DOI: 10.1016/0006-8993(86)90127-7. CPP, a new potent and selective NMDA antagonist. Depression of central neuron responses, affinity for [3H]d-AP5 binding sites on brain membranes and anticonvulsant activity

CPP, a new potent and selective NMDA antagonist. Depression of central neuron responses, affinity for [3H]d-AP5 binding sites on brain membranes and anticonvulsant activity

10.1016/0006-8993(86)90127-7

Crossref journal-article

Elsevier BV

Brain Research (78)

Bibliography

Davies, J., Evans, R. H., Herrling, P. L., Jones, A. W., Olverman, H. J., Pook, P., & Watkins, J. C. (1986). CPP, a new potent and selective NMDA antagonist. Depression of central neuron responses, affinity for [3H]d-AP5 binding sites on brain membranes and anticonvulsant activity. Brain Research, 382(1), 169â173.

Authors 7

J. Davies (first)
R.H. Evans (additional)
P.L. Herrling (additional)
A.W. Jones (additional)
H.J. Olverman (additional)
P. Pook (additional)
J.C. Watkins (additional)

References 20 Referenced 271

Chapman, A.G., Meldrum, B.S., Nanji, M.J. and Watkins, J.C., Anticonvulsant and neurochemical action in DBA/2 mice of a novel piperazine derivative that acts on the NMDA receptor,Soc. Neuroscie. Abstr., in press.
Davies, J., Miller, A.S. and Sheardown, M.J., Amino acid receptor mediated excitatory synpatic transmission in the cat red nucleus,J. Physiol. (London), in press.
{'key': '10.1016/0006-8993(86)90127-7_bib3', 'first-page': '43', 'article-title': 'Recent advances in the pharmacology of excitatory amino acids in the mammalian central nervous system', 'volume': 'Vol. 39', 'author': 'Davies', 'year': '1983'} / Recent advances in the pharmacology of excitatory amino acids in the mammalian central nervous system by Davies (1983)
10.1016/0304-3940(81)90061-6 / Neurosci. Lett. / 2-Amino-5-phosphonovalerate (2APV), a potent and selective antagonist of amino acid-induced and synaptic excitation by Davies (1981)
10.1016/0006-8993(82)91017-4 / Brain Research / Actions ofd andl forms of 2-Amino-5-phosphonovalerate and 2-amino-4-phosphonobutyrate in the cat spinal cord by Davies (1982)
10.1007/BF00238587 / Exp. Brain Res. / Role of excitatory amino acid receptors in mono- and polysynaptic excitation in the cat spinal cord by Davies (1983)
10.1111/j.1476-5381.1979.tb08706.x / Br. J. Pharmacol. / Antagonism of excitatory amino acid-induced responses and of synaptic excitation in the isolated spinal cord of the frog by Evans (1979)
10.1111/j.1476-5381.1982.tb08758.x / Br. J. Pharmacol. / The effect of a series of ω-phosphonic α-car☐ylic amino acids on electrically evoked and amino acid induced responses in isolated spinal cord preparations by Evans (1982)
10.1016/0014-2999(78)90007-9 / Eur. J. Pharmacol. / Specific antagonism of excitant amino acids in the neonatal isolated spinal cord preparation by Evans (1978)
10.1016/0006-8993(86)90128-9 / Brain Research / Actions of 3-((±)-2-car☐ypipe-razin-4-yl)propyl-1-phosphonic acid, a new and highly potent antagonist of N-methyl-d-aspartate receptors in the hippocampus by Harris (1986)
10.1016/0306-4522(84)90250-1 / Neuroscience / Structure-activity relations of dipeptide antagonists of excitatory amino acids by Jones (1984)
10.1016/0301-0082(83)90004-7 / Progr. Neurobiol. / Receptors for the excitatory amino acids in the mammalian central nervous system by McLennan (1983)
10.1042/cs0680113 / Clin. Sci. / Possible therapeutic applications of antagonists of excitatory amino acid neurotransmitters by Meldrum (1985)
10.1038/307460a0 / Nature (London) / l-Glutamate has higher affinity than other amino acids for [3H]-d-AP5 binding sites in rat brain mebmranes by Olverman (1984)
10.1016/0304-3940(82)90230-0 / Neurosci. Lett. / Isomers of 2-amino-7-phosphonoheptanoic acid as antagonists of neuronal excitants by Perkins (1982)
10.1016/0304-3940(81)90021-5 / Neurosci. Lett. / Phosphonate analogues of car☐ylic acids as amino acid antagonists on rat cortical neurones by Perkins (1981)
10.1126/science.6093256 / Science / Blockade of NMDA receptors may protect aginst inschaemic damage in the brain by Simon (1984)
10.1016/0304-3940(85)90558-0 / Neurosci. Lett. / Muscle relaxant action of excitatory amino acid antagonists by Turski (1985)
10.1146/annurev.pa.21.040181.001121 / Annu. Rev. Pharmacol. Toxicol. / Excitatory amino acid transmitters by Watkins (1981)
{'key': '10.1016/0006-8993(86)90127-7_bib20', 'series-title': 'Piperazine derivatives', 'author': 'Watkins', 'year': '1985'} / Piperazine derivatives by Watkins (1985)

Dates

Type	When
Created	22 years, 3 months ago (April 24, 2003, 11:52 a.m.)
Deposited	6 years, 4 months ago (March 23, 2019, 4:52 a.m.)
Indexed	1 month, 4 weeks ago (June 25, 2025, 12:27 a.m.)
Issued	38 years, 11 months ago (Sept. 1, 1986)
Published	38 years, 11 months ago (Sept. 1, 1986)
Published Print	38 years, 11 months ago (Sept. 1, 1986)

Funders 0

None

BibTeX

@article{Davies_1986, title={CPP, a new potent and selective NMDA antagonist. Depression of central neuron responses, affinity for [3H]d-AP5 binding sites on brain membranes and anticonvulsant activity}, volume={382}, ISSN={0006-8993}, url={http://dx.doi.org/10.1016/0006-8993(86)90127-7}, DOI={10.1016/0006-8993(86)90127-7}, number={1}, journal={Brain Research}, publisher={Elsevier BV}, author={Davies, J. and Evans, R.H. and Herrling, P.L. and Jones, A.W. and Olverman, H.J. and Pook, P. and Watkins, J.C.}, year={1986}, month=sep, pages={169–173} }

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