurofilament M‐protein share a continuous epitope but not extended sequences

α‐MSH and neurofilament M‐protein share a continuous epitope but not extended sequences

10.1016/0014-5793(85)80289-1

Crossref journal-article

Wiley

FEBS Letters (311)

Abstract

The long recognized neurofibrillary immunoreactivity of the nervous system with α‐MSH antibodies arises from an epitope on neurofilament M‐protein which we have now characterized. It is situated in the amino terminal residues where M‐protein and α‐MSH exhibit similar but not identical sequences. Their divergence past residue 5 precludes a physiological significance of the crossreactivity which seems to have arisen fortuitously. Our results question previous speculations as to the existence of extrapituitary α‐MSH‐like hormones.

Bibliography

Shaw, G., Fischer, S., & Weber, K. (1985). Î±âMSH and neurofilament Mâprotein share a continuous epitope but not extended sequences. FEBS Letters, 181(2), 343â346. Portico.

Authors 3

Gerry Shaw (first)
Stefan Fischer (additional)
Klaus Weber (additional)

References 16 Referenced 24

10.1146/annurev.bi.53.070184.003313
10.1073/pnas.80.20.6408
10.1016/0304-3940(78)90219-7
10.1159/000122796
10.1016/0006-8993(79)90873-4
10.1016/0006-8993(80)90849-5
10.1083/jcb.66.2.351
10.1016/S0021-9258(18)33008-4
10.1002/j.1460-2075.1984.tb02196.x
10.1002/j.1460-2075.1982.tb01368.x
10.1002/j.1460-2075.1984.tb01965.x
{'key': 'e_1_2_1_13_1', 'first-page': '130', 'volume': '34', 'author': 'Shaw G.', 'year': '1984', 'journal-title': 'Eur. J. Cell Biol.'} / Eur. J. Cell Biol. by Shaw G. (1984)
10.1038/311123a0
10.1038/186922a0
10.1073/pnas.46.11.1463
10.1038/312127a0

Dates

Type	When
Created	23 years, 1 month ago (July 25, 2002, 3:58 a.m.)
Deposited	1 year, 11 months ago (Sept. 16, 2023, 4:31 a.m.)
Indexed	1 month, 2 weeks ago (July 14, 2025, 11:36 p.m.)
Issued	40 years, 6 months ago (Feb. 25, 1985)
Published	40 years, 6 months ago (Feb. 25, 1985)
Published Online	23 years, 9 months ago (Nov. 2, 2001)
Published Print	40 years, 6 months ago (Feb. 25, 1985)

Funders 0

None

BibTeX

@article{Shaw_1985, title={α‐MSH and neurofilament M‐protein share a continuous epitope but not extended sequences: An explanation for neurofibrillary staining with α‐MSH antibodies}, volume={181}, ISSN={1873-3468}, url={http://dx.doi.org/10.1016/0014-5793(85)80289-1}, DOI={10.1016/0014-5793(85)80289-1}, number={2}, journal={FEBS Letters}, publisher={Wiley}, author={Shaw, Gerry and Fischer, Stefan and Weber, Klaus}, year={1985}, month=feb, pages={343–346} }

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